Despite a slight overall decline in psychiatric bed capacity between 2011 and 2023, the share of beds at freestanding psychiatric facilities owned by large for-profit chains increased. ja.ma/4nRKcgw

Soft drink consumption is linked to an increased risk of major depressive disorder and greater depressive symptom severity, mediated by changes in gut microbiota, particularly Eggerthella abundance. ja.ma/4oDZmr3

A Swedish register-based cohort study involving almost 3.5 million individuals followed from birth found that offspring exposed to parental mental disorders had an increased risk of mortality up to the age of 51 years. ja.ma/3WKsYH1

Adults exposed to sexual assault were at higher risk of developing functional somatic disorders, including single-organ and multiorgan subtypes—over five years, finds this cohort study. ja.ma/4oAMySk

RCT: Daily oxytocin administration combined with positive physical intimacy was linked to improved wound healing and reduced cortisol; oxytocin alone or positive interactions without physical intimacy did not enhance healing. ja.ma/4hVrWBW

A growing body of literature suggests that transgender and nonbinary individuals experience poorer mental health outcomes compared to cisgender people. This review summarizes current evidence and identifies knowledge gaps in the existing literature. ja.ma/47OsnJx

An automated treatment decision rule (TDR) can effectively assign older adults with late-life depression to psychotherapy or usual care, improving treatment outcomes and potentially increasing precision and cost-effectiveness. ja.ma/47KbZcQ

RCT: In patients with #schizophrenia, #prediabetes, and #obesity, once-weekly #semaglutide injections, up to 1.0 mg/week, were safe and effective. ja.ma/4hRQmw6

Viewpoint: OTC naltrexone may address gaps in treatment for unhealthy alcohol use by supporting early intervention and harm reduction, especially for individuals not seeking traditional care or facing barriers to access. ja.ma/4nzRBkO

Chronic, delayed, and shifting patterns of PTSD, CPTSD, and PGD were linked to higher levels of somatization and pain, highlighting the need for integrated trauma-informed care addressing physical and psychological health. ja.ma/3Xc8p6u

Individuals with chronic opioid use, with or without opioid addiction, exhibited stronger learning from negative reinforcement and reduced choice consistency, supporting preclinical models of avoidance-driven behaviors. ja.ma/4hyf1p2

Use of psilocybin mushrooms has sharply increased in the US, with variability in potency and frequent co-use with cannabis. This Special Communication reviews emerging evidence on the public health implications of unregulated psilocybin mushroom use. ja.ma/4qINcyr

Is soft drink consumption related to depression diagnosis and severity? Could gut microbiome alterations mediate and explain disassociation?" 🎙️ In this podcast, Sharmili Edwin Thanarajah, MD discusses this and more, with John Torous, MD. ja.ma/4ontc2O

Soft drink consumption is linked to an increased risk of major depressive disorder and greater depressive symptom severity, mediated by changes in gut microbiota, particularly Eggerthella abundance. ja.ma/4hFDeKe

This systematic review and meta-analysis found that ketogenic diet interventions were associated with small to moderate improvements in depressive symptoms, especially in RCTs with ketone monitoring. ja.ma/3Ll8emE

💬 Viewpoint: Clinical application of psychedelics in psychiatry should advance through empirical evaluation of biological, psychological, and contextual factors, emphasizing scientific rigor over uncritical idealism. ja.ma/4qGxzry

Integrating complexity theory into mental health research may reveal unique resilience dynamics and inform more effective, individualized interventions. ja.ma/47w8W7U

Case-control analyses of matched veterans discharged from VA and VA-paid community mental health residential treatment found lower postdischarge all-cause mortality in VA programs by up to 27% at one year. ja.ma/47wlqNa

Viewpoint: Integrating psychologists into inpatient teams can reduce coercive practices, improve diagnosis and risk management, boost staff morale, and contribute to more effective treatment and discharge planning. ja.ma/3JdTQvW

Higher prenatal lead exposure, especially during the third trimester, was associated with increased risk of major depressive disorder and anxiety symptoms in adults in their 60s. ja.ma/47mPD15

In this podcast, Declan McLoughlin, PhD, of St Patrick’s University Hospital and Trinity College Dublin, discusses the KARMA-Dep 2 randomized clinical trial with host John Torous, MD. 🎧 Listen now: ja.ma/4nlRoRY

Serial intravenous ketamine infusions were not superior to midazolam in reducing depressive symptoms among inpatients with moderate to severe depression, with no significant differences in efficacy, cognitive, economic, or quality-of-life outcomes. ja.ma/47aDnAo

Chronic diseases were more strongly linked to suicide attempt, while severe conditions and psychiatric polygenic scores were more associated with suicide, indicating overlapping but distinct risk factors for attempt and death by suicide. ja.ma/3IVjPZ2

Today, the JAMA Psychiatry Editorial Board met to discuss future plans for the journal, which is committed to publishing original, state-of-the-art research and commentary of broad interest to clinicians and researchers in psychiatry and related fields. Watch this space for the latest updates.

Viewpoint: Measuring and modeling financing variables is essential for evaluating how behavioral health policies are implemented and their impact on outcomes. ja.ma/4qdvIdh

Across the JAMA Network, we seek submission of manuscripts describing original research that examines the application of #AI in clinical settings. 🔗 Learn more about submission criteria: ja.ma/48p3TbH

Diagnoses of noncocaine psychostimulant use disorder (UD) among young adult Medicaid enrollees rose sharply from 2001 to 2020, while cocaine UD rates stayed stable. ja.ma/3WEaurA

From @jama.com: #Microplastics are increasingly detected in human tissues, with potential links to cognitive, cardiovascular, and inflammatory outcomes. 📌 Learn more in this JAMA Insights: ja.ma/42K4EbM

Primary care treatment of #PTSD with either SSRIs or written exposure therapy (WET) was found to be feasible and effective; for patients not responding to an #SSRI, switching to an SNRI may be more effective than WET augmentation. ja.ma/4h7A01O

Viewpoint: As closed-loop neuromodulation advances, its clinical adoption requires rigorous comparative trials, well-matched neural biomarkers, and careful assessment of clinical effort versus benefit. ja.ma/4o87G1w

Among individuals with psychosis, cannabis use increased by 9.53 percentage points after recreational cannabis legalization, a sharper rise than in the general population. ja.ma/46YufyO

There is an urgent need for research on strategies to manage psychiatric disorders associated with restricted reproductive health services. Learn more in this Special Communication. ja.ma/4q5Q20o

Brief cognitive behavioral therapy significantly reduced suicide attempts among US military personnel and veterans compared to present-centered therapy. ja.ma/3Wphokm

Pain reprocessing therapy (PRT) showed durable reductions in chronic back pain compared to placebo and usual care, with 55% of PRT participants nearly or completely pain-free. ja.ma/430LhuZ

Attending #WCP25? Read this timely article from @jamapsychiatry.com: 👇 RCT: In patients with #schizophrenia, #prediabetes, and #obesity, once-weekly #semaglutide injections, up to 1.0 mg/week, were safe and effective. ja.ma/4mO9gEY

Don't miss this article from @jamapsychiatry.com, selected to enhance your #WCP25 takeaways: 👇 Liafensine was efficacious and well tolerated in ANK3-positive patients with treatment-resistant #depression. ja.ma/4nLj8jO

While at #WCP25, dive into recent research from @jamapsychiatry.com: Higher polygenic risk scores for bipolar disorder were associated with favorable treatment outcomes after lithium augmentation in antidepressant non-responders with unipolar depression. ja.ma/46VTf9X

At #WCP25? Consider this article from @jamapsychiatry.com: Low-dose #semaglutide reduced alcohol craving and consumption in adults with alcohol use disorder. ja.ma/4h0f8K2

Looking for more to discuss at #WCP25? A study published in @jamapsychiatry.com found that gut bacteria may be behind the association of soft drink consumption and #depression. Watch the video and read the full study: ja.ma/4o4PQg1#WCP25

Are you at #WCP25? JAMA Psychiatry is now on Bluesky! 🦋 Stay connected for innovative, clinically relevant research that covers the field broadly, from genetic mechanisms to psychotherapeutic intervention trials.