Kingfisher: An open‐sourced web‐based platform for the analysis of hydrogen exchange mass spectrometry data onlinelibrary.wiley.... --- #proteomics #prot-paper

“You don't start out writing good stuff. You start out writing crap and thinking it's good stuff, and then gradually you get better at it. That's why I say one of the most valuable traits is persistence.” ― Octavia E. Butler #WritingSky #AcademicSky

Celebrate International Women's Day by reading the Special Issue of the Journal of Proteome Research, highlighting the essential contributions women scientists have made—and continue to make—in the fields of Proteomics and Metabolomics. ow.ly/eBcV50TWOpV #InternationalWomensDay 🧪

Upon learning that yesterday would be my last day as a program officer at the National Science Foundation, I shared this parting message with my colleagues. The next few months will be frenetic and stressful for them. Here are some things that you can do to help them with the mission ahead. (1)

Absolutely captivating article from @fraserlab.bsky.social and Mark Murcko! Very down to earth discussion on what protein "structures" really are www.cell.com/cell/fulltex...

Radha follows up her work with a publication in Langmuir. She used NMR hydrogen exchange and methylation mass spec to probe the structure of a small protein binding to a polystyrene nanoparticle. She finds evidence consistent with the adsorbotope model. doi.org/10.1021/acs....

#MassspecSOS

Here’s a good one for TeamMassSpec (I hope!)- I’m working on a small project which involves enrichment and MRM of circulating neuropeptides (from blood plasma). Most are hydrophilic peptides (< 3 kDa), 1 is amphipathic (~60 kDa).

Anyone with experience of converting Waters .raw files into mzML (or something) that can be searched with Fragpipe and other software? MS Convert settings that work would be very helpful. #MassSOS

Pls reskeet: We're accepting PhD apps to Syracuse University Biology! (Priority deadline of 1/4/24) Join a vibrant department: we are also recruiting three new faculty in epigenetics and neuroscience! Labs actively recruiting grad students are here: artsandsciences.syracuse.edu/biology/grad...

#massspecsos Best way/software for peptide mapping from limited proteolysis or full proteolysis experiments for a single, purified recombinant protein? Something that I can use/search against the Fasta for so the search would be our protein and contaminants with Thermo data.

A new season of #TheProteomicsShow with me and @proteomicsnews.bsky.social?!!! Find it wherever you podcast and expect a weekly-ish release schedule to bath your ears in proteomic goodness.

Learning my way around Bluesky; hoping to re-establish the many awesome scientific connections from X! We are a molecular biophysics lab also doing cell biology to better understand protein quality control mechanisms in ALS and other neurodegenerative disorders; keen on IDPs, condensates, and NMR!

A novel clinical metaproteomics workflow enables bioinformatic analysis of host-microbe dynamics in disease https://www.biorxiv.org/content/10.1101/2023.11.21.568121v1

A Review of Fifteen Years Developing Computational Tools to Study Protein Aggregation www.mdpi.com/2673-41... --- #proteomics #prot-paper

A true tour de force by Ben Orsburn ( @proteomicsnews.bsky.social) killing it with some metabolomic and proteomic badassery. Well done!

To all you #TeamMassSpec and proteomics tweeps who came over, or maybe came over and left, read this blog post: federation is real.

Wait, The Proteomics Show is one years old today?!!! 7300 listens later and no one has told us to stop, but @proteomicsnews.bsky.social said that would accomplish the opposite anyways, so 🤷‍♂️. Glad people are liking it, we definitely are enjoying doing it. So thanks!

Okay my MS peeps- I feel like I am going crazy. I *thought* I read there is a way to calculate a "threshold"/limits for significant fold-changes in a data set based on CV/confidence intervals or something. Arbitrarily going with 2-fold change in abundances as sig always makes me uncomfortable.

Can you believe it’s time for the Proteomics Old-Time Radio Hour again?! This Wednesday at 10am Pacific/1pm eastern with me, @leannewg.bsky.social, @ucdproteomics.bsky.social and you! Join on clubhouse and bring your friends/questions/topics/secrets.

Conversation in my house tonight: Me: Really? You fell asleep at 2 am? When I came to bed at midnight you were snoring. Him (slightly insulted): I don't snore. I "breathe agressively". Me:🤨 Him:😁 Me: You snore.

👀 @tnzeczycki.bsky.social!

@rcsbpdb.bsky.social has joined Bluesky! Please follow them and post to them. Let's form a strong structural biology community on this site as the bird site continues to descend into...

The final episode of #TheProteomicsShow Faces of US HUPO series (well, maybe a special is on deck 😉). @proteomicsnews.bsky.social and I sat down with @garcialabms.bsky.social. Definitely deserves a listen. 🧪 Find it here or anywhere you find podcasts. #proteomics

The mismeasurement of synergistic effects / non-additive interactions seems to happen regularly in some many fields. "Moreover, additive compound pairs with distinct growth/death effects can appear synergistic when only assessed by viability." www.nature.com/articles/s41... ⚕️🤖🧪📈🖥️

They ultimately extended their work to cryo-EM analysis of the complex--WOW!! It confirmed and extended things hypothesized in the other paper 15/n

Playing the "how long do we *really* have before we need to submit the poster for printing vs. How much sleep do I *really* need vs. How anxious will I be *not* having said poster printed two days before leaving for the conference" game...it is a dangerous one my friends. Dangerous. #acedemicsky

Shameless self promotion...but really. Go listen to the rest of these episodes. Because @neely.bsky.social and @proteomicsnews.bsky.social do a kick ass job of chatting with whoever they have on (like actual mass spectrometrists....)

Oh this looks cool....

I take apart high-precision instruments that are worth hundreds of thosands of dollars every day. Yet today, I am filled with panic as I attempt to replace my kitchen faucet. Wish me luck my friends.

#TeamMassSpec roll call. Who’s on this platform?

Slowly making the transition. Missing all my academic and mass spec chats on the "other" site.....