For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.

Having a fantastic time listening to all the progress in kidney research in the UK @kidneyresearchuk.org driving discoveries. Fantastic talk @willkidney.bsky.social about how large well designed trials have changed our practice in nephrology

QUOD's National Operational Coordinator, Sarah Cross, is at the Kidney Research UK #DrivingDiscoveries conference today in Bristol and is ready to talk to you about how the QUOD biobank can support your kidney research. Come and say hello! 👋 @nhsbt.bsky.social @ndsurgicalsci.bsky.social @ox.ac.uk

Congratulations to @gregfindlay.bsky.social on being awarded a €1.5 million Starting Grant from the @erc.europa.eu to take a closer look at possible disease variants hiding in the dark genome. www.crick.ac.uk/news/2025-09...

The Leeds Transplant teams are amazing humans. Great to see this celebration.

If you're a kidney transplant recipient who has been diagnosed with BK virus infection, please consider reading our evidence-based patient information leaflet that was co-developed alongside BK nephropathy patients. We hope it helps and welcome any feedback to develop it. www.kidney.org.uk/bk-virus

"A highly potent human antibody neutralizing all serotypes of BK polyomavirus" journals.plos.org/plospathogen...

YBRI (@ybri-uoy.bsky.social) are hosting @alanawelm.bsky.social for an online seminar on 9th May 2pm BST. Prof Welm will be presenting her work on "Modeling metastatic breast cancer to advance therapeutic strategies". Please share, and register to join at www.eventbrite.co.uk/e/ybri-onlin...

🚨 Breaking News: The Tobacco and Vapes Bill has passed its Second Reading in @ukhouseoflords.bsky.social! 🚨 This marks another hugely important step towards ending cancers caused by smoking. Please share to show your support for a #SmokefreeUK 🔁

We’re #hiring! It’s an exciting time as we expand and create brand new roles within our passionate charity, committed to changing lives for people with kidney disease. Take a look and share with your network. Find out more and apply here: bit.ly/3umf9kS #Recruitment #CharityJobs

APOBEC drives genetic variation in lung tumors, especially in response to tyrosine kinase inhibitor therapy 🧪. Inhibition of APOBEC during use of tyrosine kinase inhibitors could improve outcomes. In a paper just out in Lung Cancer, we show how much. www.sciencedirect.com/science/arti...

Excited for the AJ Bell Great North Run 2025? There’s still time to join Team Action Bladder Cancer UK and run for a great cause! Whether you’re a seasoned runner or a first-timer, it’s an event you won’t want to miss. 🏅 [email protected] #GreatNorthRun #BladderCancer #Fundraising

If anyone is looking for a lab technician/manager with nucleic acid isolation, library prep, and sequencing analysis experience preferably in the DMV, my former biologist is looking for a job. She was unfortunately terminated in Feb as part of the probationary employee firings. DM me for her info

Did you know that blood in your urine or needing to urinate frequently are symptoms of kidney disease? This #WorldKidneyDay, let’s help more people spot the early warning signs with our ‘Take a wee look’ campaign. What do the colours mean? Find out more: www.kidneyresearchuk.org/2025/02/21/b...

#job 🚨for a laboratory technician in the Wright group within dept. Biology/HYMS and @ybri-uoy.bsky.social to work on creating genome-scale arrays of human cell surface receptors to discover new host-pathogen interactions. Apply by 20/3/2025: jobs.york.ac.uk/vacancy/labo...

New preprint: results from a collaborative project funded by the GCRF Global Network for NTDs investigating Leishmania deubiquitinase 16 as a potential drug target. @ybri-uoy.bsky.social @mottramlab.bsky.social www.biorxiv.org/content/10.1...

As scientists we are often exposed to upsetting findings and we should not have to bury the feelings that our research elicit - I'm glad it's adressed openly here (and yes these results are bleak)

I've written a big feature piece for @cancerresearchuk.org's News site, about a cutting-edge new brain tumour trial they're supporting. It's aimed at the researcher community so a bit techier than usual, but was great fun pulling together. news.cancerresearchuk.org/2025/03/04/a...

The HPV vaccine is an anti-cancer vaccine

The Trump administration terminates funding for polio, HIV, malaria and nutrition programs around the world. “People will die,” said Dr. Catherine Kyobutungi of the African Population and Health Research Center, “but we will never know, because even the programs to count the dead are cut.”

Disturbing to see another rise in recreational ketamine use in the UK. We did some of the early work showing how ketamine kills the cells that line our bladders: www.sciencedirect.com/science/arti... It's sad to think of all the pain and lifelong consequences for young people caused by ketamine.

Great story on the potential of new cancer prevention vaccines. They focus on vaccines for people with Lynch syndrome (as they have an elevated risk of cancer) that targets “neoantigens,” which are proteins unique to tumours but that can activate the immune system. www.science.org/content/arti...

We would love to speak to people with the following experiences: ◼ Changes in your urine before being diagnosed with kidney disease? ◼ Have been affected by Alport syndrome, acute kidney injury (AKI), or BK virus, leading to kidney problems? Click here: www.kidneyresearchuk.org/become-a-kid...

Our funding partners like Kidney Research UK make Daphne Jackson Fellowships possible, helping people return to research after a career break: daphnejackson.org/2025/01/fund...

So pleased to have the paper out, available here: www.nature.com/articles/s41586-024-08423-8 For me this was discovery science as I had always hoped it would be. A lot of fun, and some proper detective work with plenty of twists & turns on the way. Brief thread below

Interested in #bladdercancer? Come to the Bladder Cancer Translational Research Meeting in Brimingham on the 28th Feb. I'm presenting on APOBECs and cancer initiation. Prof Maria De Santis is talking about treating metastatic disease and loads more exciting speakers. www.kcl.ac.uk/events/7th-b...

Today @naturesmb.bsky.social 🥳, we report that the activation of NF-κB after DNA damage can occur through two distinct mechanisms. While ATM triggers NF-κB activation after DSBs, we found that IRAK1 specifically induces NF-κB in response to DNA damage causing transcriptional stress.

The reprehensible behaviour of a fellow honoured by the @royalsociety.org, the UK’s national science academy.

Lovely to see our biology phlebotomy team being recognised! 🤩

I'm really looking forward to speaking at the 7th Bladder Cancer Translational Research Meeting which is in Birmingham on the 28th February 2025. If you're involved in bladder cancer research, please submit an abstract and join us. It's a great, collaborative meeting. www.kcl.ac.uk/events/7th-b...

Exciting PhD opportunity in my group, a prestigious CASE Yorkshire Bioscience DTP studentship. We are looking for candidates with the passion to work on a project that aims to transform the lives of cancer patients worldwide! The project is in collaboration with @tsakiridis.bsky.social

PhD project with Ioannis Kourtzelis, our lab and Mesenbio in lovely York! Macrophage, EV and innate immune responses, what's not to love! www.findaphd.com/phds/project...

Anyone interested in APOBECs and/or DNA editing should consider attending The 6th International Conference on Base Editing, Prime Editing & Related Enzymes. "Deaminet" runs January 22-24, 2025 at Hotel Zoso in Palm Springs, California. It's a great meeting! uthscsa.edu/medicine/edu...

Nice to see the preprint published now in EMBO J. Lovely work on APOBEC3s in the skin from Tim Fenton's group in Southampton. We need to do more work in urothelial differentiation, but so far we don't see much APOBEC3A in healthy tissues. www.embopress.org/doi/full/10....

This is a brilliant piece of work led by Steph, Alan and Matt. There is a lot of hope around neutralising antibodies for BK virus right now and we're also waiting for the MAU868 trials data to be published.