How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

Jamie Raskin not only graduated from Harvard with his JD, (editor of the Harvard Law Review)...he is so dedicated to our country and our constitution that this man BURIED HIS SON, came into work the next day to experience an insurrection, and started writing articles of impeachment THAT DAY. 1/

Roses are red, platelets are too, Hematology keeps thriving with every breakthrough. 🩸💌 This Valentine’s Day, show some love by supporting hematology research through the ASH Foundation: ow.ly/9v8r50YcZaK #ValentinesDay #Hematology #Donate #Fight4Hematology

In honor of Blood's 80th anniversary, we're looking back at all of the journal's past Editors in Chief. Today we're kicking off with our Founding Editor, Dr. William Dameshek (served 1946-1969). Learn more about him in this special feature: linkedin.com/feed/update/...

You don't really want to know, but... 2021: 412 awards 2022: 430 awards 2023: 442 awards 2024: 497 awards 2025: 252 awards 2026 (to date): 0 awards

BREAKING NEWS: Steve has had a shower. He's got a busy week ahead (his words, not mine).

Noooooo!!!! Not JJJ!!!!!!

When you agree to serve in a committee

Judge Biery is a badass and my hero

“I just checked—it turns out that Art. II, Sec. 1 of the Constitution of the United States does *not* say ‘The executive Power shall be vested in a bunch of sociopaths who think they can do whatever the f*ck they want and make sh*t up as they go along.’” — George Conway

If this nation has a conscience, what will it take to shake it from its slumber?

An unexpected topic I encountered during my PhD: tricellular junctions. I first knew them as local regulators of tissue mechanics, but over time have realised their broader impact at the tissue scale. I wrote a brief overview of this in a thread for @epimechfc.bsky.social.

Here is a picture of a baby otter for no good reason.

Lots of problems with multi year funding mechanism. Far fewer grants can be funded and they can only be funded for 4, not 5 years even though most grants funded by the normal mechanism are 5 years. It’s a back door way for Russell Vought to choke off science funding

Have you ever wondered about Pig HSCs? Today is your lucky day! Check out this excellent work from @ganuzalab.bsky.social. Well done! Pig and human adult hematopoietic stem and progenitor cells are overall transcriptionally similar. www.exphem.org/article/S030... @isehsociety.bsky.social

The struggle is real! Studying HSCs during inflammatory is a challenge as their phenotype changes. Check out this excellent new work in Experimental Hematology reporting another useful tool for identifying HSCs under these conditions. www.exphem.org/article/S030... @isehsociety.bsky.social

It’s so special to be nominated for this by my trainees. Their hard work makes my job easy and I am so grateful to work with them every day. Mentorship is hard and I benefit from the awesome example of my own fantastic mentors. Thank you Colleen, Peggy @goodell-lab.bsky.social and George!

Gratitutde to all NIH study section participants who are participating in rescheduled meetings now and in January. Thank you for your service and thanks also to the hard working NIH staff who are making these happen. 🥰🧪

For decades, the mystery of how DICER1 mutations promote pediatric rhabdomyosarcoma remained unsolved. Mark Hatley, MD, PhD, and his lab cracked the case, powered by advancements in single-cell RNA sequencing, revealing new paths for intervention. https://ow.ly/UiCG50XU294

NIH grant applicants: October and November grant application submission *deadlines* will be rescheduled (🤯). Specific dates TBD. grants.nih.gov/grants/guide...

New issue of Experimental Hematology out! Check it out! Articles on novel molecular markers of HSCs, engineering red cells from sickle cell disease-derived iPSCs, and classifying HSPCs in LR-MDS. www.exphem.org/issue/S0301-...

Join the Junior Faculty Career Session: Meet the Editors: Insights from Behind the Scenes. Attend this free session during the lunch hour on Thursday, 25 September at #ISEH2025 🏯! iseh.org/Annual-Meeting/54th-Annual-Meeting/Registration

Join the Junior Faculty Committee at their FREE 22 October webinar on Responsible AI in Research and Publishing featuring Laura Watts, PhD from @lumanity.bsky.social and @p4sc4l.substack.com from Wiley. Learn more and register 👉 iseh.org/Webinars-Eve...

Super excited to attend the 54th @isehsociety.bsky.social conference in Japan next week! First time in Japan. First time at a hematology conference. Great chance to network with the world's best and share our CH work in Down Syndrome. @crnicinstitute.bsky.social @cuanschutz.bsky.social

Enjoying Japan’s autumn flavors together yesterday after a full day of teamwork & remarkable effort toward multi-year strategic planning for @isehsociety.bsky.social, future scientists, and the prestige of #ExpHem. @thekinglab.bsky.social @smckinneyfreeman.bsky.social @einsteinmededu.bsky.social

Hard to think of a better group of people to work with towards a strong future for the ISEH. The BEST society for folks interested in the fundamentals of hematopoiesis and HSC Biology. @isehsociety.bsky.social

Memphis Mayor Paul Young confirmed reports that Gov. Bill Lee and the White House were in talks to send National Guard troops to Memphis.

This year's Lasker Awards went to scientists who studied the wiring diagram of life, a new state of biological matter, and a potent treatment for cystic fibrosis. Here's my story with Gina Kolata. Gift link: nyti.ms/4mZlH1F

This is a really important analysis. Scientists in the US need to pay attention.

The ISEH just launched a brand new website! Check it out and join our society today to network with your colleagues and keep abreast of the latest advances in basic and translational experimental hematology research! iseh.org

Still time to register for the annual ISEH meeting! No better place to learn about the latest advances in fundamental HSC biology!

Targeted therapeutic disruption of ribosome biogenesis is a potential strategy against NPM1-mutant AML. buff.ly/UFBcfEZ #hemesky

Hitoshi Takizawa, PhD from Kumamoto University recommends attending the awards sessions at #ISEH2025 🏯. Visit ISEH's blog at www.simplyblood.org and view the 2025 Interview Spotlight Series to learn more about our award winners!

Some great content In latest issue of Experimental Hematology! www.exphem.org/issue/S0301-...

This week on #SimplyBlood we're highlighting the first study to demonstrate that both the SARS-CoV-2 spike (S) protein and BNT162b2 mRNA vaccine can inhibit (HbF) production by and reduce γ-globin mRNA accumulation in β-thalassemic (ErPCs). Read on www.simplyblood.org

This week on #SimplyBlood🩸 we're delighted to share an inspiring conversation with Dr. Toshio Suda, Editor-in-Chief of ExpHem! @keisukeito-lab.bsky.social had the unique opportunity to discuss the journal’s evolution including its future vision and ongoing efforts➡️https://www.simplyblood.org/

Looking forward to this #ISEH webinar by two amazing women in the field

Not every study needs to be a 20-page paper that takes months—or years—to write. Negative results, small studies, and datasets deserve a home, too. That’s why we created the 2-pager at @StacksJournal.bsky.social — a simple format to share all credible findings. 🧪 #SciPub #AcademicPublishing

My quote of the day We the people are the rightful masters of both Congress and the courts, not to overthrow the Constitution but to overthrow the men who pervert the Constitution. Abraham Lincoln

All US scientists need to understand the horrible effect of this new policy: many fewer grants funded until the system normalizes (several years). How many labs will close in the meantime? Likely many.

Hell yeah, keep the pressure on. If you live in one of these states, call your Senators, thank them, and remind them that there are related issues where their states and the nation needs their support and willingness to stand up.

Turns out our *literal* rocket scientists have lots of options other than "stay here and get treated like shit"... But losing large numbers of our top top space and rocket scientists overseas could never hurt us, right? I'm sure starlink will take care of everything...

Shout out to the WSJ journalists who reported on Vought’s impoundment by footnote, causing the White House to walk it back. Impact journalism!!

Researchers at #CUAnschutz, @einsteinmededu.bsky.social and @utrechtuniversity.bsky.social have found the first direct evidence that common respiratory infections, including #COVID-19, can awaken dormant #breastcancer cells that have spread to the lungs, setting the stage for new metastatic tumors.

Happy Birthday, Rosalind Franklin. She captured an X-ray diffraction image of DNA and stated that a helical structure was probable. Watson and Crick then created a detailed model based on her results. They initially received credit for the discovery and were awarded the Nobel Prize after her death.🧪

Last chance for a possible oral presentation at ISEH! Submit today!

As a pediatrician this breaks my heart but sadly doesn’t surprise me.

Sometimes The Onion gets it just right…well done for pointing out the callousness of his comments so perfectly. Shameful.

H3K4 methylation instructs blood specification in vivo Bivalent chromatin instructs lineage specification during hematopoiesis | Cell #Hematopoiesis #CellFate #Chromatin www.cell.com/cell/abstrac...