Great talk about the Hidden initiative from Kate Bramham and detecting CKD in the community in London. Absolutely inspirational @kidneyresearchuk.org

Having a fantastic time listening to all the progress in kidney research in the UK @kidneyresearchuk.org driving discoveries. Fantastic talk @willkidney.bsky.social about how large well designed trials have changed our practice in nephrology

Your kidneys are working hard for you every day, every hour. Return the favor with these small habits that lead to lifelong health. 💬 Which of these do you already do? Which one could you start this week? #KidneyFacts #HealthyKidneys #NephrologyTips #BIGKiDsStudy #KidneyHealthAwareness #sampsonlab

Sibeprenlimab inches closer to approval www.hcplive.com/view/fda-acc... feat @brendonneuen.bsky.social Phase 3 RCT next week at #ERA25 (& some journal?)

Sparsentan for FSGS?? It's alive.... ir.travere.com/press-releas...

It’s #WorldImmunizationWeek Vaccines have saved 154 million lives in the last 50 years. That’s 6 lives every minute. A reminder of what is #HumanlyPossible. Science saves lives. #VaccinesWork bit.ly/wiw2025

So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵 www.nature.com/articles/s41...

Interesting!

Other than the brain, our immune system is the most complex part of the human body. For the first time, sequencing receptors of B and T cells, along w/ generative A.I., enabled diagnosis of medical conditions such as lupus. That's just for starters. erictopol.substack.com/p/the-first-...

What an exciting time to be a nephrologist. Yet another really promising therapy for IgA. Decreases proteinuria significantly, likely will be spoilt for choice soon but how will be choose the right meds for the right patient?

Not apologising for posting this paper twice as really excited about ProtGPS. Logical next step in protein modelling after the success of alphafold2. Not only will help predict pathogenicity of genetic variants but can incorporate elements for subcellular compartmentalisation in gene therapy design

🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/... Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social

Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.

No idea how the academic world would cope without pubmed

Fascinating read: history of ISKDC. Our current management of nephrotic syndrome not very different from this first nephrotic syndrome RCT. (Other than AZA which was shown not to be useful in iNS) media.springernature.com/full/springe...

Why we need to start monitoring #BP before adulthood for #cardiovascular #prevention #CvPrev Adolescent #BloodPressure & Early Age #Stroke in @nejm.org Evidence evidence.nejm.org/doi/full/10....

This 13-year-old received 3 antivirals and plasma exchange for #H5N1. In over a decade as an ID doctor, I've never used such measures for #Influenza— not even during H1N1. #H5N1 is alarming; we must boost surveillance, testing, prevention, and education to control it. www.nejm.org/doi/full/10....

Chronic Kidney Disease is rising in prevalence--I have signed this petition for the World Health Organisation to recognise kidney health as a priority, do consider signing to prioritise preventing premature death from kidney disease #nephsky #medsky #pedsky

😱 Have never dared to use any of these but surely you would check through carefully if you did! Worrying that these passed peer review, editorial boards etc 🤔

#PedSky appreciation post: Dr. Weyand’s posts are why I now check ferritin/CRP for every anemia screen (w CBC + retic)! I’ve caught so many w single digit ferritin levels even if Hgb is “normal” 😱 It’s also an issue in “picky eaters” even if they’re not menstruating

A great keynote by Moin Saleem from Bristol UK, followed by a terrific discussion @rfsgsinitiative.bsky.social @genetickidneydoc.bsky.social @opeyemiolabisi.bsky.social @gbadegesinlab.bsky.social

Some papers are very difficult to read but that doesn’t necessarily mean they're deeper than other papers. Authors must work very hard to make their story easy to read and understand by others. Or as Stephen King says: "the shorter the book, the less bullshit".

Hello and thank you to all who have followed us so far! Look out for some of our posts coming to #Bluesky soon 😍 In the meantime, if you are living with #ChronicKidneyDisease and need support from us, please visit our website: kidneycareuk.org/get-support/ #KidneyCareUK #CKD #CKDSupport #Dialysis

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️ So how can we ever achieve #gender #equality? We discuss various strategies in this #Cell Commentary #WomeninSTEM www.cell.com/cell/fulltex... 🧵 1/

1/9 🤔 Why doesn't an elevated BUN lead to extreme thirst? If increased serum osmolarity compels us to seek water, uremia should be a significant driver of this craving. And yet, it isn't. Let's examine why.

❤️Great visual abstract of the original ISKDC study for NS from 50 years ago! high dose steroids magically melts away childhood NS but can we do better? In an ideal world: ✔️equally efficacious induction therapy ✔️minimal side effects ✔️cost effective-equal access in LMICs where NS incidence higher

😱 although hopefully a risk factor only in select age groups.

To celebrate the growing #medsky / #nephsky community, I will post one silly med/kidney cartoon every day for one month! d6: you guessed it - postrenal AKI

To celebrate the growing #medsky / #nephsky community, I will post one silly med/kidney cartoon every day for one month! d5: intrarenal AKI

Loving these kidney cartoons 🥰

theipna.org/ipna-2024-pr... Please support the phenomenal @RukshanaShroff who is running as President Elect for @IPNA_PedNeph - the future of paeds neph would be in safe hands if successful.

Looks like a great resource, will be directing vaccine hesitant parents to this, as often tricky to cover this in any great detail in a paediatric nephrology clinic.

& Paediatrics starter pack here

Starter pack specific for #PedNeph professionals. Hard to keep to with everyone joining so please let me know if you want to be added or see anyone missing! go.bsky.app/DEJdD5

Bristol Royal Hospital for Children Journal Club today: NefIgArd (Lancet 2023). Really promising data showing oral targeted-release Budesonide for 9 months results in significant eGFR difference (5.05ml/min/m2, p<0.0001) and reduction in proteinuria at 2 years when compared against placebo. 1/