📢 New publication in Scientific Reports by @natureportfolio.nature.com A new study led by Dr @arnaudmachelart.bsky.social reveals that the route of BCG vaccination critically shapes protection against bacterial pneumonia. @inserm.fr @pasteurlille.bsky.social @cnrs.fr @univlille.bsky.social

Very happy to have participated in the “Health Effects of Vaccines: From Genomics to Policy” conference at Wellcome Connecting Science. Inspiring discussions on vaccines, host responses, genomics & public health. Congrats to Carine and Valentin for presenting their [email protected]

Very happy to share our group’s second publication this month! In this work, we investigate the intrinsic anti-tuberculosis activity of polymeric β-cyclodextrin nanoparticles. Proud of the team’s efforts!

🚀Thrilled to announce our latest publication in Journal of Controlled Release! Our team reveals a key property of antimicrobial nanovectors in the fight against infectious diseases. 🎉🔬 www.sciencedirect.com/science/arti...

📢 A new pub in Journal of Controlled Release by Dr @arnaudmachelart.bsky.social group and Dr Ruxandra Gref team “Selective accumulation of nanoparticles in infected cells for targeted drug delivery” @inserm.fr @cnrs-hautsdefrance.bsky.social @rechercheulille.bsky.social @pasteurlille.bsky.social

Ravis d’accueillir le public pour les Journées Européennes du Patrimoine à l’Institut Pasteur de Lille ! 🧬 Notre équipe passionnée a présenté nos travaux sur la tuberculose. Merci à tous pour cette belle journée ! 👏

The @ciilofficiel.bsky.social team is at #IUIS2025 in Vienna! N. Mielcarek on BPZE1 pertussis vaccine, E. Hoffmann on ERA4TB drug testing, while @joanfine.bsky.social , I. Leleu, @vsencio.bsky.social & @arnaudmachelart.bsky.social are showcasing their work in poster sessions. #Immunology

🦠✨ Exciting science at #IUIS2025 in Vienna! Don’t miss posters on host–pathogen interactions by: 🔹 #338 Joan Fine 🔹 #342 Valentin Sencio 🔹 #347 Ines Leleu

Institut @pasteurlille.bsky.social teams joined the GRC #TB Drug Discovery and Dev. to present their latest work. With rising resistance and 1.5M deaths/year, better TB treatments are urgent. A week of fruitful talks & new collaborations! @hartkoorn-lab.bsky.social @arnaudmachelart.bsky.social

🚨 New review from our group! PhD student Amine Pochet dives into the use of cyclodextrins beyond drug delivery — as active agents against infectious diseases. @ciilofficiel.bsky.social @pasteurlille.bsky.social @inserm.fr @univlille.bsky.social www.sciencedirect.com/science/arti...

À l’Institut Pasteur de Lille, le Dr F. Real et son équipe (@ciilofficiel.bsky.social) montrent que le #VIH infecte les mégacaryocytes en réduisant IFITM3, une protéine antivirale. Ces cellules pourraient former un réservoir viral caché, empêchant de parvenir à une guérison du VIH ➡️ bit.ly/3FSMc8C

Excited to share our latest work on incorporating an antiviral molecule into delivery vectors to target pulmonary infections. 🍃🦠 www.sciencedirect.com/science/arti...

🎤 Laurye Van Maele, chercheuse @inserm.fr au @ciilofficiel.bsky.social à l'Institut Pasteur de Lille, a joué le jeu de l’interview menée par une élève de 3e pour “Ta voix », le media jeune de @lavoixdunord.fr. Une belle rencontre intergénérationnelle autour de la #recherche 👉 bit.ly/4k3D2o1

À l’Institut Pasteur de Lille, l’équipe du Dr François Trottein au @ciilofficiel.bsky.social montre qu’un microbiote intestinal déséquilibré chez les aînés aggrave le #COVID19. Probiotiques et prébiotiques pourraient améliorer la récupération 👉 pasteur-lille.fr/2025/04/16/m...

🚨New Pub🚨 #PulmonaryDelivery of clofoctol-loaded #Nanoparticles inhibits #SARSCoV2 replication and reduces pneumonia 💥 Study co-led by Drs Brodin, Trottein, Machelart ( @arnaudmachelart.bsky.social ) & Dr. R. Gref ( @ismolab.bsky.social ) | Institut des Sciences Moléculaires d'Orsay

@arnaudmachelart.bsky.social , chercheur @inserm.fr Comment le #réchauffement #climatique favorise-t-il l’ #émergence des maladies tropicales ?

@arnaudmachelart.bsky.social , chercheur @inserm.fr avec les doctorants Axelle Grandé et Amine Pauchet @univlille.bsky.social L’ #antibiorésistance, une bombe à retardement ?

Réchauffement climatique et maladies infectieuses émergentes : (re)découvrez la conférence de nos chercheurs @inserm.fr @cnrs-hautsdefrance.bsky.social Dr A. Machelart @arnaudmachelart.bsky.social Dr M. Gissot. @gissotlab.bsky.social Dr S. Pied Dr S. Bontemps-Gallo @sebbontempsgallo.bsky.social

Excited to introduce our (expanded) research group for 2025!

I am happy to have participated in the @anrs-mie.bsky.social Start Day. Young researchers have talent too!

24 mars, journée mondiale de lutte contre la #tuberculose ! À l’Institut Pasteur de Lille, Albert Calmette et Camille Guérin ont créé le BCG en 1921. Plus de 130 ans plus tard, nos chercheurs poursuivent cet héritage et continuent de lutter contre cette maladie mondiale 👉 bit.ly/4iFrsiS #EndTB.

Colloque I3M at Strasbourg! @joanfine.bsky.social @vsencio.bsky.social

#StandUpforScience 2025 – Because science is a common good. The @ciilofficiel.bsky.social was present alongside all colleagues on the @pasteurlille.bsky.social campus. #ScienceForAll @cnrs-hautsdefrance.bsky.social @inserm.fr @chulille.bsky.social @univlille.bsky.social

🔴 Women scientists at @ciilofficiel.bsky.social were joined by their colleagues from @pasteurlille.bsky.social, all dressed in red for the #Coquelicots initiative on #InternationalWomensDay Women in science exist! Let’s be visible: wear red & form a vast poppy field from the sky! 🌍🔬

📣 Stand Up for Science 2025 à l'Institut Pasteur de Lille parce que la science est un bien commun. 📣 Plus d'infos sur le mouvement 👉 standupforscience.fr #pasteurlille

Bravo Joan! @joanfine.bsky.social

#FluorescenceFriday The macrophage (nucleus in blue) protein Tirap (in red) is recruited to the Mycobacterium tuberculosis (in green)-containing vacuole. This recruitment is essential to enable bacterial replication. Belhaouane et al. PLoS Pathogens 2023

The Center for Infection and Immunity of Lille (CIIL) is now on Bluesky ! 📢 Follow us for updates on our latest research, collaborations, and breakthroughs in #infectious #diseases, #immunology, and #microbiology. 📍 Follow us here: @ciilofficiel.bsky.social

Rev-erb-α antagonism in alveolar macrophages protects against pneumococcal infection in elderly mice: Cell Reports www.cell.com/cell-reports...

🦠 How does #Tuberculosis survive the journey through the air? New research from C. Nathan’s lab shows that Mtb actively resists desiccation, remodeling its transcriptome and using anti-desiccant proteins to endure aerosolization! #InfectiousDisease #MycroSky #TBSky www.biorxiv.org/content/10.1...

The state of Kansas is experiencing a massive tuberculosis outbreak, just as the Trump administration has ordered the Centers for Disease Control and Prevention and the National Institutes of Health to cease communications with the public. https://newrepublic.com/post/190797/tuberculosis-outbreak-…

A tuberculosis (TB) outbreak in Kansas City has become the largest documented TB outbreak on record in the United States. www.cidrap.umn.edu/tuberculosis...

#TBSky #IDSky

⚠️ Bit of an alarm bell to MDR-TB regimen BPaL/M - resistance to constituent antibiotics developing and transmission of such strains already occurring #TBSky #IDSky @nejm.org www.nejm.org/doi/10.1056/...

OUT NOW - A BCG kill switch strain protects against Mycobacterium tuberculosis in mice and non-human primates with improved safety and immunogenicity www.nature.com/articles/s41...

Reducing #TB burden requires understanding local contexts. Our new preprint emphasizes the importance of considering social contact patterns for interventions like active case finding, infection prevention & control, & cluster trial design #TBsky #IDsky #GlobalHealth www.medrxiv.org/content/10.1...

New from @cidjournal.bsky.social Linezolid TDM for TB from UF ID PK Lab If dose reducing from 600mg, 3x/week more likely to achieve appropriate trough (<2) and peak (12-26) compared to 300mg daily (inadequate peaks) Really interesting/useful data #IDSky #TBSky academic.oup.com/cid/advance-...

I'm very happy to have contributed to this recently-released review on macrophage heterogeneity in TB granulomas. #TBSky www.nature.com/articles/s41...

After a BioRxiv preprint, here is the final published version of our article dealing with the ph-driven mode of action of salicylic acid derivatives @pierresantucci.bsky.social @canaanlab.bsky.social and more febs.onlinelibrary.wiley.com/doi/10.1002/...