Huntington’s disease treated successfully for first time in gene therapy trial

New landscape of the diagnosis of Alzheimer's disease www.thelancet.com/journals/lan... by @thelancet.com #Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence

Lab’s latest is out in Imaging Neuroscience, led by Kirsten Peterson: “Regularized partial correlation provides reliable functional connectivity estimates while correcting for widespread confounding”, where we demonstrate a major improvement to standard fMRI functional connectivity (correlation) 1/n

A program in Flint, MI, gave $1,500 to any/all pregnant people and $500/month for the first year of their infant’s life. Among the benefits, those babies experienced lower rates of prematurity and low birth weight, which resulted in fewer NICU admissions, saving the city of Flint $6.2 million/year.

📱EMA is increasingly used in intervention studies to acquire a more fine-grained and ecologically valid assessment of change. But EMA is relatively burdensome. What's the added value? We tried to address this question in our new paper now out @jmirpub.bsky.social www.jmir.org/2025/1/e69297 1/n

Will ICE send guys to Boston looking for red hair and listening for brogues? Or stake out delis in Chicago to see who buys a kielbasa? No. This is about profiling people by skin color and language. www.theatlantic.com/newsletters/...

How do sex, stress & anxiety shape risk for Alzheimer’s disease? Join Dr. Holly Hunsberger on Sept 15 for our next #WHSS talk on vulnerabilities to aging & AD. 📅 Sept 15 | 12pm ET 💻 Free, virtual — register today: ow.ly/KR1150WJEny #Alzheimers #Research #WomensHealth

So, kudos to both #Democrats & #Republicans in the House for their draft mark-up for next year's #budget, which maintains funding for #NIH (just like the Senate). This is rare, true #bipartisanship and should be praised. But #RussellVought will not be stopped by an appropriations bill. Why? 1/

After 5 years, I finally carved out time to turn this blog post on FDR (markallenthornton.com/blog/fdr-pro...) into a manuscript. The preprint features a much broader range of simulations showing how FDR promotes confounds, and how this effect compounds with publication bias: osf.io/preprints/ps...

This is the definition of a failed social media platform.

Here is the Priorities document (long thread) 1/n

Are similar representations in neural nets evidence of shared computation? In new theory work w/ Lukas Braun (lukasbraun.com) & @saxelab.bsky.social, we prove that representational comparisons are ill-posed in general, unless networks are efficient. @icmlconf.bsky.social @cogcompneuro.bsky.social

🚨 New Preprint 🚨 Targeting intracranial electrical stimulation (ES) to network regions defined within individuals causes network-level effects By Cyr et al. *** Q: Can we use individualized network maps from precision fMRI to modulate a targeted network via intracranial ES? A: Yes! 🧵:

A randomized trial (N>2,100 participants, multi-center) of structured vs self-guided lifestyle interventions in older adults shows the former improved cognitive function jamanetwork.com/journals/jam...

🚨We are recruiting a lab manager who will spend 80% of their effort in my lab and 20% of their effort in @leorhackel.bsky.social's lab. Please share widely! Apply at usccareers.usc.edu/job/los-ange... with: completed questionnaire (socolab.org/lab-manager-application), CV & Cover Letter!

PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.

Please repost! We're hiring a postdoc to work with me and @salagapan.bsky.social on an exciting interdisciplinary project in human neuroscience and brain-body interactions underlying effortful behavior in health and mood disorders. siplab.gatech.edu/postdoc_ad_2...

🧠 What if Alzheimer’s risk starts at the synapse? In our new study led by Mariana Barata, we show that BIN1, a key AD risk gene, regulates inhibitory synapses—loss of BIN1 → hyperexcitability before Aβ. www.cell.com/cell-reports...

1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements... doi.org/10.1038/s415...

Hi world - its been a hard year with #cancer meaning I missed out lots of fun things. It would mean a lot if you checked out my new album of tracks. Out on all platforms including #Soundcloud (free). Let me know which tracks you like and a special prize if you work out the two levels to the project

If you are a student and postdoc interested in body-brain communication - check out Chris's lab!

Just sent this as an email to my department but figured I'd share more broadly in case it is useful. This describes the procedure happening now for science funding in Congress (@davidimiller.bsky.social can correct me if I got this wrong). Importantly, there are still actions that can be taken.

Hot Summer Nights the new album by the Natural Philosophers is out now. If you would like to help: Stream it a few times Post reply mentioning a track you like by name. Spotify: open.spotify.com/album/0Tju52... Apple Music music.apple.com/us/album/hot... Soundcloud soundcloud.com/npwa/sets/ho...

Oh no! mamdanitimes.com

Enough of you asked me about this that I wrote some brief thoughts on Ocean Ramsey's particular brand of pseudoscientific nonsense. I believe this addresses almost all of the frequently asked questions I receive, but as always I am happy to answer serious questions asked in good faith. 🧪🦑🌎🦈

Elon Musk casually, and illegally, dismantled USAID. According to a new study in the Lancet, that action will lead to *14 million* premature deaths between 2025 and 2030. Again: Elon Musk is directly responsible for 14 million coming deaths. 4.5 million will be children.

We are looking for a Postdoc who loves fMRI, psychophysiology and data analysis 🎉. We run studies on social cognition and related processes with a focus on schizophrenia. German skills could be beneficial, bc the position involves teaching, but not mandatory. stellen.uni-konstanz.de/jobposting/4...

I am privileged to announce the publication of the Anti-Autocracy Handbook: sks.to/autocracy 1/12

Lando you muppet

Getting my “the Pacers had an easy path to the title” takes ready for if they win in 5

Hi friends, I have news! Giga connectome, a BIDS app for post-fMRIPrep connectome extraction, is now in @joss-openjournals.bsky.social 🎉 Thanks to @remigau.bsky.social, @clarken.bsky.social, Quentin Dessain, and @lune-bellec.bsky.social for working on this together

Someone during the ECF said the Lakers would beat this Pacers team 😂

I just want at least one person to suffer at least one real consequence. Is that too much to ask?

NBA: Celtics WNBA: still shopping for a team but liked watching the Lynx last year NFL: Bills NHL: sorry one sport had to lose out MLB: Mets Soccer: Brighton & Hove Albion College: whoever is the underdog usually

I’m posting 1 queer tweet a day during #PrideMonth. 🏳️‍🌈 For 6/2, we’re looking at nature. Gay sex has been documented in 1,500+ animal species, 261 mammals and 51 primates. What all these species have in common: living in social groups. Biology is queer AF, babies. 🌈 www.nature.com/articles/s41...

Jayson Tatum: 27 wins, 2 Conference Finals Apps.

Just heard an undergrad refer to Avicii as “old school” 😣

There is no "science-wide replication crisis" because every word in that phrase carries unfounded assumptions. 🧵 1. There is no evidence that progress has generally stalled in the sciences. Also, no one has actually tried to estimate replicability across fields.

How does the brain reorganize in the context of age and AD? Are functional changes in age and AD similar? Are these changes dynamic across the age/AD spectrum? We unpack these questions in a sample of N=973 with AD biomarkers Preprint: tinyurl.com/ymv8s7h8 ⬇️🧵 1/

Politics is all messed up. I'm being inspired by the Royals? While being continually disappointed by left-leaning politicians?

🚨 Two PhD positions open in Barcelona! Work with Diego Vidaurre on machine learning at the intersection of methods, neuroscience, and clinical applications. Details: 🔗 www.crm.cat/call/89/phd-... 🔗 www.crm.cat/call/88/phd-... #neuroskyence #psychscisky

Just as an anecdotal note, when Arnold was starting to fund metascience/reproducibility and when I knew nothing about the guy, I naively sent an inquiry about asking funding for this project, basically suggesting we needed to understand reproducibility before making policy. 1/3

I recommend the #metascience community spends a day reading about agnatology and how interests undermine science. Half of the discourse is people really not understanding how earnest people get selectively funded to bias the literature.

Together with @macshine.bsky.social & @elimuller.bsky.social we have a cool interdisciplinary project on compositional cognition, and we’re looking for a PhD student. More details here www.findaphd.com/phds/project... DM or email any questions Please RT or pass on to interested students. Thanks!

There are two wolves inside me. One wants the Knicks to get embarrassed. The other wants more of this series. I guess the second one gets fed tonight.

Brunson with nobody in rebounding position with the game on the line:

America cannot long remain free, nor first among nations, if it becomes the kind of place where universities are dismantled because they don't align politically with the current head of the government.

Just to be clear this is not something we can tell from this study and any suggestion that it might be seems dangerous to me.

Three things made the US a rich and powerful nation: the rule of law, its science & innovation system, and openness to foreign talent. Remarkable how Trump has taken a sledgehammer to all three. No enemy of this country could do more.