Sorry, but this is dumb. The limiting factor for these weapons is not the design of new agents. Chemical structures are known, viral genomes are published. The bottlenecks are manufacturing, formulation, and delivery, where AI isn't particularly advantaged.

Marty Makary might be out at FDA (a welcome development, to be sure), but there's no easy path back to normalcy -- especially when the political pressures on the agency aren't going anywhere. My latest for @opinion.bloomberg.com:

This is basically harassment of scholars willing to question the Trump administration’s targeting of Chinese colleagues. Innes already had the FBI investigate his lab and was given the all clear. Now USDA is shutting down the Lab, which focuses on making fungus-resistant plants.

You should be able to criticize the government for its racism and not have your chickenshit employer take the side of the racists.

Biocatalysts can build big molecules. A team at Merck & Co. developed a suite of enzymes that stitch together their oral PCSK9 inhibitor enlicitide. My latest for @cenmag.bsky.social cen.acs.org/pharmaceutic... #chemsky

This is the big one! So proud to have played a part on this team. www.science.org/doi/10.1126/... Enlicitide is an exciting potential molecule for cardiovascular disease, but if we were going to make it on a commercial scale, existing chemical techniques just weren't going to cut it.

We should fucking riot www.nytimes.com/2026/05/05/u...

Help me think this through, what *is* protein thermostability?

Like most drug discovery researchers, I’ve been watching the “peptides for everything” craze with a mixture of amusement and alarm:

When I spend all day in meetings

All the worst cunts in the world - from journalism to politics, the Kermlin to the White House - are suffering tonight.

#nokings #nokingsnj #nokingsdenville

Perfect

Tagging Gov @mikiesherrill.bsky.social

We don't always win the Super Bowl, but when we do we absolutely humiliate the other team #12

We're sliding into a polio-ridden runaway-warming white-supremacist fascist dystopia. But Jake Bobo just caught a touchdown pass and that still makes me happy.

"Who would bring a gun to a protest?" mfs when they're the ones protesting.

FYI: Seattle #ICE #ICEWATCH

Just staggered by the complete moral void of not even *pretending* to wait for more information before pivoting to “the opponent of the state deserved it.” It is so insanely depraved. Soulless.

“Federal agents briefly detained our reporter at the scene, who says he was tackled to the ground and had a gun put in his face.”

The Seahawks defense was so dominant that the team scored 41 points and everyone's like "the offense did ok too I guess"

9. Directed evolution campaigns yield new lipid-binding domains from a variety of protein scaffold precursors, from @takinishimura.bsky.social and Noboru Mizushima, on @biorxiv-cellbio.bsky.social www.biorxiv.org/content/10.1...

amazing how the entire machine can pivot within 24 hours. no need to slowly upsell the argument; just issue new marching orders

this is your mission. our pedophile president needs you to jump out of a helicopter to kidnap a head of state and his wife so some oil ceos can make a lot of money. we’ll be watching from a resort in florida that still serves wedge salad and checking how many retweets we get. good luck soldier

Maduro is a brutal and oppressive dictator of Venezuela. Trump has no legitimate legal basis for military action against Venezuela under United States or international law. Both of those facts are simultaneously true.

Did we just do a fucking coup in Venezuela?

In 2005 Benedict became Pope and the Seahawks won 13 games and went to the Super Bowl In 2013 Francis became Pope and the Seahawks won 13 games and went to the Super Bowl In 2025 Leo became Pope and the Seahawks have won 13 games...

You've just opened a chemistry themed pub, what are you calling it? The H-Bar (ħ) #chemsky

Per NY Times’s Michael Grynbaum on X, this is Sharyn Alfonsi’s email to her “60 Minutes” colleagues in full:

Demon escapes because you didn't have enough wizards to form a binding circle? Problematic mage gap.

Alternate between AlphaFold3 "hallucinations" and fixed-backbone sequence design to generate or optimize proteins. www.biorxiv.org/content/10.1...

The shutdown delayed applications opening for the NIST Summer Undergraduate Research Fellowship (SURF) program, but their website says they will start accepting applications 12/1. www.nist.gov/surf #chemsummer There’s an example of a project from last year in the quoted post

NEW pub in @science.org 🥳 Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life? For over 15 years, #phylogenomic studies have been divided. We provide new evidence suggesting that... 🔗: www.science.org/doi/10.1126/...

Nearly ten years in the making and finally out in print! www.nature.com/articles/s41... Entotheonella are insanely biosynthetically rich bacteria, but few genomes were available. Working with far-flung collaborators, we obtained genomes for 14 candidate species from 8 sponges.

Atropisomers are popular as chiral ligands and have been showing up in drugs and drug candidates. Making just one atropisomer isn’t trivial, though. That could change, thanks to @alisonnarayan.bsky.social and @narayanlab.bsky.social. My latest for @cenmag.bsky.social cen.acs.org/synthesis/bi...

Imagine being part of one of the most important scientific discoveries of all time, and then when you die all anyone wants to talk about is what a huge piece of shit you were. I think there's a lesson there.

Today they're going to ask Mike Johnson about the election results and he'll say that he hasn't heard about them yet.

I love going to my polling place on Election Day and seeing it packed, especially with families bringing their kids. Democracy is beautiful you guys, and we should hang on to it.

New online! De novo design and evolution of an artificial metathase for cytoplasmic olefin metathesis

That was a great game but ooof. Maybe in another 25 years we'll get another shot.

a tyrant is ignoring the constitution, firing live artillery at americans, invading our cities, and tearing down the white house to build himself a palace our institutions won't react because they're lost in a digital dreamstate, unable to decide what is true because of social media poisoning

Somehow people who found the goals of the “Tea Party” crystal clear just can’t wrap their heads around what “No Kings” is getting at.

"Tyranny, like hell, is not easily conquered, but we have this consolation: The harder the struggle, the more glorious the triumph." —Tom Paine

Honestly if we were a real country anymore this video would start an armed revolution

A bit of chemistry to start your day! Sharing our latest review on sponge peptides 🧪 Surprisingly, we know so little about them... www.publish.csiro.au/CH/CH25100

Ric Grenell, Kennedy Center president, organized a claque of Republicans to heckle a musician critical of Trump. It's like junior high school www.washingtonian.com/2025/09/23/l...

Joe Biden got old *one time* and now we have to live in a world where the President of the United States is shilling miracle supplements from the White House podium.

Nature Reviews Methods Primers (2025): "Flow biocatalysis" https://paradisiresearch.com/research-highlights/nature-reviews-methods-primers-2025-flow-biocatalysis/

Also, notice Trump's complaint here - about the news, about Kimmel - IS NOT anything to do with Charlie Kirk. It's that he was personally criticized. He's not even hiding it! That's what this is all about. "Are you allowed to criticize the president?"

This is so messed up.