In a cohort study, #PolygenicScores identified more patients at risk for #ADHD, #Depression, and #Schizophrenia than recurrent copy number variants, while both methods were complementary for risk assessment in #Autism. ja.ma/4eemQjD

Normative modeling of morphometric similarity networks in #ADHD identified three distinct biotypes with unique clinical-neural profiles, supporting more neurobiologically informed stratification for ADHD management. ja.ma/42UNTu3

Reduced #GripStrength is observed in patients with #Schizophrenia, current and remitted #Depression vs healthy controls, reflecting persistent motor and motivational dysfunction across diagnostic groups. ja.ma/4wHzfE4

Military sexual trauma prevalence remains high among US veterans, especially females, and is associated with increased risk for suicidal thoughts and behaviors. ja.ma/4dWCaRP

Individual variability in synaptic gene expression and synapse density in induced pluripotent stem cell–derived neurons predicted macro-scale alterations in gray matter volume and gamma-band activity in patients with #Schizophrenia. ja.ma/42KpwiJ

Systemic interleukin-6 inhibition demonstrated treatment-sensitive outcomes and clinically meaningful effect sizes in patients with difficult-to-treat #Depression and low-grade #Inflammation. ja.ma/4nzowaC

Family genetic risk scores across 18 psychiatric disorders indicated six correlated factors: psychotic, externalizing, anxiety, neurodevelopmental, mood, and eating disorders. ja.ma/4dQ82HM

Among adults with severe mental illness, integrating #PhysicalActivity into psychiatric care improves psychiatric symptoms, cognitive health, and cardiometabolic outcomes, supporting longer life expectancy. ja.ma/49JAVTD

Normative modeling of morphometric similarity networks in #ADHD identified three distinct biotypes with unique clinical-neural profiles, supporting more neurobiologically informed stratification for ADHD management. ja.ma/4dNwBVU

Psilocybin, 25 mg, with adjunct psychotherapy was not significantly superior to placebo in treatment-resistant #Depression for primary response, but produced greater reductions in depressive symptoms at 6 weeks and was generally well tolerated. ja.ma/4nxKTgL

Among adults with #PTSD, intermittent oral TSND-201 treatment produced greater reductions in PTSD symptoms than placebo and was well tolerated, supporting its potential as a rapid-acting, durable pharmacologic option. ja.ma/4dfKKep

A network meta-analysis indicates that FDA-approved adjunctive atypical antipsychotics for #Depression differ in efficacy and acceptability, with lumateperone highest for efficacy and aripiprazole for acceptability. ja.ma/3PrtN7o

#PsychedelicTherapy was not more effective than open-label traditional antidepressants for major #Depression. Blinding improved outcomes for antidepressants but not for psychedelic-assisted therapy. ja.ma/48UfCP2

#DigitalInterventions for #EatingDisorders produced consistent, durable improvements in core symptoms and comorbid mental health outcomes in randomized clinical trials across acute and follow-up periods. ja.ma/431kmyL

Among outpatients with #BorderlinePersonalityDisorder, dialectical behavior therapy and schema therapy produced similar and substantial improvements in symptoms, functioning, and quality of life, with no significant differences in treatment retention. ja.ma/4dmff0S

The first European Board Examination in Psychiatry had 161 candidates from 36 countries and a 91% pass rate, supporting efforts to harmonize psychiatric training standards. ja.ma/3PyrjnU

Intermittent #ThetaBurst stimulation targeting the dorsomedial prefrontal cortex enhanced placebo-induced mood improvement by potentiating default mode network activity in adults with depressive symptoms. ja.ma/4tuMbdA

Functional unblinding and expectation may confound efficacy signals in #Psilocybin trials for #Depression, making it difficult to isolate therapeutic effects of psychedelic experiences from placebo and expectancy responses. ja.ma/4tvrJt9

Adult sleep GWAS-derived polygenic scores demonstrated comparable associations with corresponding sleep phenotypes in #Adolescents, suggesting genetic influences on sleep persist across developmental stages. ja.ma/4dzn9oQ

#Ketamine infusions reduced suicidal and depressive symptoms rapidly in patients with a major depressive episode, with transient adverse events resolving during trials; longer-term outcomes remain unclear. ja.ma/431IZLC

Intermittent #ThetaBurst stimulation targeting the dorsomedial prefrontal cortex enhanced placebo-induced mood improvement by potentiating default mode network activity in adults with depressive symptoms. ja.ma/3RaiJMv

Street psychiatry for people experiencing unsheltered #Homelessness relies on temporary public and private grants, while sustainable expansion will require health plan payment reforms and broader Medicaid reimbursement for outreach-based care. ja.ma/4u2IEo4

A network meta-analysis indicates that FDA-approved adjunctive atypical antipsychotics for #Depression differ in efficacy and acceptability, with lumateperone highest for efficacy and aripiprazole for acceptability. ja.ma/4wbuFh3

Intermittent #ThetaBurst stimulation targeting the dorsomedial prefrontal cortex enhanced placebo-induced mood improvement by potentiating default mode network activity in adults with depressive symptoms. ja.ma/4tUonkm

In overweight or obese patients with #Depression, adjunctive oral semaglutide reduced effort discounting and improved motivation on a validated effort-expenditure task compared with placebo. ja.ma/42azg5B

In overweight or obese patients with #Depression, adjunctive oral semaglutide reduced effort discounting and improved motivation on a validated effort-expenditure task compared with placebo. ja.ma/4djk4Z5

A multimedia antistigma campaign and a primary care health worker-led digital intervention improved knowledge, attitudes, and behavior toward mental health and reduced depressive symptoms among adolescents in Indian slums. ja.ma/3QWzc6V

A multimedia antistigma campaign and a primary care health worker-led digital intervention improved knowledge, attitudes, and behavior toward mental health and reduced depressive symptoms among adolescents in Indian slums. ja.ma/4cFH19A

Among individuals with severe, treatment-resistant #Schizophrenia, dementia was common and showed a distinct clinical and genetic profile not explained by Alzheimer disease, cardiovascular risk, or medication effects. ja.ma/3NSP8WT

Among adults with #TreatmentResistantDepression, single-day inhaled GH001 resulted in rapid, significant symptom reduction and remission vs placebo, with no severe adverse events and sustained effects over 6 months. ja.ma/4dxghZU

Across versions of ChatGPT, responses to psychotic prompts were frequently inappropriate or partially appropriate, raising safety concerns for users at risk for #psychosis. ja.ma/4smwzbN

In adults with acute #Schizophrenia, once-daily LB-102 provided greater symptom reduction than placebo over 4 weeks and was generally well tolerated, showing a manageable safety profile and low rates of extrapyramidal symptoms. ja.ma/4tVaMJk

In adults with methamphetamine use disorder, mirtazapine reduced methamphetamine use by approximately two more days per month vs placebo, with no unexpected safety concerns. ja.ma/3PZiiEi

Among individuals with severe, treatment-resistant #Schizophrenia, dementia was common and showed a distinct clinical and genetic profile not explained by Alzheimer disease, cardiovascular risk, or medication effects. ja.ma/4cydXAB

Among adults with #TreatmentResistantDepression, single-day inhaled GH001 resulted in rapid, significant symptom reduction and remission vs placebo, with no severe adverse events and sustained effects over 6 months. ja.ma/4ct0N83

Functional unblinding was common in most psychedelic randomized clinical trials for psychiatric disorders, with >70% correctly identifying treatment allocation, raising concerns for trial validity. ja.ma/4cvmTWg

Across versions of ChatGPT, responses to psychotic prompts were frequently inappropriate or partially appropriate, raising safety concerns for users at risk for #psychosis. ja.ma/4c48aS4

Serial bias in spatial working memory differed by group, with patients with schizophrenia showing repulsive bias, most healthy controls showing attractive bias, and individuals with bipolar disorder demonstrating mixed patterns. ja.ma/41FsQuS

First-episode psychosis was marked by elevated medial prefrontal glutamate levels compared with chronic schizophrenia and controls, with higher glutamate associated with lower verbal and visual learning scores. ja.ma/4vuGPRW

In adults with methamphetamine use disorder, mirtazapine reduced methamphetamine use by approximately two more days per month vs placebo, with no unexpected safety concerns. ja.ma/3Q3639K

⏰ Last call! Applications for the JAMA Psychiatry Editorial Fellowship Program are due Wednesday, April 15. 🔗Learn more and apply here: ja.ma/4sve7xL

Among individuals with severe, treatment-resistant #Schizophrenia, dementia was common and showed a distinct clinical and genetic profile not explained by Alzheimer disease, cardiovascular risk, or medication effects. ja.ma/47QhSpZ

From 2014 to 2023, Medicaid paid for a rising share of US inpatient psychiatric care, with urban hospitals seeing consistently higher Medicaid coverage than rural hospitals by 2023. ja.ma/4msAbHV

Actigraphy-derived measures of sleep phase variability and activity amplitude identified individuals at higher risk of relapse in #Depression, supporting their potential as scalable biomarkers in ongoing monitoring. ja.ma/4mo5544

🎧 Listen to this interview with Hemant Bhargav, MD, PhD, author of Yoga for Opioid Withdrawal and Autonomic Regulation: A Randomized Clinical Trial. Hosted by John Torous, MD.

In adults with methamphetamine use disorder, mirtazapine reduced methamphetamine use by approximately two more days per month vs placebo, with no unexpected safety concerns. ja.ma/4vjX4kL

Administration of ketamine during general anesthesia preserved high-frequency EEG changes but lacked low-frequency modulation, suggesting neurophysiologic components of ketamine can be selectively altered. ja.ma/4czqVOA

📢 Applications are open for the @jamapsychiatry.com Editorial Fellowship Program! Early-career psychiatrists or doctorate level clinicians with an interest in medical publishing and editorial processes are invited to apply. 🔗ja.ma/4c4R5HN

Earlier #ADHD diagnosis was associated with higher school performance, more academic educational track selection, and reduced risk of school dropout, while later diagnosis indicated greater dropout risk. ja.ma/4sTLI5f

Across versions of ChatGPT, responses to psychotic prompts were frequently inappropriate or partially appropriate, raising safety concerns for users at risk for #psychosis. ja.ma/4vdFwqp