Drs. Michael Welsh, Jesús González, and Paul Negulescu have won the 2025 Lasker–DeBakey Clinical Medical Research Award for their roles in developing treatments for cystic fibrosis. Learn more: nej.md/41L3UCI #MedSky #PulmSky #Genetics

Discovery of a brain center (BNST) that controls consumption (including sweets, fats, salt and other foods) in mice www.cell.com/cell/fulltex...

We are proud of Omprakash Singh's new study just out in Cell Reports. Supported by Sepideh Sheybani-Deloui et al, Om's work identifies GHSR expressing SCN neurons as regulating food intake + feed efficiency at a single time of day, accounting for at least 7% of a mouse's BW doi.org/10.1016/j.ce...

Excited to share work led by my PhD student Hayley McMorrow now published in @jclinical-invest.bsky.social. Hayley showed that GIP and GLP-1 receptor agonists rapidly inhibit AgRP neurons and that endogenous GIP is important for nutrient-mediated AgRP neuron inhibition. doi.org/10.1172/JCI1...

The hindbrain cAMP pathway is essential for GLP-1R dependent #weightloss www.biorxiv.org/content/10.1...

Amid lots of uncertainty, anger, and exhaustion I am excited to share this work from my incredibly talented MSTP and @nuincomm.bsky.social student Haley Province. In it we explore the fascinating and powerful anti-aversive properties of GIPR agonists

How do animals decide if they should forage for food or stay home to take care of newborn offspring? Whose needs come first? For my PhD work now out in Nature, we examined how hunger and parenting neurons interact and are reshaped postpartum in mice 🧵⬇️ www.nature.com/articles/s41...

Very excited for this review to be out! A dive into PET/MRS techniques for measuring brain glucose concentrations and cerebral metabolic rate of glucose in the context of diabetes and obesity. #neuroimaging #obesity #diabetes #metabolism #neuroendocrinology link.springer.com/article/10.1...

Studies in mice of CNS GLP-1R circuits reveals that state-dependent synaptic regulation by GLP-1 in PVNGLP-1R→DVC descending circuits is important for energy homeostasis @natmetabolism.nature.com www.nature.com/articles/s42...

Excited to share our latest paper led by Kuldeep Shrivastava out now in @natcomms.nature.com www.nature.com/articles/s41... 1/

Nice article in NY Times today about AgRP neurons, GLP1s, and hunger. By Gina Kolata. www.nytimes.com/2025/04/26/h...

The plan for NIH is in, source with full 64 page proposal for all of HHS is linked. Reported in WaPo. This is catastrophic. Reduction to 8 centers. 40% cut in budget. 15% IDC cap. This will decimate science across America open.substack.com/pub/insideme...

Dysregulated cell metabolism in sleep deprivation www.science.org/doi/10.1126/...

Even Pikachu is out protesting Erdogan in Turkey. 🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣

Why does obesity change the pleasure of eating, the dopamine rush from hedonic foods? A neural circuit mechanism involving explanation www.nature.com/articles/s41...

🚨iGluSnFR4 is finally out!🚨🧪 We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️ www.biorxiv.org/content/10.1... 🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX #Neuroscience

New from Prof Satch Panda and colleagues. Time of day variation in metabolic phenotypes and implications for basic science research #circadian @naturemetabolism.bsky.social @salkinstitute.bsky.social www.nature.com/articles/s42...

Today, the study section I am a member of is one of 26 out of 26 canceled. No new post on the federal registry and councils are postponed indefinitely. Universities focused on overhead cuts considering these a challenge to their survival. But *no grant at all* seems like the issue to battle first..

Nothing else to say.

Thalamic opioids from POMC satiety neurons switch on sugar appetite www.science.org/doi/10.1126/...

Whenever you hear someone sneer about scientific research that seems useless to them — “they’re studying the spit of lizards?!” — remind them that’s exactly how we got Ozempic. globalnews.ca/news/9793403...

Congratulations to @amdouglass.bsky.social and to the whole team, great work!...and glad to see our main findings were confirmed. "Acute and circadian feedforward regulation of agouti-related peptide hunger neurons" www.cell.com/cell-metabol...

GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/15

A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs https://www.biorxiv.org/content/10.1101/2024.12.12.628169v1

Parallel gut-to-brain pathways orchestrate feeding behaviors www.nature.com/articles/s41...

New work stemming from an amazing collaboration with @addisonwebster0 and @AUGCsoup using a combination of rabies mapping and single cell sequencing to identify a GLP1R-expressing local input to AgRP cells that curbs appetite rdcu.be/d2gB5

A little late for Thanksgiving but if you have friends and family members curious about anti-obesity medications, this is very easy to digest piece (nailed that pun....still got it) authors.elsevier.com/a/1kCED3QW8S...

This month, a phase 3 trial of tirzepatide (a GLP-1 drug) found that it reduced the chances of developing type 2 diabetes by around 90% (!), among people with obesity and pre-diabetes. That's a reduction if I ever saw one. www.nejm.org/doi/full/10....