How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.

Like, look at this wonderful hand drawn structures! www.quantamagazine.org/how-colorful...

If you work with proteins, make sure to show your students Jane Richardson’s early drawings and sketches of protein structures. Not only because they are the foundation of virtually all protein representations today, but also because they are just beautiful!

Stories from #WomenInScience who changed how we visualize #proteins: Ahead of her 85th birthday, Jane Richardson (Duke Univ, @biophysicalsoc.bsky.social president 2012-13) discussed her life from making a telescope to developing ribbon diagrams for 3D protein structure www.nature.com/articles/s41...

Amazing!

As scientists, we always hope to do something meaningful that improves people’s lives. @kwplaxco.bsky.social is achieving just that. Very exciting to see aptamer sensors moving one step closer to patients, and proud to have contributed my (little) grain of sand!

Wavelength AND lifetime multiplexed imaging, cool! By @ciqus.bsky.social onlinelibrary.wiley.com/doi/full/10....

This is how we first teach chirality to our undergrads !

Very interesting study on the cardiac toxicity of doxorubicin chemotherapy. By researchers from CNIC, Spain: academic.oup.com/eurheartj/ad...

I knew it!

New preprint🚨 Imagine (re)designing a protein via inverse folding. AF2 predicts the designed sequence to a structure with pLDDT 94 & you get 1.8 Å RMSD to the input. Perfect design? What if I told u that the structure has 4 solvent-exposed Trp and 3 Pro where a Gly should be? Why to be wary🧵👇

We are proud to introduce the Program Planning Committee for the 40th Anniversary Symposium of The Protein Society! This outstanding team will curate an unforgettable scientific program for our 2026 meeting. Stay tuned for more info! #PS40 #TheProteinSociety #ProteinScience #TPS2026

They are going down the folding funnel

🙌👇👏

“There were some cells in there that were very messed up” In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man go.nature.com/44yj4MN

#bioGUNE_Outreach | 🎨 La ciencia y el arte vuelven a encontrarse en #CICbioGUNE @brtaeus.bsky.social Recibimos al alumnado de #ArgiArte en una nueva edición de #CICbioArte para explorar el metabolismo a través del #Pointillismo 🙏 Eskerrik asko! 🔗 www.cicbiogune.es/news/cic-bio...

#bioGUNE_Seminars | 👥 Yesterday we held a new #OncoSeminar session at #CICbioGUNE @brtaeus.bsky.social under #PreMetaCan, where researchers shared recent advances and challenges. A participatory format that fostered synergies, collaboration, and new connections @contracancerinv.bsky.social

Not only an impressive high-throughput characterization of protein stability, but so many interesting take away messages... Arginines bad for solubility Solubility predictors not great Anti-correlation between aggregation and folding stability ... Amazing work!

New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!

#bioGUNE_Research | The @caixaresearch.bsky.social funds nearly €1M for #GlycoTARGET, led by June Ereño-Orbea #CICbioGUNE #Ikerbasque @brtaeus.bsky.social, to boost cancer immunotherapy with partners from Spain & Portugal 🔗 cicbiogune.es/news/la-caix... @urv.cat @champalimaudr.bsky.social

Giant telescope project, long planned for Hawaii, gets cozy with Spain | Science | AAAS 🔭🧪 @science.org www.science.org/content/arti...

NEW pub in @science.org 🥳 Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life? For over 15 years, #phylogenomic studies have been divided. We provide new evidence suggesting that... 🔗: www.science.org/doi/10.1126/...

Saw this on the other site by @smead2.bsky.social Synuclein spreading as prions… great news for all researchers ever working with synuclein!

ahem, ONE of THE chemical biology conferences of 2026:) www.janelia.org/you-janelia/...

Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social www.embl.org/about/info/c...

If you believe either that Franklin discovered the double helix, and / or Watson and Crick stole her data, ask yourself how you know this. Then take a read of this article.

#bioGUNE_News | 💡 The European project #RGNcestry, awarded an #ERCSyG, brings together #CICbioGUNE and Instituto Biofisika to study CRISPR evolution and develop next-gen gene-editing and diagnostic tools 🔗 www.cicbiogune.es/news/cic-bio... @erc.europa.eu

Nature research paper: Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites go.nature.com/47qdigV

γδ T cells are a unique population of immune cells that can recognize and kill tumors. A 2024 #ScienceReview explores current research efforts focused on how γδ cells naturally discriminate cancers from healthy tissues. https://scim.ag/3L4i3oU #ScienceMagArchives

¿Qué son y para qué sirven los biosensores? Aquí hablo de ello en #BioEnredados el podcast de divulgación científica de @cicbiogune.bsky.social Enjoy!

📢 New preprint: Experiment-guided AlphaFold3 resolves accurate protein ensembles. doi.org/10.1101/2025... AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇

BREAKING: The Nobel Prize in Physics has been awarded to John Clarke, Michel H. Devoret, and John M. Martinis "for the discovery of macroscopic quantum mechanical tunnelling and energy quantisation in an electric circuit" Stay tuned for more.

‼️Premio Nobel de Física 2025 a los descubridores del efecto túnel cuántico macroscópico www.eldiario.es/1_c1383c?utm...

⚫Hoy decimos adiós a la primatóloga Jane Goodall. Maravillosa su entrada el pasado mes de abril en @larevueltafans.bsky.social, enseñando a Broncano a hablar chimpancé. D.E.P. www.rtve.es/noticias/202...

Placental organoids, cool!

"Adapting ProteinMPNN for antibody design without retraining" Our several-years-old fix to ProteinMPNN's tendency to make weird antibody CDR sequences is finally preprinted

🚨 New paper alert! We used AI to make nanobodies more stable, easier to produce, and just as effective at binding their targets. 🔗 Gift link here: academic.oup.com/peds/advance...

Still boggles my mind that we can leave frameworks as-is and only edit CDRs and still reliably get nM binders. Complete opposite of what I would have expected given how hard it is to graft CDRs from one FW to another (such as humanizing mouse mAbs). First RFantibody and now this

In another preprint from the @brianhie.bsky.social Lab and @synbiogaolab.bsky.social, they introduce Germinal, a generative AI system for de novo antibody design. Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.

It’s gonna be a butchery. As if the MSCA evaluation was not random enough…

Interesting discussion between Reviewer 1 and the authors of "Redox-driven mineral and organic associations in Jezero Crater, Mars" and whether the paper will attract media attention as evidence of past Martian life doi.org/10.1038/s415...

BREAKING NEWS: NASA has found a potential sign of past life on Mars. www.nasa.gov/news-release...

Amazing how Bindcraft just got published now, and yet it already was (or so is my impression) one of the most established and powerful tools for de novo protein design.

Predicting Experimental Success in De Novo Binder Design: A Meta-Analysis of 3,766 Experimentally Characterised Binders https://www.biorxiv.org/content/10.1101/2025.08.14.670059v1

What is this marvel of the universe?🤯 www.nature.com/articles/s41...

The American Chemical Society announced Luis M. Liz-Marzán, a leader in the colloidal synthesis of metal nanoparticles, as the recipient of the first Dong Qin ACS Award in Nanochemistry. cen.acs.org/acs-news/Lui... #chemsky

Las respuestas a este hilo son oro 🤣

Have no fear if you weren't in the packed audience this week for @martinpacesa.bsky.social's awesome seminar, because you can check out the recording 👇 youtu.be/qQihl6If9vU

(1/7) Training biomolecular foundation models shouldn't be so hard. And open-source structure prediction is important. So today we're releasing two software packages: AtomWorks and RosettaFold3 (RF3) [https://www.biorxiv.org/content/10.1101/2025.08.14.670328v2](www.biorxiv.org/content/10.1...)