J. Chem Ed (2026): "Introducing Enzyme Immobilization and Flow Biocatalysis to the Undergraduate Curriculum" https://paradisiresearch.com/research-highlights/j-chem-ed-2026-introducing-enzyme-immobilization-and-flow-biocatalysis-to-the-undergraduate-curriculum/

Trump on Lindsey Graham: "He had one bad moment in the January 6 thing when he stood up -- 'alright, now I've had it, that's it, I can't do it anymore' -- then he called me about 40 minutes later and said, 'Did I really said that? I can't believe it.' And he took it back."

You may have heard about the OMB rule change that will put politics over federal grants. However bad you think it is? It's probably worse. Thanks to @theverge.com for letting me report this one out. There is still time to comment. bit.ly/4v2X4nQ

One prominent group has been totally silent about the Trump administration’s latest attempt to grab control of all federal science funding. That’s the biopharma companies, and their suddenly shy, quiet CEOs. Here’s the calculation they’re making:

Two new activities for #barettin, extracted from my pet sponge 'Geodia barretti' : promising activity against 1) chronic pain and 2) the most common and aggressive type of pancreatic cancer! Two papers from the Cartmell Lab👇 www.mdpi.com/1660-3397/24... doi.org/10.1021/acs....

Biocatalysis! Process chem! Job! #PfizerChemistry is hiring! PhD 0-5 years exp #ChemJobs #ChemSky

We're about to submit a paper and my collaborator fed it into an LLM and asked for critical reviews from numerous perspectives: subject matter experts in each technique, a journal editor, copy-writer, graphic designer... To be honest I've never gotten more helpful feedback from my actual peers.

In just 17 years, Seattle went from not having light rail to having the most ridden system in the nation. We’ve proven how leadership & investment can change a city and people’s lives for the better

This is insane. Pulte is the failson of a major RE developer, and before 2025 was next known as a memestock conspiracist. At FHA, he's been responsible for scrutinizing the mortgage applications of Trump critics to find "crimes". Clearly that's what Trump wants US intelligence services working on.

This is bad. Bad for researchers. Bad for science. Bad for universities. Bad for professional associations. For example: 1. Every award would be vetted by political appointees, who could overrule peer reviewers and deny the award if it doesn't advance the president's priorities. 1/🧵

Big, if true! @jrossibarra.bsky.social 😹🪰🌽

The people of Kentucky sent a clear message to the nation tonight: the Epstein files should stay buried and no one implicated should face any consequences.

Found a legitimate exception to "Vote Blue No Matter Who"

Sorry, but this is dumb. The limiting factor for these weapons is not the design of new agents. Chemical structures are known, viral genomes are published. The bottlenecks are manufacturing, formulation, and delivery, where AI isn't particularly advantaged.

Marty Makary might be out at FDA (a welcome development, to be sure), but there's no easy path back to normalcy -- especially when the political pressures on the agency aren't going anywhere. My latest for @opinion.bloomberg.com:

This is basically harassment of scholars willing to question the Trump administration’s targeting of Chinese colleagues. Innes already had the FBI investigate his lab and was given the all clear. Now USDA is shutting down the Lab, which focuses on making fungus-resistant plants.

You should be able to criticize the government for its racism and not have your chickenshit employer take the side of the racists.

Biocatalysts can build big molecules. A team at Merck & Co. developed a suite of enzymes that stitch together their oral PCSK9 inhibitor enlicitide. My latest for @cenmag.bsky.social cen.acs.org/pharmaceutic... #chemsky

This is the big one! So proud to have played a part on this team. www.science.org/doi/10.1126/... Enlicitide is an exciting potential molecule for cardiovascular disease, but if we were going to make it on a commercial scale, existing chemical techniques just weren't going to cut it.

We should fucking riot www.nytimes.com/2026/05/05/u...

Help me think this through, what *is* protein thermostability?

Like most drug discovery researchers, I’ve been watching the “peptides for everything” craze with a mixture of amusement and alarm:

When I spend all day in meetings

All the worst cunts in the world - from journalism to politics, the Kermlin to the White House - are suffering tonight.

#nokings #nokingsnj #nokingsdenville

Perfect

Tagging Gov @mikiesherrill.bsky.social

We don't always win the Super Bowl, but when we do we absolutely humiliate the other team #12

We're sliding into a polio-ridden runaway-warming white-supremacist fascist dystopia. But Jake Bobo just caught a touchdown pass and that still makes me happy.

"Who would bring a gun to a protest?" mfs when they're the ones protesting.

FYI: Seattle #ICE #ICEWATCH

Just staggered by the complete moral void of not even *pretending* to wait for more information before pivoting to “the opponent of the state deserved it.” It is so insanely depraved. Soulless.

“Federal agents briefly detained our reporter at the scene, who says he was tackled to the ground and had a gun put in his face.”

The Seahawks defense was so dominant that the team scored 41 points and everyone's like "the offense did ok too I guess"

9. Directed evolution campaigns yield new lipid-binding domains from a variety of protein scaffold precursors, from @takinishimura.bsky.social and Noboru Mizushima, on @biorxiv-cellbio.bsky.social www.biorxiv.org/content/10.1...

amazing how the entire machine can pivot within 24 hours. no need to slowly upsell the argument; just issue new marching orders

this is your mission. our pedophile president needs you to jump out of a helicopter to kidnap a head of state and his wife so some oil ceos can make a lot of money. we’ll be watching from a resort in florida that still serves wedge salad and checking how many retweets we get. good luck soldier

Maduro is a brutal and oppressive dictator of Venezuela. Trump has no legitimate legal basis for military action against Venezuela under United States or international law. Both of those facts are simultaneously true.

Did we just do a fucking coup in Venezuela?

In 2005 Benedict became Pope and the Seahawks won 13 games and went to the Super Bowl In 2013 Francis became Pope and the Seahawks won 13 games and went to the Super Bowl In 2025 Leo became Pope and the Seahawks have won 13 games...

You've just opened a chemistry themed pub, what are you calling it? The H-Bar (ħ) #chemsky

Per NY Times’s Michael Grynbaum on X, this is Sharyn Alfonsi’s email to her “60 Minutes” colleagues in full:

Demon escapes because you didn't have enough wizards to form a binding circle? Problematic mage gap.

Alternate between AlphaFold3 "hallucinations" and fixed-backbone sequence design to generate or optimize proteins. www.biorxiv.org/content/10.1...

The shutdown delayed applications opening for the NIST Summer Undergraduate Research Fellowship (SURF) program, but their website says they will start accepting applications 12/1. www.nist.gov/surf #chemsummer There’s an example of a project from last year in the quoted post

NEW pub in @science.org 🥳 Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life? For over 15 years, #phylogenomic studies have been divided. We provide new evidence suggesting that... 🔗: www.science.org/doi/10.1126/...

Nearly ten years in the making and finally out in print! www.nature.com/articles/s41... Entotheonella are insanely biosynthetically rich bacteria, but few genomes were available. Working with far-flung collaborators, we obtained genomes for 14 candidate species from 8 sponges.

Atropisomers are popular as chiral ligands and have been showing up in drugs and drug candidates. Making just one atropisomer isn’t trivial, though. That could change, thanks to @alisonnarayan.bsky.social and @narayanlab.bsky.social. My latest for @cenmag.bsky.social cen.acs.org/synthesis/bi...

Imagine being part of one of the most important scientific discoveries of all time, and then when you die all anyone wants to talk about is what a huge piece of shit you were. I think there's a lesson there.