Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification https://www.biorxiv.org/content/10.1101/2025.09.26.678883v1

Great collaborative work driven by @pierresantucci.bsky.social which provides clear evidence on the mode of action of a well-known first-line anti-TB drug.

Now out in Trends In Microbiology! Iron-sulfur proteins in mycobacteria: Master regulators of physiology and pathogenesis. Kudos to Valentin Berdal and Wassim Daher. Fantastic exchanges and discussions with leaders in the field: Béatrice Py, Sandrine Ollagnier de Choudens lnkd.in/dKGd2P8S

🚨 New review from our group! PhD student Amine Pochet dives into the use of cyclodextrins beyond drug delivery — as active agents against infectious diseases. @ciilofficiel.bsky.social @pasteurlille.bsky.social @inserm.fr @univlille.bsky.social www.sciencedirect.com/science/arti...

🎉🎉🎉 Big congrats to Kien Lam UNG, recipient of the 2025 #ATIP-Avenir award! From decoding antibiotic resistance in M. abscessus to revealing plant hormone transporters in Nature, he is now launching a bold project on how sugar tweaks shape host–pathogen battles. Sweet science! 👏👏👏 shorturl.at/TJiHg

Today is a great day! Our article accepted on March 19, 2025 is published in Wiley mLife journal. Great collaborative work with JM Bolla's lab, @map-proteomique.bsky.social @canaanlab.bsky.social Céline Crauste from @ibmm-balard.bsky.social, and more... 👉 onlinelibrary.wiley.com/doi/10.1002/...

It is my real pleasure to share our ASAP article published in ACS Infect Dis. Another great collaboration with @pierresantucci.bsky.social @canaanlab.bsky.social @lkremer1.bsky.social @ibmm-balard.bsky.social @map-proteomique.bsky.social and more... Enjoy 😊 pubs.acs.org/doi/10.1021/...

⚠️ Breaking News ⚠️ Another great collaborative work with Victoria Magrioti, @canaanlab.bsky.social @map-proteomique.bsky.social now just published in @rscmedchem.rsc.org pubs.rsc.org/en/content/a...

Happy to share our new article in Current Research in Microbial Sciences @canaanlab.bsky.social Nice work with Priscille Brodin, Aurelie Tasiemski, Celine Boidin-Wichlacz @pasteurlille.bsky.social, and more, on the use of antimicrobial peptides against Mtb. www.sciencedirect.com/science/arti...

If you are interested in lipids in bacteria, check out this awesome new review written by my talented student Alyssa Carter, super postdoc Emily Woods and me. #chembio www.sciencedirect.com/science/arti...

"This looks bad"’ A Harvard infectious disease researcher is targeted in President Trump’s review

New paper from the Beatty Lab! 👇 Proteomic characterization of Mycobacterium tuberculosis subjected to carbon starvation | mSystems journals.asm.org/doi/10.1128/...

Congratulations to group leader @maxgg.bsky.social, who received a £3.4m @wellcometrust.bsky.social Discovery Award to study the effectiveness of antibiotics against tuberculosis. www.crick.ac.uk/news/2025-04...

Great collaborative work @lkremer1.bsky.social @pierresantucci.bsky.social @camoinluc.bsky.social @audebertstephane.bsky.social and more!

Thrilled to share the last work from the lab! Generating a mycobacterial strain lacking all T7SS and studying the contribution of ESX-3 and ESX-4 in M. abscessus pathogenesis. Great collab with E Tocheva and JL Herrmann. rdcu.be/d8uHH

Watch out for those bastard professors

Big Change in TB treatment recommendations. 6 months of RIPE (also called RHEZ) was once the only treatment in town for susceptible TB. Now there's an all oral FOUR months of: Rifapentine INH PZA Moxifloxacin t.co/8EHiWEhEk8

🔊 JOB ALERT! L'IPBS Toulouse recrute un personnel technique pour rejoindre l'équipe émergente "Biochimie et Biologie Structurale des Protéines Membranaires" dirigée par le Dr Kien Lam UNG @unglam.bsky.social à partir de février 2025. Voir l'offre et candidater : emploi.cnrs.fr/Offres/CDD/U...

Relaxation time and Christmas lunch at @canaanlab.bsky.social

After a BioRxiv preprint, here is the final published version of our article dealing with the ph-driven mode of action of salicylic acid derivatives @pierresantucci.bsky.social @canaanlab.bsky.social and more febs.onlinelibrary.wiley.com/doi/10.1002/...

Our last article dealing with Cyclipostin & Cyclophostins compounds to counteract macrolide-induced resistance in Mabscessus is out! Great collaborative work @lkremer1.bsky.social @canaanlab.bsky.social @pierresantucci.bsky.social @camoinluc.bsky.social jbiomedsci.biomedcentral.com/articles/10....

🚀💥🔥Happy to Share that Our Latest Story is Now Published in FEBS Letters! 💙💎💡 Have a look & find out about the new subset of Mycobacterial CRISPRi vectors we optimised for our community! 🦠🔦🔬💊 @cnrs.bsky.social @addgene.bsky.social 👇👇👇 febs.onlinelibrary.wiley.com/doi/full/10....

A new preprint from Matthew Bogyo. They developed and screened cyclic peptide libraries using mRNA display with a genetically encoded oxadiazolone (Ox) electrophile that was previously shown to potently and covalently inhibit multiple Fph enzymes in S. aureus. www.biorxiv.org/content/10.1...

I made a Starter Pack for the Myco & TB community. Hope to find more good friends here on Bluesky to keep in touch about mycobacterial infections. Please join and repost! go.bsky.app/3nwpcVV