The CRG PhD call is now open. Exciting opportunities across diverse topics and within a world-class scientific environment. Our group is offering one PhD position to study chromatin evolution. Consider applying or share with anyone who might be interested! www.crg.eu/en/content/t...

Protein Structure Evolution (ProSe) Seminar is now on BlueSky! Every 2nd Tuesday, 4PM GMT. Sign-Up: tinyurl.com/prose-seminar2 Organized by Claudia Alvarez Carreño, Zachary Ardern, Lars Eicholt, Carolina Sanchez-Rocha, Sergio Romero Romero and Md. Hassan Uz-Zaman.

Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you. More info: www.crg.eu/en/content/t...

#Research #Biomedicine Generative AI is more efficient than nature at designing proteins to edit the genome 🧬💻✂️ This is the conclusion of research published at @natbiotech.nature.com by @marcguellc.bsky.social Integra Therapeutics & @noeliaferruz.bsky.social - @crg.eu 📰 tuit.cat/n7ap6

This work has been possible thanks to an incredible team effort w/ Alejandro, @marcguellc.bsky.social @noeliaferruz.bsky.social and the integra therapeutics team!

my father-in-law is a “I know a guy” Guy. sadly all the old Guys are aging out of the Guy Economy. Guys are fundamentally incompatible with Hustle Culture because it’s not about “winning” a deal, it’s about collecting favors and goodwill in a mutually-beneficial cycle. protect your local Guy Economy

What is this marvel of the universe?🤯 www.nature.com/articles/s41...

CATH turns 30 years old this year! We are organising a 1-day symposium on September 16th at UCL, highlighting recent AI-based developments to enhance protein family classifications, annotations and analyses. www.eventbrite.co.uk/e/protein-an...

Woke up this morning in Greenland. It is game time for my cameras. National Geographic Endurance safely crossed the Denmark Straight and into this fjord! #EastCoastKin #photography #Greenland

This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

Evaluating zero-shot prediction of protein design success by AlphaFold, ESMFold, and ProteinMPNN [new] Zero-shot protein design assessment filters, but accuracy predicting success is limited.

🚀 We’re excited to share our latest publication in collaboration with Verena Ruprecht's group at @crg.eu Mechanobiology meets Nuclear Metabolism www.nature.com/articles/s41...

Thank you everyone for the congratulations and the large number of applications! I want to specifically encourage applications for these positions: * Postdoc in structural biology (cryoEM, ideally with X-ray too) * Full time lab manager/technician with wetlab experience

Uncancelled! 🥳

🚨🚨🚨 Please RT! We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets. Deadline: 30/09/25👇

Join Martin’s new lab, great location, super cool project, and the best advisor! What’s not to like?

Struct bio ms titles over the years 1965 - A three-dimensional model of X 1985 - The structure of X 1995 - The structure of X reveals Y 2005 - Structural basis of 2015 - The molecular mechanism of 2025 - Harnessing AlphaFold

The internet remains undefeated 😂😅

We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).

What

An insightful thread by Miguel as usual! - worth reading

In our newest preprint, we discuss current explainable AI (XAI) methods. We divided the workflow of a generative decoder-only model into four information contexts for XAI: training dataset, input query, model components, and output sequence. See here: arxiv.org/abs/2506.19532 @aichemist.bsky.social

Are you curious about what protein language models learn? Check out our newest preprint! 🚀https://arxiv.org/abs/2506.19532 We reviewed explainable AI (XAI) techniques across all parts of the generative protein design workflow and discussed their applications, limitations, and untapped potential!

Noooo😭 This was the BEST workshop at NeurIPS!!

This is absolutely nuts and I wonder how the future of peer review is gonna look like

An excellent assay on the fall of critical thinking

🚨 New paper 🚨 RNA modeling just got its own Gym! 🏋️ Introducing RNAGym, large-scale benchmarks for RNA fitness and structure prediction. 🧵 1/9

Then, according to this doctor's logic, why do whales have menopause? 🧪

End-to-end differentiable homology search for protein fitness prediction. @yaringal.bsky.social @deboramarks.bsky.social @pascalnotin.bsky.social arxiv.org/abs/2506.089...

Congratulations to all the 2025 Awardees of L’ Oréal- UNESCO For Women in Science & Thanks L’ Oréal Spain for the fantastic networking event!! 💜 #WomenInScience #newPI

Finally someone said it

People always come up with the best of names?!

Endinsa’t en una vivència sensorial única que connecta ciència i art immersiu. “SEEING: Un ull i una caixa” arriba del 5 al 14 de juny al Centre Cívic Convent de Sant Agustí (Carrer del Comerç 36, Barcelona). www.crg.eu/en/event/see...

Do protein language models store different structural elements in factorizable subnetworks? To find out, we masked out PLM weights to suppress performance on CATH subcategories or secondary structure elements while maintaining performance on other sequences or residues.

@nickywhiffin.bsky.social at #VariantEffect25

Patrick Hsu at #VariantEffect25

@isabellease.bsky.social is drawing amazing artwork for each speaker at #VariantEffect25 - crazy beautiful and super good summaries in all cases, have a look🤯

Day 3 of #VariantEffect25 and what a beautiful morning! 🌞🌊🧬 First up: Tim Whitehead presents An experimental platform for learning antibody molecular recognition

Back from the #VariantEffect25 coffee break and on to @nickywhiffin.bsky.social who is Interpreting variation in small nuclear RNAs in neurodevelopmental disorders. (Absolutely stoked to be seeing her present live. I’ve been looking forward to this for years!)

Next at #VariantEffect25 we have @pascalnotin.bsky.social who is Advancing Protein Fitness Prediction via Differentiable Retrieval and Cross-Landscape Transfer Learning #AI #ProteinML

A one-slide intro to retrieval!

Good morning #VariantEffect25! Kicking things off we have Mafalda Dias, @bennibolo.bsky.social @muffley.bsky.social welcoming us to this 8th annual symposium. We have 250 in-person participants, 60 people online, from 20 countries!

Countdown officially started! #VariantEffect25 @varianteffect.bsky.social

Welcome to everyone arriving in Barcelona and the @crg.eu today ahead of #VariantEffect25! 🌞🌊🧬 Can’t wait to catch up at the workshop tomorrow!

We have two open Master’s internship projects for the 2025/2026 academic year in our lab! 🔬🧬 You can apply directly through the BIST website: mmres.bist.eu/research-pro... We’re looking forward to hearing from you! 👋 @crg.eu @prbb.org @upf.edu

Postdoc opportunity! The Comparative Genomics lab (@IBE_Barcelona, @UPFBarcelona) is seeking a postdoc with experience to work on environmental DNA and mammalian monitoring together with @estherlizano ! CVs -> [email protected] #postdoc #genomics #eDNA #conservation #Barcelona

Welcoming @lassemiddendorf.bsky.social as Mayor of iGEM’s Biomanufacturing Village. This Village explores how we can grow the medicines, materials and commodities of the future using synthetic biology- powered by shared tools, scalable ideas and practical roadmaps. villages.igem.org

"Me apasiona enseñar y compartir conocimiento, pero para que el mensaje llegue, hay que traducir la complejidad sin perder el rigor. La divulgación debe ser un puente entre la ciencia y la curiosidad de las personas." @maradierssen.bsky.social hoy en @lavanguardia.com

If you're a grad student or an undergrad interested in research I need to you listen to me very carefully. You cannot learn to write good research papers if you do not read good research papers. Stop asking LLMs to summarize papers for you.

AFESM: a metagenomic guide through the protein structure universe! We clustered 821M structures (AFDB&ESMatlas) into 5.12M groups; revealing biome-specific groups, only 1 new fold even after AlphaFold2 re-prediction & many novel domain combos. 🧵 🌐 afesm.foldseek.com 📄 www.biorxiv.org/content/10.1...