Manuel M. G贸mez de las Heras, PhD
@mmgomezheras.bsky.social
馃摛 58
馃摜 150
馃摑 3
Postdoc 馃К馃ゼ | Tissue Immunity | Metabolism | Aging | PhD in Mar铆a Mittelbrunn's lab
pinned post!
Fresh from the oven 馃Ж馃挜 We show that CD4 T cells, especially Tregs, control host-microbiota symbiosis and intestinal barrier integrity to prevent inflammaging, tissue senescence and aging-related multimorbidity 馃敟 馃懙馃徎
www.science.org/doi/10.1126/...
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CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity
Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.
https://www.science.org/doi/10.1126/sciimmunol.adv0985
7 months ago
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reposted by
Manuel M. G贸mez de las Heras, PhD
Waggoner Lab
6 months ago
Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV
@cellcellpress.bsky.social
@ragoninstitute.bsky.social
@harvardmed.bsky.social
www.cell.com/cell/fulltex...
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Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV
PPAR纬 downregulation in colonic CD8+ T cells from people with HIV (PWH) on antiretroviral therapy (ART) disrupts lipid metabolism and promotes contact-dependent epithelial apoptosis, leading to intest...
https://www.cell.com/cell/fulltext/S0092-8674(25)00979-1
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reposted by
Manuel M. G贸mez de las Heras, PhD
Nature Aging
11 months ago
Online now! Soto-Heredero et al. show that Tregs characterized by the expression of KLRG1 accumulate with age in both mice and humans, and exhibit features like mitochondrial decline and an inflammatory phenotype.
doi.org/10.1038/s435...
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KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging
Nature Aging - T cells undergo age-related changes that impair their organismal functions. Here Soto-Heredero et al. show that regulatory T cells characterized by the expression of KLRG1 accumulate...
https://rdcu.be/ekJSM
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reposted by
Manuel M. G贸mez de las Heras, PhD
Centro de Biolog铆a Molecular Severo Ochoa
8 months ago
El grupo de Mar铆a Mittelbrunn en el CBM descubre un mecanismo celular que altera la microbiota intestinal y aumenta la aparici贸n de enfermedades. Con una terapia celular lograron restaurar la inmunidad intestinal y prevenir estos efectos.
www.cbm.uam.es/index.php/20...
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Descubren un mecanismo celular que altera la microbiota intestinal y aumenta la aparici贸n de enfermedades m煤ltiples - Centro de Biolog铆a Molecular Severo Ochoa
La p茅rdida de funci贸n de los linfocitos T CD4 altera la microbiota intestinal y, en consecuencia, acelera el envejecimiento celular y aumenta el riesgo de enfermedades m煤ltiples. Es lo que [鈥
https://www.cbm.uam.es/index.php/2025/08/04/descubren-un-mecanismo-celular-que-altera-la-microbiota-intestinal-y-que-aumenta-la-aparicion-de-enfermedades-multiples/?lang=es
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reposted by
Manuel M. G贸mez de las Heras, PhD
CSIC
8 months ago
馃敩Un estudio del CSIC demuestra que el deterioro asociado a la edad de los linfocitos T CD4 debilita la barrera intestinal y favorece la inflamaci贸n cr贸nica y el envejecimiento celular 馃拤 El trabajo tambi茅n presenta una posible terapia 鉃★笍
https://tinyurl.com/97ssrv74
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reposted by
Manuel M. G贸mez de las Heras, PhD
Ivan Zanoni
8 months ago
#WeekendRead
!
#LiveForever
&
#MicrobiotaPower
! Mittelbrun &co show @ Science Immunology that mitochondria alteration in T cells drives premature
#inflammaging
by decreasing Tfh & Treg cells which causes gut permeability & dysbiosis that can be corrected by T cell transfer!
doi.org/10.1126/scii...
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CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity
Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.
https://doi.org/10.1126/sciimmunol.adv0985
0
7
3
Fresh from the oven 馃Ж馃挜 We show that CD4 T cells, especially Tregs, control host-microbiota symbiosis and intestinal barrier integrity to prevent inflammaging, tissue senescence and aging-related multimorbidity 馃敟 馃懙馃徎
www.science.org/doi/10.1126/...
loading . . .
CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity
Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.
https://www.science.org/doi/10.1126/sciimmunol.adv0985
7 months ago
2
7
2
reposted by
Manuel M. G贸mez de las Heras, PhD
Seth Thomas Scanlon
8 months ago
This week's cover, illustrated by the amazing Ashley Mastin, highlights work by
@mmgomezheras.bsky.social
& al.!
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CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity
Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.
https://www.science.org/doi/10.1126/sciimmunol.adv0985
1
4
5
reposted by
Manuel M. G贸mez de las Heras, PhD
Seth Thomas Scanlon
8 months ago
The August issue of
#Science
#Immunology
is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid
#arthritis
; vagal TRPV1+ sensory
#neurons
protect against
#influenza
virus infection; & transfer of
#Tregs
alleviates
#inflammaging
in mice!
wwwscience.org/toc/sciimmun...
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reposted by
Manuel M. G贸mez de las Heras, PhD
Waggoner Lab
8 months ago
Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging
@sciimmunology.bsky.social
@mmgomezheras.bsky.social
www.science.org/doi/10.1126/...
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