Great paper from UK RaDaR dataset on outcomes in adult and childhood nephrotic syndrome journals.lww.com/jasn/fulltex...

A stylized representation of the unmet need in a typical adult patient with IgA Nephropathy #IgAN ca. 2024 #ERA25 🇦🇹 #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/39211339/

10 years of SGLT2i trials shared by Dr Kaitlyn Mayne at #era25!

Disease-modifying anti-nephropathic drugs ‘DMANDs’ in NDT this month @ndt-era.bsky.social The right drug for the right patient…that’s how we keep changing the story for patients with kidney disease academic.oup.com/ndt/article/...

Foundational therapies in ESRD for heart failure Dr Matt Graham-Brown from Leicester presents at #NephGR www.youtube.com/watch?v=Ar11... (Rounds from Feb, late share!)

KFRE underestimates risk in people with CKD and frailty journals.lww.com/cjasn/abstra...

That’s what we just did in Canada! Target is SBP < 130 mmHg for all www.cmaj.ca/content/197/...

A randomized controlled trial of intravenous immunoglobulin vs standard of care for the treatment of chronic active antibody-mediated rejection in kidney transplant recipients doi.org/10.1016/j.kint.2025.04.023 #NephSky #MedSky @dialysisbloke.bsky.social #kidneytransplant #KTx

Discontinuing aspirin during surgery for chronic subdural hematoma did not lower recurrence rates compared to continuous treatment. by Kamenova M, Pacan L (...) Soleman J et 9 al. in JAMA Neurol #MedSky 👉 get more here 📖 read the article:

#archive30 #day24 It's very hard to choose 😵‍💫 But this is a pretty #popularitem - an original X ray tube Plus the man who set up the world's very first X ray department in 1896 at #glasgowroyalinfirmary our medical electrician Dr John McIntyre ❤️ @arascot.bsky.social

This seems like a - let us write more guidelines that will get heavily cited and boost my h-index - piece I will argue we need less guidelines They should be like wars - waged only when absolutely necessary (stealing from @cardiobrief.bsky.social Larry Husten www.forbes.com/sites/larryh...)

Exclusive: Towana Looney, a 53-year-old woman who received a kidney from a gene-edited pig on 25 November 2024, had it removed last week after the organ suddenly stopped functioning, Science has learned. scim.ag/3EiaJmM

Overall they sleep poorly Median ~ 6.5 hours - and look at the spread 2/

Very interesting pilot trial from @bhanu24.bsky.social and colleagues in @ajkd.bsky.social Renal Denervation in .....loin pain hematuria syndrome! www.ajkd.org/article/S027... #NephSky

Nearly all patient representatives on the Organ Procurement and Transplantation Network board have resigned. #MedSky

hyponatremia: serum sodium tells us where you are and urine osm/lytes tell us how you got there

#archive30 #day3 #soundandvision #musicinthegri our concert series, a wonderful project instigated & led by Arthur Doyle, a man who definitely has vision & makes some wonderful sounds on his violin. The last concert in GRI was in1883; recitals were a common means of raising £ in the days pre #nhs

Anti-Nephrin Antibodies in Adult Chinese Patients with Minimal Change Disease and Primary Focal Segmental Glomerulosclerosis doi.org/10.1016/j.kint.2025.02.028 #NephSky #MedSky #minimalchangedisease #FSGS #IgG #IgM #focalsegmentalglomeruloscelrosis

Delivering a trial with adequate power to answer the question of anticoagulation and AF should now be a priority for the nephrology community. journals.lww.com/jasn/abstrac...

Haven’t entered for #nephmadness for couple of years as Twitter toxic. Really enjoyed entering for 2025. Excellent CME. Great work as ever from all involved. mild dismay at infiltration of “… up to x%” instead of “approximately x%” from general journalism in to nephrologist prose. up to x = 0 to x 🫣

5 minute resting + 60 seconds between measurements is the current standard for Blood Pressure Could 3 minutes resting + 30 seconds between measurements also work? from @spjuraschek.bsky.social et al 🔗 academic.oup.com/ajh/article/... 🔓 #OpenAccess #Free

So @danfuster.bsky.social and colleagues seem to find HCTZ doesn’t work for anything! In a post hoc analysis of NOSTONE (where CT scans were done in all & repurposed for calculating bone density) HCTZ doesn’t increase it vs placebo journals.lww.com/cjasn/pages/... in @asnpublications.bsky.social

ACEi and ARBs are not “nephrotoxic.” We all know about their long term renal protective benefits… But even in the short term, they improve renal blood flow! They do reduce GFR and impair K+ excretion, which is why we might hold them for a bit in AKI. But bad for kidneys? No

More evidence that DDAVP is not useful to reduce the risk of kidney biopsy bleeding journals.lww.com/kidney360/ab...

I've never been to an M&M about kidney injury attributable to iodinated contrast. I've been to several M&Ms for adverse outcomes from missed/delayed diagnoses because people hesitated to use IV contrast for fear of what we now know to be a ghost

Did you catch our smallpox exhibition yet? Still plenty of time and it is well worth a view -even if we do say so ourselves 😜 We include several old newspaper clippings from the last outbreak in Glasgow in March 1950. The parallels with the covid pandemic make for interesting reading....

3/3 I am prepared to believe that screening for BK viraemia in the first year post transplant is beneficial but guideline writers and authors if reviews need to stop pretending that we have RCT evidence to show that

2/3The statement is based on 1 single centre ‘study’, published only as meeting abstract in 2008 that had no graft loss in 648 intervention patients v 25% of the remaining subjects on routine care. Surely the Cochrane process is designed to exclude such nonsense as evidence

1/3 This Cochrane review states: “Intensive screening for the early detection of BKviraemia or BK viruria prevents graft loss”. But this is highly flawed www.cochranelibrary.com/web/cochrane...

Interesting retrospective cohort study (⚠️ limitations), showing: 👉 CV risk not increased with corticosteroids, after adjusting for CV factors 🔥 calcineurin inhibitor ⬆️ CV risk up to 2-3x (dose-dependent) 👉Every 10g of cyclophosphamide ➡️1.5x ⬆️CV events www.kidney-international.org/article/S008...

Bain maries & a dumb waiter on the site of the former kitchens on the 6th floor Meals would travel from here to the patients & to the staff dining rooms. Patients would enjoy meals often prescribed from diet tables; these included booze, available for patients and staff.

study shows % isotope uptake of the remaining kidney does not correlate with %recovery of GFR one year after living donation. pubmed.ncbi.nlm.nih.gov/39827110/ But does anyone have a plausible explanation of how remaining kidney reliably gets to 70% of predonation total GFR? #askrenal

Excellent review. We should stop using hypertensive nephropathy as a primary renal diagnosis. Much more useful to diagnose as CKD of unknown cause than imply we’ve made the diagnosis and stop thinking academic.oup.com/ndt/advance-...

great recent editorial from Dr. Agarwal on that topic!, #NephJC bsky.app/profile/sara...

In a prespecified interim analysis of a phase 3, randomized, controlled trial, the selective endothelin type A receptor antagonist atrasentan reduced proteinuria in patients with IgA nephropathy, without apparent safety issues. Full ALIGN trial results: nej.md/3NzvISW #MedSky #Nephrology

Further evidence that sustained immunological tolerance can be achieved in selected living donor kidney transplant. Most centres would not be able to replicate this regimen easily. www.amjtransplant.org/article/S160...

8/Simultaneous publication #ISNWCN www.nejm.org/doi/full/10....

George Hogarth Pringle pictured with Lister in 1854 as a resident at Edinburgh Royal Infirmary. Photo @wellcomecollection His son, James worked with Macewen & Strong. Pringle, pictured to the right of the seated anaesthetist, invented the Pringle manoeuvre which controls blood loss from the liver.

How much bicarbonate is in a tablet of sodium bicarbonate This came up on rounds today. I thought I covered this on the blog before but if I did, Google failed me. The answer is 7.7 mEq of Na and 7.7 mEq of HCO3 in every 650 mg tablet of baking soda. This is just 650 mg divided by the molecular…

New ERA document on vitamin D use in CKD Bottom line: the use of vitamin D is to…….increase blood levels of vitamin D academic.oup.com/ndt/advance-... in @ndt-era.bsky.social #NephSky

Excited to share our article today published in JAMA Pediatrics. Using target trial emulation methods, we found no difference between cyclophosphamide vs calcineurin inhibitors for preventing childhood nephrotic syndrome relapses. jamanetwork.com/journals/jam...

Between 2019 and 2023, researchers paid $8.968 billion to make papers open access. Imagine what else could be done with this money if it wasnt paid to for profit publishing companies... 👉 arxiv.org/abs/2407.16551