Tom Yates
@tomayates.bsky.social
š¤ 6254
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Epidemiology, infection
https://profiles.ucl.ac.uk/37299-tom-yates/about
pinned post!
NEW PREPRINT! We systematically reviewed molecular epidemiology studies looking at strain discordance in pairs of people with TB disease and history of household contact We found 30 studies from 18 countries. Excluding 4 studies at high risk of bias, we had data on 1544 household case pairs [1/n]
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Mycobacterium tuberculosis complex Strain Discordance Among People With Tuberculosis and a History of Household Contact, a Systematic Review and Meta-Analysis
Background: In this systematic review of molecular epidemiology studies, we describe the prevalence of Mycobacterium tuberculosis complex strain discordance amo
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5929224
5 days ago
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Dr Roz Eggo
9 days ago
Symposium & workshop on inequalities in infectious disease dynamics at LSHTM in April 2026. We aim to will bring together leading researchers and practitioners to share ideas, discuss recent advances, and reflect on future directions. Details & application:
iddconf.org/lshtm-sympos...
Closing 21 Jan
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Social Inequalities in Infectious Disease Dynamics: a Symposium and Workshop
https://iddconf.org/lshtm-symposium/
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Tom Yates
NEW PREPRINT! We systematically reviewed molecular epidemiology studies looking at strain discordance in pairs of people with TB disease and history of household contact We found 30 studies from 18 countries. Excluding 4 studies at high risk of bias, we had data on 1544 household case pairs [1/n]
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Mycobacterium tuberculosis complex Strain Discordance Among People With Tuberculosis and a History of Household Contact, a Systematic Review and Meta-Analysis
Background: In this systematic review of molecular epidemiology studies, we describe the prevalence of Mycobacterium tuberculosis complex strain discordance amo
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5929224
5 days ago
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Marcel Behr
5 days ago
šGreat thread on TB strain concordance/strain discordance among household contacts. If I read correctly, findings from a 1998 small series from San Francisco consistent with the much greater analysis. ++ Implications for transmission and management of contacts.
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Jason Andrews
4 days ago
Cool work! Was just thinking that someone needs to do this analysis as we need better quantitative estimates. Reaffirms concern that studies using cross-sectional HH IGRA to investigate determinants of infectiousness (e.g. symptoms) are going to have major limitations.
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Exploring transmission dynamics in epidemiologically linked pulmonary tuberculosis cases and household contacts: a WGS-based investigation - BMC Genomics
Background The genotyping of the M. tuberculosis complex has significantly enhanced the comprehension of transmission dynamics and is employed to substantiate transmission dynamics among epidemiologic...
https://link.springer.com/article/10.1186/s12864-025-12441-9
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NEW PREPRINT! We systematically reviewed molecular epidemiology studies looking at strain discordance in pairs of people with TB disease and history of household contact We found 30 studies from 18 countries. Excluding 4 studies at high risk of bias, we had data on 1544 household case pairs [1/n]
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Mycobacterium tuberculosis complex Strain Discordance Among People With Tuberculosis and a History of Household Contact, a Systematic Review and Meta-Analysis
Background: In this systematic review of molecular epidemiology studies, we describe the prevalence of Mycobacterium tuberculosis complex strain discordance amo
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5929224
5 days ago
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5 days ago
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Tom Yates
MRC Clinical Trials Unit at UCL
7 days ago
š Big news! The MRC Centre for Clinical Research Efficiency (CoRE) is here. By accelerating the testing of new medicines, the MRC CoRE will help bring better treatments to patients sooner. š Learn more:
www.mrcctu.ucl.ac.uk/news/news-st...
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Groundbreaking £50m MRC Centre will overhaul clinical trials for patients | MRC Clinical Trials Unit at UCL
https://www.mrcctu.ucl.ac.uk/news/news-stories/2025/december/groundbreaking-50m-mrc-centre-will-overhaul-clinical-trials-for-patients/
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I can't strike but, for those dunking on my colleagues who are striking tomorrow, here is a super useful figure from
@instituteforgovernment.org.uk
This uses CPI rather than RPI, i.e. the more conservative of the measures by which real terms pay has been cut for NHS workers
9 days ago
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This is a really lovely paper by
@dopapus.bsky.social
and team Self report of TB symptoms depends on lots of external factors and there are more robust markers of disease extent / severity available to inform surveillance and clinical management
#TBSky
#EpiSky
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Reported Tuberculosis Symptoms: An Inadequate Classifier of Disease State
We provide evidence that self-reported symptoms are an inadequate classifier of disease state, heavily influenced by context and substantial interviewer va
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaf611/8374620
14 days ago
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Epidemiology friends, is there good primary research on any of this? Potentially challenging, as most of us buy food wrapped in plastic. My starting point - I don't give a toss about "naturalness", don't think "synthetic chemicals" is a coherent category, and like my exposures/outcomes well defined!
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15 days ago
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Standing Together
16 days ago
We canāt accept this attempt to hide the destruction that two years of a genocidal war has brought on Gaza. Palestinians must be allowed to recover, and foreign journalists must be able to report freely. (2/2)
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Standing Together
16 days ago
The ban on foreign journalists entering Gaza was just extended today ā almost two months into the ceasefire. International reporters still arenāt allowed to talk to Palestinians on the ground and report on whatās happening. (1/2)
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High Court lets government delay response on bid to allow foreign journalists into Gaza, for the 9th time
* * *
https://www.timesofisrael.com/liveblog_entry/high-court-lets-government-delay-response-on-bid-to-allow-foreign-journalists-into-gaza-for-the-9th-time/
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Ian Fraser
20 days ago
āIāll never forget the look of hatred he had for me, simply for existing.... Nigel Farage has suggested itās inconceivable that anyone could recall such events of more than four decades ago. I would simply ask: can a victim of such abuse ever forget?ā Yinka Bankole
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Iāll never forget the look of hatred Nigel Farage had for me at school, simply for existing
The Reform UK leader doubts people can recall their abuse from years ago. Iāve never forgotten his ā it felt malicious
https://www.theguardian.com/politics/2025/dec/05/ill-never-forget-the-look-of-hatred-nigel-farage-had-for-me-at-school-simply-because-of-how-i-looked?utm_term=Autofeed&CMP=bsky_gu&utm_medium=&utm_source=Bluesky#Echobox=1764957957
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Has anything good been published on the mechanism of nausea due to first line TB drugs?
#IDSky
#TBSky
22 days ago
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'In her telling, racism and xenophobia seem not themselves objectively bad things that must be combatted, but a natural outcome that occurs when too many rights are given to immigrants ... If only they had fewer rights, then ... we would hit some golden ratio where everyone will be happier.'
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24 days ago
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Are heat pump tariffs a good idea if you have solar panels? House is only being heated for e.g. four months of the year. Hot water can be had for free when solar panels firing in middle of day, perhaps with a 6am topup. Without a battery, hard to avoid peak time electricity use, esp with kids
25 days ago
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Have there been UK/NHS based outpatient RCTs that were as light touch as RECOVERY? What is the best way to randomise to low risk interventions whilst not creating too much disruption in a busy clinic?
@davidadambarr.bsky.social
27 days ago
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Tom Yates
Resolution Foundation
28 days ago
Overall, the combination of tax rises and giveaways since last yearās Budget is progressive. Incomes for households in the bottom half of the distribution have increased by 1.0 per cent and incomes for households in the top half fell by 0.7 per cent.
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Jo Michell
29 days ago
Thatās the right way round for a labour budget.
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Leo Murray
29 days ago
Announcing an end to the fuel duty freeze is also pretty momentous! Though people are a bit more believe-it-when-I-see-it about this good news as chancellors always like to pretend they will soon (but not today) increase fuel duty, as this really helps to balance budget projections.
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Welcome moves to tackle vehicle taxation
Welcome moves to tackle vehicle taxation Commenting on todayās announcement in the Chancellorās Budget of a new pay as you drive charge for electric vehicles1, the freeze on rail fares2, the gradual w...
https://transportactionnetwork.org.uk/welcome-moves-to-tackle-vehicle-taxation/
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Tom Yates
Child Poverty Action Group
29 days ago
Scrapping the two-child limit will be transformational for children. This is a much-needed fresh start in our countryās efforts to eradicate child poverty and while there is more to do it gives us strong foundations to build on. 1/2
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The Guardian
30 days ago
Donāt believe Nigel Farageās denials. He targeted me for being Jewish ā and it hurt | Peter Ettedgui
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Donāt believe Nigel Farageās denials. He targeted me for being Jewish ā and it hurt | Peter Ettedgui
Now that my former classmate has finally spoken about the allegations of his behaviour at school, I feel compelled to address his points directly, says Peter Ettedgui, a film director and producer
https://www.theguardian.com/commentisfree/2025/nov/25/dont-believe-nigel-farage-denials-targeted-me-for-being-jewish-and-it-hurt?utm_term=Autofeed&CMP=bsky_gu&utm_medium=&utm_source=Bluesky#Echobox=1764100594
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Or is everyone using
#unionconf25
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about 1 month ago
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What did I miss at
#WCLH2025
? Big trials, key studies, etc
#TBSky
about 1 month ago
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Stella Creasy MP
about 1 month ago
Leaving those who flee persecution or their kids in limbo- either when making a claim or when they try to rebuild lives- is not just cruel. Itās counterproductive to integration & costly to all. Asylum reform needs to be both effective & ethical. And those of us not frightened to fight for it.
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Brennan Kahan
2 months ago
New PhD position available at
@mrcctu.bsky.social
to develop guidance on balancing statistical and clinical considerations when choosing an estimand in RCTs.
www.findaphd.com/phds/project...
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Optimising the choice of estimand in randomised trials: developing guidance on balancing statistical and clinical considerations to ensure results matter to stakeholders at University College London o...
PhD Project - Optimising the choice of estimand in randomised trials: developing guidance on balancing statistical and clinical considerations to ensure results matter to stakeholders at University Co...
https://www.findaphd.com/phds/project/optimising-the-choice-of-estimand-in-randomised-trials-developing-guidance-on-balancing-statistical-and-clinical-considerations-to-ensure-results-matter-to-stakeholders/?p188615
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Tax switch is good idea Equalise CGT and income tax Remove tax relief from wealthy pensioners Tax land / expensive property Criminal justice reform, so no need to build new prisons Let asylum seekers work Put some of money raised into pockets of people on low incomes
@stellacreasy.bsky.social
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about 1 month ago
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How football fans can campaign against sportswashing | Letter
Letter: There are ways to raise your voice against Manchester Cityās owners and their links to Sudan while remaining supporters, says Kathryn Fletcher, in response to an article by Barney Ronay
https://share.google/Sthr6enjjzbTEEOJn
about 1 month ago
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The genius of Mamdani is that he advanced progressive positions within the major party of the left I fear Polanski's impact will be more Stein than Mamdani The people united, and all that
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about 1 month ago
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NEW PAPER! Here is the intro to our theme issue, incl a summary of included papers and overview of key debates in the field Increasing mechanistic understanding but little work robustly quantifying impact of CMV indirect effects on population health We suggest a few ways forward!
#IDSky
#ViroSky
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The indirect effects of cytomegalovirus infectionāmechanisms and consequences | Philosophical Transactions of the Royal Society B: Biological Sciences
In this introduction, we summarize the research papers, review articles, opinion pieces and important aspects of the facilitated discussion from the meeting āThe indirect effects of cytomegalovirus in...
https://royalsocietypublishing.org/doi/10.1098/rstb.2024.0398
about 2 months ago
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Barney Ronay
about 2 months ago
My beautiful laundrette
www.theguardian.com/football/202...
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Silence over Sudan: why do Manchester Cityās owners get away with so much?
Two midweek matches in England had a backdrop of war and geopolitics, but only one drew large protests
https://www.theguardian.com/football/2025/nov/08/silence-over-sudan-manchester-city-owners-football?CMP=Share_iOSApp_Other
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Tom Yates
Resolution Foundation
about 2 months ago
Why should we switch 2p of tax from National Insurance to Income Tax? ā¤µļø Income Tax raises more money and spreads the burden more fairly. The switch would raise Ā£6 billion, and leave the vast majority of payslips unaffected.
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Naive question I have yield of case finding data at 0-3 months, 9-12m, 13-24m, etc, with associated estimates of uncertainty (can be converted into a set of proportions) Precision different at different time points How best to combine if I want e.g. yield over first two years (with CI)?
#StatSky
about 2 months ago
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NEW PAPER! Here is the intro to our theme issue, incl a summary of included papers and overview of key debates in the field Increasing mechanistic understanding but little work robustly quantifying impact of CMV indirect effects on population health We suggest a few ways forward!
#IDSky
#ViroSky
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The indirect effects of cytomegalovirus infectionāmechanisms and consequences | Philosophical Transactions of the Royal Society B: Biological Sciences
In this introduction, we summarize the research papers, review articles, opinion pieces and important aspects of the facilitated discussion from the meeting āThe indirect effects of cytomegalovirus in...
https://royalsocietypublishing.org/doi/10.1098/rstb.2024.0398
about 2 months ago
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Tom Yates
Zoe Gardner
about 2 months ago
Dear GOD if you want to save money in the asylum system 1. LET ASYLUM SEEKERS WORK 2. FAST TRACK STATUS FOR EVERYONE FROM CLEARLY UNDAFE COUNTRIES like Sudan, Syria, etc 3. Run an asylum accommodation system that is NOT FOR PROFIT
#r4today
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NEW JOURNAL ISSUE! The indirect effects of cytomegalovirus infection: mechanisms and consequences Enjoyed editing this with Helen Payne and
@strangviruslab.bsky.social
Includes protocol for NIRVANA trial, which is getting started in Uganda and South Africa
#idsky
#virosky
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Philosophical Transactions of the Royal Society B: Biological Sciences: Vol 380, No 1938
https://share.google/ndyifyoD9CyfjjUZ6
about 2 months ago
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NEW JOURNAL ISSUE! The indirect effects of cytomegalovirus infection: mechanisms and consequences Enjoyed editing this with Helen Payne and
@strangviruslab.bsky.social
Includes protocol for NIRVANA trial, which is getting started in Uganda and South Africa
#idsky
#virosky
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Philosophical Transactions of the Royal Society B: Biological Sciences: Vol 380, No 1938
https://share.google/ndyifyoD9CyfjjUZ6
about 2 months ago
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Have to say, I am tempted to do a second PhD!
add a skeleton here at some point
about 2 months ago
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Tom Yates
Guardian Environment
2 months ago
When trains are pricier than planes, thereās a heavy social, financial and environmental cost
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When trains are pricier than planes, thereās a heavy social, financial and environmental cost
In this weekās newsletter: whether itās a holiday or work trip, railway travellers find themselves burdened by astronomical prices
https://www.theguardian.com/environment/2025/oct/23/down-to-earth-climate-travel-train-plane?utm_source=dlvr.it&utm_medium=bluesky&CMP=bsky_gu_env
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Good this, from
@kenanmalik.bsky.social
Given status quo is unacceptable, the international community must apply overwhelming pressure to ensure one of the two potential solutions comes to pass Cross community organising, of the kind
@standing-together.bsky.social
undertake, also important
add a skeleton here at some point
2 months ago
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Stephen Bush
2 months ago
One reason why the government is in a mess is that āis that true tho?ā doesnāt get anywhere near enough weight against āwhat do the public think?ā
add a skeleton here at some point
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Tom Yates
MRC Clinical Trials Unit at UCL
2 months ago
š Thinking about a PhD in clinical trial
#methodology
? We have two funded PhD opportunities for students passionate about trial design and statistical methods: ⢠One in estimands ⢠One in non-inferiority trials š More info and how to apply here:
buff.ly/lCpqcF6
@mrcnihrtmrp.bsky.social
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Current Opportunities
We have an iCASE studentship available to start for the 2025/2026 academic year, and applications to our fifth round of recruitment to our DTP to start in October 2026 are now also open. Please seeā¦
https://buff.ly/lCpqcF6
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Amesh Adalja
2 months ago
āModerna is still developing the CMV vaccine for patients undergoing a bone marrow transplant.ā
www.statnews.com/2025/10/22/m...
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Moderna says key study of its CMV vaccine, expected to be its next big win, failed
Moderna said its experimental vaccine for cytomegalovirus failed in a key trial, a significant setback for a company already facing pressure from Wall Street and Washington.
https://www.statnews.com/2025/10/22/moderna-cmv-vaccine-study-failure/
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2 months ago
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Tom Yates
Resolution Foundation
2 months ago
Switching 2p from National Insurance to Income Tax would raise Ā£6 billion while protecting pay packets. The increase in the state pension would mean that all pensioners with incomes below Ā£40,000 would still be better off next year than this year. Read 'Call of duties' now ⤵ļø
buff.ly/BKL1NyD
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What do we think about cefazolin for late latent syphilis?
@drmichaelmarks.bsky.social
#IDsky
2 months ago
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Good listen
add a skeleton here at some point
2 months ago
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Tom Yates
NEW EDITORIAL! Me,
@drjesspotter.bsky.social
and Rouxjeane Venter argue - that rapid near patient DST should be developed alongside new RRTB treatment regimens - for changes in the design of Phase 3 treatment trials - we must oppose unprecedented cuts to research funding and development assistance
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Priorities in addressing rifampicin resistant TB
Progress in testing and trial design are needed Rifampicin is a critical component of tuberculosis (TB) treatment regimens. Recent positive developments in rifampicin resistant TBāthe emergence of ne...
https://share.google/Vp2kRw1F2jNatUVqi
3 months ago
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NEW EDITORIAL! Me,
@drjesspotter.bsky.social
and Rouxjeane Venter argue - that rapid near patient DST should be developed alongside new RRTB treatment regimens - for changes in the design of Phase 3 treatment trials - we must oppose unprecedented cuts to research funding and development assistance
loading . . .
Priorities in addressing rifampicin resistant TB
Progress in testing and trial design are needed Rifampicin is a critical component of tuberculosis (TB) treatment regimens. Recent positive developments in rifampicin resistant TBāthe emergence of ne...
https://share.google/Vp2kRw1F2jNatUVqi
3 months ago
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Tom Yates
The Guardian
3 months ago
Young lives cut short on an unimaginable scale: the 18,457 children on Gazaās list of war dead
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Young lives cut short on an unimaginable scale: the 18,457 children on Gazaās list of war dead
The childrenās names below appear on a list of victims of Israelās offensive in Gaza, maintained by health authorities in the territory. As of the end of July it ran to 60,199 names, of whom 18,457 were under 18s. Far from comprehensive, the list does not include the thousands still buried under the rubble of destroyed buildings, as well as the warās many indirect victims As of the end of July there were 18,457 children named on the long official list of Palestinian victims of Israelās war in Gaza. Over almost two years, that is equivalent to bombs, bullets and shells killing a boy or girl every hour of every day. In reality the deaths are not spaced out so evenly. Siblings, cousins and playmates are often killed together, by an airstrike or artillery shell. Even children shot by snipers or quadcopters are sometimes brought into hospitals in groups, doctors say. Continue reading...
https://www.theguardian.com/world/ng-interactive/2025/oct/08/young-lives-cut-short-on-an-unimaginable-scale-the-18457-children-on-gazas-list-of-war-dead?utm_source=dlvr.it&utm_medium=bluesky&CMP=bsky_gu
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