【採用情報】 理研BDRの栄養応答研究チーム (チームディレクター: 小幡史明)から、研究員または特別研究員の公募が出ています。 栄養に関する研究に興味のある方はぜひ！ 随時受付、審査を行い、ポストが埋まり次第締め切ります。 詳細は👇 www.riken.jp/careers/rese...

New study from the lab posted to @biorxivpreprint.bsky.social PhD student Yuka discovered the beautiful mechanism for overcoming nutrient deficiency by microbiota and a new metabolic pathway! Dietary requirement of choline for phospholipids is very complicated www.biorxiv.org/content/10.6...

Our new study out @BMC Biology. The first Mosquito study from the lab, driven by a great effort of phd student Yusuke Kato with the hard work of Chisako Sakuma. Amino acid economy meets a blood-sucking insect. link.springer.com/10.1186/s129...

a tiny contribution from my lab to the great work! Amino acid biology in tumour growth. Congrats! A pint ahead in Melbourne!

Tagging first author @joannaqd.bsky.social and collaborators @obataf-lab.bsky.social

How does the #tumor #microenvironment modulate sensitivity to nutrient restriction? @chengflylab.bsky.social &co show that this is regulated by the SCL36 amino acid transporter Pathetic at the #BloodBrainBarrier perineural glial cells in #Drosophila #brain tumors @plosbiology.org 🧪 plos.io/4ibwXWY

Latest exciting work from me and @mirresimons.bsky.social (and the first bit of data from my @vivensa.bsky.social ECR Fellowship) now out as a preprint, looking at effects of knocking down individual spliceosome components on lifespan in vivo: www.biorxiv.org/content/10.1...

New study out! We developed the protocol for dietary manipulation of protein and amino acids in marmoset! FGF21 induction and taurine drop observed. Achieved by intra-RIKEN collab and the first author Yuka's effort. Here comes Primate Nutritional Biology! www.nature.com/articles/s41...

A long-standing mystery in the development of fly embryos has been resolved go.nature.com/4nhVxaa

「読み進めるほどに「腹八分目」という漠然とした言葉の奥深さが沁みてくる」 「江戸時代に「腹八分目」と言い表したヒト（貝原益軒）の直感にも感心する、楽しい読書だった」 8/24読売新聞で、奈倉有里さんが小幡史明『「腹八分目」の生物学』をご書評くださいました。☞ iwnm.jp/029735 お陰さまで売れています！

！重版決定！ 先月刊行された『「腹八分目」の生物学――健康長寿の食とはなにか』（http://iwnm.jp/029735）、早々に2刷が決定しました！ なお現在、一部ネット書店でカート落ちが発生しております。お近くのリアル書店などで、ぜひお探しいただけますと幸いです。 近日中に電子書籍版も配信開始予定ですので、そちらもぜひご利用ください🐭

Drosophila research without FlyBase would be untenable. Time for all labs who can afford it to step up.

自分でも気に入っている部分がいくつかあるのですが、そのうちの一つがここのカロリーです。ドーナツはカロリーゼロの衝撃！

8/3産経新聞で、小幡史明『「腹八分目」の生物学――健康長寿の食とはなにか』（iwnm.jp/029735）が紹介されました： 「気鋭の研究者による「食の科学」の一冊」 「生存戦略とも結びついた食の奥深さに驚かされる」 www.sankei.com/article/2025...

『「腹八分目」の生物学――健康長寿の食とはなにか』（iwnm.jp/029735）著者の小幡史明さんに、岩波書店本社へおいでいただきました！ ご著書と記念撮影です。 ただいま好評発売中。 腹八分目のかたも、つい食べ過ぎちゃうかたも、ぜひどうぞ。

#Throwback 🧪 COMMENT | ‪ Subcellular quantitative imaging of metabolites at the organelle level @siuzdak.bsky.social‬

＼　本日 ☆ 刊行　／ 小幡史明『「腹八分目」の生物学――健康長寿の食とはなにか』（岩波科学ライブラリー） 試し読みなどはこちら！　→ iwnm.jp/029735 長寿の鍵となる栄養素とは。腹八分目で、老化そのものも防げるか。不老長寿の薬は……！？ 飽くなき探究をいきいきと伝える。 ※電子書籍は8月配信予定です。

📢 New preprint: “Liver FGF21 mediates sex-specific adaptation to juvenile protein malnutrition” Led by @ameliejoly.bsky.social, co-supervised with @francoisleulier.bsky.social. We’re proud to share this story. 👉 www.biorxiv.org/content/10.1...

A new review from the lab is out. A phd student Ayano and me summerises the current view of amino acid signalling, revealed by Drosophila genetics. www.sciencedirect.com/science/arti...

Why use #CRISPR in #Drosophila when RNAi works so well? Because for some genes well is not good enough. Check out new preprint from the lab demonstrating a role for Vps15 in Wingless trafficking. Something that was missed in several RNAi screens. www.biorxiv.org/content/10.1...

CRISPR mutagenesis is also not perfect. A common limitation is generation of genetic mosaics, where only some cells carry gene knockouts. But our new generation of tools substatially improves on that. Described in the preprint below with flies on their way to VDRC: www.biorxiv.org/content/10.1...

De novo serine biosynthesis is protective in mitochondrial disease: Cell Reports www.cell.com/cell-reports...

www.crick.ac.uk/news/2025-05... by Clare Green @crick.ac.uk

Taurine from tumour niche drives glycolysis to promote leukaemogenesis www.nature.com/articles/s41...

Calorie restriction extends lifespan in many animal models, but the effects in humans and the mechanisms of action are not clear. A Review in Nature Reviews Endocrinology summarizes evidence regarding potential adverse effects of calorie restriction. go.nature.com/42XV1Xa 🔒

RESEARCH | TS Nicolaisen, B Kiens et al. (UCPH, DK) Dietary protein restriction in men increases energy intake to maintain body weight partly by FGF21-driven alterations to adipose mitochondria

We are happy to post our first study using common marmosets! We can now manipulate dietary amino acids in primate! FGF21 is highly responsive to dietary amino acids. Via a fruitful collaboration with Takuya Hayashi lab. www.biorxiv.org/cgi/content/...

Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis: Molecular Cell www.cell.com/molecular-ce...

Amazing work done in the Rewitz lab where a gut hormone governs the protein appetite, sleep, and lifespan! more amino acid responsive hormones to come?

Latest preprint. We tested the idea that dietary restriction (DR) is an ancient response. www.biorxiv.org/content/10.1... Across Drosophila the lifespan phenotype and the transcriptomic response to DR are conserved. Yet, many genes were Diptera (fly) specific. Mechanisms may not be conserved…

This is very disturbing. Harvard PhD student Kseniia Petrova (Russian citizen) was arrested by ICE for transporting xenopus embryos into Boston from Paris. She has been detained in Louisiana since Feb. 16. www.theguardian.com/us-news/2025...

new work out from the lab @cellreports.bsky.social A brave phd student Ayano revealed the mechanism how immune activation disrupts renal tubules! The key is a nonsecretory antimicrobial peptide! www.cell.com/cell-reports...

Our review has been out! We summarised the current view how diet, esp. amino acids, regulate ageing and lifespan. It highlights context dependency, lifestage, sex, and others, and proposes how early life nutrient signals impact longevity. Check it! www.annualreviews.org/content/jour...

We will have "Towards Redesigning Lifecycles" at RIKEN BDR, Kobe Japan, March 3-5! Gorgeous Speakers🤓, Free Registration🤑, Japan in Spring🌸. What else do you want? The oral abstract deadline is Dec 15. www2.bdr.riken.jp/sympo/2025/i...

Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation 🧪 www.cell.com/cell-metabol...

Feastive season! and the end of 2024 is approaching

📢Register for the RIKEN BDR Symposium 2025 "Towards Redesigning Lifecycles," which will be held March 3-5, 2025 at @BDR_RIKEN Kobe Campus, Japan. Participation fee: FREE (separate fees required for lunch/banquet- optional) For details & deadlines👇 🔗https://www2.bdr.riken.jp/sympo/2025/

Welcome to the #EDRC2025 account of the 28th European Drosophila Conference which will take place in Alicante from the 25th to the 28th of September 2025! Stay tuned for the upcoming news!

Is anyone creating a Drosophilist starter pack?