#BonneAnnée 🌟 Le #CNRS vous présente ses meilleurs vœux pour l'année 2026 ! #HappyNewYear 🌟 The French National Centre for Scientific Research (CNRS) wishes you the very best for 2026!

A fascinating Review in Nature Reviews Microbiology shows how ancient pathogen genomics reshapes our understanding of infectious diseases. For Yersinia pestis, it synthesizes decades of work on plague evolution, while highlighting key open questions ahead. #microsky

Pourquoi certaines bactéries résistent-elles aux antibiotiques ? 🦠💊 Sébastien Bontemps-Gallo, bactériologiste au CNRS, tente d'y répondre.

🦠 "Maladie de Lyme : comment la bactérie Borrelia burgdorferi nous infecte", un article de @sebbontempsgallo.bsky.social (@cnrs-hautsdefrance.bsky.social / @univlille.bsky.social) pour @france.theconversation.com 👇 theconversation.com/maladie-de-l...

📢 A new pub in Journal of Controlled Release by Dr @arnaudmachelart.bsky.social group and Dr Ruxandra Gref team “Selective accumulation of nanoparticles in infected cells for targeted drug delivery” @inserm.fr @cnrs-hautsdefrance.bsky.social @rechercheulille.bsky.social @pasteurlille.bsky.social

#Recherche Issus du décryptage de la méthode de camouflage très efficace de la bactérie responsable de la maladie de #Lyme, 2 projets de #vaccins permettent de l’attaquer avant qu’elle ne puisse recourir à ce stratagème. Par @sebbontempsgallo.bsky.social de @cnrs.fr

Nouvel article dans @theconversation.com FR : Maladie de Lyme : comment la bactérie Borrelia burgdorferi nous infecte Comment cette bactérie déjoue notre système immunitaire et inspire de nouvelles pistes vaccinales @cnrs-hautsdefrance.bsky.social @univlille.bsky.social

🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨 (2.5y) 🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a @anrs-mie.bsky.social PEPR-funded project! 🔬 Profile: PhD in microbiology #Postdoc #Microbiology #YersiniaPestis #ResearchJobs

🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨 🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a PEPR-funded project! (2.5y) 🔬 Profile: PhD in microbiology #Postdoc #Microbiology #YersiniaPestis #ResearchJobs

The Plague & Yersinia pestis team @pasteurlille.bsky.social , led by F Sebbane, shared their latest research at the Yersinia 15th Symposium in Ulaanbaatar! A Baillez presented his thesis work, A Dewitte and @sebbontempsgallo.bsky.social showcased their recent findings. @rolandelliagus.bsky.social

First day of the 15th International #Yersinia symposium in Ulaanbaatar, Mongolia

🎓 Funded PhD position available in the team of M. Pichavant & P. Gosset! Send your CV and a brief note on why you’re excited about this opportunity. @cnrs-hautsdefrance.bsky.social @pasteurlille.bsky.social @univlille.bsky.social @inserm.fr @chulille.bsky.social

⚠️ Cas de peste détecté aux USA : peut-on encore mourir de cette maladie ? Le 19 août 2025 un cas a été confirmé en Californie Dans un article @ouest-france.fr Dr Sebbane, Chef d'équipe @inserm.fr fait le point. @pasteurlille.bsky.social @cnrs-hautsdefrance.bsky.social @rechercheulille.bsky.social

Protocol to monitor activation of a two-component system in Dickeya dadantii during chicory leaf infection using Phos-tag gel #protocol #starprotocols #cellpress

Just out in Nature Genetics @natureportfolio.nature.com ! Wu et al. analyzed 242 Yersinia pestis genomes, uncovering IS-driven rearrangements, which enhanced #phylogenetic resolution and resolved the third #pandemic’s polytomy, revealing adaptive changes in #virulence and #stress response.

New pub in STAR Protocols @cp-starprotocols.bsky.social to detect the phosphorylation level of response regulators of two-component systems during host infection using a Phos-tag approach. By @ugsf-lille.bsky.social @ciilofficiel.bsky.social @univlille.bsky.social @cnrs-hautsdefrance.bsky.social

[Resources] #AlphaFold protein and PPI prediction databases 1️⃣ Predictomes (genome maintenance & H2A/H2b) predictomes.org 2️⃣ Flypredictome www.flyrnai.org/tools/fly_pr... 3️⃣ Human interactome prodata.swmed.edu/humanPPI 4️⃣ BFVD (viral proteins) bfvd.steineggerlab.workers.dev 1/2

Bacterial cell wall & periplasm paradigm shift - important read #MicroSky www.nature.com/articles/s41...

#Climate extremes may reduce #Lymedisease risk? Broughton et al. show Borrelia burgdorferi prevalence in Ixodes pacificus ticks declines under climate stress—challenging long-held assumptions about vector-borne disease and global warming. #VectorBiology

We will soon hire a postdoctoral fellow. Please contact me for more details.

#VSS Merci @thiebaultceline.bsky.social de faire vivre la coalition féministe entre associations et parlementaires pour une loi cadre intégrale. Les travaux avancent ! Pour les concrétiser il faudra évidemment aussi des moyens #PLF2026 @socialistesan.bsky.social @socialistes-senat.bsky.social

You thought all OMPs were trimeric? 🧐 Not in our predator B. bacteriovorus! 🦠 Excited to have contributed to this great collab with the Lovering lab on this intriguing protein. @lalouxlab.bsky.social 👉 Paper here! www.nature.com/articles/s41... #BacterialPredation #Bdellovibrio #StructuralBiology

A new study delivers the most comprehensive phylogenomic analysis of Spirochaetes to date, revealing their deep evolutionary roots and shedding light on the loss of spiral morphology and host adaptation. ✍️ @microbiomol.bsky.social and coll. @pasteur.fr 📖 shorturl.at/UxAWu #MicroSky

Recently interviewed by Mark Martin for his “Matters Microbial” podcast! m.youtube.com/watch?si=O6w...

At long last, the genome of Xenopsylla cheopis — the infamous Oriental rat flea and historic vector of plague — has been sequenced and published! A genomic treasure trove for vector biologists, evolutionary entomologists, and plague researchers alike. #Genomics #Entomology #VectorBiology #NIH

🚨 New review from our group! PhD student Amine Pochet dives into the use of cyclodextrins beyond drug delivery — as active agents against infectious diseases. @ciilofficiel.bsky.social @pasteurlille.bsky.social @inserm.fr @univlille.bsky.social www.sciencedirect.com/science/arti...

1/8 - New in @natcomms.nature.com ! ☣️ Meet Yersinia enterocolitica (Ye) — a lesser-known but still dangerous cousin of Yersinia pestis. We uncover how this invasive pathogen can survive and adapt for 14 years inside a human host under constant antibiotic pressure 👇 www.nature.com/articles/s41...

📢 Our latest article is out! We present a cost-effective in-house #RNASeq workflow using @nanoporetech.com direct cDNA, perfect for high-risk pathogens. Applied to #Yersinia pestis, transcriptomic profiling (21 °C/flea vs 37 °C/host) reveals novel operons & sulfur metabolism upregulation.

🔬 Maladie de #Lyme : à l'Institut Pasteur de Lille (@ciilofficiel.bsky.social) le Dr Bontemps-Gallo décrypte Borrelia burgdorferi, rôle des tiques, défis du diagnostic et impact de l’environnement. 🔎 Un regard captivant sur une zoonose discrète mais complexe ➡️ bit.ly/4kNtQF9

Excited to share our latest review! Check it out to see what we know so far about how Staphylococcus aureus coordinates key processes during its cell cycle

🦠 The plague bacillus became less virulent, extending the duration of two major pandemics. @yersiniaunit.bsky.social @pierrelebury.bsky.social @mcmasteruniversity.bsky.social @ravneetksidhu.bsky.social

🚨 New publication in Star Protocols @cp-starprotocols.bsky.social A step-by-step #protocol to quantify Yersinia pestis colonization in the #flea Xenopsylla cheopis using #fluorescence #microscopy & #ImageJ. @ciilofficiel.bsky.social @plbs-lille.bsky.social #plague #microbiology #OpenAccess

Two great papers in @science.org this month on the #evolution of #vector-borne #pathogens 1 #Yersinia pestis attenuates virulence over 3 pandemics 2 Ancient #Borrelia genomes trace the rise of louse-borne relapsing fever Fascinating reads (links below)

1/12 - New in @science.org ! ☠️ Curious of what happened to Yersinia pestis, the bacterium responsible for the Black Death, throughout plague pandemics? Check out our new study 👇 www.science.org/doi/10.1126/...

First run using the Direct RNA kit from @nanoporetech.com An exciting step forward in our transcriptomics workflow! #Nanopore #DirectRNA #RNAseq #LabUpdate

Our @ucl.ac.uk @crick.ac.uk work, out this week in @science.org, traces a genetic time series of bacterial infections to reveal when and how Borrelia recurrentis jumped from ticks to humans—via our body lice. www.science.org/doi/10.1126/...

Offre de thèse disponible dans notre équipe au @mmsb-lyon.bsky.social Si vous êtes étudiant(e) en Master 2 et intéressé(e) par la génétique bactérienne, microscopie à épifluorescence et biochimie, contactez-nous et postulez à l'offre! Dossier pour le 13/06 Concours école doctorale E2M2: 8 et 9/07.

📽️ Maladie de Lyme : comment s’en protéger ? 👉 Réponse avec Sébastien Bontemps-Gallo, chercheur au Centre d'infection et d'immunité de lille (CIIL) et spécialisé en microbiologie. @univlille.bsky.social @pasteurlille.bsky.social @ufr3s-ulille.bsky.social @cnrs.fr @chulille.bsky.social @inserm.fr

@sebbontempsgallo.bsky.social , Chercheur @cnrs-hautsdefrance.bsky.social @cnrsbiologie.bsky.social Maladie de #Lyme : comment s’en protéger ?

Réchauffement climatique et maladies infectieuses émergentes : (re)découvrez la conférence de nos chercheurs @inserm.fr @cnrs-hautsdefrance.bsky.social Dr A. Machelart @arnaudmachelart.bsky.social Dr M. Gissot. @gissotlab.bsky.social Dr S. Pied Dr S. Bontemps-Gallo @sebbontempsgallo.bsky.social

🚨 Another opportunity to join the PYP team at @ciilofficiel.bsky.social 🦠 We're hiring an Engineer to support the technical and administrative work on an exciting project studying the #biology of #fleas! 🧬 🔬Profile: MSc in Biology or related fields. 📅Start: June–July 2025 (up to 3 years) #VBD

🚨 We're hiring! 🚨 Exciting #Postdoc opportunity to lead a project on #flea #biology and #microbe #interactions, in the PYP team at the @ciilofficiel.bsky.social ! 🧬🦠 🔬 Profile: PhD in Biology, Immunology, or related. 📆 Start: June-July 2025 (up to 3 years) Apply now! #VBD #PostdocJobs #Plague

Thanks for highlighting our work. There’s a couple very slight inaccuracies in the release, so we encourage folks to read the papers, but an excellent synopsis nonetheless! We also do not refute Amy’s thought of intact bacteria in patients, and we’ve ’looked’, the numbers don’t add up…

Vous avez un projet innovant sur les Maladies Infectieuses Emergentes (traitements, vaccins, diagnostics) ? Candidatez à la chaire junior #ANRS pour nous rejoindre ! Envoyez CV + résumé du projet à jean.dubuisson (at)ibl.cnrs.fr avant le 20/05/2025. On vous accompagne pour maximiser vos chances !

In B. subtilis, TerC proteins function in Mn export to support the metalation of exoenzymes. MeeY is also required (directly or indirectly) for production of surfactin, a lipopeptide required for swarming motility! (collab. with Dan Kearns' lab @IU). #MicroSky journals.asm.org/doi/10.1128/...

At the @anrs-mie.bsky.social START 2025 day at the @pasteur.fr in Paris.

Last week to apply in order to join us as a group leader at @irim-life.bsky.social!

Shout-out to @pierredupuy.bsky.social and colleagues! Excited to share our latest study, where we uncovered a previously unknown bacterial defense system in M. #tuberculosis: effluxosomes — dynamic membrane clusters that coordinate resistance to multiple toxic metals. shorturl.at/Ek0HD #MicroSky

🌍 Today is #WorldTBDay! At the @ciilofficiel.bsky.social , several labs are working together to better understand, detect, and fight Mycobacterium tuberculosis. Let's keep pushing science forward to #EndTB. @pasteurlille.bsky.social @cnrs-hautsdefrance.bsky.social @inserm.fr @univlille.bsky.social

When a woman is empowered, the world is empowered.💜️ #InternationalWomensDay