Machine learning analyses in the MYRIAD trial found only clinically trivial personalization of school-based mindfulness for adolescent #Depression prevention, underscoring limited differential benefit in universal programs. ja.ma/4qUhbCL

John Torous, MD, speaks with Christian A. Webb, PhD, of Harvard Medical School and McLean Hospital, about the limits of population-level prediction and the need for more potent and targeted interventions for #YouthMentalHealth. 🎧 Listen now: ja.ma/3OSGiIw

Beyond the headline results, we discuss why meaningful personalization proved elusive – and what promising directions may move the field forward – on the @jamapsychiatry.com podcast: 🎙️https://edhub.ama-assn.org/jn-learning/audio-player/19039530

New paper from our team: Can ML identify which adolescents benefit most from school-based mindfulness? In 8,376 students (MYRIAD trial), models detected statistically significant but clinically negligible differential effects (d ≈ .07–.08). Precision prevention is hard...

Machine learning analyses in the MYRIAD trial found only clinically trivial personalization of school-based mindfulness for adolescent #Depression prevention, underscoring limited differential benefit in universal programs. ja.ma/3OkeH2P

⭐ NEW PAPER ⭐ on a Bayesian approach to sample size calculations for external validation of risk prediction models - account for uncertainty in the assumed true performance of the model - plus calculate assurance probabilities & the value of information onlinelibrary.wiley.com/doi/10.1002/...

Interesting to see how our lab's recruitment sources have shifted over the last 3 years (see plot). FB/Instagram used to pull 100+ responses/month, now much less productive. Methods like flyers and mailing lists remain steady. Curious if any other labs are seeing this or have found new methods?

Matthew 25:40-45 “Then he will say to them... ‘Depart from me, you who are cursed, into the eternal fire prepared for the devil and his angels. For... I was a stranger and you did not invite me in, I needed clothes and you did not clothe me, I was sick and in prison and you did not look after me.’

The special issue call for papers is now live on the JCCP website: “Innovations in Digital Phenotyping for Scalable Personalization of Mental Health Care.” Details and submission information are available here: www.apa.org/pubs/journal...

🚨 Upcoming JCCP Special Issue: "Innovations in Digital Phenotyping for Scalable Personalization of Mental Health Care" Edited by Sigal Zilcha-Mano, Roee Admon, & me. 🗓 Pre-proposals due March 2, 2026 Will show on JCCP website soon (sharing early for planning) ⬇️ Call for Papers tinyurl.com/3tkps63c

🚨 Upcoming JCCP Special Issue: "Innovations in Digital Phenotyping for Scalable Personalization of Mental Health Care" Edited by Sigal Zilcha-Mano, Roee Admon, & me. 🗓 Pre-proposals due March 2, 2026 Will show on JCCP website soon (sharing early for planning) ⬇️ Call for Papers tinyurl.com/3tkps63c

Built a pipeline that automatically runs each morning and pulls new papers + preprints, merges them with CV (recent pubs + grants), and prepares an LLM-ready summary of emerging research directions and relevant funding opportunities. First pass, please improve. OSF: lnkd.in/ev3T2ibn

We're hiring! The Computational Clinical Science Lab @ Yale is seeking a full-time lab manager/research coordinator to start in early summer 2026. For more information about the position and to apply: forms.gle/LtQwVgPUfaGk... Please share widely & consider applying!

Interested in research on depression in youth? New opening for a full-time research assistant in our lab (webbslab.com) to work on a range of projects focused on the causes & treatment of depression in teens. Come join our growing lab. Please RT and share! Apply⬇️ webbslab.com/job-postings

Fantastic post-bacc opportunity! ⬇️

Interested in research on depression in youth? New opening for a full-time research assistant in our lab (webbslab.com) to work on a range of projects focused on the causes & treatment of depression in teens. Come join our growing lab. Please RT and share! Apply⬇️ webbslab.com/job-postings

Honored to have our work recognized by @bbrfoundation.bsky.social, alongside many colleagues doing important work in the field.

Lab dinner with the growing team! 🎉 Thrilled to welcome new postdocs Poorvesh Dongre and Francesca Morfini. Very grateful to work with this brilliant and dedicated group every day.

Join us next week at the Technology in Psychiatry Summit #TIPS2025! Dec 11–12 | Virtual | 11AM–5PM ET 💡 Topics: • AI-driven mental health apps • LLMs in dementia caregiving • Digital Navigators bridging tech + care • AI for eating-disorder treatment ...& much more 🔗 tips.societyconference.com/v2/

Great work on this meta-analysis Hadar!

💫 Excited to share new preprint a systematic review & meta-analysis of 123 studies (40k+ ppl) on how well language-based models detect depression from text. www.researchsquare.com/article/rs-8...

Join us at the Technology in Psychiatry Summit (TIPS) #TIPS2025! Dec 11–12 | Virtual | 11 AM–5 PM ET 💡 Topics: • AI-driven mental health apps • LLMs in dementia caregiving • Digital Navigators bridging tech + care • AI for eating-disorder treatment ...& much more 🔗 tips.societyconference.com/v2/

Check out this write-up of a recent DPN article from @bbrfoundation.bsky.social highlighting BBRF awardees @christianwebb.bsky.social, @erika-forbes.bsky.social, and @diegopizzagalli.bsky.social. Congrats! bbrfoundation.org/content/smar...

Thanks to @bbrfoundation.bsky.social for highlighting our lab's study (led by @hadarfisher.bsky.social & @nigeljaffe.bsky.social) using📱smartphone sensors + LLM-derived text ratings to track behavioral activation and symptom change in teens with anhedonia. bbrfoundation.org/content/smar...

📢 New large study of ~1.5 million patients in NHS Talking Therapies finds that teens/young adults (ages 16-24) had 17-26% *lower* odds of reliably improving vs 25-65 year-olds. Time to rethink youth-centred mental-health delivery? 🔗 tinyurl.com/532y6v67

Great work Hadar!

Now out in NPP – Digital Psychiatry and Neuroscience! 📱🧠 Can LLMs and smartphone sensing help us track therapy progress in real time?

🆕 study by @hadarfisher.bsky.social @nigeljaffe.bsky.social @diegopizzagalli.bsky.social @christianwebb.bsky.social tested whether smartphone mobility sensing & LLM ratings of text can track behavioral activation in teens to boost engagement in rewarding activities www.nature.com/articles/s44...

Grateful to @willemkuyken.bsky.social for being such a gracious host and insightful guide at Oxford — and to Jamie Delgadillo for the same at King’s College London. Inspiring conversations, wonderful campuses, and a fantastic trip all around. 🇬🇧🎓

"Dr. Balfour Mount, who coined the term 'palliative care' and whose profound empathy helped revolutionize health-care in North America, died peacefully on Sept. 25 at the palliative care unit that bears his name." www.cbc.ca/news/canada/...

@mcleanhospital.bsky.social Technology in Psychiatry Summit #TIPS returns this year Dec 11-12. We have exciting keynotes lined up, including Drs. Pattie Maes (MIT Media Lab), Isaac Galatzer-Levy (Google DeepMind), and Derrick Hull (Slingshot AI). Submissions are now open. See below for info.

📱EMA is increasingly used in intervention studies to acquire a more fine-grained and ecologically valid assessment of change. But EMA is relatively burdensome. What's the added value? We tried to address this question in our new paper now out @jmirpub.bsky.social www.jmir.org/2025/1/e69297 1/n

There is still time to submit your symposium, workshop, or poster for the 2025 Technology in Psychiatry Summit (TIPS). Submission deadline is Oct 9. TIPS is taking place virtually as a 2-day meeting Dec 11th and 12th, 2025. #TIPS #technologyinpsychiatry Link: techinpsych.org

🚨 New research alert We applied machine learning to the large MYRIAD trial (84 schools and 8,376 UK teens) to ask: 👉 Which adolescents benefit most from mindfulness delivered in schools? Bottom line: One-size-fits-all doesn’t work. Paper link: tinyurl.com/vvpvfunh 1/n

🚨 New research alert We applied machine learning to the large MYRIAD trial (84 schools and 8,376 UK teens) to ask: 👉 Which adolescents benefit most from mindfulness delivered in schools? Bottom line: One-size-fits-all doesn’t work. Paper link: tinyurl.com/vvpvfunh 1/n

My lab has an open post-doc position! We will begin reviewing applications as they come in. The post-doc will work with a vibrant research team at Penn State in the Department of Psychology and the Child Study Center. psu.wd1.myworkdayjobs.com/PSU_Academic... 1/3

Excellent new paper spearheaded by lab member @hadarfisher.bsky.social finding that emotion rigidity (assessed via EMA) in youth predicts future depressive symptoms over a 2 year follow-up.

For those interested in the target paper, see here for the link (it's open access). We use a much larger sample than is typical, that is clinically heterogeneous, and examines associations bw passive sensing and broad domains of psychopathology jamanetwork.com/journals/jam...

Check out our thoughts on the growing use of passive sensing for digital phenotyping. In this commentary, we reflect on excellent work by @whitneyringwald.bsky.social et al., who use a large, clinically heterogeneous sample to examine assoc. bw passive sensing and domains of psychopathology.

Thoughtful summary of the promise and limitations of passive sensing >>

🧠📱Excited to share our invited commentary in @jamanetworkopen.com on the promise and pitfalls of using smartphones (and wearables) to track psychopathology w/ @hadarfisher.bsky.social and linked to excellent paper by @whitneyringwald.bsky.social, @aidangcw.bsky.social & team. tinyurl.com/5n8z4r6e

And @christianwebb.bsky.social on predictions of negative affect states from mobile phenotyping data and machine learning models. "Borrowing" information from other subjects' models improved accuracy. #SPRKrakow2025

📣 Hey #SPRKrakow2025! If you're into EMA and clinical practice, don’t miss our panel Enhancing Clinical Practice with EMA — happening today at 11:30 in Aula Duża A. With @christianwebb.bsky.social , @kopf-beck.bsky.social, @odedbein.bsky.social & Jessica Fritz

If you’re heading to @sprofficial.bsky.social meeting in Krakow, check out our panels on tech, personalization, & precision in psychotherapy! 📱 Enhancing Clinical Practice w/ EMA (Fri, 11:30am) 📊 Innovations in Personalization/Precision in Therapy (Sat, 2pm) 🧠 Neuroscience in Therapy (Sat, 3:15pm)

If you’re heading to @sprofficial.bsky.social meeting in Krakow, check out our panels on tech, personalization, & precision in psychotherapy! 📱 Enhancing Clinical Practice w/ EMA (Fri, 11:30am) 📊 Innovations in Personalization/Precision in Therapy (Sat, 2pm) 🧠 Neuroscience in Therapy (Sat, 3:15pm)

New paper from the lab testing whether passive📱smartphone data (like GPS and activity levels) and LLMs applied to teen texts can help us objectively measure behavioral change during behavioral activation therapy (led by @hadarfisher.bsky.social and @nigeljaffe.bsky.social). osf.io/preprints/ps...

New paper from the lab testing whether passive📱smartphone data (like GPS and activity levels) and LLMs applied to teen texts can help us objectively measure behavioral change during behavioral activation therapy (led by @hadarfisher.bsky.social and @nigeljaffe.bsky.social). osf.io/preprints/ps...

Can we track therapeutic change outside the clinic? In a new preprint, we explored whether digital tools - smartphone passive sensors📱 and LLM (GPT-4o) 🤖 - can track daily-life activation in adolescents with anhedonia receiving Behavioral Activation. osf.io/preprints/ps...

And I’m one of them 🥹