Next up is Robbie Burton from Newcastle University

Crystallography for the "dark proteome"? From @nudrugdiscovery.bsky.social and @chemistryncl.bsky.social : #FragLites map protein–protein interaction sites including regions with no previously known function. 🧵1/3 #DrugDiscovery #ChemBio 📖 www.sciencedirect.com/science/arti...

Just published: Our paper on high-throughput analysis of cyclin docking interactions, led by the group of Norman Davey @icr.ac.uk and with some small-complex-plus-peptide #cryoEM by @natalia-mg.bsky.social from my lab. Congratulations, everyone! www.nature.com/articles/s41...

🧬 Engineered nanobodies binding and stabilizing cancer-mutant p16INK4a—without blocking its CDK6 interaction or cell-cycle arrest function, in press at Structure from Endicott @nucancer.bsky.social and @lauraitzhaki.bsky.social groups! 📖 www.cell.com/structure/fu...

this is the thing. it's not nothing. in certain contexts it is really extraordinary, I am excited to be living to see what it does. it's also not erm <checks notes> going to be god-level general intelligence in two years time (or probably ever).

Crystallography for the "dark proteome"? From @nudrugdiscovery.bsky.social and @chemistryncl.bsky.social : #FragLites map protein–protein interaction sites including regions with no previously known function. 🧵1/3 #DrugDiscovery #ChemBio 📖 www.sciencedirect.com/science/arti...

Today was one of those Good Days in Academia where (a) an experiment gave me a result I was hoping for, which is Super Cool, and (b) an undergrad emailed asking for advice and I could give them resources and context to point them on the next step of their journey. Little important wins 🩷

Chatbots — LLMs — do not know facts and are not designed to be able to accurately answer factual questions. They are designed to find and mimic patterns of words, probabilistically. When they’re “right” it’s because correct things are often written down, so those patterns are frequent. That’s all.

I'm at #DurhamHPCDays today to present in the Computational Biosciences workshop. Always lovely to come back to Durham, and this time to see a shiny new Maths+CompSci building!

New Presidential executive order on proteins: All amino acids now to be right w̶i̶n̶g̶ handed. Leftist amino acids to be outlawed. (Also, Z-DNA is deemed to be Communist, and is prohibited.) Trans- and cis- peptide bonds to be banned. Non-binary amino acid Glycine to be banned. Proline is […]

@xtaldave.xtaldave.net.ap.brid.gy Your post to the ccp4bb is a thing of beauty.

Latest preprint out in the wild! This is some older work which lingered on our to-do lists; we published the crystal structure of the human IRF4 DNA-binding domain (6TD4) in 2020!

And thanks to the team at Newcastle for stepping up to the challenge!: @creechem.bsky.social, Rachael Pirie, @bieniekmat.bsky.social, @jthorton22.bsky.social, Ayaz Ahmad, Aaron Campbell, Kallie Friston, Natalie Roper, Roly Armstrong, Kate Harris, & @nataliejtatum.bsky.social

My daughter messaged me after her chem class the other day and asked if i could do a cartoon about Trump and Musk as isomers. Dear followers, inspired by Amelia i present to you, unconstitutional arsomers. *insert applause here* #chemsky

🌍👩‍🔬 Celebrating International Women in Science Day! Thank you to all the women in our drug discovery team, their dedication, innovation and inspiration. Together we are pushing boundaries to discover novel anticancer drugs! @nucancer.bsky.social @crhorizons.bsky.social @newcastleuni.bsky.social

A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it. www.science.org/content/blog...

Read about our potential breakthrough in oncology - restoring wild type p53 function with ASTX295. This molecule was co-developed with Astex Pharmaceuticals, and is currently showing great phase I trial readout! #cancer #medchem #clinicaltrials www.linkedin.com/posts/cancer...

Our research is critically dependent on funding we receive from @cancerresearchuk.org and we are also willing to do our bit towards fundraising. In 2024: Funds Raised: £6,440 (+£1,031 gift aid) Online Donations: 283 Events: Great North Run, Race for Life, Shine Walk, Leeds Marathon, bake sale, quiz

Setting up some crystallisation plates today for a new year treat/Christmas miracle. First time setting up an in situ plate for some work with @diamondlightsource.bsky.social VMXi 💎

In early phase drug discovery, biology and assays are make-or-break. I can remember very few programs I worked on which were hampered by the inability to make molecules, but plenty that were hampered by the inability to capture disease biology complexity on a chip or in an enzyme readout.

Been flying the @newcastleuni.bsky.social and @nudrugdiscovery.bsky.social flags recently, talking to @mosmedcdt.bsky.social Cohort 6 about applying computational methods appropriately + short talk at the Durham BSI bit.ly/4d7nlbB on our cyclin D3 work! bit.ly/3D6SwHF🧬🧶#academicskycsky

Thrilled to share the new collaboration between @diamondlightsource.bsky.social + @crhorizons.bsky.social + @newcastleuni.bsky.social to accelerate structure-based drug development via fragment screening! More here: bit.ly/4g7Et3f 🧬🧶 #chemsky #chembio We're already hard at work on exciting targets 💪

Per an email from Google DeepMind: Alphafold 3 is not licensed for academics to use for work that leads to a vaccine (pandemic preparations, anyone?). If structure prediction performance is comparable, people will leave AF3 for competitors with more permissive licenses

In case you missed it on the other site, we've written up some of our experiences from the CACHE2 hit finding challenge in this blog: cole-group.github.io/2024/09/10/c... Thanks to the organisers for a well-run challenge! @creechem.bsky.social @bieniekmat.bsky.social @nataliejtatum.bsky.social

Well, there’s a story.

Congratulations to Kenneth Tan who passed his PhD viva on Tuesday 🎉 Kenneth has also recently taken up a position as a Technical Specialist in our structural biology group. Many thanks to his examiners, @nucancer.bsky.social's Luke Gaughan and @universityofleeds.bsky.social's Richard Bayliss!

#CASP16 results are in! Template-based VFold seems to be lead method for nucleic acid structure prediction! AlphaFold2 and 3 still seem to be best methods for protein monomer and complex prediction.

Pleasure to be on the judging panel for the @mosmedcdt.bsky.social Project Ideation session! An excellent showcase of ideas from all of the teams. Congratulations to our winners, who really emphasised patient need and presented a clear way forward to address it. 👏

Spent today with @newcastleuni.bsky.social development team on their new leadership induction course! Lots to take away and reflect upon 💪

I am looking for 2 postdoctoral researchers to join my lab to work on the role of HIV-1 accessory proteins in the pathogenesis of HIV/AIDS and viral latency. Please contact me informally or ‘re-sky’ to anyone you think may be interested. Closing Dec 10th www.jobs.ac.uk/job/DKV639/p...

The Newcastle Drug Discovery group are on BlueSky! Follow for updates and insights and probably photos of funrunners and cakes 🧬🧶 #chemsky 🧪 #academicsky #chembio #biophysics

Optimist: The cup is half full Pessimist: The cup is half empty Referee 1: Yeah, cups are fine, but can you do it with jars, mugs & glasses? Referee 2: You need to cite these 12 papers showing how to fill things (all ref. 2’s papers) Referee 3: You misspelled ‘container’ on page 6

The Newcastle Drug Discovery group are on BlueSky! Follow for updates and insights and probably photos of funrunners and cakes 🧬🧶 #chemsky 🧪 #academicsky #chembio #biophysics

Optimist: The cup is half full Pessimist: The cup is half empty Structural biologist: The cup requires further optimisation

Look, do I regret betraying my siblings? Sure. Would I do it again for the great taste of Turkish delight? Of course I would

Done in the lab for today (multitasking a protein purification and setting up an SPR assay) so now I get to sit down, have a coffee, and start writing a fresh new talk for a symposium I'm speaking at in December! #ecrchat #academicsky 🧪 🧶🧬

Very informative thread on hallucinations by AF3. Wonder whether we need another community assessment effort (as for AF2) probing its usefulness and limits. Given that hallucinated helices are much more difficult to identify as garbage than spaghetti structures, prob better sooner rather than later!

Want more biological database resources & tools in your feed? Welcome EMBL-EBI (@ebi.embl.org) to 🦋💙 Bluesky 🦋💙! PDBe is part of EMBL-EBI & behind various resources: - founding partner of the wwPDB, - community-led PDBe-KB resource - AlphaFold Protein Structure Database (with Google DeepMind)

Our Newcastle University Centre for Cancer has its own account @nucancer.bsky.social Follow us to hear from our 100+ cancer researchers & how they translate their research into the clinic. For example our Drug Discovery group developed the clinically approved Rucaparib (PARPi) & Erdafitinib (FGFRi)

Since @markhamillofficial.bsky.social has joined Bluesky I think it totally appropriate to call ourselves Skywalkers instead of Twitterati

Newcastle Chemistry @chemistryncl.bsky.social is on BlueSky! Give them a follow for research and teaching news from colleagues at @newcastleuni.bsky.social

Beware, this "BBC Breaking News" account is fake. It's not an official BBC News account. If BBC News ever joins this platform, it'll be publicised via official BBC platforms.

There’s a new Practical Cheminformatics post, “Some Thoughts on Dataset Splitting,” (with code and a robot cartoon) at practicalcheminformatics.blogspot.com/2024/11/some... .

This is a great thread about the potential impact of some of the mutations found in the H5N1 virus from the patient in BC. A lot of people want to know what this means for pandemic risk and the answer is a very complex but unsatisfying “we don’t know”. Host adaptation is complicated.

Revisiting this post because while I did finish Northanger Abbey, I recently failed to beat my all time Pride and Prejudice record (25% 😅). I'm just not a Victorian prose girly.

⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️ 🔄Share to help people finding its topic/field - STRUCTURAL BIOLOGY Structural Biology 1: bsky.app/starter-pack... Structural Biology 2: bsky.app/starter-pack... Crystallography: bsky.app/starter-pack... Synchrotron&CryoEM: bsky.app/starter-pack...

Latest paper on CDK structural biology from the Endicott & Noble labs is in press at Structure! Good old fashioned mutational studies and fun newfangled AlphaFold modelling to characterise the interaction of CRABP2 with CDK4/6-Cyclin D3. 🧶🧬 #biophysics www.cell.com/structure/fu...

I've been riding the high of a positive experimental result on Friday morning all through the weekend. One of those ones you weren't getting your hopes up about, but then you see something binds something else and the mutants don't and you do an involuntary little dance and maybe swear a bit. 🧶🧬

Discussing Bluesky migration in terms of liberal flight misses the simple fact that most people use social media for fun not influence and this platform, unlike X and cruddified Facebook, doesn’t feel like you’re wading through shit to reach your friends. It’s not that deep.

one of my labmates is a genius, behold her tiny arabidopsis farm made from a 96-well plate and pcr strip lids 🤩😆