Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance? www.nature.com/articles/s41... More info 👇

Super cool: a glycosylated polyene polyketide that has potent antifungal activity by targeting several phospholipids to permeabilize membranes! #lipidtime

🚨New preprint: There's this overlooked phospholipid with 3 acyl tails called NAPE that is made during ischemia. We identified its interactome & found it regulates lactate flux, suggesting metabolic functions in response to hypoxia. Congrats to Dylan Chiu! doi.org/10.26434/che... #lipidtime #chembio

Spatiotemporal temperature control by holographic heating microscopy unveils cellular thermosensitive calcium signaling https://www.biorxiv.org/content/10.1101/2025.01.09.632068v1

Very cool #lipidtime preprint from Taki Nishimura and colleagues: engineering of new lipid-binding probes from PH domains and nanobodies from a high-throughput assay where liposomes bind to cell surfaces displaying members of the protein probe library. www.biorxiv.org/content/10.1...