We hoped this would take 5 years, but in fact it took 14! Thanks to all co-authors, but particularly Mark Jobling who held it all together, and more. A proper magnum opus. Hope it is useful for those in the field or adjacent. Phew.

New preprint! with @a-solernunez.bsky.social Rethinking a textbook example of human adaptation "AMY1 copy number evolution in light of demographic history" Once population structure is accounted for, the classic starch–agriculture narrative becomes much less clear www.biorxiv.org/content/10.6...

🧬 Avui ha tingut lloc l'acte inaugural del "25è aniversari de la publicació del Genoma Humà", amb la xerrada de l'investigador Tim Hubbard i la taula rodona amb els investigadors Pep Abril, Roderic Guigó i Gemma Marfany, sobre la contribució catalana a la recerca del genoma #25APGH

In #GENETICS, Jacob Marsh, Sachin Kaushik, and @johriparul.bsky.social examine why and when rescaling of forward simulations in population genetics is not accurate, identifying pitfalls in simulation methods. buff.ly/wpzDRV9

Fun news! @gcbias.bsky.social and I are teaching a 2-week online population genetics workshop this summer to raise money for the Center for Population Biology at UC Davis. We're trying to gauge interest -- please fill this out if you might be interested! And please share broadly!

Why did consciousness evolve at all? A superb special issue of @royalsocietypublishing.org brings together experts across disciplines to explore the functions of consciousness and why it emerged in some species but not others. @tecumsehfitch.bsky.social royalsocietypublishing.org/rstb/issue/3...

Excited and proud 😊 to share the final chapter of @hjorvik.bsky.social 's PhD thesis: Seven Millennia of Human Exploitation drove genomic Changes in Iberian Sheep Comments welcome! 🧬🧪🏺🐑 www.biorxiv.org/content/10.6... 🧵(1/8)

Interested in using aDNA time-series datasets to estimate selection? Our study "Assessing Ancient DNA Sampling Strategies for Natural Selection Inference in Humans Using Allele Frequency Time Series Data" is now out in GBE! doi.org/10.1093/gbe/... @genomebiolevol.bsky.social @cegamorim.bsky.social

We hope this little guide and review of the recent literature on SVs will be useful for the community in #ecology #evolution #genomics #PopGen. Great lead by Kat!!

📣 The @scilifelab.se #ddls postdoc (2yrs) offers a great community + training + all social benefits! Happy to discuss your own project ideas! I also have some ideas on ARGs, pangenomes or biobank-scale datasets 🧬🐏🧪🖥️ Deadline is Mar 31 but some admin things need to be handled well in advance!

Cost of being female lead/corresponding author in biomedical sciences: "[T]he median amount of time spent under review is 7.4%–14.6% longer for female-authored articles than for male-authored articles" even in disciplines where women well-represented. #AcademicSky journals.plos.org/plosbiology/...

Linkage disequilibrium scaling improves robustness and power to detect genomic regions under selection. https://www.biorxiv.org/content/10.64898/2026.01.19.700334v1

📖 Big news! We just released the first five chapters of our new book, Hello Data Science. It is a fully open-access resource written for beginners. Please help us spread the word! A few points about the book are below 👇 🔗 www.hellodata.science #rstats #datascience #tidyverse

SciLifeLab has opened a call for #postdoc fellows in Data-Driven Life Science. We would be happy to host such fellows! Get in touch if you are interested in applying with a project on the evolution of humans and domestic animals using ancient and/or modern DNA 🧪🏺 www.scilifelab.se/data-driven/...

Characterising the detectable and invisible fractions of genomic loci under balancing selection https://www.biorxiv.org/content/10.64898/2026.01.13.698512v1

Postdoc position call @univie.ac.at - happy to host projects related to introgression, great ape genomics, and more! careers.univie.ac.at/en/postdoc/e...

Global patterns of natural selection inferred using ancient DNA https://www.biorxiv.org/content/10.64898/2026.01.07.697984v1

Our paper is out! Learning evolutionary parameters from genealogies using allelic trees url: academic.oup.com/genetics/art... With Aleksandra Walczak and @thierrymora.bsky.social Congrats to first author Antoine Aragon, well done Antoine!

Our new paper is out in PNAS! We analyzed 125 high-coverage whole genomes from five Sudanese ethnolinguistic groups, to understand the evolutionary and demographic history of the region. www.pnas.org/doi/10.1073/... 🧵👇

The group I work in at Michigan (along with other two UK unis) will jointly host total four postdocs. All three will have different but related research focuses and we will work on developing ARG driven/inspired quantitative genetics at Michigan. Formal job posting to follow (1/2).

📢 We're hiring a postdoc (33 months) in human evolutionary genomics / paleogenomics / statistical genetics, Paris 🇫🇷 Project on selection on disease-associated variants, integrating ancient genomes, GWAS, and Ancestral Rec. Graphs. Start May 2026 (flexible). Apply here: emploi.cnrs.fr/Offres/CDD/U...

demografr: A toolkit for simulation-based inference in population genetics https://www.biorxiv.org/content/10.64898/2025.12.18.694482v1

Our lab’s first paper on host-microbiome interactions is out today! www.nature.com/articles/s41...

Hallazgos en distintas localizaciones del interior de la Meseta central ibérica refuerzan la hipótesis de una a ocupación humana del Pleistoceno final más frecuente de lo que se suponía: New prehistoric occupations identified in the eastern Iberian Plateau

Our latest preprint revisits the classic model of mutation-selection balance. Do human recessive genes fit Haldane's 100-year old model? This work is by the wonderful @jonj-udd.bsky.social, and co-mentored by @jeffspence.github.io www.biorxiv.org/content/10.6...

I think they missed something. April's Fools day has passed and Spanish Innocent day is on two weeks. www.nature.com/articles/d41...

10/ Bonus reading: Why do tree-based models still outperform deep learning on tabular data? arxiv.org/abs/2207.08815

All the material for my Bayesian Data Analysis course is available online, including the lectures, which we re-recorded this fall (some of them by @aloctavodia.bsky.social and Noa Kallioinen while I was on vacation). The video links are listed in the schedule at avehtari.github.io/BDA_course_A...

Oh, look! My friends around Magdalena Fraser & Federico Sanchez-Quinto et al have a new study analyzing more high-coverage Neolithic #aDNA genomes from the Baltic island of Gotland (including pathogens!!!) 👀 🧪 🏺 www.biorxiv.org/content/10.6...

1/28 New preprint up, which I think is the best theoretical idea I've ever had. We asked a simple question: what are the costs of investment into non-reproductive somatic cells? Turns out these costs decrease with the *logarithm* of organism size! www.biorxiv.org/content/10.6...

I'm teaching Statistical Rethinking again starting Jan 2026. This time with live lectures, divided into Beginner and Experienced sections. Will be a lot more work for me, but I hope much better for students. I will record lectures & all will be found at this link: github.com/rmcelreath/s...

"Diversity dynamics do not appear to be governed by clade-level processes expected from adaptive radiations or diversity dependence." 👀👀👀 www.nature.com/articles/s41...

I'm excited to present this new model to detect positive selection on regulatory sequences, which has been 3 years in the making! Thanks to Alexandre Laverré and @Phylogenetrips for their amazing work on this project. 😃 https://doi.org/10.1101/2025.11.26.690685 #bioinformatics #MolecularEvolution

Neural posterior estimation for population genetics https://www.biorxiv.org/content/10.64898/2025.12.01.691638v1

Are you working on detecting selection in populations that are not usually easy to get selection detected? We'd love to hear you on "S15 Detecting selection and local adaptation on (im)possible systems" where @aidaandres.bsky.social will tell you more about her work around this area as well :D

Long journey, greater end

Our paper in the PNAS Special Feature on 🐕 is out! We demonstrated the accuracy of imputing ancient canid genomes, looked at inbreeding levels over the past 10,000 years and found genomic regions resistant to ROH which were enriched for immunity and chemosensory genes. www.pnas.org/doi/10.1073/...

The debate on when people first arrived in Australia continues! www.science.org/doi/10.1126/...

Free to read here: rdcu.be/d64zN

Interested in pleiotropy dissection but not sure where to start, which methods are useful, which studies offer illustrative examples, or how to robustly validate your results? Look no further 👀 rdcu.be/eSfAZ

🧬 New preprint out on bioRxiv! Using single-cell WGS and Bayesian phylodynamics, we show that some CRC tumors arise decades before diagnosis, remain indolent, then expand rapidly in the last ~2 years. 📄 doi.org/10.1101/2025... 🙏 Huge thanks to all co-authors

"Postdoc in the job market"

I taught (and co-taught) a course on human population genetics from 2000-2024. Having retired, I'm now making all the course materials public: github.com/alanrogers/p... #popgen #evbio

Do you know how crayfish arrived to the Iberian Peninsula? Tomorrow I´ll be describing the introductions of the Italian crayfish in the 1580s and the red swamp crayfish in the 1970s Historical events with long-lasting biodiversity effects 14:30 Lisbon time Link & details below @ebdonana.bsky.social

We are excited to share our recent work on the surprising robustness of Ancestral Recombination Graph (ARG) inference tools to computational phasing errors, now available on BioRxiv: biorxiv.org/content/10.1.... This work is co-advised by @yundeng.bsky.social and Rasmus Nielsen. 1/7

Are you interested in messy, imprecise concepts in science with huge social implications? Join us online on Tuesday, Dec 2nd, for Yasmin’s talk. Register here: hugera.org/lecture-seri... #philsci #STS #popgen #HPbio

Delighted to see our paper characterising the inbreeding history of dogs and wolves over the past 10,000 years published this week in @pnas.org. Work led by the excellent @katiabou.bsky.social, and co-supervised by me, Laurent Frantz and Fernando Racimo www.pnas.org/doi/10.1073/...

Latest in #GENETICS: @petrelharp.bsky.social and the team show how non-coalescing haplotypes can be inserted into ancestral recombination graphs (ARGs), resulting in ARGs that are smaller, faster to compute with, and have additional ancestral information. buff.ly/X801LTO

And another paper from the admixlab: SAI - statistics for adaptive introgression! doi.org/10.1093/molb...

Paper out now: A curated dataset of the great ape genome diversity! rdcu.be/eQLCi