Butyrate extends health and lifespan in mice with mitochondrial deficiency www.nature.com/articles/s41...

🚨 Happy to share our work published in @natcomms.nature.com We show that strategies to preserve microbiota-derived butyrate delay multiorgan failure and prolong lifespan in mice with mitochondrial disease, linked to epigenetic remodeling 🔋 💪🏼 @enriquegab.bsky.social www.nature.com/articles/s41...

🦠Las mitocondrias producen la energía de las células 🔎Su mal funcionamiento altera la #microbiota, según un estudio de @cbm-csic-uam.bsky.social  🔬Restaurar una molécula producida por bacterias intestinales prolonga la vida de ratones con enfermedades mitocondriales ➡️ http://tiny.cc/laq0101

Una molécula producida por la microbiota intestinal podría ser clave para tratar enfermedades mitocondriales. Investigadores del CBM muestran que restaurar el butirato mejora la salud y prolonga la vida en modelos animales. www.cbm.uam.es/index.php/20...

Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV @cellcellpress.bsky.social @ragoninstitute.bsky.social @harvardmed.bsky.social www.cell.com/cell/fulltex...

Online now! Soto-Heredero et al. show that Tregs characterized by the expression of KLRG1 accumulate with age in both mice and humans, and exhibit features like mitochondrial decline and an inflammatory phenotype. doi.org/10.1038/s435...

El grupo de María Mittelbrunn en el CBM descubre un mecanismo celular que altera la microbiota intestinal y aumenta la aparición de enfermedades. Con una terapia celular lograron restaurar la inmunidad intestinal y prevenir estos efectos. www.cbm.uam.es/index.php/20...

🔬Un estudio del CSIC demuestra que el deterioro asociado a la edad de los linfocitos T CD4 debilita la barrera intestinal y favorece la inflamación crónica y el envejecimiento celular 💉 El trabajo también presenta una posible terapia ➡️ https://tinyurl.com/97ssrv74

#WeekendRead! #LiveForever & #MicrobiotaPower! Mittelbrun &co show @ Science Immunology that mitochondria alteration in T cells drives premature #inflammaging by decreasing Tfh & Treg cells which causes gut permeability & dysbiosis that can be corrected by T cell transfer! doi.org/10.1126/scii...

Fresh from the oven 🧨💥 We show that CD4 T cells, especially Tregs, control host-microbiota symbiosis and intestinal barrier integrity to prevent inflammaging, tissue senescence and aging-related multimorbidity 🔥 👵🏻 www.science.org/doi/10.1126/...

This week's cover, illustrated by the amazing Ashley Mastin, highlights work by @mmgomezheras.bsky.social & al.!

The August issue of #Science #Immunology is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid #arthritis; vagal TRPV1+ sensory #neurons protect against #influenza virus infection; & transfer of #Tregs alleviates #inflammaging in mice! wwwscience.org/toc/sciimmun...

Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging @sciimmunology.bsky.social @mmgomezheras.bsky.social www.science.org/doi/10.1126/...