Our latest paper is out! We built a large-scale mutational map of amylin to understand how sequence drives #amyloid formation, a process linked to type 2 #diabetes🩸📈📉. It’s a step towards connecting molecular mechanisms with human genetic variation in a systematic way.

This time we went “functional.” 🙂 After years studying pathological amyloids, we followed RIPK1/3 into the other side of aggregation - where amyloids help cells decide when to die. 🔗🔗 🔗 www.biorxiv.org/content/10.6...

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out! rdcu.be/eq975

New cocktail 🍹 in town - in collaboration with @benlehner.bsky.social : Massive combinatorial mutagenesis + amyloid kinetics selection + thermodynamic modelling showing us the portrait 🎨 of an amyloid transition state. Read about it in this great thread:

A black hole in the early universe? Sometimes I like to imagine that I operate a telescope, not a microscope 😁. The hole in the middle of the image is actually a blood vessel. The stars are astrocytes🟡 in the human brain, interacting with beta-amyloid🔵. The brain is from a donor with #Alzheimer.

Candle-lit commuting sponsored by @rodalies.info 🕯️🕯️🕯️

Full slide deck here from our talk yesterday on the gender divide and relationship recession, featuring many more countries and plenty of economic data too: www.dropbox.com/scl/fi/1lp1d...

I urge everyone to read Unbreaking’s new page on everything the govt is doing to destroy & diminish medical research funding. It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job. unbreaking.org/issues/medic...

And what a great talk to end #VariantEffect25 ! Thanks to the amazing crowd that travelled to Barcelona and made MSS25 such a fantastic meeting. Lots to think about now! 🧦🗺️☀️

Fantastic talk #VariantEffect25 by @pollyfordyce.bsky.social on how much we can understand about sequence-function relationships once we are able to factor in kinetic 🏎️rates. Microfluidics 💧💧for the win!

@pollyfordyce.bsky.social at #VariantEffect25

Good views, food and even better company at #VariantEffect25

The first poster session just started! #VariantEffect25

Welcome back from the lunch break. Kicking off the afternoon session at #VariantEffect25 we welcome ​​Patrick Hsu @pdhsu.bsky.social all the way from @arcinstitute.org – Bridging biology and AI for genome design 💥🧬🤖 #SynBio #AI Let’s gooo! 🚀

It is a deeply inspiring story, reminding us why we do what we do.

Welcome back from the coffee break and to the last session of Workshop 1 of #VariantEffect25. @pascalnotin.bsky.social is giving us an overview of protein fitness prediction models! #AI #ProteinML

Next up at #VariantEffect25 Workshop 1 we have Noelia Ferruz! From Rosetta to Flow Matching: The Evolution of Protein Design -How Should You Begin Today?

Let’s get this party started! Kicking off workshop 1 of #VariantEffect25 we have Albert Escobedo — From Fitness to Free Energy: Thermodynamic Modeling of Protein DMS Data for Accurate Genetic Prediction with MoCHI 🍡🧬

Our "Atlas of Variant Effects 2030 Roadmap" is live: zenodo.org/records/1542... 1/n

there are 1,100 words in this article and zero of them are "bus"

@marianomartin.bsky.social discussing amyloid formation from random sequence extensions at our first CNS 🧠network event @ibecbarcelona.eu Find out more this week on @pnas.org! www.pnas.org/doi/10.1073/...

Countdown officially started! #VariantEffect25 @varianteffect.bsky.social

CAT 1/ 🧵 Una IA catalana desxifra el llenguatge secret de les proteïnes "enganxoses" CANYA, desenvolupada pel @crg.eu i l’ #IBEC, pot predir quan i per què es formen agregats proteics, un procés relacionat amb malalties com l’Alzheimer 👇

Blackout pipetting @ibecbarcelona.eu

🏆 Congrats to #IBEC researcher Dr. Irene Marco-Rius on winning the 2025 Anatole Abragam Prize! 🎉 Her groundbreaking work in hyperpolarized #MRI & organ-on-a-chip tech is transforming disease diagnosis & therapy monitoring. 🔬👏 #MagneticResonance #ScienceExcellence #ISMARENC2025

David Baker talks about how the current uncertainty and instability hinder creativity because of the difficulty in thinking long-term. From this week’s Night Science Podcast nightscience.buzzsprout.com/1744020/epis... @nightsciencepod.bsky.social

We’re looking for fellow nerds to help us make disordered proteins druggable. Love #IDPs, #MD, #NMR, #AI, #DrugDiscovery, or #MassSpec? Let’s talk. @bindresearch.org is hiring across the board: bindresearch.org/careers/ #compchem #compbio #NMRChat #TeamMassSpec #chemjobs @chemjobber.bsky.social

“If she wants to know something specific, but doesn’t want people to notice her asking questions, she should simply make incorrect statements while in the company of experts. Her companions will correct her, especially if they're men.” - Advice for female agents in WW2, provided during SOE training

In my 25 years since high school I’ve seen 1. HIV/AIDS go from death sentence to manageable with drugs 2. Cystic fibrosis go from pretty much an extended death sentence to manageable with drugs 3. Sickle cell go from a horrible disease to (almost maybe) cured by gene therapy Simply incredible

Light chain dimers in native conditions are not all the same, check what we found! #alAmyloidosis

A few weeks ago, I had an incredibly emotional call with James Coney, a writer for the Sunday Times whose son Charlie was in the @genomicsengland.bsky.social 100k project and was recently diagnosed with ReNU syndrome. This beautiful article tells their story ❤️ www.thetimes.com/article/0bcc...

By @katherinejwu.com "The NIH... supported 99 percent of the drugs approved in the U.S. from 2010 to 2019. The agency has had a hand in “nearly all of our major medical breakthroughs over the past several decades,” The NIH is in a struggle for its (and our) lives. This is existential to America:

⏰ Deadline alert! 🔴 Last week to submit abstracts & get early bird registration for the 8th Mutational Scanning Symposium! Join experts in genomics, protein science & precision medicine to discuss cutting-edge variant interpretation #VariantEffect25 🔗 events.ibecbarcelona.eu/mutational-s...

The 8th Annual Mutational Scanning Symposium is just around the corner! #VariantEffect25 What we are looking forward to: 🗣️Great talks! 🛠️Workshops! 🏆Poster session and awards! 🌏Amazing community! ⌛️March 1st deadline for abstracts!

Register soon to receive the early bird rate! Mutational Scanning Symposium "Mapping and Modelling Variant Effects at Scale" #VariantEffect25 🗓️ May 21-23, 2025 📍Barcelona (or online) ℹ️ www.varianteffect.org/mss2025

👇👇 check this out for exciting+impactful science in a great working environment. 💻☀️

🚨 PhD Opportunities at IBEC! 🚨 Join #IBEC, a Severo Ochoa Research Centre, and start your research career with one of 12 fully-funded PhD fellowships in bioengineering! 🌟

Countdown has started! Excited to welcome you in Barcelona for the 8th Mutational Scanning Symposium #VariantEffect25 🌍 @ibecbarcelona.eu @crg.eu @varianteffect.bsky.social events.ibecbarcelona.eu/mutational-s...

🗓️ Mark your calendars! This is one not to miss! www.varianteffect.org/seminar-series

Wanna work with us? This is one great vehicle for international postdoc applicants to join a UK lab, including ours: royalsociety.org/grants/newto...

Iranian authorities detain Italian war correspondent Cecilia Sala and jail her in Evin prison. Journalism is not a crime. Bring her home. www.ilfoglio.it/esteri/2024/...

Award-winning Italian reporter and podcaster Cecilia Sala was arrested in Tehran earlier this month. Our colleague @marinaadami.bsky.social profiled this pioneering and fearless journalist in this piece we published back in 2022 reutersinstitute.politics.ox.ac.uk/news/how-pio...

Calling all systems and computational biologists in search of a faculty position: We have Assistant and Associate Professor positions! 🚀 Pittsburgh is beautiful, and we are doing amazing science here. cfopitt.taleo.net/careersectio... cfopitt.taleo.net/careersectio... Please apply by Dec 2!

Models for predicting the effect of genetic variation have come a long way in the last few years. When it comes to diagnosis and preventative care, how can we make safe and yet efficient use of them? Here are some of our thoughts authors.elsevier.com/c/1k7J9_4GsX...