It’s gonna be a butchery. As if the MSCA evaluation was not random enough…

Interesting discussion between Reviewer 1 and the authors of "Redox-driven mineral and organic associations in Jezero Crater, Mars" and whether the paper will attract media attention as evidence of past Martian life doi.org/10.1038/s415...

BREAKING NEWS: NASA has found a potential sign of past life on Mars. www.nasa.gov/news-release...

Amazing how Bindcraft just got published now, and yet it already was (or so is my impression) one of the most established and powerful tools for de novo protein design.

Predicting Experimental Success in De Novo Binder Design: A Meta-Analysis of 3,766 Experimentally Characterised Binders https://www.biorxiv.org/content/10.1101/2025.08.14.670059v1

What is this marvel of the universe?🤯 www.nature.com/articles/s41...

The American Chemical Society announced Luis M. Liz-Marzán, a leader in the colloidal synthesis of metal nanoparticles, as the recipient of the first Dong Qin ACS Award in Nanochemistry. cen.acs.org/acs-news/Lui... #chemsky

Las respuestas a este hilo son oro 🤣

Have no fear if you weren't in the packed audience this week for @martinpacesa.bsky.social's awesome seminar, because you can check out the recording 👇 youtu.be/qQihl6If9vU

(1/7) Training biomolecular foundation models shouldn't be so hard. And open-source structure prediction is important. So today we're releasing two software packages: AtomWorks and RosettaFold3 (RF3) [https://www.biorxiv.org/content/10.1101/2025.08.14.670328v2](www.biorxiv.org/content/10.1...)

I thought it might be helpful to do a more general immunology explainer which I can then build on for example when I discuss specific papers or political actions. Do let me know if its useful and other topics if so. This first one is a general one about how we tackle infections... 🧪 #ImmunoSky

Play the PDB board game that explores the process of structure discovery and deposition. Then, move on to the next project...but keep an eye on the competition and try not to get scooped! #GenCon pdb101.rcsb.org/lear...#GenCon

We are hiring!! 📢 📢 Looking for a motivated (bio)chemist/biophysicist/biotechnologist to work in an exciting project funded by Ramon Areces Foundation together with the group of Matías Picchio at POLYMAT.

Evaluating zero-shot prediction of protein design success by AlphaFold, ESMFold, and ProteinMPNN [new] Zero-shot protein design assessment filters, but accuracy predicting success is limited.

Why don’t you get a job… in molecular biology?

Y aquí va la distribución completa de proyectos: - 2/3 partes de los proyectos tienen 50.000€ o menos por año. Esto no cambia. - La financiación media por proyecto baja ligeramente (2%) respecto al PID2023. - El porcentaje de éxito cae al 46% (49% en el PID2023). La ciencia en España se estanca. 😕

Been playing with ChatGPT o3 model lately. Quite impressed it! It browsed through the literature and distilled efficiently key information. Very useful tool for exploring new research directions!

Amazing work by @albertescobedo.bsky.social and the @benlehner.bsky.social lab!

Recently I learnt that EMBL-EBI has a free online course about AlphaFold — how it works, strengths and limitations, how to use it — and it's very good! There are also little quizzes and interactives. www.ebi.ac.uk/training/onl...

Abrumada y feliz por este reconocimiento tan increíble. GRACIAS a todos los que habéis contribuido a que sea posible, Especialmente, a mi equipo de investigación, que estas cosas solo son posibles gracias a un Equipazo. Y un deseo: Que logremos entre todos una tecnología al servicio de las personas

Binders for disordered proteins!

Using nanobodies to guide regioselective modification, nice! pubs.acs.org/doi/10.1021/...

In a recent paper in ACS Central Science, researchers report a strategy for targeting covalent modifications to specific sites on proteins. cen.acs.org/biological-c... #chemsky 🧪

Spin echo in NMR pulse sequences ☺️

Given the increasing frequency of extreme heat and important health risks of dehydration, this wearable whole-body hydration sensor seems worthy of pursuit www.pnas.org/doi/abs/10.1...

Nice! The possibilities of massive scale structure prediction… amazing!

Interesting. Possibly true also for evolution across environments. For example, extreme halophiles (salt-adapted) have widely different super acidic surfaces, and also less Phe and Tyr. Always assumed it was to reduce the hydrophobic content, but reducing energetic cost maybe helps too.

Nice read on the history of infectious diseases. Recommend!

Now do PIZZA!

🚨 New paper 🚨 RNA modeling just got its own Gym! 🏋️ Introducing RNAGym, large-scale benchmarks for RNA fitness and structure prediction. 🧵 1/9

Sad… we lost a giant today. Que la Tierra te sea leve

Healthspan has a proteomic signature! About 3,000 plasma proteins assessed and validated in 2 cohorts. Immune response and inflammation proteins stood out. www.pnas.org/doi/10.1073/...

This would have a terrible impact in health and technology innovation worldwide!

Amazing how fast we just got used to this.

Extension of ERC StG elegibility window from 7 to 10y after PhD. A necessary and welcome change (although too late for me already). Consolidator also extends from 12 to 15y. Good. However, disappointed at the zero improvement in the provisions for paternity leave. erc.europa.eu/news-events/...

60% cut overall, 70% in bio, 75% in engineering… what a disgrace. This is gonna stall innovation, not only in US, but worldwide too.

Wonderful example of thermodynamics vs kinetics. This is def gonna change the way I think about phase separation and condensates from now on!

Teeth evolved from sensory organs in the exoesqueleton of fish?!? WTF biology! www.nature.com/articles/s41...

Didn’t see that coming…

We quantify the aggregation of >100,000 random protein sequences to train CANYA, a convolution-attention hybrid neural network to predict aggregation from sequence. With @bennibolo.bsky.social www.science.org/doi/10.1126/...

ENG 1/ 🧵 A Catalan AI decodes the secret language of sticky proteins 🧠 CANYA, developed by @crg.eu & #IBEC, predicts when and why harmful protein aggregation occurs, a key step in diseases like Alzheimer’s.👇

Predicting pose distribution of protein domains connected by flexible linkers is an unsolved problem https://www.biorxiv.org/content/10.1101/2025.04.27.650885v1

Watching animals eat is like my biology crack. I don’t need it, I don’t have to do it, I don’t even always like it, but there’s just something about critters noshing on one another that leaves me gobsmacked. And nothing does it like the comb jelly Beroe [Thread 🧵] 📽️ www.youtube.com/watch?v=1xkN...

Great timing, we are hosting Jenn Prescher @stanfordchemistry.bsky.social tomorrow 😃

#bioGUNE_News |🗣️ We are thrilled to announce that #CICbioGUNE @brtaeus.bsky.social is now accredited by @contracancerinv.bsky.social as one of #Spain's top 13 cancer research centers A huge thank you and congrats to all accredited centers! 🔗 ow.ly/Px6K50VtJzP

Nature research paper: A natural experiment on the effect of herpes zoster vaccination on dementia https://go.nature.com/3XHRhq5

"The world keeps running out of helium. There is now a race to prepare for the next shortage" www.bbc.com/future/artic... #chemsky #NMRchat