Jackson Cahn
@jkbcahn.bsky.social
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Learning from evolution to make drugs with enzymes.
Tagging Gov
@mikiesherrill.bsky.social
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4 days ago
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We don't always win the Super Bowl, but when we do we absolutely humiliate the other team #12
20 days ago
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We're sliding into a polio-ridden runaway-warming white-supremacist fascist dystopia. But Jake Bobo just caught a touchdown pass and that still makes me happy.
about 1 month ago
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"Who would bring a gun to a protest?" mfs when they're the ones protesting.
about 1 month ago
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Cascadia-PNW
about 1 month ago
FYI: Seattle
#ICE
#ICEWATCH
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Philip Bump
about 1 month ago
Just staggered by the complete moral void of not even *pretending* to wait for more information before pivoting to “the opponent of the state deserved it.” It is so insanely depraved. Soulless.
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Bill Childs
about 1 month ago
“Federal agents briefly detained our reporter at the scene, who says he was tackled to the ground and had a gun put in his face.”
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BREAKING: Federal agent shoots man in south Minneapolis
A Bring Me The News reporter was near the scene, and recorded multiple gunshots.
https://bringmethenews.com/minnesota-news/breaking-federal-agent-shoots-man-in-south-minneapolis
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Sanjay Srivastava
about 1 month ago
The Seahawks defense was so dominant that the team scored 41 points and everyone's like "the offense did ok too I guess"
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Jeremy Baskin
about 2 months ago
9. Directed evolution campaigns yield new lipid-binding domains from a variety of protein scaffold precursors, from
@takinishimura.bsky.social
and Noboru Mizushima, on
@biorxiv-cellbio.bsky.social
www.biorxiv.org/content/10.1...
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Rational engineering of lipid-binding probes via high-throughput protein-lipid interaction screening
Lipid-binding domains, originally isolated from natural proteins, are useful tools essential for analyzing membrane lipids in cells, and their applications are varied. Yet, there is no general strateg...
https://www.biorxiv.org/content/10.1101/2025.01.05.627504v1
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derek guy
about 2 months ago
amazing how the entire machine can pivot within 24 hours. no need to slowly upsell the argument; just issue new marching orders
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leon
about 2 months ago
this is your mission. our pedophile president needs you to jump out of a helicopter to kidnap a head of state and his wife so some oil ceos can make a lot of money. we’ll be watching from a resort in florida that still serves wedge salad and checking how many retweets we get. good luck soldier
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Adam Schwarz
about 2 months ago
Maduro is a brutal and oppressive dictator of Venezuela. Trump has no legitimate legal basis for military action against Venezuela under United States or international law. Both of those facts are simultaneously true.
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Did we just do a fucking coup in Venezuela?
about 2 months ago
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Shiv Ramdas Mens Rice Activist
2 months ago
In 2005 Benedict became Pope and the Seahawks won 13 games and went to the Super Bowl In 2013 Francis became Pope and the Seahawks won 13 games and went to the Super Bowl In 2025 Leo became Pope and the Seahawks have won 13 games...
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You've just opened a chemistry themed pub, what are you calling it? The H-Bar (ħ)
#chemsky
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2 months ago
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Anna Bower
2 months ago
Per NY Times’s Michael Grynbaum on X, this is Sharyn Alfonsi’s email to her “60 Minutes” colleagues in full:
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Demon escapes because you didn't have enough wizards to form a binding circle? Problematic mage gap.
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3 months ago
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Kevin K. Yang 楊凱筌
3 months ago
Alternate between AlphaFold3 "hallucinations" and fixed-backbone sequence design to generate or optimize proteins.
www.biorxiv.org/content/10.1...
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Stephanie
3 months ago
The shutdown delayed applications opening for the NIST Summer Undergraduate Research Fellowship (SURF) program, but their website says they will start accepting applications 12/1.
www.nist.gov/surf
#chemsummer
There’s an example of a project from last year in the quoted post
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🧬Jacob L Steenwyk
4 months ago
NEW pub in
@science.org
🥳 Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life? For over 15 years,
#phylogenomic
studies have been divided. We provide new evidence suggesting that... 🔗:
www.science.org/doi/10.1126/...
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Nearly ten years in the making and finally out in print!
www.nature.com/articles/s41...
Entotheonella are insanely biosynthetically rich bacteria, but few genomes were available. Working with far-flung collaborators, we obtained genomes for 14 candidate species from 8 sponges.
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Chemical richness and diversity of uncultivated ‘Entotheonella’ symbionts in marine sponges - Nature Chemical Biology
Marine sponges host bacteria that produce diverse bioactive compounds. Here, the authors conduct a large-scale metagenomic, single-bacterial and biochemical study to reveal the untapped biosynthetic p...
https://www.nature.com/articles/s41589-025-02066-0
4 months ago
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Bethany Halford
4 months ago
Atropisomers are popular as chiral ligands and have been showing up in drugs and drug candidates. Making just one atropisomer isn’t trivial, though. That could change, thanks to
@alisonnarayan.bsky.social
and
@narayanlab.bsky.social
. My latest for
@cenmag.bsky.social
cen.acs.org/synthesis/bi...
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An enzyme gives atropisomers a specific twist
Biocatalytic approach could be used to make chiral ligands and drugs
https://cen.acs.org/synthesis/biocatalysis/enzyme-gives-atropisomers-specific-twist/103/web/2025/11
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Imagine being part of one of the most important scientific discoveries of all time, and then when you die all anyone wants to talk about is what a huge piece of shit you were. I think there's a lesson there.
4 months ago
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Today they're going to ask Mike Johnson about the election results and he'll say that he hasn't heard about them yet.
4 months ago
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I love going to my polling place on Election Day and seeing it packed, especially with families bringing their kids. Democracy is beautiful you guys, and we should hang on to it.
4 months ago
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Nature Catalysis
4 months ago
New online! De novo design and evolution of an artificial metathase for cytoplasmic olefin metathesis
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De novo design and evolution of an artificial metathase for cytoplasmic olefin metathesis
Nature Catalysis, Published online: 03 November 2025; doi:10.1038/s41929-025-01436-0The creation of artificial metalloenzymes compatible with complex biological settings could enable broad applications. Now a de novo-designed artificial metalloenzyme containing an abiological ruthenium cofactor is reported and optimized for ring-closing metathesis in the cytoplasm of whole cells.
https://bit.ly/4ooNN78
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That was a great game but ooof. Maybe in another 25 years we'll get another shot.
4 months ago
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Will Stancil
4 months ago
a tyrant is ignoring the constitution, firing live artillery at americans, invading our cities, and tearing down the white house to build himself a palace our institutions won't react because they're lost in a digital dreamstate, unable to decide what is true because of social media poisoning
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Schooley
4 months ago
Somehow people who found the goals of the “Tea Party” crystal clear just can’t wrap their heads around what “No Kings” is getting at.
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Rep. Jamie Raskin
4 months ago
"Tyranny, like hell, is not easily conquered, but we have this consolation: The harder the struggle, the more glorious the triumph." —Tom Paine
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Will Stancil
5 months ago
Honestly if we were a real country anymore this video would start an armed revolution
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Paco Cardenas
5 months ago
A bit of chemistry to start your day! Sharing our latest review on sponge peptides 🧪 Surprisingly, we know so little about them...
www.publish.csiro.au/CH/CH25100
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Ribosomally synthesised and post-translationally modified peptides (RiPPs) from marine demosponges and their microsymbionts
Marine sponges are among the oldest animals to have emerged on Earth. They are metazoan holobionts that host diverse microbial symbionts, which constitute more than 40% of their biomass. Despite their...
https://www.publish.csiro.au/CH/CH25100
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Anne Applebaum
5 months ago
Ric Grenell, Kennedy Center president, organized a claque of Republicans to heckle a musician critical of Trump. It's like junior high school
www.washingtonian.com/2025/09/23/l...
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Log Cabin Republicans Disrupted Yasmin Williams’s Kennedy Center Performance - Washingtonian
Staffers say center president Ric Grenell's office set aside passes for the group, which booed and heckled the musician.
https://www.washingtonian.com/2025/09/23/log-cabin-republicans-yasmin-williams/
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Joe Biden got old *one time* and now we have to live in a world where the President of the United States is shilling miracle supplements from the White House podium.
5 months ago
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Jackson Cahn
Paradisi Research
5 months ago
Nature Reviews Methods Primers (2025): "Flow biocatalysis"
https://paradisiresearch.com/research-highlights/nature-reviews-methods-primers-2025-flow-biocatalysis/
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Will Stancil
5 months ago
Also, notice Trump's complaint here - about the news, about Kimmel - IS NOT anything to do with Charlie Kirk. It's that he was personally criticized. He's not even hiding it! That's what this is all about. "Are you allowed to criticize the president?"
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John Collins
5 months ago
This is so messed up.
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Stephanie Wankowicz
6 months ago
Structural bioinformatics is incredibly powerful on its own or when paired with theory or experiment. One of the PDB's superpowers isn’t from one structure, but comparing many to uncover folds, binding sites, and subtle conformational shifts.
chemrxiv.org/engage/chemr...
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10 Rules for a Structural Bioinformatic Analysis
The Protein Data Bank (PDB) is one of the richest open‑source repositories in biology, housing over 277,000 macromolecular structural models alongside much of the experimental data that underpins thes...
https://chemrxiv.org/engage/chemrxiv/article-details/68bf31c823be8e43d6c8660e
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Radley Balko
6 months ago
We're witnessing the most aggressive, fanatical crackdown on free speech in my lifetime. The speed and breadth of government censorship and private sector and nonprofit capitulation has been astonishing. As has the lack of urgency/silence from people who've long claimed to care about this stuff.
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NY Times Pitchbot
6 months ago
Any criticism of Patel and Bongino’s failure to solve crimes must also acknowledge past FBI director Chris Wray’s failure to podcast and sell supplements.
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Marnix Medema
6 months ago
We are looking for a 3-year postdoc to work with Daniel Probst, Justin van der Hooft and myself on an exciting project involving federated learning and integrative omics for discovery of new antibiotics from natural products. Apply here:
www.wur.nl/en/vacancy/p...
Please share!
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https://www.wur.nl/en/vacancy/postdoc-position-on-federated-learning-and-integrative-omics-for-antibiotic-discovery.htm
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Slightly diminish a book On the Origin of Genera
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6 months ago
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Christophe 🔬 L
6 months ago
Ponzi Chain Reaction
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6 months ago
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Merck has opened applications for Summer 2026 Internships and Co-ops! If you are (or know) an undergrad or graduate student interested in spending a summer doing cutting-edge research in pharma, apply before Nov 2nd by going to
jobs.merck.com
and searching "2026 Future Talent Program."
6 months ago
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Rodger Sherman
6 months ago
Making them wear high-visibility vests over camo is such a good joke you couldn’t write it
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Brendan Nyhan
7 months ago
Very bad sign when masked, unidentified agents of the security state are not just grabbing people off the street but openly identifying with the regime's politics
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I was going to try eating healthy this weekend but I woke up craving tortilla chips simmered in salsa with eggs and cream... It's my chilaquiles heel.
7 months ago
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Dan Udwary
7 months ago
Hey, calling all Natural Products and Secondary Metabolism people!
@jgi.doe.gov
is looking for feedback prior to reorganizing data structures and portals.
#secmet
is underrepresented right now. Hit the link if you want to share your ideas or complaints! Even (especially) if you don't use our stuff!
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Tell Us Your BER Data Integration Stories
JGI, EMSL, ESS-DIVE, NMDC and KBase would love to sit with you (over Zoom) for 45 minutes to hear your stories relating to data integration or provide feedback on some of our proposed solutions. How ...
https://docs.google.com/forms/d/e/1FAIpQLSfCRN5A58COMDCt7EuCJgJqXK1JaunQh9KrFVwEyYgpSAK2qw/viewform
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John Logsdon
7 months ago
1) Are you an Assistant Professor studying evolutionary biology? 2) Are you in the US? 3) Would you like to give a research seminar in Iowa? 4) Are you available to travel September 4-6? If you can answer YES x4, please DM me ASAP, or comment below.
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