Tom Yates
@tomayates.bsky.social
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Epidemiology, infection
https://profiles.ucl.ac.uk/37299-tom-yates/about
pinned post!
NEW JOURNAL ISSUE! The indirect effects of cytomegalovirus infection: mechanisms and consequences Enjoyed editing this with Helen Payne and
@strangviruslab.bsky.social
Includes protocol for NIRVANA trial, which is getting started in Uganda and South Africa
#idsky
#virosky
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Philosophical Transactions of the Royal Society B: Biological Sciences: Vol 380, No 1938
https://share.google/ndyifyoD9CyfjjUZ6
3 days ago
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Barney Ronay
about 16 hours ago
My beautiful laundrette
www.theguardian.com/football/202...
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Silence over Sudan: why do Manchester Cityās owners get away with so much?
Two midweek matches in England had a backdrop of war and geopolitics, but only one drew large protests
https://www.theguardian.com/football/2025/nov/08/silence-over-sudan-manchester-city-owners-football?CMP=Share_iOSApp_Other
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Resolution Foundation
1 day ago
Why should we switch 2p of tax from National Insurance to Income Tax? ā¤µļø Income Tax raises more money and spreads the burden more fairly. The switch would raise Ā£6 billion, and leave the vast majority of payslips unaffected.
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Naive question I have yield of case finding data at 0-3 months, 9-12m, 13-24m, etc, with associated estimates of uncertainty (can be converted into a set of proportions) Precision different at different time points How best to combine if I want e.g. yield over first two years (with CI)?
#StatSky
1 day ago
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NEW PAPER! Here is the intro to our theme issue, incl a summary of included papers and overview of key debates in the field Increasing mechanistic understanding but little work robustly quantifying impact of CMV indirect effects on population health We suggest a few ways forward!
#IDSky
#ViroSky
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The indirect effects of cytomegalovirus infectionāmechanisms and consequences | Philosophical Transactions of the Royal Society B: Biological Sciences
In this introduction, we summarize the research papers, review articles, opinion pieces and important aspects of the facilitated discussion from the meeting āThe indirect effects of cytomegalovirus in...
https://royalsocietypublishing.org/doi/10.1098/rstb.2024.0398
2 days ago
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Zoe Gardner
2 days ago
Dear GOD if you want to save money in the asylum system 1. LET ASYLUM SEEKERS WORK 2. FAST TRACK STATUS FOR EVERYONE FROM CLEARLY UNDAFE COUNTRIES like Sudan, Syria, etc 3. Run an asylum accommodation system that is NOT FOR PROFIT
#r4today
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Tom Yates
NEW JOURNAL ISSUE! The indirect effects of cytomegalovirus infection: mechanisms and consequences Enjoyed editing this with Helen Payne and
@strangviruslab.bsky.social
Includes protocol for NIRVANA trial, which is getting started in Uganda and South Africa
#idsky
#virosky
loading . . .
Philosophical Transactions of the Royal Society B: Biological Sciences: Vol 380, No 1938
https://share.google/ndyifyoD9CyfjjUZ6
3 days ago
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NEW JOURNAL ISSUE! The indirect effects of cytomegalovirus infection: mechanisms and consequences Enjoyed editing this with Helen Payne and
@strangviruslab.bsky.social
Includes protocol for NIRVANA trial, which is getting started in Uganda and South Africa
#idsky
#virosky
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Philosophical Transactions of the Royal Society B: Biological Sciences: Vol 380, No 1938
https://share.google/ndyifyoD9CyfjjUZ6
3 days ago
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Have to say, I am tempted to do a second PhD!
add a skeleton here at some point
13 days ago
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Tom Yates
Guardian Environment
16 days ago
When trains are pricier than planes, thereās a heavy social, financial and environmental cost
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When trains are pricier than planes, thereās a heavy social, financial and environmental cost
In this weekās newsletter: whether itās a holiday or work trip, railway travellers find themselves burdened by astronomical prices
https://www.theguardian.com/environment/2025/oct/23/down-to-earth-climate-travel-train-plane?utm_source=dlvr.it&utm_medium=bluesky&CMP=bsky_gu_env
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Good this, from
@kenanmalik.bsky.social
Given status quo is unacceptable, the international community must apply overwhelming pressure to ensure one of the two potential solutions comes to pass Cross community organising, of the kind
@standing-together.bsky.social
undertake, also important
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14 days ago
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Stephen Bush
17 days ago
One reason why the government is in a mess is that āis that true tho?ā doesnāt get anywhere near enough weight against āwhat do the public think?ā
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Tom Yates
MRC Clinical Trials Unit at UCL
17 days ago
š Thinking about a PhD in clinical trial
#methodology
? We have two funded PhD opportunities for students passionate about trial design and statistical methods: ⢠One in estimands ⢠One in non-inferiority trials š More info and how to apply here:
buff.ly/lCpqcF6
@mrcnihrtmrp.bsky.social
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Current Opportunities
We have an iCASE studentship available to start for the 2025/2026 academic year, and applications to our fifth round of recruitment to our DTP to start in October 2026 are now also open. Please seeā¦
https://buff.ly/lCpqcF6
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Amesh Adalja
17 days ago
āModerna is still developing the CMV vaccine for patients undergoing a bone marrow transplant.ā
www.statnews.com/2025/10/22/m...
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Moderna says key study of its CMV vaccine, expected to be its next big win, failed
Moderna said its experimental vaccine for cytomegalovirus failed in a key trial, a significant setback for a company already facing pressure from Wall Street and Washington.
https://www.statnews.com/2025/10/22/moderna-cmv-vaccine-study-failure/
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21 days ago
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Tom Yates
Resolution Foundation
27 days ago
Switching 2p from National Insurance to Income Tax would raise Ā£6 billion while protecting pay packets. The increase in the state pension would mean that all pensioners with incomes below Ā£40,000 would still be better off next year than this year. Read 'Call of duties' now ⤵ļø
buff.ly/BKL1NyD
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What do we think about cefazolin for late latent syphilis?
@drmichaelmarks.bsky.social
#IDsky
26 days ago
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Good listen
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28 days ago
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NEW EDITORIAL! Me,
@drjesspotter.bsky.social
and Rouxjeane Venter argue - that rapid near patient DST should be developed alongside new RRTB treatment regimens - for changes in the design of Phase 3 treatment trials - we must oppose unprecedented cuts to research funding and development assistance
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Priorities in addressing rifampicin resistant TB
Progress in testing and trial design are needed Rifampicin is a critical component of tuberculosis (TB) treatment regimens. Recent positive developments in rifampicin resistant TBāthe emergence of ne...
https://share.google/Vp2kRw1F2jNatUVqi
29 days ago
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NEW EDITORIAL! Me,
@drjesspotter.bsky.social
and Rouxjeane Venter argue - that rapid near patient DST should be developed alongside new RRTB treatment regimens - for changes in the design of Phase 3 treatment trials - we must oppose unprecedented cuts to research funding and development assistance
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Priorities in addressing rifampicin resistant TB
Progress in testing and trial design are needed Rifampicin is a critical component of tuberculosis (TB) treatment regimens. Recent positive developments in rifampicin resistant TBāthe emergence of ne...
https://share.google/Vp2kRw1F2jNatUVqi
29 days ago
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Tom Yates
The Guardian
about 1 month ago
Young lives cut short on an unimaginable scale: the 18,457 children on Gazaās list of war dead
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Young lives cut short on an unimaginable scale: the 18,457 children on Gazaās list of war dead
The childrenās names below appear on a list of victims of Israelās offensive in Gaza, maintained by health authorities in the territory. As of the end of July it ran to 60,199 names, of whom 18,457 were under 18s. Far from comprehensive, the list does not include the thousands still buried under the rubble of destroyed buildings, as well as the warās many indirect victims As of the end of July there were 18,457 children named on the long official list of Palestinian victims of Israelās war in Gaza. Over almost two years, that is equivalent to bombs, bullets and shells killing a boy or girl every hour of every day. In reality the deaths are not spaced out so evenly. Siblings, cousins and playmates are often killed together, by an airstrike or artillery shell. Even children shot by snipers or quadcopters are sometimes brought into hospitals in groups, doctors say. Continue reading...
https://www.theguardian.com/world/ng-interactive/2025/oct/08/young-lives-cut-short-on-an-unimaginable-scale-the-18457-children-on-gazas-list-of-war-dead?utm_source=dlvr.it&utm_medium=bluesky&CMP=bsky_gu
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Even if you disregard likely overfitting, the tiny validation sample and whether the outcome is pathophysiologically coherent, what is this test for? You don't need a £1000 test to distinguish folk with profound fatigue from people with normal activity levels - you can just ask them
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about 1 month ago
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The Guardian
about 1 month ago
Reform UKās ex-leader in Wales Nathan Gill pleads guilty to bribery charges
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Reform UKās ex-leader in Wales Nathan Gill pleads guilty to bribery charges
Gill admits to eight charges while an elected member of the European parliament Nathan Gill, a former leader of Reform UK in Wales, has pleaded guilty at the Old Bailey to eight bribery charges while an elected member of the European parliament. More details soon ⦠Continue reading...
https://www.theguardian.com/uk-news/2025/sep/26/reform-uk-ex-leader-wales-nathan-gill-pleads-guilty-bribery-charges?utm_source=dlvr.it&utm_medium=bluesky&CMP=bsky_gu
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Powell or Phillipson? I am leaning Powell
about 1 month ago
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Cohort of 29 compared to a propensity score matched group of comparator patients Unclear from press release whether RCT will be required by regulator Clear potential for harm - drug instilled during a lengthy neurosurgical procedure Thoughts?
#medsky
#statsky
add a skeleton here at some point
about 2 months ago
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Jonathan Portes
about 2 months ago
There are actually credible and competent analysts looking at the data.
www.laurenpolicy.com/p/are-recent...
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There is a big financial penalty to pursuing a clinical academic career - delay to CCT (consultant salary), loss of out of hours supplements whilst on research blocks Unless this can be addressed, it will increasingly become a choice restricted to doctors from wealthy families
add a skeleton here at some point
about 2 months ago
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The Guardian
about 2 months ago
Starmer finally said it: āWe recognise Palestine.ā But Gaza desperately needs action ā where is that? | Nesrine Malik
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Starmer finally said it: āWe recognise Palestine.ā But Gaza desperately needs action ā where is that? | Nesrine Malik
The British PM and others offered fine words, but after all the horror, many will say too little, too late. Palestinians need unfettered support ā and now, says Guardian columnist Nesrine Malik
https://www.theguardian.com/commentisfree/2025/sep/22/starmer-finally-said-recognise-palestine-gaza-desperately-needs-action-where-that?utm_term=Autofeed&CMP=bsky_gu&utm_medium=&utm_source=Bluesky#Echobox=1758515514
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Sarah Alexander
about 2 months ago
The
@ukhsa.bsky.social
STI Reference Lab has identified a strain of Neisseria gonorrhoeae which evades detection on the Cepheid Xpert CT/GC Assay. Read more in our eurosurveillance article
www.eurosurveillance.org/content/10.2...
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Detection and characterisation of Xpert CT/NG assay Neisseria gonorrhoeae diagnostic escape mutants, England, June 2025
We report the timely detection of a strain of Neisseria gonorrhoeae which was confirmed as a diagnostic escape mutant on the Cepheid Xpert CT/NG assay in England in June 2025. The reason for assay failure was a likely recombination event with Neisseria meningitidis, which removed both assay target sites. Seven historical putative Xpert CT/NG assay diagnostic escape mutants were also identified following subsequent in silico screening of gonococcal genome collections, but currently there is no evidence of widespread circulation.
https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2025.30.36.2500673
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Mainstream
2 months ago
There's overwhelming support amongst Labour's membership for a more radical offer on democracy, the economy, child poverty & more. We believe the voices of radical realists, the vast majority of the Labour Party, must be heard and heeded. Join us:
mainstreamlabour.org/get-involved
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All feels very New Labour - disaster unfolding in the Middle East, performative cruelty in the media, and genuinely progressive changes going mostly unnoticed
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2 months ago
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Looking for good papers on the impact of recent funding cuts on TB treatment and research, ideally with a focus on RRTB Have seen this from TB Think Tank (
pmc.ncbi.nlm.nih.gov/articles/PMC...
) and this from
@lshtm-tbmod.bsky.social
(
pubmed.ncbi.nlm.nih.gov/40659023/
) What else?
#IDSky
#TBSky
2 months ago
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So many villains Starmer driving progressive folk away from the Labour Party Rayner weakening Labour left Polanski / Corbyn failing to understand that dividing left leads to Tory / Reform govt, hurting everything they believe in Everyone failing to see PR is also unfair, just in a different way
2 months ago
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Tom Yates
NY Times Pitchbot
2 months ago
Whether it's Democrats making it harder for kids to get cigarettes or Republicans making it harder for kids to get vaccines, both sides have imposed the will of government on America's children.
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Alexandra Phelan
2 months ago
DRC health authorities have sadly declared an outbreak of Ebola in Kasai Province. Sample testing confirms Ebola Zaire. At 4 Sept 2025: - 28 suspected cases - 15 deaths, including 4 health workers DRC has significant expertise with Ebola and 2000 vaccine doses.
www.afro.who.int/countries/de...
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Democratic Republic of the Congo declares Ebola virus disease outbreak in Kasai Province
Kinshasa ā Health authorities in the Democratic Republic of the Congo have declared an outbreak of Ebola virus disease in Kasai Province where 28 suspected cases and 15 deaths, including four health w...
https://www.afro.who.int/countries/democratic-republic-of-congo/news/democratic-republic-congo-declares-ebola-virus-disease-outbreak-kasai-province
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Tom Yates
IDSA
2 months ago
As national medical, scientific, public health and patient organizations, we call for the resignation of HHS Secretary Robert F. Kennedy Jr. to ensure the health of the American people. Our statement:
https://bit.ly/45LeJHi
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Michael Marks
2 months ago
In early October we will be hosting an open evening on Academic Clinical Fellowships & Lectureships in Infectious Diseases across all the London programmes. These are integrated clinical academic training programmes for doctors training in the UK. You can sign up here:
forms.gle/T867P8qQ2SMvvHhZ9
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https://forms.gle/T867P8qQ2SMvvHhZ9
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Today's NHS fire safety training was a classic of the genre
2 months ago
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Find it hard to like a player who signed for Newcastle after it became a sportswashing project - I'm sure he'll score goals, but I'm not sure how much I'll enjoy his success
#LFC
2 months ago
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Tom Yates
The Guardian
3 months ago
Declaration of famine in Gaza lays bare Israelās disregard for humanitarian duty
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Declaration of famine in Gaza lays bare Israelās disregard for humanitarian duty
The IPCās findings that a quarter of Palestinians in Gaza are starving should mark an urgent turning point in this war The declaration on Friday of widespread famine in Gaza by the Integrated Food Security Phase Classification (IPC) should mark a turning point in the war. The IPC, which represents a fastidious survey of available data, is regarded as the international gold standard in nutritional crises. Long-criticised by humanitarians in other emergencies for its overabundance of caution, the IPCās declaration of Level 5 ā ācatastrophicā hunger ā in Gaza is a significant moment. Famine, under the IPCās exacting criteria, requires three critical thresholds to be passed: extreme food deprivation, acute malnutrition and starvation-related deaths, all of which are now visible in Gaza. Continue reading...
https://www.theguardian.com/world/2025/aug/24/gaza-famine-declaration-israel-humanitarian-duty-analysis?utm_source=dlvr.it&utm_medium=bluesky&CMP=bsky_gu
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I am not at all convinced by this. If you want to extend inference from RCTs into understudied populations, do a trial emulation. Nothing in inclusion criteria about what was considered an acceptable adjustment set.
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3 months ago
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Looks like a genuinely progressive change Next step should be drug policy reform - with a medical approach, we could avoid criminalising people with substance dependence and young people caught up in the drugs trade (and save a lot of money!)
@stellacreasy.bsky.social
add a skeleton here at some point
3 months ago
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Financial Times
3 months ago
UK green power surges with record approvals for new renewable energy capacity
on.ft.com/3Va0S7b
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UK green power surges with record approvals for new renewable energy capacity
Rise in planning permission for projects reflects growing momentum behind Labour governmentās clean power push
https://on.ft.com/3Va0S7b
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3 months ago
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Nurses are right to demand more You can donate to the RCN strike fund here
@stellacreasy.bsky.social
add a skeleton here at some point
3 months ago
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Yair Wallach
3 months ago
By continuing business as usual, Israelās international partners are allowing the Israeli government to continue with its genocidal campaign with no consequences beyond symbolic gestures of disapproval and statements. The time to act is now - me
@theguardian.com
www.theguardian.com/commentisfre...
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I live in Britain; I grew up in Israel. Itās painful to say, but we need real UK sanctions to save Gaza | Yair Wallach
Symbolic gestures and empty statements are no longer enough. In Israelās globalised economy, hereās what will shift public opinion, says says senior lecturer in Israeli studies Yair Wallach
https://www.theguardian.com/commentisfree/2025/jul/29/israel-uk-government-gaza-economy-sanctions
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The Guardian view on starvation in Gaza: it will take more than words to halt Israelās genocide | Editorial
Editorial: Condemnation is rightly growing. But until concrete action is taken, western allies will remain complicit with these horrifying crimes
https://www.theguardian.com/commentisfree/2025/jul/23/the-guardian-view-on-starvation-in-gaza-it-will-take-more-than-words-to-halt-israels-genocide
4 months ago
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Jonathan Portes
4 months ago
It is very hard to see how the UK government can sign this statement, which makes it absolutely clear that it recognises that Israel is committing - as a matter of state policy - deliberate and systematic war crimes, without at a minimum cutting all military cooperation with Israel.
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Tom Boyles
4 months ago
The upcoming NIRVANA study will randomise these folk to valganciclovir or placebo to test safety, with a view to a phase 3 trial powered for mortality.
add a skeleton here at some point
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Clinical pharmacology friends, how likely is it that patients would develop sulfamethoxazole crystals in urine if given prophylactic doses of co-trim PLUS methenamine? The case reports I have seen are all patients on high dose co-trim
#IDSky
#ClinPharm
4 months ago
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SƩbastien Poulin
4 months ago
SNAP trial update ā”ļø The DSMC provided a recommendation to close the ADJUNCTIVE domain (Clindamycin), due to a statistical trigger for futility being met.
#IDsky
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