Our recent paper offers insights into unligated Okazaki fragment by the absence of Rad27/FEN-1 leading to severe rDNA copy number changes. doi.org/10.1002/1873...

The paper from our lab came out on how the histone chaperone CAF-1 prevents the formation of circular rDNA! doi.org/10.1093/nar/...

congratulations to our DB colleague Maria Jasin, recognized by the Greengard Prize! when she started her lab @mskcancercenter.bsky.social, she was the first to insert DNA into a defined location of a mammalian genome! her work underlies today's CRISPR-mediated HDR. here in convo with Rick Lifton.🧬

Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Congratulations! #WomenInScience

Our preprint on Pol-η usage during genome replication has been uploaded. It addresses the biased use of Pol-η in the lagging strand and late-replicating regions, which may be correlated with cancer mutagenesis. www.biorxiv.org/content/10.1...

While our judges deliberate the top 3 winners of MSK Postdoc Slam, let’s celebrate our #NPAW2025 📸 contest champs! 🎉 🥇 @meganekelley.bsky.social – @agnelsfeir.bsky.social lab 🥈 Zhendong Cao – @sawyerslabmskcc.bsky.social 🥉 Manendra Lankadasari – Jones lab Congrats to our amazing #MSKPostdocs! 👏📷

Excited to join the @cri-utsw.bsky.social community to advance discoveries in genome instability. We are grateful to UTSW Pathology for 6 wonderful years. 🚨 We are also recruiting motivated postdocs to study how mitotic errors and aberrant nuclear structures drive cancer genome evolution—join us!

#ecDNA is reshaping biomedical science. Now recognized as a key player in ~30% of cancer patients, understanding its biology could unlock new therapeutic strategies for #cancer & other diseases. Join us at #ecDNA25 for discussions at the forefront of this rapidly advancing field ➡️ bit.ly/XecDNA25

🎉 Exciting News! 🎉 Registration grants have been released to support ECR's attending #ecDNA25! Don't miss the chance to engage with cutting-edge research & connect with experts in the field. 🌟Find out more: bit.ly/XecDNA25

Early bird & talk submission close on 01 May 2025 for #ecDNA25! 🧬 Join us in Riviera Maya for a packed program featuring top speakers & cutting-edge science 💰 Travel grants available 🎉 Bonus: it’s Día de los Muertos - experience the Mexican culture! Register & submit: bit.ly/3YmCmBY

Combining bacterial end joining with programmable nucleases, we induced mtDNA deletions in human cells at varying heteroplasmy and examined their metabolic and cellular effects. Simple tool to apply across any cell type and engineer pathogenic mtDNA deletions. www.sciencedirect.com/science/arti...

Our new preprint is out＠bioRxiv: www.biorxiv.org/content/10.1... @masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/

Here we go! #newPI #WomenInSTEM @mskeducation.bsky.social @mskcancercenter.bsky.social

How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!

Also see two accompanying papers by the labs of Scott Keeney and Ming-Han Tong reporting similar findings, focusing on the SPO11-TOP6BL complex. www.nature.com/articles/s41... www.nature.com/articles/s41... And here is a nice News&views by Mendez Diaz and Corbett. www.nature.com/articles/d41...

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

Our new review on how the #chromatin domain is formed in the cell is now available @Curr Opin Struct Biol.📄✨ We critically discuss the domain formation mechanism from a physical perspective, including #phase-separation and #condensation. 📥 Free-download link: authors.elsevier.com/a/1keGn,LqAr...

🥳Just published @nature.com. Over 25 years after the discovery of SPO11 as the enzyme responsible for initiating meiotic recombination, we finally succeeded in reconstituting its DNA cleavage activity.🧵 www.nature.com/articles/s41...

🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/... Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social

Job alert: My collaborator, Camilla Björkegren at Karolinska Institutet, is looking for a postdoc to study the mechanisms of chromosome organization! ki.varbi.com/en/what:job/...

Sadly, our colleague and friend Scott Hawley passed away this morning. He was an irreplaceable presence and force for good in the meiosis an Drosophila communities and will be sorely missed.

Feeling very lost today with the news of the passing of my undergrad advisor Scott Hawley. He had a huge impact on the field and on me personally. He was the first person to see me as a scientist and gave me the confidence to apply to grad school. I am so grateful to be a part of his legacy.

We are deeply sadden by the sudden loss of Scott. He was an astounding mentor and brought so much to the community on top of his excellent science. His legacy will live on #Meiosis4ever

Exciting new paper 🔥🔥👇🏻👇🏻

@science.org Genome recombination on demand | Science www.science.org/doi/10.1126/... a Perspective by @seczmarta.bsky.social Lars Steinmetz @stanford.edu on two studies bit.ly/4hzFRMg + bit.ly/4jyT4Hf that generate large genome rearrangements in mammalian cells @ unprecedented scale #synbio #genome

Hello Bluesky. For my first post here, I am happy to share that our paper is finally out in Nucleic Acids Research, highlighting how collision between transcription machinery and arrested replication fork triggers circular rDNA formation in budding yeast. academic.oup.com/nar/article/...

Delighted to share the ground-breaking work from BBSRC Discovery Fellow @whgittens.bsky.social mapping physiological Top2 activity without poisons. Acute sensitivity enables sub-minute visualisation of Top2 hotspots hidden within sites of latent topological stress: www.nature.com/articles/s41...