Demon escapes because you didn't have enough wizards to form a binding circle? Problematic mage gap.

Alternate between AlphaFold3 "hallucinations" and fixed-backbone sequence design to generate or optimize proteins. www.biorxiv.org/content/10.1...

The shutdown delayed applications opening for the NIST Summer Undergraduate Research Fellowship (SURF) program, but their website says they will start accepting applications 12/1. www.nist.gov/surf #chemsummer There’s an example of a project from last year in the quoted post

NEW pub in @science.org 🥳 Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life? For over 15 years, #phylogenomic studies have been divided. We provide new evidence suggesting that... 🔗: www.science.org/doi/10.1126/...

Nearly ten years in the making and finally out in print! www.nature.com/articles/s41... Entotheonella are insanely biosynthetically rich bacteria, but few genomes were available. Working with far-flung collaborators, we obtained genomes for 14 candidate species from 8 sponges.

Atropisomers are popular as chiral ligands and have been showing up in drugs and drug candidates. Making just one atropisomer isn’t trivial, though. That could change, thanks to @alisonnarayan.bsky.social and @narayanlab.bsky.social. My latest for @cenmag.bsky.social cen.acs.org/synthesis/bi...

Imagine being part of one of the most important scientific discoveries of all time, and then when you die all anyone wants to talk about is what a huge piece of shit you were. I think there's a lesson there.

Today they're going to ask Mike Johnson about the election results and he'll say that he hasn't heard about them yet.

I love going to my polling place on Election Day and seeing it packed, especially with families bringing their kids. Democracy is beautiful you guys, and we should hang on to it.

New online! De novo design and evolution of an artificial metathase for cytoplasmic olefin metathesis

That was a great game but ooof. Maybe in another 25 years we'll get another shot.

a tyrant is ignoring the constitution, firing live artillery at americans, invading our cities, and tearing down the white house to build himself a palace our institutions won't react because they're lost in a digital dreamstate, unable to decide what is true because of social media poisoning

Somehow people who found the goals of the “Tea Party” crystal clear just can’t wrap their heads around what “No Kings” is getting at.

"Tyranny, like hell, is not easily conquered, but we have this consolation: The harder the struggle, the more glorious the triumph." —Tom Paine

Honestly if we were a real country anymore this video would start an armed revolution

A bit of chemistry to start your day! Sharing our latest review on sponge peptides 🧪 Surprisingly, we know so little about them... www.publish.csiro.au/CH/CH25100

Ric Grenell, Kennedy Center president, organized a claque of Republicans to heckle a musician critical of Trump. It's like junior high school www.washingtonian.com/2025/09/23/l...

Joe Biden got old *one time* and now we have to live in a world where the President of the United States is shilling miracle supplements from the White House podium.

Nature Reviews Methods Primers (2025): "Flow biocatalysis" https://paradisiresearch.com/research-highlights/nature-reviews-methods-primers-2025-flow-biocatalysis/

Also, notice Trump's complaint here - about the news, about Kimmel - IS NOT anything to do with Charlie Kirk. It's that he was personally criticized. He's not even hiding it! That's what this is all about. "Are you allowed to criticize the president?"

This is so messed up.

Structural bioinformatics is incredibly powerful on its own or when paired with theory or experiment. One of the PDB's superpowers isn’t from one structure, but comparing many to uncover folds, binding sites, and subtle conformational shifts. chemrxiv.org/engage/chemr...

We're witnessing the most aggressive, fanatical crackdown on free speech in my lifetime. The speed and breadth of government censorship and private sector and nonprofit capitulation has been astonishing. As has the lack of urgency/silence from people who've long claimed to care about this stuff.

Any criticism of Patel and Bongino’s failure to solve crimes must also acknowledge past FBI director Chris Wray’s failure to podcast and sell supplements.

We are looking for a 3-year postdoc to work with Daniel Probst, Justin van der Hooft and myself on an exciting project involving federated learning and integrative omics for discovery of new antibiotics from natural products. Apply here: www.wur.nl/en/vacancy/p... Please share!

Slightly diminish a book On the Origin of Genera

Ponzi Chain Reaction

Merck has opened applications for Summer 2026 Internships and Co-ops! If you are (or know) an undergrad or graduate student interested in spending a summer doing cutting-edge research in pharma, apply before Nov 2nd by going to jobs.merck.com and searching "2026 Future Talent Program."

Making them wear high-visibility vests over camo is such a good joke you couldn’t write it

Very bad sign when masked, unidentified agents of the security state are not just grabbing people off the street but openly identifying with the regime's politics

I was going to try eating healthy this weekend but I woke up craving tortilla chips simmered in salsa with eggs and cream... It's my chilaquiles heel.

Hey, calling all Natural Products and Secondary Metabolism people! @jgi.doe.gov is looking for feedback prior to reorganizing data structures and portals. #secmet is underrepresented right now. Hit the link if you want to share your ideas or complaints! Even (especially) if you don't use our stuff!

1) Are you an Assistant Professor studying evolutionary biology? 2) Are you in the US? 3) Would you like to give a research seminar in Iowa? 4) Are you available to travel September 4-6? If you can answer YES x4, please DM me ASAP, or comment below.

This needs to be headline news for weeks. Shocking levels of fascist behavior on display.

Lysenko was an amateur

More on Trump’s nominee to lead the office investigating Jack Smith: ➡️ He said that the descendants of slaves should pay reparations to the descendants of slave owners ➡️ He urged Congress to make J6 a national holiday ➡️ He called for Trump’s birthday to be made a national holiday (“MAGA Day”)

Every day a new parade of horribles. There is so much amazing science coming out of UCLA.

Okay but what the fuck is this? www.washingtonpost.com/entertainmen...

I NEED to tell you the story of Tae Heung “William” Kim. He's a graduate student at Texas A&M where he's working on a vaccine for Lyme disease. He's a *legal permanent resident* of the United States. And he's been in ICE detention for 12 days & counting, transferred Tuesday to South Texas.

“I trust it as far as I can throw it” is basically mass spec Determining how you feel about things by throwing them real hard

In 1965, Margaret Dayhoff published the Atlas of Protein Sequence and Structure, which collated the 65 proteins whose amino acid sequences were then known. Inspired by that Atlas, today we are releasing the Dayhoff Atlas of protein sequence data and protein language models.

About time the investor class started paying attention to the destruction of the biomedical innovation pipeline.

I'm really proud of this work by Jae Kennemur and Yueming Long. #Enzymes rock, with some help from #directed evolution to do chemistry not known in nature (and really hard for humans, too). @caltechcce.bsky.social pubs.acs.org/doi/10.1021/...

Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C

Hard to overstate how bleak this is.

Here's a fun perspective piece on Cyanobacteria as prolific natural product producers with great potential for drug discovery. Thanks especially to @philmuslab.bsky.social for ringleading and letting us contribute! pubs.rsc.org/en/content/a...

These people are so dumb.

🚨 Preprint! 🚨 We show that enzyme catalysis can be accurately simulated with ML/MM, >1000x faster than with DFT/MM! Combining gasphase MLPs with our EMLE approach, we show ML(EMLE)/MM fully captures catalysis in two enzyme reactions. See also: github.com/chemle/ doi.org/10.26434/che...