This systematic review and meta-analysis found that ketogenic diet interventions were associated with small to moderate improvements in depressive symptoms, especially in RCTs with ketone monitoring. ja.ma/45yxxc8

Higher cumulative adverse prenatal exposure burden was associated with persistent increases in psychopathology risk and accelerated cortical thinning in adolescents, with dose-dependent effects confirmed in sibling comparisons. ja.ma/45I5pDt

Yoga as an adjunct to standard buprenorphine therapy for #OpioidUseDisorder accelerated withdrawal stabilization, improved heart rate variability, and reduced anxiety, sleep latency, and pain compared with standard care alone. ja.ma/4jspCCZ

#Semaglutide reduced HbA1c and body weight over 26 weeks in individuals with #schizophrenia spectrum disorders and early glycemic abnormalities taking clozapine or olanzapine. ja.ma/3Lj4v9E

#Dopamine synthesis capacity is reduced in psychosis with #depression compared to mixed/mania syndromes, while positive psychotic symptoms correlate with higher dopamine synthesis in the associative striatum. ja.ma/4pseK9J

Serial intravenous ketamine infusions were not superior to midazolam in reducing depressive symptoms among inpatients with moderate to severe depression, with no significant differences in efficacy, cognitive, economic, or quality-of-life outcomes. ja.ma/3YSSwTh

Individuals with #ADHD treated with stimulants have a nonnegligible risk of developing psychosis or bipolar disorder, with a higher risk associated with amphetamines compared to methylphenidate. ja.ma/4qHCveZ

#Semaglutide reduced HbA1c and body weight over 26 weeks in individuals with #schizophrenia spectrum disorders and early glycemic abnormalities taking clozapine or olanzapine. ja.ma/3YRjo69

#Semaglutide reduced HbA1c and body weight over 26 weeks in individuals with #schizophrenia spectrum disorders and early glycemic abnormalities taking clozapine or olanzapine. ja.ma/45fhqQE

💬 Viewpoint: Prolonged grief disorder may manifest differently in neurodivergent individuals, requiring clinicians to assess behavioral changes and loss of support rather than relying solely on typical diagnostic criteria. ja.ma/4awZWmi

Among US #Veterans, higher cumulative burden of adverse social determinants of health was associated with greater risk of past-year suicidal ideation, suicide attempt, and future suicidal intent. ja.ma/3YGSLAH

The numbers are in. This year's most popular JAMA Network content spans a range of topics, from #fluoride to #Parkinson disease to #GLP-1s. What was your favorite article in 2025, and did other readers agree? 🔗 ja.ma/3MTBgdW

First-trimester Z-drug use was not associated with increased risk of major congenital malformations in more than 4 million US pregnancies, providing reassurance for #Pregnancy sleep management. ja.ma/4sd5qck

Meta-analysis indicates that individuals with #Schizophrenia show pronounced deficits in symbol coding tasks, with processing speed impairment exceeding most other cognitive domains. ja.ma/49qUikE

The numbers are in. The numbers are in. This year's most popular JAMA Network content spans a range of topics, from #fluoride to #Parkinson disease to #GLP-1s. What was your favorite article in 2025 -- and did other readers agree? 🔗 ja.ma/3L6fcvZ

Survey study identifies that most patients with depression interpret the Patient Health Questionnaire instructions incorrectly, raising questions about its validity for clinical and research use. ja.ma/4s27WSt

Distinct #Depression and #Psychosis blood-brain signatures were identified in early-stage patients, shaped by inflammatory markers, brain volume, childhood trauma, and cognition, independent of medication effects. ja.ma/4j4qvBt

Viewpoint: Integrating psychologists into inpatient teams can reduce coercive practices, improve diagnosis and risk management, boost staff morale, and contribute to more effective treatment and discharge planning. ja.ma/4pzqM1Z

🎧 Listen to JAMA Psychiatry authors Amy N. Cohen, PhD and Matthew Chinman, PhD discuss their article "Tailored Weight Loss Programs for Adults With Serious Mental Illness," with @JohnTorousMD. ja.ma/3N3PIjr

A 6-month peer-supported, technology-enabled #obesity intervention for veterans with serious mental illness produced greater weight and BMI reductions than usual care, with 22.6% achieving ≥7% weight loss, while cardiorespiratory fitness did not improve. ja.ma/4oUmdOp

Neither high-intensity interval training nor strength and resistance training improved hippocampal health in individuals with cannabis use disorder (CUD), however people with CUD can maintain an intensive exercise regimen to curb cravings. ja.ma/4iPMMTH

Viewpoint: Measuring and modeling financing variables is essential for evaluating how behavioral health policies are implemented and their impact on outcomes. ja.ma/44lYYp7

A brief behavioral activation psychotherapy significantly reduced suicide ideation in perinatal populations by 80% at 3 months post-randomization, effective regardless of clinician type or delivery modality. ja.ma/48xjO7s

Higher prenatal lead exposure, especially during the third trimester, was associated with increased risk of major depressive disorder and anxiety symptoms in adults in their 60s. ja.ma/4aJKkfe

Viewpoint: As closed-loop neuromodulation advances, its clinical adoption requires rigorous comparative trials, well-matched neural biomarkers, and careful assessment of clinical effort versus benefit. ja.ma/3KSirqS

💬 Viewpoint: Global mental health policies are shifting from individual disease models toward preventive, culturally competent approaches that address structural, social, and environmental determinants. ja.ma/4pxVvMA

Serial intravenous ketamine infusions were not superior to midazolam in reducing depressive symptoms among inpatients with moderate to severe depression, with no significant differences in efficacy, cognitive, economic, or quality-of-life outcomes. ja.ma/4oKI4rp

Among Kenyan health care workers surveyed, 43.1% met criteria for major depression during at least one assessment over 12 months. ja.ma/3KF28xG

Primary care treatment of #PTSD with either SSRIs or written exposure therapy (WET) was found to be feasible and effective; for patients not responding to an #SSRI, switching to an SNRI may be more effective than WET augmentation. ja.ma/3KBQWlp

Neuropsychiatric disorders impose a substantial burden on individuals and societies worldwide. 📢 This Special Communications reflects the broad consensus of experts to advance the agenda for precision psychiatry. ja.ma/48uWZRW

This case-control study found that adults with schizophrenia had significantly greater frontal cortex serotonin release than healthy controls, and greater release correlated with more severe negative symptoms. ja.ma/3XLg5gs

This Viewpoint describes the mental health burden experienced by Muslim populations exposed to war and discrimination and recommends strategies for mental health services to address this burden. ja.ma/4azW8AI

In a male Swedish cohort, higher IQ at age 18 was associated with reduced risk of alcohol use disorder, and genetic analyses support a causal link with cognitive performance, though the association varied by sociocultural context. ja.ma/3KkDDFX

Liafensine was efficacious and well tolerated in ANK3-positive patients with treatment-resistant depression, highlighting ANK3 as a predictive genetic biomarker for liafensine. ja.ma/4plVfjL

Viewpoint: Heavy alcohol use is a public health issue, prompting the Alcohol Clinical Trials Initiative to advocate for @who.int risk drinking level reduction as a dynamic treatment endpoint in AUD trials to facilitate new medication development. ja.ma/4oARyFK

Viewpoint: Muscarinic receptor activators, such as xanomeline-trospium, offer an alternative mechanism for treating #schizophrenia, with potential benefits for positive, negative, and cognitive symptoms. ja.ma/4iDwJYN

Among adults with substance use disorder (#SUD), heart rate variability biofeedback reduced negative affect, craving, and substance use, suggesting it may be an effective adjunctive, low-cost treatment for SUD. ja.ma/4pHEn6W

Antipsychotic use among US adults aged 65 years or older increased by 51.6% from 2015 to 2024, with long-term use rising 64.9%. ja.ma/4iziog2

Alcohol use disorder (AUD) is a prevalent and costly psychiatric disorder. This Review examines the use of reductions in World Health Organization (WHO) risk drinking levels as an end point in pharmacotherapy trials for people with alcohol use disorder. ja.ma/4ovSGug

📢 This Special Communication recommends hybrid survey designs—combining online panels with probability samples—as a new standard for psychiatric epidemiological research. ja.ma/4pJWWam

Brief cognitive behavioral therapy significantly reduced suicide attempts among US military personnel and veterans compared to present-centered therapy. ja.ma/3MkLnIo

In a male Swedish cohort, higher IQ at age 18 was associated with reduced risk of alcohol use disorder, and genetic analyses support a causal link with cognitive performance, though the association varied by sociocultural context. ja.ma/3JVWWoP

Among adults with substance use disorder (#SUD), heart rate variability biofeedback reduced negative affect, craving, and substance use, suggesting it may be an effective adjunctive, low-cost treatment for SUD. ja.ma/4pAIIZv

#Semaglutide reduced HbA1c and body weight over 26 weeks in individuals with #schizophrenia spectrum disorders and early glycemic abnormalities taking clozapine or olanzapine. ja.ma/3Xj2WLe

💬 Viewpoint: Xanomeline-trospium offers a dopamine-independent approach to schizophrenia care. Clinicians should discuss potential impacts of dopamine blockers on motivation and quality of life. ja.ma/3MmorIG

Recent US #opioid overdose deaths have declined 41%, mainly due to a shrinking at-risk population and plateauing mortality rates. Continued surveillance is needed to predict and prevent harm. ja.ma/4prWfCA

On December 1 at 10 AM ET, JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new @who.int guideline concerning #GLP-1 therapy and adults with #obesity. Register for the webinar: ja.ma/4pBrEm2

Neuronal autophagy may bridge stress and psychiatric pathology; ongoing research explores its role in #depression, brain regions, biomarkers, and response to #antidepressants. ja.ma/3XOVHuC

Paternal genetic risk for psychiatric and substance use disorders may predict offspring risk, with indirect genetic and rearing effects strongest for substance use conditions. ja.ma/49BQwpd

On December 1 at 10 AM ET, JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new WHO guideline concerning #GLP-1 therapy and adults with #obesity. Register for the webinar: ja.ma/3XOwS22