"Gene editing reaches the clinic" session was superb! #eshg2026

I am learning so much about NMD at the interactive session this morning #eshg2026

Great to see cilia and ciliopathies get a shout out in the wonderful plenary talk by Emma Lundberg (who I don't think is on 🦋) #eshg2026

Great talk by @dougfowler.bsky.social about large scale assays to determine variant effect. These assays with 100,000s of variants are 🤯 #eshg2026

Excited to be attending the European Society of Human Genetics Meeting in Gotenberg this week! I'll be presenting a poster on in session A on Saturday and I am looking forward chatting about my work modelling rare diseases in C. elegans. #eshg2026 #celegans #worms

Tagging C. elegans septins disrupts cytoskeletal scaffolding but not post-embryonic roles https://www.biorxiv.org/content/10.64898/2026.06.09.731194v1

🏆 GRAND PRIZE WINNER 🏆 Congratulations to Smilla-Maria Koy (BSc Student, Mick Lab, Saarland University, Germany) for winning our Image Competition! 🔬 "IMCD3 Spheroid with Cilia" captures primary cilia emerging into the lumen to show cell polarity. #FluorescenceFriday #Cilia #ConfocalMicroscopy

'If a control experiment fails, does that mean that the entire experiment is poorly designed and you must restart from scratch? Often, yes— but not always. I present five examples where failed control experiments triggered entirely new fields of research.' link.springer.com/article/10.1...

Worm friends, we need your help! For the next C. elegans Mentor Match cycle, we’re gathering testimonials from past mentors and mentees. One of our biggest challenges is recruiting new mentees, and hearing directly from past participants could really help. Please record a short video, and share!

We’re excited to announce #Worm27 will be in Kobe, Japan, July 18–22, 2027. Join the global Worm community for science, collaboration, and connection in a stunning city between mountains and sea. Save the date—Kobe awaits! What are you most excited for? Tell us below.⬇️

🧬 Thrilled to share our new preprint describing the discovery of novel sleep-regulating genes in C. elegans using a worm-picking robot! 🤖 🔗 Now available on bioRxiv: www.biorxiv.org/content/10.6...

A chromatin-associated pool of Aurora A controls kinetochore-microtubule attachments to ensure chromosome biorientation | Science Advances www.science.org/doi/10.1126/...

Love live imaging? Join us to study cell division, cytoskeletal dynamics, and morphogenesis in C. elegans embryos. Postdoctoral Researcher in Developmental Cell Biology, Sugioka lab UBC University of British Columbia See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-b

The International C. elegans meeting #worm27 is going to Kobe, Japan in 2027! genetics-gsa.org/celegans/ Organizers: Erik Andersen @erikandersen.bsky.social, Johns Hopkins University Kavita Babu @kavita-babu.bsky.social, IISc Bangalore Suhong Xu, Zhejiang University @genetics-gsa.bsky.social

🚨 Deadline Extended! 🚨 The Cilia 2027 Best Image Competition is now open until May 7, 2026. Got a striking microscopy image? This is your chance to have it showcased at #Cilia2027 🦠🏆 Submit now and share your science through art! #MicroscopyContest #ScienceArt #CellBiology #BioImaging

Genomic sequence and structural variations accumulating between laboratory lineages of wild type C. elegans https://www.biorxiv.org/content/10.64898/2026.04.27.720957v1

www.protocols.io/view/cryo-ex... New protocol alert!! Cryo-expansion microscopy of C. elegans and Tardigrades using the high pressure freezer!

How many proteins in the human proteome have transmembrane domains? And of those, how many examples with n TMDs are there? Couldn't find an answer, so I calculated it from Uniprot data with some #RStats magic (and I did some model organisms while I was at it). 🧪 quantixed.org/2026/04/16/m...

Glad to hear it's not just us! I always have to image red then green.

Lovely!

Stereotypical interciliary contacts in a C. elegans sense organ https://www.biorxiv.org/content/10.64898/2026.04.10.717756v1

That spermatheca looks so cool.

“We’ve lost out on the ability to continue to improve this work to make it more effective, and to explore how to apply it to other areas…There are a lot of different ways that genetics has been used to justify prejudice and…that human-made social categories interface with biological categories“🧪

Guangshuo Ou's lab is a powerhouse. Here they create a C. elegans mutant collection to model human disease variants of uncertain significance. The limitation section raises the challenge of storing & sharing strains. The NIH funds the CGC. How can we build international resources w/cost sharing?

Using EMS mutagenesis, authors generated & sequenced 12,069 viable C. elegans strains, identifying 541,102 missense mutations. They developed TaoChongBao, an open-access database integrating mutation data, greatly expanding functional variant resources. www.life-science-alliance.org/content/9/6/...

The impact of bioRxiv in numbers @richardsever.bsky.social

I've submitted my abstract!

Abstract submission deadline extended to Monday, February 16, 23:59 hrs CET (no exceptions). Last chance to submit an abstract for inclusion in the programme of #eshg2026 #hybridconference! More information on: 2026.eshg.org/abstracts/

This makes me want to get to the lab and inject some worms!

These strains just arrived from CGC! Very exciting!

The Caenorhabditis Genetics Center Curated Special Collections: a guide to protein degradation systems academic.oup.com/genetics/adv...

𝗠𝗲𝗲𝘁 𝗼𝘂𝗿 𝗸𝗲𝘆𝗻𝗼𝘁𝗲 𝘀𝗽𝗲𝗮𝗸𝗲𝗿𝘀 𝗳𝗼𝗿 #𝗖𝗶𝗹𝗶𝗮𝟮𝟬𝟮𝟳! We are grateful for their participation and look forward to welcoming the cilia community on 8-12, March 2027. Wishing you all a happy and inspiring 2026! 🎉 #Cilia #Milan

Yikes! Glad everyone is okay. Lab safety is no joke. www.irishtimes.com/ireland/educ...

You should be able to respond to reviewer comments with memes to liven up the peer review process.

Unfortunately I couldn't get the website to work on my phone. Love the idea of this resource.

Im considering a human genectics conference for next year. Do any C. elegans researchers go to the ASHG or ESHG meetings?

We built this site to allow you to probe our single-nucleus RNA-seq data for adult #Celegans neurons (wt & daf-2 herms, and wt males v herms): cestaan.princeton.edu and a microPub about how to use it: www.micropublication.org/journals/bio... We hope the #Celegans community finds it useful! 🧪

Beautiful images like this make me consider working on muscle 😍

New must-read review article for all lovers of #centrioles and #centrosomes 😍👇

I clicked this link so fast! Right up my alley. Removal of the Ciliary Gate Allows Axoneme Extension in the Absence of Retrograde IFT www.biorxiv.org/content/10.1...

Dias Maia Henriques, Dumont, Maton et al. @ijmonod.bsky.social uncover an #anaphase A pathway, driven by the #kinesin-13 KLP-7 and opposed by the kinesin-12 KLP-18, that contributes to chromosome segregation in early #Celegans embryos. rupress.org/jcb/article/... #Mitosis #CellDivision #Spindle

Lovely work by @emiliafil.bsky.social looking at how septins affect cilia in worms

In #GENETICS, @jsrinivasanwpi.bsky.social and the team present a rescue-by-feeding approach, showing that feeding engineered E. coli containing neuropeptides to #Celegans mutants can successfully rescue behavior defects in worms. buff.ly/Qdw9Nsq

Model organisms, in particular non-mammalian model organisms, such as yeast, Caenorhabditis elegans, #Drosophila and zebrafish, have long stood at the centre of biological discovery www.nature.com/articles/s41...

🧠 Dopamine and forgetting A new study shows dopamine helps the brain forget old memories. Worms lacking dopamine held onto memories longer, suggesting forgetting is an active, dopamine-driven process. 🔗 doi.org/10.1111/jnc.70200 #SciComm 🧪 #Neuroscience #Memory

Hi fellow C. elegans scientists, I've made a few videos that may be of use for new trainees working in worm labs. Hoping to add more in the future, but figured I'd share this resource as is in case it's helpful :) www.youtube.com/@Workingwith...

New cures feel sudden, but the seeds were planted decades ago by basic scientists. Which seeds will turn into cures? Unpredictable looking forward, a straight line looking back. 🧪🧬 🧵

C. elegans CED-1 acts in neurons to modulate ciliary protein abundance and extracellular vesicle shedding https://www.biorxiv.org/content/10.1101/2025.09.15.676301v1

Why would anyone want to screen drugs against the model nematode #Celegans? Check out the latest review in #GENETICS where Peter Roy provides insight and perspective into why scientists choose worms for #drugdiscovery. buff.ly/0Xo54vJ

“‘She uncovered the social experience of women in science’ — the lab assistants who never became managers, the geologists poring over data in government offices while their male peers were doing fieldwork, those who despite their advanced degrees didn’t get hired or promoted, or who were sidelined…”