Dr. Zeest Khan @doctor_zeest developed Long COVID and says it changed how she practices medicine, pushing doctors to listen, admit uncertainty, and partner with patients while research like RECOVER-TLC tests treatments for a condition with 200+ symptoms fnih.org/patient-enga...

Dr. Sara Cherry breaks down antiviral strategies, how the innate immune system (specifically interferons & the CNOT2 pathway) controls infections, and the GI tract’s role as a potential reservoir for Long COVID. www.youtube.com/live/hhKu6RZ...

A mitochondrial drug is being tested for long COVID fatigue with post exertional malaise (PEM). What it does, and what the prior trials found 🧵 clinicaltrials.gov/study/NCT072...

something abled people don't get is you can have just one day a week where you are too sick to work, and that's enough to disqualify you from nearly all full-time jobs. it doesn't take a lot

Interessant: Ausmaß der Tachykardie war hier bei #POTS v orthostatischer Intoleranz bei Kindern nicht relevant für Ausmaß der funktionellen Einschränkung. Passt zur Diskussion, dass es bei POTS eher um reduzierten zerebralen Blutfluss gehen könnte. www.jpeds.com/article/S002...

NIH researchers launched a 380 participant randomized trial to test IVIG, ivabradine, and coordinated care for Long COVID POTS, aiming to improve orthostatic intolerance symptoms and guide treatment. www.sciencedirect.com/science/arti...

Jan. 2026, Medscape: 'New-Onset Allergies Another Woe for Patients With Long COVID' “Long COVID is, at its core, a condition of immune dysfunction,” Becker said. “New allergies are one manifestation of that dysfunction.”- Jacqueline H. Becker, PhD, Mount Sinai www.medscape.com/viewarticle/...

"...acetylcholine deficiency and resultant parasympathetic hypofunction with relative sympathetic hyperactivity..." Spannender #POTS Fallbericht mit konkreter genetischer Erklärung, aber generell etwas, das oft dem klinischen Eindruck entspricht. academic.oup.com/ehjcr/articl...

She can dive 30 feet underwater, but some days she cannot stand long enough to shower. Long Covid took her career and independence. At 34, she is back with her parents, sleeping many hours just to function. Still, she keeps going. www.theguardian.com/society/2026...

Many neurologic diseases keep worsening even after the trigger is controlled In MS and Alzheimer disease, damage can drive self sustaining inflammation and neurodegeneration, a process called progression independent of the triggering event www.neurology.org/doi/10.1212/...

Ein Artikel über das Vorkommen von Urticaria bei einer Subgruppe von Menschen mit #POTS, wo es ja Überschneidungen mit Mastzellenaktivierung gibt. Auch bei POTS ist das therapeutische Herangehen individuell und sollte Evaluation von #MCAS beinhalten. www.tandfonline.com/doi/10.1080/...

Bambino Gesu Children’s Hospital in Rome treated 8 children with life threatening autoimmune disease using CAR T cells that target rogue B cells. All improved, 3 with lupus reached full remission, and some organ damage was reversed. www.nature.com/articles/d41...

Exercise pumps up your muscles — but it might also be pumping up your neurons go.nature.com/4r94ftv

Kristaps Porzingis Isn’t Long for the Golden State Warriors Key Points: Kristaps Porzingis is on an expiring contract. Porzingis has a serious health problem called POTS The Warriors May Miss the 2025-26 Playoffs The Golden State Warriors traded Jonathan Kuminga and Buddy Hield for Kristaps…

Iliac vein stenting for symptom improvement in Postural Orthostatic Tachycardia Syndrome or POTS retrospective studies: www.thelancet.com/action/showP...

Researchers used mouse models to show that gut immune cells absorb misfolded Parkinson’s proteins, trigger T cells, and send them to the brain, where they spark neuron loss and motor symptoms. www.nature.com/articles/d41...

Can you Prevent SLE? Dr. David Karp lecturing at UTSW Showing that autoantibodies exist long before the onset of SLE @drdavidkarp @utswrheum

Factors that may augment future development of SLE - includes Vitamin D levels, poor sleep, EBV reactivation & social determinants of health. Can you Prevent SLE? Dr. David Karp lecturing at UTSW @drdavidkarp @utswrheum

History suggests caution: When medicine cannot yet measure a disease, labeling it psychogenic may reflect limits of tools, not limits of the patient.

Many diseases were once called “psychological” or “all in the mind”. Again and again, biology later proved otherwise. This thread shows clear cases where medicine got it wrong, then changed its mind once real mechanisms were found.

Tianjin Medical University researchers review how extracellular vesicles from dying cells may drive autoimmune diseases by carrying nuclear and cytoplasmic molecules that trigger inflammation, activate T cells, and break immune tolerance. www.jci.org/articles/vie...

Flinders University assessed 9 long COVID-19 patients with neurological symptoms and found that 33% had small fibre neuropathy using non-invasive nerve tests. All had major fatigue and disability despite normal standard nerve studies. neurologyopen.bmj.com/content/8/1/...

Rheumatoid arthritis is one of the most common autoimmune conditions, and it affects far more than joints. It’s shaped by genetics, environment, hormones, and health factors that vary widely from person to person. No two RA stories look exactly the same.

Air pollution ups ANA+: Ontariio Canadi study of 3548 serum samples (2010-13) corrlated particulate matter (PM2.5) w/ serologies. Highest vs lowest quartile PM2.5 showed higher risk of ANA ≥1:640 (OR 1.46) & ≥1:1280 (OR 1.54). Pollution has systemic immune effects! academic.oup.com/rheumatology...

Dr. Kevin Tracey showed that the vagus nerve links the brain to the immune system. One minute of daily stimulation can reduce inflammation and just got FDA approval for hard-to-treat rheumatoid arthritis. His book was one of my favorites last year. erictopol.substack.com/p/vagus-nerv...

"Proteomic analysis revealed 35 differentially expressed proteins in hEDS, with 43% involved in the complement cascade and 80% linked to immune, coagulation, or inflammatory pathways."

Yeah, what they said #LongCovid “you wake up with a certain amount of energy currency each day (let’s say 100 units). A healthy person might have 1,000 units. Everything costs energy: showering 10, getting dressed 5, making breakfast 8, driving to work 15. Work shift 300 units”

1) "...While studies on biopsychosocial factors in physiologic disorders like POTS can be informative, they can also be weaponized by those who continue to erroneously believe that patients with POTS have abnormal behavioral, emotional and coping mechanisms..."

Make Visible Podcast: 'The truth about exercise & pacing in ME/CFS, Long Covid, POTS, with Todd Davenport' www.youtube.com/watch?v=uAXJ...

“One of your big points is that .. post exertional symptom exacerbation.. is NOT de conditioning “ open.spotify.com/episode/7bgT...

Our latest work now posted as a pre-print on Research Square: "ME/CFS and Long COVID Demonstrate Similar Bioenergetic Impairment and Recovery Failure on Two-Day Cardiopulmonary Exercise Testing" Read more: www.researchsquare.com/article/rs-8... #MECFS #LongCOVID #PEM @sunsopeningband.bsky.social

Rome-based researchers studied 96 people post-COVID and found that those with long COVID showed a flattened daily cortisol rhythm. Morning levels were low, evening levels were high, and severity of symptoms matched the degree of hormonal disruption. www.frontiersin.org/journals/cel...

Scientists just mapped tiny veins across the entire living human brain in under 7 minutes using ultra-high resolution MRI. Previously this kind of detailed view was mainly built from postmortem (after death) methods. Here’s what they did and why it matters.

#POTS and Mast Cell Activation - Dr. Amro Stino, MD , University of Michigan youtu.be/47s4eMYdA54?...

#Medsky🧪 #IDsky #Neurosky #publichealth Histological evidence that autonomic small fiber damage is a central feature of painful #longCOVID www.frontiersin.org/journals/hum... Patients with painful #longCOVID show a significant reduction in autonomic nerve fiber densities, specifically

UC Davis studied 11 cats with FIP and found the virus infects not just macrophages but also T and B cells. It replicates inside lymphocytes and can linger even after treatment, offering clues to how long COVID might persist in humans. www.discovermagazine.com/what-cats-ar...

New important publication in #LongCovid & #MECFS! After a viral infection, cells lining our blood vessels can become damaged and enter senescence, similar to accelerated aging. These cells are not healthy, but they also don’t disappear. Instead, they send out constant stress & inflammatory signals.

Researchers from the University of Adelaide reviewed over 30 years of data and found that POTS is a complex, often misdiagnosed disorder that affects mostly women and can take 5 to 7 years to diagnose. Symptoms often worsen after COVID-19. www.heartlungcirc.org/article/S144...

"We believe that internal tremors [in #LongCovid] represent... dysautonomia & small fiber neuropathy... caused by hypovolemia, cerebral hypoperfusion, hyperadrenergic state, mast cell hyperactivation, & neuropathic processes affecting small nerve fibers." www.mdpi.com/2035-8377/17...

So many Athletes have had their whole careers derailed by long covid. Busting the narrative proving it can happen to anyone. COVID doesn’t care what our plans are sadly.

@lisanoren.bsky.social @stenhelmfrid.bsky.social @bmhughes.bsky.social @davetuller1.bsky.social Some Swedish researchers are hard at work to revive the pseudoscience of "illness prone personality" of Eysenck, now considered unsafe, as well as the BPS model (hysteria), applied for long covid & ME.

More evidence that exercise should be approached with extreme caution in people with #MECFS , as well as those with #longcovid or other chronic illnesses who experience post-exertional malaise: www.medscape.com/viewarticle/...

Khoryati et al. identify a T cell receptor Vβ21.3 signature in #SARSCoV2–related multisystem inflammatory syndrome in adults (MIS-A) similar to that previously reported in children (MIS-C), suggesting a shared immune-related mechanism between the two conditions. rupress.org/jhi/article/...

BBC Radio 4 Inside Science interview with Professor @daltmann.bsky.social (8 mins) discussing the Rosetta Stone study, a £1.1m research programme funded by the @meassociation.org.uk to investigate shared immunological pathways between #MECFS and #LongCovid. youtu.be/eu8Lj_R-OtQ?...

Nature research paper: Neuro-epithelial circuits promote sensory convergence and intestinal immunity go.nature.com/4qeRjlt

The Scientist: 'The Ear as a Therapeutic Gateway to the Vagus Nerve' 'Auricular vagal neuromodulation therapy is a non-invasive and non-surgical treatment that could aid cardiovascular disease management, Long COVID relief, and more.' www.the-scientist.com/the-ear-as-a...

New Cell paper from the team that discovered glymphatic clearance (how your brain removes waste during sleep). Sleep hours DIDN'T predict brain cleaning. Neither did REM or deep sleep. They found what actually matters - and why some sleeping pills might undermine it 🧵

Telegraph Journal: 'Patient pushes for ER protocol for uncommon disorder' 'She would like to see the health authorities establish a protocol for when patients with POTS or dysautonomia present to the emergency departments...' tj.news/moncton-mira...