How does ageing influence the way our bodies handle infection? go.nature.com/4sMZuqW

☕Zhang et al. characterize the #mitochondrial inner membrane subdomain organizer (MISO) protein, which responds to inner #mitochondria membrane stress by inducing membrane subdomains promoting homeostatic fission and mtDNA degradation. 👉https://rdcu.be/eXjMB bit.ly/3YZ0PNj

Inside #macrophages, #Salmonella faces Mg2+ scarcity that disrupts cAMP synthesis & metabolism. @npokorzynski.bsky.social @microbelab.bsky.social &co show that PhoP restores control by promoting Mg2+ uptake & directing cAMP production to sustain growth via CRP @plosbiology.org 🧪 plos.io/3Lcav3T

A paper in Nature presents a detailed map of human chromosomes within the nucleus. This resource provides a foundation for an improved understanding of how the physical layout of human DNA is associated with biological expression. go.nature.com/4pI8knB 🧬 🧪

Astrocytes make up one-quarter of the brain. Nature reports how researchers are learning their value in shaping our behaviour, memory, and health. #Neuroskyence 🧪

Nature research paper: Inhibitors supercharge kinase turnover through native proteolytic circuits go.nature.com/3JWgIk4

Nature research paper: Thalamocortical transcriptional gates coordinate memory stabilization go.nature.com/48CjZy8

The method might one day overcome a key stumbling block faced by gene-editing therapies: the need to design a bespoke treatment for each disease go.nature.com/4a0QoQ6

L’ANDCS est heureuse de vous proposer un évènement inédit : une soirée de découverte de l’Institut Pasteur se déroulant le jeudi 23 novembre ! Voici le formulaire d'inscription : forms.gle/v8QYsYz7s2q8...

Nature research paper: SIGLEC12 mediates plasma membrane rupture during necroptotic cell death go.nature.com/4hSSG5Q

Human biomass movement may be up to 40 times greater than that of all land animals combined, according to research in Nature Ecology & Evolution. A second Nature Communications paper finds that wild mammal biomass has more than halved since 1850. go.nature.com/4oID33i go.nature.com/3LhSD7n 🧪

In a meta-analysis of 17,801 patients with myocardial infarction and preserved LVEF (≥50%), beta-blockers did not reduce death, MI, or heart failure over a median 3.6 years of follow-up. Full results: nej.md/43U5Ppo #AHA25

Polymer-coated liposomes specifically target and deliver interleukin-12 to metastatic ovarian cancer, strongly sensitizing the tumours to combination therapy with immune checkpoint inhibitors, according to a paper in Nature Materials. go.nature.com/4ouOWds 🧪

Le lundi 17 novembre 2025 à 19h30, à l’ @ibensens.bsky.social, nous aurons le plaisir d’accueillir @lacombekarine.bsky.social , professeure des universités - practicienne hospitalière (PUPH) en infectiologie à @sorbonne-universite.fr. Inscrivez-vous ici : forms.gle/iguhqmQndjw1...

A paper in Nature reports that mRNA vaccines targeting SARS-CoV-2, COVID-19, also sensitize tumours to immune checkpoint inhibitors. #medsky 🧪

Researchers in #ScienceTranslationalMedicine present a new method to generate stable, antigen-specific regulatory #Tcells in large quantities using the body’s own conventional T cell pool, and show the resulting cells can treat IBD and GvHD in mouse models. https://scim.ag/47dDYBm

In low-risk patients with severe aortic stenosis, transcatheter and surgical aortic-valve replacement had similar 7-year survival and valve durability outcomes, with no evidence of differences in composite end points. Full PARTNER 3 trial results: nej.md/4nieHfx   #TCT2025 | @crfheart.bsky.social

Nature research paper: Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion go.nature.com/4nlQFQK

Vaccines for #H5N1 based on either mRNA or an adenovirus vector can shield macaques from the virus when delivered via an intramuscular prime and a mucosal boost regimen, according to new experiments in #ScienceTranslationalMedicine. https://scim.ag/47aS1HR

This ‘fundamental’ work substantially reveals how the cell’s glycocalyx (a dense layer of sugars and proteins on the cell surface) acts as a non-specific barrier, making it harder for viruses to interact with receptors. buff.ly/YkpiWzD

New paper finally out on @natcomms.nature.com! Led by first author Maria Dramé with the collaboration of Francisco Garcia, @cbuch.bsky.social and @jytinevez.bsky.social at @pasteur.fr. Early mitochondrial signals in single human macrophages predict later Legionella replication. Link + details👇🧵

Le jeudi 23 octobre 2025 à 19h30, à l’ @ibensens.bsky.social , nous aurons le plaisir d’accueillir @thomasdavergne.bsky.social , enseignant-chercheur en sciences de la rééducation et de la réadaptation, à l'occasion du premier dîner double cursus de l'année ! Inscrivez-vous ici : urls.fr/RA1rrO

Nature research paper: The astrocytic ensemble acts as a multiday trace to stabilize memory go.nature.com/4hc7zQp

Replicating RNA vaccines based on older #H5N1 antigens can shield macaques from lethal infections with contemporary H5N1 strains, according to new work that hints current vaccine stockpiles can still offer cross-protection. #ScienceTranslationalMedicine https://scim.ag/3W1QdMn

Mild stresses on the body, like fasting or cold exposure, can delay ageing. But how? A new Insight Article explores how oxygen-sensing neurons in C. elegans trigger body-wide stress signals that boost resilience and extend lifespan. buff.ly/wJIQKfm

Can we exploit past phage infection events (prophages) to decipher the specificity of phage receptor-binding proteins such as depolymerases?🔎 Happy to share our recent work at @natcomms.nature.com 🔽 #microsky #phagesky www.nature.com/articles/s41...

The newfound ensemble of neurons could lead to therapies to treat persistent pain go.nature.com/4gZHzrv

I love these new layers of complexity that people are discovering in the brain! Dendrites of different neurons can connect via nanotubes, which transport calcium and cargo such as amyloid-beta www.science.org/doi/10.1126/...

Nature research paper: Connecting chemical and protein sequence space to predict biocatalytic reactions go.nature.com/4gUrL9t

Inside a thylakoid membrane The molecular architecture of the thylakoid membrane in a vascular plant has been determined with single-molecule precision. buff.ly/U9TzrOh

Nature research paper: Protecting double Holliday junctions ensures crossing over during meiosis go.nature.com/46zKMcj

ResultatScientifique🔎| Le VIH profite d’une protéine humaine pour mieux s’installer dans notre ADN : une découverte qui ouvre de nouvelles pistes pour le combattre 🦠 ✍️ Vincent Parissi 📕 @natmicrobiol.nature.com | buff.ly/Hqeu6kO

Scientists have created the first ever viruses designed by AI, and they’re capable of hunting down and killing strains of E. coli go.nature.com/4nA8E6p

Nature research paper: Learning the natural history of human disease with generative transformers go.nature.com/4gzhLCo

VPS13A & VPS13C are lipid transport proteins linked to #ChoreaAcanthocytosis & #ParkinsonsDisease. @pengxu.bsky.social @pdc-lab.bsky.social &co shows that mice lacking either protein are viable but absence of both results in defective #hematopoiesis & lethality @plosbiology.org 🧪 plos.io/46rTEAy

Nature research paper: Fluctuating DNA methylation tracks cancer evolution at clinical scale go.nature.com/4pzikAa

The amino acid transporter SLC38A2 is linked to a higher risk of #hypertension and can be targeted to lower blood pressure, show new experiments in #ScienceTranslationalMedicine involving mice and an analysis of population cohorts in China and the U.K. Biobank. https://scim.ag/4mQ3Ji0

Many bacteria use #QuorumSensing to control genes based on population density. @jrchandler.bsky.social &co explore a @plosbiology.org study showing that in P. aeruginosa, 2 QS circuits activate each other, enhancing robustness & explaining redundancy 🧪 Paper: plos.io/3I7DhRG Primer: plos.io/4niSZZd

Nature research paper: Supervised learning in DNA neural networks go.nature.com/4mOb9lH

What are the neural mechanisms behind short-term #memory errors? This study shows that they are primarily linked to a drift in neural activity in posterior #ParietalCortex, highlighting a need for stable neural representations to support accurate memory performance @plosbiology.org 🧪 plos.io/4p85IzD

The endoplasmic reticulum donates lipids through a tunnel-like protein to help lysosomes expand. Learn more in a new #SciencePerspective: https://scim.ag/45GWQrS

A paper published in Nature Medicine presents multimodal data from 347 individuals, linking gut microbiome diversity and resting heart rate to glucose levels. This approach enhances understanding of Type 2 diabetes beyond traditional HbA1c measurements. go.nature.com/4mmNCbi 🧪

Research team @nadlerlab.bsky.social, A. Honigmann @biotec-tud.bsky.social, B.Drobot @hzdr.bsky.social, M. Hof @heyrovskeho-ustav.bsky.social develops approach to visualize lipids in cells & uncovers the main transport mechanism for lipids within the cell. @nature.com www.mpi-cbg.de/news-outreac...

A study in Nature Aging identifies ferritin light chain 1 (FTL1), an iron-associated protein, as a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain improved cognition in old mice. go.nature.com/3JQQIG3 #medsky 🧪

Nature research paper: Thymic epithelial cells amplify epigenetic noise to promote immune tolerance go.nature.com/41TUQLE

Adverse experiences in early life affect brain development. A Review in Nature Reviews Neuroscience discusses evidence for how these adversity-induced changes to human brain architecture alter developmental trajectories that may underpin adult psychopathology. go.nature.com/45xZOii 🔒

🧠​ #SAVOIRSENS (Re)écouter la conférence Lumière sur le cerveau : "La science a-t-elle un sexe ?", par @charlottejacquemot.bsky.social chercheuse en sciences cognitives et directrice du département d’Études Cognitives de l'ENS-PSL. 👉​ https://ens.pulse.ly/lxthg3sqmd

Nature research paper: NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers go.nature.com/458lmmL

Hidden in the lungs of some breast cancer survivors are tumour cells that can remain dormant for decades — until they one day trigger a relapse go.nature.com/45uez6N

A paper in Nature Neuroscience suggests that the brain detects when a potential source of infection enters the immediate surroundings and prepares the body’s immune defenses. This may occur even before physical contact is made, in a virtual reality environment. go.nature.com/45cCSF7 #medsky 🧪