Brian Huntly and I are looking to recruit a postdoc to investigate a promising novel therapeutic target in B-ALL @scicambridge.bsky.social. This new CRUK-funded project will involve collaboration with Prof Sir Steve Jackson's group @cruk-ci.bsky.social and the CRUK Functional Genomics centre.

The November Issue of #ExpHem is here! Explore the lineup, including Honoring giants in hematopoietic and progenitor cell biology www.exphem.org/article/S030...

This month on #SimplyBlood 🩸 we're featuring the Cancer and Bone Lab at The University of Sheffield, UK. Led by Alanna Green, the lab played a central role in developing a new drug to clinical trials for myeloma patients. Read more on iseh.org/Publications...

Correct link: www.findaphd.com/phds/?Keywor...

3 PhD positions in the lab for British Students. Inflammasome, cell death and skin immunity, with fantastic colleagues. Check them out or share it with curious and motivated PhD students: www.findaphd.com/phds/?Keywor... @yorkshirebiodtp.bsky.social @ybri-uoy.bsky.social @biologyatyork.bsky.social

All #PhD adverts are now live with some deadlines upcoming: www.findaphd.com/phds/?Keywor...

🚨 We have 3 fully funded PhD studentships open! Join the Grey Lab & collaborators at @biologyatyork.bsky.social, @universityofleeds.bky.social & @ybri-uoy.bsky.social to explore stem cells, proteomics & leukaemia biology 📍Start Oct 2026 | 💡Apply via MRC & BBSRC 👇Details in thread 👇

A decade of bold ideas, brilliant minds & real impact. 💡 Our John Goldman Fellowships are driving progress in leukaemia research, from identifying new drug targets to repurposing existing medicines. Read more: www.leukaemiauk.org.uk/stories/a-de...

Explore the October Issue of #ExpHem including the article Mer receptor expression promotes multiple myeloma disease development via a cell-extrinsic mechanism ➡️ www.exphem.org/current

Surprising finding that standard chemo renders AML resistant to subsequent treatment with menin inhibitors. Published in @isehsociety.bsky.social journal Exp. Hem.: www.exphem.org/article/S030...

We all must take the responsibility and don’t just complaint about these problems. Take action and don’t be a spectator!

Our latest work is available on BioRxiv! WS6 allows extended culture of basal epithelial cells and allows clonal expansion of primary airway epithelial cells after CRISPR editing, with clonal populations retaining their differentiation capacity. www.biorxiv.org/content/10.1...

Humanized MPN xenograft model that offers valuable insights into how human BM MSCs interact with JAK2V617F mutant clone. onlinelibrary.wiley.com/doi/10.1002/... @hemasphere-journal.bsky.social

New Preprint 🚨. Our latest work is now available in biorXiv: A new double reporter strategy reveals a subset of non-migratory hematopoietic stem cells localized in a dynamic bone marrow niche. www.biorxiv.org/content/10.1...

Congratulations to everyone! It’s incredibly exciting to see our lab getting recognition with the postdoc grant to Keiki. www.stemcellcenter.lu.se/article/thre...

Thrilled to share our latest research just published in Leukemia. www.nature.com/articles/s41... Grateful to all co-authors for their dedicated effort and collaboration. @lundstem.bsky.social @lunduniversity.bsky.social

Excited to share our collaborative work with Sheila Singh's lab: we performed an in vivo genome-wide CRISPRa screen using a lung TRACERx PDX model to uncover drivers of brain metastasis. BACE1 - already investigated as target in Alzheimer's - was as a key hit. www.science.org/doi/10.1126/...

Following on from our recent paper showing novel post-transcriptional roles for B-catenin in leukaemia cells, a very well done to Drs Sevim & Park for writing a superb review in @natureportfolio.nature.com Oncogene summarising our current understanding of this field. www.nature.com/articles/s41...

Interested in innate immunity and inflammation? Join us in September for a great meeting! Superb lineup of speaker and lots of opportunities for Ecrs to present!

Excited to see the first commentary in Experimental Hematology (@isehsociety.bsky.social)! Kudos to Aishwarya, Linde ‪@lindemileslab.bsky.social, and Grant @challenlab.bsky.social for highlighting recent papers in Exp Hem on cell-extrinsic factors in Tet2-mutant clonal hematopoiesis!! bit.ly/4k3pEAI

Excited to share our perspective just out in @leukemia journal! What is bone marrow niche doing in shaping clonal dynamics in MDS and Leukemias. www.nature.com/articles/s41...

We're excited to see the launch of the TARGET study, co-led by @billgrey.bsky.social, to tackle AML relapse by targeting chemo-resistant stem cells. This could mean oral treatments at home, fewer side effects, and safer options for all. 🧡

A new research study @leedsth.nhs.uk and @york.ac.uk is set to transform treatments for one of the most aggressive and hard-to-treat blood cancers. Read ▶️ www.leedsth.nhs.uk/news/new-res... @leukaemiauk.bsky.social @bloodcanceruk.bsky.social @cbr-uoy.bsky.social

📢 New PhD Opportunity 🧬🧪 Excited to share a fully funded PhD studentship is available in my lab @gdsc-sussex.bsky.social 📅 Deadline: 2nd May 2025 👉 www.sussex.ac.uk/study/fees-f... Please share with anyone who might be interested.

🚨Today our phenotypic screening work with primary human airway basal cells is published @jcellsci.bsky.social! We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo. doi.org/10.1242/jcs....

Excited to share our work - online today as a preprint. Here, we characterize precocious aging in HSCs of mice and people with sickle cell disease. Excitingly, we demonstrate the potential of senolytics to restore HSC function to the bone marrow of mice with SCD. www.biorxiv.org/content/10.1...

New pre-print from Thomas Höfer, Daniel Hübschmann, @haas_lab and myself, with first authors @Esther_RCorrea @FloGrunschlager and Tamar Nizharadze doi.org/10.1101/2025... @DKFZ @NCT_HD @ChariteBerlin @hi_stem_lab BIH & MDC

ICYMI... #ExpHem featured incredible research in 2024. Our journal has a variety of different content available, including Special Issues. Check out our collections, including guest editors @krikirschner.bsky.social @keisukeito-lab.bsky.social and more on www.exphem.org/content/spec....

Really enjoyed talking about the value of joining our community of scientists, working to solve the most difficult problems in hematopoiesis, HSPCs, leukemia and more. The International Society for Experimental Hematology welcomes burgeoning scientists and group leaders. Join! #ISEH #HSC #leukemia

The first issue of #ExpHem for 2025 is here, marking the beginning of what promises to be a great year of new science! Don't miss articles in this issue from @charles-debock.bsky.social, Lev Kats, Hitoshi Takizawa, and more! www.exphem.org/issue/S0301-...

Here's a new preprint from our group. This manuscript continues our efforts to understand the mechanisms that distinguish fetal/juvenile versus adult hematopoiesis to better understand pediatric blood diseases. www.biorxiv.org/content/10.1...

In the Jan issue of @isehsociety.bsky.social journal, the very first “Society Voices article: Advice for effective leadership and hitting the ground running as a new group leader - Experimental Hematology www.exphem.org/article/S030...

Humans tend to inherently believe that context matters. But context doesn’t seem to matter all that much in genetics. Epistasis between mutations doesn’t seem to influence their stability in this amazing saturation mutagenesis paper. www.nature.com/articles/s41...

Open call from Royal Microscopical Society for nominations to join a Committee - great opportunity for those enthusiastic and active in microscopy, cytometry or imaging www.rms.org.uk/community/sc...

Please share our new PhD position: We are looking for a data scientists to work on leukaemia models of #AML and cancer stem cells or #LSCs. This mixes wet and dry lab and aims to replace animals in research by developing new in vitro tools. tinyurl.com/6rfan796 tinyurl.com/fmys7cay

Interested in #bladdercancer? Come to the Bladder Cancer Translational Research Meeting in Brimingham on the 28th Feb. I'm presenting on APOBECs and cancer initiation. Prof Maria De Santis is talking about treating metastatic disease and loads more exciting speakers. www.kcl.ac.uk/events/7th-b...

Check out our new review in @isehsociety.bsky.social journal Experimental Hematology, asking the question: to what degree is HSC dysfunction responsible for hematologic aging www.exphem.org/article/S030...

Winter break is good for catching up on some reading 😉! #ISEH #SimplyBlood @isehsociety.bsky.social

Good news. #fullyfunded #phdstudentship to be announced early Jan. DM or email now if you want to know more.

In the spirit of being like old twitter and not x, I thought a first post should be something sensible and realistic. As a group our work is most relevant to #paedLeukaemias and hope to contribute towards a wider/real-world impact one day. In reality…

Registration and abstract submission is now open for this EMBO Childhood Leukaemia workshop that I am excited to help organise. See you in Kolkata!!

Blood-generating heart-forming organoids recapitulate co-development of the human haematopoietic system and the embryonic heart. Open access www.nature.com/articles/s41...

go.bsky.app/FrzB2bf Send me a message if you want to be added or you have some suggestions! The more the merrier 🩸🔬

The final #ExpHem issue of 2024 is here! Explore the latest findings, innovative studies and thought-provoking insights in the December Issue of Experimental Hematology ➡️ www.exphem.org/issue/S0301-...

Check out the talk by my amazing grad student, Ian Ghezzi, this morning at #ASH2024. Using a novel mouse model, he’s been able to identify a rare population of dormant JAK2-mutant HSCs that drive disease propagation and therapy resistance in MPNs.

Confused about possible biomarkers for blood cell aging? Check out this review by Wolfgang Wagner, including exploration of how transferable such markers are between mice and humans - Experimental Hematology exphem.org/article/S0301-… @isehsociety.bsky.social

This is a great review. We hope to present our own contribution to this field very soon.

Hello world! First post here, and I cannot be happier to share all those great preprints!

Apply to be a MENTOR at the new EHA Mentorship program! & help early carrer clinicians and researchers to develop their career in Hematology. A one-year program with 4 meetings (online) plus one in persona at EHA Annual Meeting (facilitated by EHA if needed) Please RT !!