Ido Caspy
@idocaspy.bsky.social
📤 98
📥 190
📝 0
Postdoc @Bharat group @MRC-LMB
reposted by
Ido Caspy
Tanmay Bharat
5 months ago
Assembly, architecture and functional roles of microbial surface layers Review article published in
@natrevmicro.nature.com
with
@bupbuse.bsky.social
, Andriko von Kügelgen and
@vikramalva.bsky.social
. S-layers are everywhere!
www.nature.com/articles/s41...
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Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
https://www.nature.com/articles/s41579-025-01258-8
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38
reposted by
Ido Caspy
Tanmay Bharat
5 months ago
An Asgard archaeon with internal membrane compartments Brilliant study led by
@fmacleod.bsky.social
and Andriko von Kügelgen. Tight collaboration with
@buzzbaum.bsky.social
and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
10
388
191
reposted by
Ido Caspy
Tanmay Bharat
7 months ago
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging Congrats Hannah Ochner and authors on this important paper! Strong collaboration with
@kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social
@wellcometrust.bsky.social
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reposted by
Ido Caspy
Kashish Singh
8 months ago
Check out our latest work now out on biorxiv
www.biorxiv.org/content/10.1...
add a skeleton here at some point
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reposted by
Ido Caspy
Tanmay Bharat
8 months ago
Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms led by
@abultarafder.bsky.social
Great collaboration with
@pearce-maths.bsky.social
and
@geiselbiofilm.bsky.social
www.biorxiv.org/cgi/content/...
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reposted by
Ido Caspy
Kelly Nguyen
9 months ago
Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with
@yiliangding.bsky.social
and
@rdaslab.bsky.social
.
www.science.org/doi/10.1126/...
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Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization
Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showe...
https://www.science.org/doi/10.1126/science.adr5817
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145
48
reposted by
Ido Caspy
Tanmay Bharat
9 months ago
Exciting study from
@kiranrpatil.bsky.social
and colleagues. Hannah Ochner from the group performed cryo FIB imaging. Congrats!
add a skeleton here at some point
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5
reposted by
Ido Caspy
Tanmay Bharat
10 months ago
Structure of the virulence-associated Neisseria meningitidis filamentous bacteriophage MDAphi Out in
@pnas.org
Congrats
@janboehning.bsky.social
@abultarafder.bsky.social
Miles Graham
@mathieucoureuil.bsky.social
@mrclmb.bsky.social
@hopitalnecker.bsky.social
www.pnas.org/doi/10.1073/...
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57
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reposted by
Ido Caspy
Tanmay Bharat
10 months ago
The mechanics of a continuous self-assembling surface-layer aids cell division in an archaeon out in
@pnas.org
Tight collaboration with Sherman Foo, Alice Cezanne and
@buzzbaum.bsky.social
, Sulfolobus cryo-ET from
@idocaspy.bsky.social
www.pnas.org/doi/10.1073/...
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A self-assembling surface layer flattens the cytokinetic furrow to aid cell division in an archaeon | PNAS
The surface layer or “S-layer” is a two-dimensional lattice of proteins that coats a wide range of archaea and bacteria in place of a cell wall or ...
https://www.pnas.org/doi/10.1073/pnas.2501044122
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reposted by
Ido Caspy
Tanmay Bharat
12 months ago
Finally in peer-reviewed form: Mapping the ultrastructural topology of the corynebacterial cell surface.
@bupbuse.bsky.social
@vikramalva.bsky.social
Please also see concurrent beautiful work from
@adriasogues.bsky.social
and Han Remaut.
add a skeleton here at some point
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reposted by
Ido Caspy
Thibaut Brunet
about 1 year ago
Striking new study from
@archaeon-alex.bsky.social
's lab just out in
@science.org
on multicellular development induced by compression in Archaea:
www.science.org/doi/10.1126/...
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Tissue-like multicellular development triggered by mechanical compression in archaea
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...
https://www.science.org/doi/10.1126/science.adu0047
6
344
146
reposted by
Ido Caspy
Tanmay Bharat
about 1 year ago
The mechanics of a continuous self-assembling surface-layer aids cell division in an archaeon Tight collaboration with
@buzzbaum.bsky.social
, Sulfolobus cryo-ET from
@idocaspy.bsky.social
www.biorxiv.org/content/10.1...
0
41
10
reposted by
Ido Caspy
Tanmay Bharat
about 1 year ago
Structural biology inside multicellular specimens using electron cryotomography by
@idocaspy.bsky.social
@zhexinwang.bsky.social
out now in Quarterly Reviews of Biophysics
doi.org/10.1017/S003...
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Structural biology inside multicellular specimens using electron cryotomography | Quarterly Reviews of Biophysics | Cambridge Core
Structural biology inside multicellular specimens using electron cryotomography - Volume 58
https://doi.org/10.1017/S0033583525000010
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reposted by
Ido Caspy
Tanmay Bharat
over 1 year ago
Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus Finally out in PLOS Pathogens. Congrats Hannah Ochner and co-authors.
@mrclmb.bsky.social
journals.plos.org/plospathogen...
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reposted by
Ido Caspy
bioRxiv Cell Biology
over 1 year ago
Tissue-Like Multicellular Development Triggered by Mechanical Compression in Archaea https://www.biorxiv.org/content/10.1101/2024.10.19.619234v1
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Tissue-Like Multicellular Development Triggered by Mechanical Compression in Archaea https://www.biorxiv.org/content/10.1101/2024.10.19.619234v1
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes
https://www.biorxiv.org/content/10.1101/2024.10.19.619234v1
0
2
2
reposted by
Ido Caspy
Alex Bisson
about 2 years ago
We have a new story out at BiorXiv! Amazing work led by Zach Curtis (Bisson), Pedro Escudeiro (Alva) and John Mallon (Bisson). Great collaboration with
@vikramalva.bsky.social
(Max Planck) and Mecky Pohlschroder (UPenn).
t.co/qGvuQ7mwO1
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Halofilins as Emerging Bactofilin Families of Archaeal Cell Shape Plasticity Orchestrators
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
https://t.co/qGvuQ7mwO1
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