Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases In new work @arcinstitute.org, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement

This was a fun one — new Endpoints Slack interview with @pdhsu.bsky.social : endpts.com/endpoints-sl...

are there good CROs for cell line engineering and generation?

Today, we're launching the Arc Virtual Cell Atlas, a growing resource for computation-ready single-cell measurements. arc-website-git-ben-virtual-cell-atlas-tool-arc-institute.vercel.app/news/news/ar...

At the @arcinstitute.org we are building AI models of cell state from the ground up, rethinking every step, from data generation to biologically relevant evaluation Today we launch scBaseCamp, the largest public repository of single cell RNAseq data, uniformly processed from raw sequencing reads.

@thejohnnyyu.bsky.social, @therealnima.bsky.social, and I, are excited to tell you about Tahoe-100M! The largest publicly available single-cell dataset that measures the effect of 1200 genes on 50 cell line models. The Vevo team has outdone itself. #Tahoe100M www.biorxiv.org/content/10.1...

Watch @thejohnnyyu.bsky.social @therealnima.bsky.social (@vevotherapeutics.bsky.social), @pdhsu.bsky.social , Dave Burke and I (@arcinstitute.org) talking about virtual cells, and how #Tahoe100M, now on. @arcinstitute.org's Virtual Cell Atlas, can change the game! www.youtube.com/watch?v=ak_f...

New from @arcinstitute.org is "the largest publicly available #AI model for biology to date"! Evo 2 now includes information from all domains in life to expand its capabilities in generative functional genomics. @pdhsu.bsky.social @brianhie.bsky.social tinyurl.com/3t83vseh

AI provides a universal framework that leverages data and compute at scale to uncover higher-order patterns Today, @arcinstitute.org in collaboration with Nvidia releases Evo 2—a fully open source biological foundation model trained on genomes spanning the entire tree of life.

Introducing Evo 2 from Arc Institute - an AI that can model and design the genetic code for all domains of life. It’s one of the largest-scale truly open source AI models for biology (and in fact more generally - most “open source” large language models are only “open weights”)