Serial bias in spatial working memory differed by group, with patients with schizophrenia showing repulsive bias, most healthy controls showing attractive bias, and individuals with bipolar disorder demonstrating mixed patterns. ja.ma/41FsQuS

First-episode psychosis was marked by elevated medial prefrontal glutamate levels compared with chronic schizophrenia and controls, with higher glutamate associated with lower verbal and visual learning scores. ja.ma/4vuGPRW

In adults with methamphetamine use disorder, mirtazapine reduced methamphetamine use by approximately two more days per month vs placebo, with no unexpected safety concerns. ja.ma/3Q3639K

⏰ Last call! Applications for the JAMA Psychiatry Editorial Fellowship Program are due Wednesday, April 15. 🔗Learn more and apply here: ja.ma/4sve7xL

Among individuals with severe, treatment-resistant #Schizophrenia, dementia was common and showed a distinct clinical and genetic profile not explained by Alzheimer disease, cardiovascular risk, or medication effects. ja.ma/47QhSpZ

From 2014 to 2023, Medicaid paid for a rising share of US inpatient psychiatric care, with urban hospitals seeing consistently higher Medicaid coverage than rural hospitals by 2023. ja.ma/4msAbHV

Actigraphy-derived measures of sleep phase variability and activity amplitude identified individuals at higher risk of relapse in #Depression, supporting their potential as scalable biomarkers in ongoing monitoring. ja.ma/4mo5544

🎧 Listen to this interview with Hemant Bhargav, MD, PhD, author of Yoga for Opioid Withdrawal and Autonomic Regulation: A Randomized Clinical Trial. Hosted by John Torous, MD.

In adults with methamphetamine use disorder, mirtazapine reduced methamphetamine use by approximately two more days per month vs placebo, with no unexpected safety concerns. ja.ma/4vjX4kL

Administration of ketamine during general anesthesia preserved high-frequency EEG changes but lacked low-frequency modulation, suggesting neurophysiologic components of ketamine can be selectively altered. ja.ma/4czqVOA

📢 Applications are open for the @jamapsychiatry.com Editorial Fellowship Program! Early-career psychiatrists or doctorate level clinicians with an interest in medical publishing and editorial processes are invited to apply. 🔗ja.ma/4c4R5HN

Earlier #ADHD diagnosis was associated with higher school performance, more academic educational track selection, and reduced risk of school dropout, while later diagnosis indicated greater dropout risk. ja.ma/4sTLI5f

Across versions of ChatGPT, responses to psychotic prompts were frequently inappropriate or partially appropriate, raising safety concerns for users at risk for #psychosis. ja.ma/4vdFwqp

Among individuals with #Schizophrenia and co-occurring #SubstanceUseDisorders, psychological and psychosocial interventions showed limited benefit for symptom reduction and no effect on substance use, except for nicotine. ja.ma/4bWrpye

JAMA Psychiatry is recruiting early career clinicians for a 2-year editorial fellowship. Gain hands-on experience with peer review, participate in editorial discussions, and complete a personalized editorial project. 🔗 ja.ma/4t7ValT

The 2024 US societal cost of #Schizophrenia was $366.8 billion, with unpaid caregiving, lost wages, and reduced quality of life accounting for over 75% of total costs. ja.ma/4tnIU04

A 6-week #KetogenicDiet produced modest improvement in depressive symptoms vs control in adults with #TreatmentResistantDepression, with no difference in secondary outcomes and uncertain clinical relevance. ja.ma/4sTC96t

More than 10% of US youth and nearly half of adults with mental health conditions turn to generative AI for advice or support, highlighting the need for clinicians to routinely ask about #AI use in mental health care. ja.ma/4ckPbny

Among individuals with severe, treatment-resistant #Schizophrenia, dementia was common and showed a distinct clinical and genetic profile not explained by Alzheimer disease, cardiovascular risk, or medication effects. ja.ma/4bWZlcz

In adults with methamphetamine use disorder, mirtazapine reduced methamphetamine use by approximately two more days per month vs placebo, with no unexpected safety concerns. ja.ma/4dVjpPd

📢 Now accepting applications: JAMA Psychiatry Editorial Fellowship Early-career psychiatrists or doctorate-level clinicians are invited to apply for this opportunity to gain hands-on training in the editorial processes and policies of a peer-reviewed psychiatry journal. 🔗 ja.ma/40Hh1Uw

This meta-analysis found no clinically meaningful difference between #psychedelic-assisted therapy (#PAT) and open-label traditional #antidepressants (#TADs) for patients with major #depression. 🎥 Watch the video and read the full article: ja.ma/48dEPmS

Individual variability in synaptic gene expression & synapse density in induced pluripotent stem cell-derived neurons predicted macro-scale alterations in gray matter volume and gamma-band activity in patients w/ #Schizophrenia. #SIRS2026 @sirsofficial.bsky.social ja.ma/4tjuqhX

Across versions of ChatGPT, responses to psychotic prompts were frequently inappropriate or partially appropriate, raising safety concerns for users at risk for #psychosis. ja.ma/4bKyvVc

In children and adolescents with #ADHD, sustained methylphenidate treatment was not associated with increased risk of #Psychosis, and may be protective for those diagnosed in childhood. ja.ma/47oUTC1

JAMA Psychiatry is recruiting early career clinicians for a 2-year editorial fellowship. Gain hands on experience with peer review, participate in editorial discussions, and complete a personalized editorial project. 🔗 ja.ma/4rIuV3A

Among adults with #TreatmentResistantDepression, single-day inhaled GH001 resulted in rapid, significant symptom reduction and remission vs placebo, with no severe adverse events and sustained effects over 6 months. ja.ma/3Nme5ty

📢 Applications are open for the @jamapsychiatry.com Editorial Fellowship Program! Early-career psychiatrists or doctorate level clinicians with an interest in medical publishing and editorial processes are invited to apply. 🔗Learn more & apply here: ja.ma/40Hh1Uw

Lutikizumab at 300 mg weekly or every other week improved clinical outcomes compared with placebo in adults with moderate to severe #HidradenitisSuppurativa who experienced anti–tumor necrosis factor therapy failure. ja.ma/4lJos76

In 2025, JAMA Psychiatry received >2,700 submissions, achieved an Impact Factor of 17.1, and exceeded 11 million annual article views. Read “JAMA Psychiatry—The Year in Review, 2025,” by Editor in Chief Dost Öngür, MD, PhD. ja.ma/4sHJXIx

📢 Now accepting applications: JAMA Psychiatry Editorial Fellowship Early-career psychiatrists or doctorate-level clinicians are invited to apply for this opportunity to gain hands-on training in the editorial processes and policies of a peer-reviewed psychiatry journal. 🔗 ja.ma/40Hh1Uw

#PsychedelicTherapy was not more effective than open-label traditional antidepressants for major #Depression. Blinding improved outcomes for antidepressants but not for psychedelic-assisted therapy. ja.ma/4d1tvhf

Functional unblinding and expectation may confound efficacy signals in #Psilocybin trials for #Depression, making it difficult to isolate therapeutic effects of psychedelic experiences from placebo and expectancy responses. ja.ma/4sbCm4u

Elevated plasma #pTau181 and #NfL levels in #AlzheimerDisease patients largely reflect broad neuropsychiatric impairment rather than psychosis alone. ja.ma/4sq0bW6

A cross-sectional study of adults affected by the 2023 Maui wildfires demonstrated that wildfire exposure was associated with higher rates of #depression and #anxiety compared to unexposed individuals, with risk extending beyond burn zones. ja.ma/4bIPvfv

Individuals with chronic opioid use, with or without opioid addiction, exhibited stronger learning from negative reinforcement and reduced choice consistency, supporting preclinical models of avoidance-driven behaviors. ja.ma/4b6e1FQ

This narrative review suggests mental disorders are statistical clusters of biopsychosocial properties, not sharply defined categories, mirroring concepts in species classification and supporting dimensional #MentalHealth frameworks. ja.ma/4bqN2VN

The first European Board Examination in Psychiatry had 161 candidates from 36 countries and a 91% pass rate, supporting efforts to harmonize psychiatric training standards. ja.ma/415kkVy

Ambient #AI scribes increased documentation of neuropsychiatric symptoms in primary care, but were associated with lower rates of psychiatric intervention compared with unscribed visits. ja.ma/4laQzvY

This narrative review suggests mental disorders are statistical clusters of biopsychosocial properties, not sharply defined categories, mirroring concepts in species classification and supporting dimensional #MentalHealth frameworks. ja.ma/4cGv4AZ

Among US #Veterans, higher cumulative burden of adverse social determinants of health was associated with greater risk of past-year suicidal ideation, suicide attempt, and future suicidal intent. ja.ma/3OWFPFh

From @jama.com: State-level decriminalization of #Psilocybin in Oregon in 2020 and Colorado in 2022 was associated with increased 12-month psilocybin use compared with synthetic control estimates. ja.ma/4bCqUZP

A cross-sectional study of adults affected by the 2023 Maui wildfires demonstrated that wildfire exposure was associated with higher rates of #depression and #anxiety compared to unexposed individuals, with risk extending beyond burn zones. ja.ma/4uudZkc

Higher cumulative adverse prenatal exposure burden was associated with persistent increases in psychopathology risk and accelerated cortical thinning in adolescents, with dose-dependent effects confirmed in sibling comparisons. ja.ma/4u9Qhta

For patients with #FirstEpisodePsychosis unresponsive to initial antipsychotic therapy, clozapine improved symptom response rates and reduced discontinuation due to insufficient efficacy vs olanzapine or amisulpride. ja.ma/3PdJfUd

📢 This Special Communication recommends hybrid survey designs—combining online panels with probability samples—as a new standard for psychiatric epidemiological research. ja.ma/4aQzALZ

Systematic review and meta-analysis: #PTSD, depressive, anxiety, and sleep disorders were associated with increased risk of #AcuteCoronarySyndrome, while bipolar and psychotic disorders were not significantly associated. ja.ma/4ssGNI3

Among adults with #Depression, complex antidepressant treatment patterns were associated with higher polygenic risk for psychiatric traits but not with sustained use of a single antidepressant. ja.ma/3N2Dk3C

Chronic, delayed, and shifting patterns of PTSD, CPTSD, and PGD were linked to higher levels of somatization and pain, highlighting the need for integrated trauma-informed care addressing physical and psychological health. ja.ma/4crr0o7

Health plan disenrollment after initiating medications for #OpioidUseDisorder was associated with increased all-cause and overdose mortality compared with remaining enrolled. ja.ma/4aYgcwE