Cansu Koyunlar
@ckoyunlar.bsky.social
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Postdoc at the Hubrecht Institute 🧬🩸 DNA replication stress, BMF and blood aging
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Cansu Koyunlar
The Groth lab
11 days ago
Our latest collaboration with the talented Susi
@sbantele.bsky.social
and Jiri Lukas is out now
@science.org
🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇
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Does anyone know of a good textbook/review broadly on erythropoiesis? I'd love to hear your suggestions! 🩸
#hemesky
#bloodsky
11 days ago
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Cansu Koyunlar
Hubrecht Institute
about 2 months ago
Ready to establish your own research group at the Hubrecht Institute for Molecular and Developmental Biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply!
https://f.mtr.cool/jncxfqkuds
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Cansu Koyunlar
Jeroen van den Berg
about 2 months ago
New method 🚀: scEpi2-seq lets us read DNA methylation+histone marks in the same single cell. Found that methylation “memory” after replication depends on chromatin+histones, and TF promoters repressed by H3K27me3 carry distinct methylation. So stoked to share this as first+co-corresponding author 🎉
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Extremely excited to be in Kumamoto for
#ISEH2025
and to share our work! We had a great start today with the new investigators workshop, and I cannot wait for the coming days!
@isehsociety.bsky.social
🍡
about 2 months ago
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Cansu Koyunlar
Björn Schumacher
about 2 months ago
🔥🔥🔥Out now: our Perspectives article in
@nataging.nature.com
outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock
@meyerdh.bsky.social
@alexeimaklakov.bsky.social
www.nature.com/articles/s43...
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Aging by the clock and yet without a program - Nature Aging
Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...
https://www.nature.com/articles/s43587-025-00975-2
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Cansu Koyunlar
Ina Sonnen
2 months ago
Preprint alert! We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.
doi.org/10.1101/2025...
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Cansu Koyunlar
Marloes Blotenburg
3 months ago
We've updated our biorxiv! Check it out if you're interested in a new technique co-profiling RNA and epigenetics in single cells, extended gastruloid culture, and our proposed model for an epigenetic timer determining sequential perceptiveness to different lineages! ➡️
www.biorxiv.org/content/10.1...
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Cansu Koyunlar
STEMCELL Technologies
3 months ago
Finally, media you can *actually* eat! 😉🍪
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Cansu Koyunlar
Alejo Rodriguez-Fraticelli
4 months ago
If you want to know about Blood Stem Cell Aging, then THIS is the meeting to go to. I will be presenting the latest results of the Fraticelli Lab regarding HSC memories and clonal dynamics. JOIN US !!!!!
ehaweb.org/connect-netw...
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Cansu Koyunlar
Hubrecht Institute
5 months ago
What if science is like solving puzzles? We spoke with
@sonnenlab.bsky.social
, a group leader who recently received tenure. She tells us about her journey, her research on signaling dynamics, and the challenges of leading a lab. Read her inspiring story here 👇
www.hubrecht.eu/ina-sonnen-t...
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Ina Sonnen earned tenure: 'science is like a puzzle' - Hubrecht Institute
https://www.hubrecht.eu/ina-sonnen-tenure/
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Cansu Koyunlar
Grant Rowe
5 months ago
Excellent obituary summarizing the contributions of Dr Till's foundational work in defining the hematopoietic hierarchy in Experimental Hematology
@isehsociety.bsky.social
www.exphem.org/article/S030...
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Remembering James Till, 1931-2025
It has been 64 years since the publication of the classic 1961 Till & McCulloch paper that described spleen colonies in lethally irradiated mice following a bone marrow transplant [1]. On May 18, 2024...
https://www.exphem.org/article/S0301-472X(25)00134-1/fulltext
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Cansu Koyunlar
BrunetLab
5 months ago
Excited to share our review on Hallmark of Stem Cell Aging! With Tom Rando and Peggy Goodell
@goodell-lab.bsky.social
!!
www.sciencedirect.com/science/arti...
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Hallmarks of stem cell aging
As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are …
https://www.sciencedirect.com/science/article/pii/S1934590925002267
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Cansu Koyunlar
Blood Journals' Portfolio
5 months ago
In a mouse model for GATA2 deficiency, leukemia emerges from BMF.
buff.ly/WPLVTrt
#hemesky
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Cansu Koyunlar
5 months ago
Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and
@simonelsasser.bsky.social
Check it out:
www.science.org/doi/10.1126/science.adr0493
🧵(1/4)
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RNA transcripts regulate G-quadruplex landscapes through G-loop formation
G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...
https://www.science.org/doi/10.1126/science.adr0493
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Cansu Koyunlar
Blake Hernandez
6 months ago
I’m excited to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in
@science.org
! (link at end of 🧵)
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Cansu Koyunlar
Caroline Bartman
6 months ago
title of assistant professor's talk: amino acid metabolism of effector T cells in LCMV infection title of senior full professor's talk: Why do cells eat?
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Cansu Koyunlar
Jeroen van den Berg
6 months ago
🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰). Come work in our collaberative team of top scientists
shorturl.at/avBBy
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Postdoctoral Researcher - Computational modeling of Epigenetic Inheritance - 38 hours p/w - Hubrecht Institute
About the Project Faithful inheritance of the epigenome in proliferating cells critically underpins human development and health. While DNA replication fidelity and DNA mutation rates are well underst...
https://shorturl.at/avBBy
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Cansu Koyunlar
Iana V. Kim
6 months ago
I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of
@arnausebe.bsky.social
and
@mamartirenom.bsky.social
.
www.nature.com/articles/s41...
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Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature
The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...
https://www.nature.com/articles/s41586-025-08960-w
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Cansu Koyunlar
Rebecca Ann Jones
7 months ago
What governs where DNA replication begins in human cells? Here, we show that origins of replication in human DNA are epigenetically specified and that crucially, this epigenetic mark is required for both DNA replication and cell proliferation!
@narjournal.bsky.social
academic.oup.com/nar/article/...
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Cansu Koyunlar
Shane Herbert
7 months ago
My first post on Bluesky! Very excited to share our work just published in
@science.org
. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues!
www.science.org/doi/abs/10.1...
www.science.org/doi/abs/10.1...
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Interphase cell morphology defines the mode, symmetry, and outcome of mitosis
During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...
https://www.science.org/doi/abs/10.1126/science.adu9628
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Cansu Koyunlar
Francesca Mattiroli
7 months ago
Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us!
doi.org/10.1021/acs....
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Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes
Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and...
https://doi.org/10.1021/acs.biochem.5c00114
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Cansu Koyunlar
Anja Groth
9 months ago
SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026. Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
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DNA replication and genome maintenance: from basic biology to disease
https://www.embl.org/about/info/course-and-conference-office/events/ees26-13/
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Cansu Koyunlar
Anna Alemany
10 months ago
Pre-print alert!! Did you know that exploration of loss and gain of eQTL regulation in normal versus disease condition from scRNAseq can reveal pos-transcriptional regulatory mechanisms (e.g. miRNA)? Have a look at our work, led by awesome
@tdwinter.bsky.social
, in which we focus on human islets.
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Cansu Koyunlar
Cassidy
9 months ago
Your outie's code works on the first try
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Cansu Koyunlar
Jeroen van den Berg
10 months ago
Happy to share this concise review and outlook for single-cell sequencing methods to unravel cell biology of the nucleus! Big shoutout to my friend and former colleague Peter Zeller for sharing the work!
www.sciencedirect.com/science/arti...
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Shining a light on cell biology of the nucleus with single-cell sequencing
From the preservation of genomic integrity to the regulation of RNA translation, nearly all cellular processes are regulated in a cell context-depende…
https://www.sciencedirect.com/science/article/pii/S0955067425000067
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Cansu Koyunlar
Michael VanInsberghe
10 months ago
Several new technologies have enabled translation profiling in single cells. In our article in
@natrevmcb.bsky.social
, Alexander and I discuss these single-cell methods for measuring ribosome profiles, ribosome-associated transcripts, and spatial translation 🧵
www.nature.com/articles/s41...
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Sequencing technologies to measure translation in single cells - Nature Reviews Molecular Cell Biology
Recent sequencing-based methods, including novel ribosome profiling, ribosome affinity purification and spatial translation methods, have enabled the measurement of translation at single-cell resoluti...
https://www.nature.com/articles/s41580-024-00822-z
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Congratulations
@fmattiroli.bsky.social
and thank you for being an inspiration to all of us 🌟
add a skeleton here at some point
10 months ago
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