So cool they discovered the cause of autism on basically day they guessed they would. I’m also glad they are withholding this information for a few days to prep for a WrestleMania-style announcement. This is how science works.

Like & share our new promo vid for Flow.bio! Capturing just a little bit of that bioinformatics trauma 🫠 www.youtube.com/watch?v=MR-R...

Acetaminophen/paracetamol use in pregnancy doesn't cause autism, no matter what RFK says this week. This is not an unsettled question. Evidence summarized here: sciencebasedmedicine.org/tylenol-and-...

Only single cell sequencing of the all these post docs will reveal why

Congratulations to @bencekover.bsky.social for winning the best talk prize for schooling us all on best practises in mass scRNA-Seq data integration #Londonomics2025

Can’t thank our career mentors enough for the great discussions in our mentorship session @margaridamcm.bsky.social @kristinaulicna.bsky.social @gavinpaulkelly.bsky.social and Mara Tatari 💪#Londonomics2025

In the afternoon we had an excellent talk about AlphaMissense and AlphaGenome from @avsecz.bsky.social who generously allowed us to heckle him during the talk, answering all our questions!

In the morning we enjoyed 11 short talks from computational biology ECRs - I especially liked @saniyakhullar.bsky.social’s talk on incorporating prior PPI knowledge into gene regulatory network inference #londonomics2025

Had such a great time at #Londonomics2025 today - excellent talks and discussions - thank you to everyone who came along and shared their ideas with us.

Sounds like a wonderful position

RUN, DON'T WALK to sign up for the londonomics symposium! we gotta order the sandwiches soon, so grab your ticket while you can! come hear about AlphaGenome & other great omics work, get career advice and hang out with us, it'll be so great i promise register.oxfordabstracts.com/event/75604?...

Not sure how many scientists here have tried Claude Code or similar command line coding assistants. I had a complicated family property tax problem that was best solved by a brute force Monte Carlo simulation approach, so I spent a few days coding up and analyzing a model with Claude Code.

Did GPT-5 make this graph?

Excited for this! Please do come and present your work :D

This work is the result of a fantastic collaboration between my lab at the University of Michigan, Mitchell Guttman lab at Caltech, and Marko Jovanovic lab at Columbia University. www.cell.com/cell/fulltex... #Ribosomes #Science #CryoEM #RNA

😂

New ENCODE4 long-read RNA-seq transcripts track for hg38 and mm10. Triplets (e.g. [1,1,3]) indicate start site, exon combination, and stop site for each transcript. Enrichment scores show how these change across tissue and cell line samples. Read more: genome.ucsc.edu/gold...

"It is not just that LLM’s fail to induce proper world models of chess. It’s that they never induce proper worlds of anything. Everything that they do is through mimicry, rather than abstracted cognition across proper world models." garymarcus.substack.com/p/generative...

Totally agree!! "How to make the next PDB" This is exactly what we've attempted to do for functional genomics with flow.bio www.biorxiv.org/content/10.1...

incredible work by an incredible scientist (and friend)! very beautiful figures too www.cell.com/cell-systems...

"Women are PIs on 58% of the canceled grants, although they are PIs on only 34% of all active NSF grants. Similarly, Blacks are PIs on 17% of the terminated grants, although they make only 4% of the total pool. Hispanic PIs and those with disabilities were twice as likely to lose a grant."

can't wait to try this out :D

🚨I could not be more excited to share our new preprint on saturation genome editing of the small nuclear RNA (snRNA) RNU4-2: www.medrxiv.org/content/10.1... A super fun collaboration with incredible duo @gregfindlay.bsky.social @joachimdejonghe.bsky.social from @crick.ac.uk 🧬🖥️🩺 🧵1/12

We're so pleased that groups have been ordering our TDP-REG vectors from Addgene! Please be aware that splicing minigenes cannot easily be used with lentiviruses, because the lentiviral RNA can get spliced before viral packaging! Better to use piggybac or similar, AAV, or just transient transfection

We are so close to AGI

(1/10) Excited to announce our latest work! @arpita-s.bsky.social, @amanpatel100.bsky.social , and I will be presenting DART-Eval, a rigorous suite of evals for DNA Language Models on transcriptional regulatory DNA at #NeurIPS2024. Check it out! arxiv.org/abs/2412.05430

ribosomal A-site m6A induces mRNA degradation 🧪 #RNASky www.cell.com/molecular-ce...

A related issue is some data (cells) appearing multiple times under different datasets or collections. Sometimes it’s obvious and sometimes it’s not, but the consequence is it’s really hard to do a clean train/test split

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨 We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research! Read more: bmcgenomics.biomedcentral.com/articles/10.... 1/8

I wonder if the participants are aware of the barriers to accessing their generously donated data

Here is a selection of medieval hedgehogs, as portrayed in illuminated manuscripts. Mostly from the 14th and 15th centuries. Why? Because they are cute and I love them. And you all seem like discerning people of good taste.

“I'm writing a first draft and reminding myself that I'm simply shoveling sand into a box so that later I can build castles.” This was probably my most viral tweet. I've seen it pop up in a lot of quote aggregators, sometimes attributed to a wonderful but definitely not-me filmmaker.

The vast majority of my "AHA!" moments are from surfing around the UCSC genome browser. Thanks, @ucscgenomics.bsky.social ! This little screenshot made my week

Very rare opportunity! Get em before they sell out until next year. Please consult your doctor before engaging in Physiological Relevance. Side effects may include sense of purpose, cessation of existential dread, mild nausea, and a dislike of peas. Ask your local Oded if PR is right for you.

is it a damning indictment of my brain that i immediately recognised this formatting to be most akin to yu-gi-oh cards

It looks like a lot of the serious issues have already been covered by other Starter Packs, so I threw together some of the funny and quirky big accounts at the old place: go.bsky.app/SMCEczT

I can't pretend to understand hackathons but this is so impressive- a diagnosis for 40% of participants at a rare disease hackathon www.nature.com/articles/s41...

My students convincing me to use google docs instead of word

AlphaFold 3 model code and weights are now available from DeepMind github.com/google-deepm...

We have a 4-year funded PhD student ship available in our lab to study RNA splicing in collaboration with Yiliang Ding Lab. please spread the word! NRPDTP biodtp.norwichresearchpark.ac.uk/projects/rna...

Hello World! New here, and a little bit scared of having to rebuild the Twitter network, but here we go: I'm a group leader at UK DRI and @kingsioppn.bsky.social. My lab works on #epigenetics in neurodegenerative diseases, to understand non-coding genetic and environmental risk factors 🧬🧠

brilliant story so excited to hear more about this phenomenon

Take two of srsly moving to Bluesky wahoo hello #rnabiology #rnabioinformatics 🧬🖥️

in this article we delve into the world of splicing models! i specifically focused on the latest omics technologies that will help us to interpret and train models, looking towards future opportunities. lots of biorxiv citations because the field is moving so fast!!! go.nature.com/4gPju63