learning that astronauts have to use microsoft outlook in space is unspeakably depressing. we have set microsoft outlook free from the bounds of earth. polluting the stars with that janky piece of shit

Earth, from Artemis II. Everything you've ever done, everyone you've ever known, all that you have traveled is contained in this picture.

OH MY HELL NO #ChemSky

Just a reminder that 1yr ago today many dedicated NIH employees received RIF notices and started the process where many others were told they must leave their positions/ICs after years of service. The pain felt across the scientific community in the last year is also felt by those serving it.

Watch this clip. Professors will recognize this kid as the student who didn't do the reading but still has very strong opinions about how it's all "bullshit," except this time he's not the callow student who's going to fail your course, he's the reviewer who's going to cancel your grant.

Drugging RAS: What a Long, Strange Trip It’s Been – Channing Der addressed this topic in a keynote address to open the AACR Special Conference on RAS Oncogenesis and Therapeutics. #AACRras26

If you’re thinking of coming to the US as a foreign national on vacation, maybe it’s time to think again…

A message from your ZX Spectrum.

Gorgeous morning on an unusually warm Valentine's day.

It’s crazy watching everything we have worked for for decades being destroyed in real time.

279 postdoctoral fellowships! Download freely our database of postdoctoral fellowships and grants. For each entry, we provide eligibility criteria, $ amount, deadline, etc. Good luck! Here: research.jhu.edu/rdt/funding-...

January 16 & 17, 2026 - Brussels Two days packed with top expertise, debate, and insights from the past year in breast cancer care. Institut Jules Bordet & UZ Leuven invite you to this annual double meeting, which has become a fixture Registration link ✍️👇 accredimix.be/debate-highl...

Sunset from The balcony this week was vivid…

Submit a late-breaking abstract by January 12 for the AACR Annual Meeting 2026 (April 17-22; San Diego), chaired by Paul S. Mischel and Alice T. Shaw. Learn more: buff.ly/BqvshQ6 #AACR26

Heads up to any pancreatic cancer research that either had their R01 yanked or missed funding due to the newly restrictive paylines in 2025 (specifically anyone who scored 15%ile or below, but didn't get funding). media.pancan.org/rsa/2026/Pan...

RFK Jr & his loyal henchmen (the Great Barrington Declaration dudes Jay Bhattacharya & Martin Kulldorff; Martin Makary; Dr Oz; Vinay Prasad) have been successfully dismantling the US vaccination system & achieved the return of deadly vaccine preventable diseases. This is the world they worked for...

The abstract deadline for the AACR Annual Meeting 2026 is 11:59 PM ET on Tuesday, November 18. Submit an abstract and join the cancer research community in San Diego, April 17-22. Learn more: buff.ly/dzZnhJr #AACR26

A metaphor for life….

The 2026 Chemistry Faculty Jobs List has 170 tenure-track positions and 19 teaching positions: docs.google.com/spreadsheets... #facultychemjobs #chemjobs #chemsky 🧪⚗️

Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!

What if treating disease meant stabilizing biology, not blocking it? We explore that idea in @ScienceMagazine with LOCKTAC molecular glues, a new class of molecules that stabilize natural interactions to either boost or block biology. science.org/doi/10.1126/sc…shorturl.at/976aj#mycompnayay

What’s your last primary literature publication(s) in the face of future funding being destroyed? I’ve got 2: 1) ADAM17 inhibition prevents pancreatic oncogenesis and tumor progression 2) TSHZ2 maintains the hybrid subtype of pancreatic cancer We will be lucky to finish #2 without more funding

Finally out! This is an amazing story on lipid trafficking and how to visualize membrane lipids inside of cells! Check it out. I am honored I could contribute a little to this story 😁

It is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit. You all have my sympathies. Unfair doesn’t even begin to describe it.

My team has updated our free database of POSTDOC fellowships. This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria. Download this updated and expanded database here: research.jhu.edu/rdt/funding-...

Grateful to Sally Church for her incisive review of our recent @science.org manuscript, capturing its significance — from target space expansion to pharmacologic implications to the evolving therapeutic landscape. @maverickny.bsky.social biotechstrategyblog.com/2025/07/how-...

Exciting news from Finland: the world’s largest sand battery (1 MW/100 MWh) is now online! The Pornainen project by Polar Night Energy is 10x bigger than the first commercial sand battery and sets a new benchmark for affordable, long-duration energy storage.

If you are a PhD or postdoc and want to present your work alongside e.g. Sarah O'Connor and @craigmcrews.bsky.social, you still have two weeks to apply for a Flash Talk at the 5th Virtual ChemBioTalks. Deadline is June 30th. chemistry-europe.onlinelibrary.wiley.com/hub/journal/... #ChemBio #ChemSky

Well, it turns out that you can actually make PyMOL do quite a lot of stuff. Here's the full workflow, integrating the amazing ReGlyco into PyMOL to re-glycosylate the LDLA linker. There's some serious magic needed to get it running as fast as it is within PyMOL. @elisafadda.bsky.social

Discovery of a New and Selective HPK1 PROTAC for Enhancing Tumor Immunotherapy through Eliminating GLK Degradation

Paracetamol (aka acetaminophen, Tylenol, Panadol, Calpol) has been one of the world’s most widely used painkillers, yet like its precise mechanism of action remained unclear...

The spread of Mpox in Sierra Leone is unlike anything we have ever seen - and we have been keeping an eye on this bug in the region for >15 years. Given geographical spread, 50/50 men vs women, this is no "sexual network". This could be the next one. clt.npha.gov.sl/outbreak.aspx

Had fun creating a cheesy cartoon on AI for a blog post on T cell engagers… biotechstrategyblog.com/2025/05/t-ce...

Huge opportunity for postdocs gearing up for an academic job search, hosted by @stanford-chemh.bsky.social @berkeleymcb.bsky.social and UCSF!

We have updated our database of funding opportunities for Early-Career Researchers (private foundations, federal, international) We have 456 entries, for which we provide $ amount, deadline, eligibility criteria, etc. Download this massive database here for free: research.jhu.edu/rdt/funding-...

So, how many genetic diseases come down to good ol’ loss-of-function in the targeted protein? Your estimate is probably too high:

Important message. Also important to remember that federal funding for science isn’t “given” to university laboratories - it is awarded based on highly competitive process, profs spend months/years on proposals that are reviewed by experts, most are rejected. www.young.senate.gov/newsroom/pre...

There's a good explainer here: www.scientificamerican.com/article/chem...

“Given the very real consequences for our competitiveness, our standard of living and, yes, also our bottom lines, we all ought to be making the case for aggressively funding basic science.” www.nytimes.com/2025/04/28/o...

Not exactly the definition of winning…

Good news on a Friday... "A federal judge on Friday ordered a permanent injunction blocking a Trump administration policy that would slash billions in research overhead payments to universities, academic medical centers, and other grant-receiving institutions." 🛟🧪😷📈

it's now within the realm of possibility that this dude's gonna build a new NAFTA that excludes the U.S., and new ice-free arctic trade routes will mean Canada has the biggest ports on this continent within 2-3 decades

I am sure that this is right. The NIH doesn’t discover many new drugs themselves (that’s not what they’re set up to do), but the fundamental research they fund is *absolutely crucial* to biomedical progress. Watching Trump and Musk destroy it all is driving me to despair.

ICYMI, NIH will be asking soon for each NIH-funded researcher to justify every draw they make (often several times a week) on their grants and every NIH officer and their boss will have to justify their agreeing on these draws. This is the death of US biomedical research by a thousand cuts

#hiring #postdoc We are looking for a postdoc to work on anti-tumor gamma delta T cells in breast cancer metastasis mouse models. Apply here: www.gla.ac.uk/explore/jobs...

As federal funding for research is uncertain, we need to diversify funding sources for our PhD students. Here is a comprehensive list of >160 PhD fellowships and funding opportunities, mostly from private foundations and scientific societies. Download it here: research.jhu.edu/rdt/funding-...

These are extremely challenging times for early-career faculty. Here is my office's small contribution to make their hard and important work a bit easier: Download our curated and comprehensive database of funding opportunities for early-career faculty. Here: research.jhu.edu/rdt/funding-...

The French are the best protesters