doi.org/10.1186/s128... Excellent paper led by Dr Charlotte Snead - we need to find ways of consulting with people about kidney disease that support them to make person-centred decisions. @lucyselman.bsky.social @rachaelmorton.bsky.social @flissmurtagh.bsky.social @peolcsw.bsky.social

We need a good biomarker for IgAN given the impoartance of immunosuppression (vs non-specific therapies: RASi, Flozins, ERA) But the Gd-IgA doesn’t seem so impressive to me? journals.lww.com/cjasn/pages/... #NephSky @asnpublications.bsky.social #CJASN VA by @corinateodosiu.bsky.social

How common is kidney failure with MCD and FSGS? More than we think … @brianrifkin.bsky.social breaks down the recent @asnpublications.bsky.social JASN paper from the RaDaR study www.nephjc.com/news/nephjc-...

🚨 Exciting Fellowships! 🚨 Join UHB NHS FT as a Clinical Research Fellow in Renal Medicine (12m fixed term, £65k, Birmingham). Apply now: 🧠 Dialysis & Cognition: jobs.nhs.uk/candidate/joba… 💉 Hypertension & Dialysis: jobs.nhs.uk/candidate/joba�#Renal #ResearchResearch

Proud of this Kidney International paper: doi.org/10.1016/j.ki.... Nephrology involves optimal delivery of treatments that prolong life, preserve & replace organ function. The art lies in shaping this care to the person. @rachaelmorton.bsky.social @lucyselman.bsky.social @flissmurtagh.bsky.social

No more fistula first, even in the @ukkidney.org vascular access guidelines Long, helpful document: bmcnephrol.biomedcentral.com/articles/10.... #NephSky

Vitamin R + Cyclophosohamide in ANCA vasculitis A case series from Edinburgh suggesting this allows faster steroid withdrawal? @kireports.bsky.social www.kireports.org/article/S246... #NephSky #Vasculitis

🙌 @barnyhole.bsky.social @lucyselman.bsky.social

Few drugs would be licensed with a > 5 % risk of liver enzyme level elevation - why are law makers so lenient with cannabidiol? jamanetwork.com/journals/jam...

Only reason to sequence the RASi first is that they are good antihypertensives (but note the BP effect in the combo arm of #confidence) #nephjc But no matter the sequence, the goal should be to have someone on the four pillars in less than 6 months

SGLT2i in CKD: impact beyond kidneys 🔻 15% all-cause hospitalizations ✅ Consistent regardless of eGFR, UACR & diabetes 🏥 ~36 fewer hospitalizations per 1000 pt-years Large absolute gains for patients & health systems Meta-analysis in @asnpublications.bsky.social journals.lww.com/cjasn/pages/...

9/10 I want more info: ✅Check out #NephJC summary by @sejalplakhani.bsky.social & @jeyakumarmeyyappan.bsky.social www.nephjc.com/news/confide... ✅Visual abstract by @shelliefravel.bsky.social www.nephjc.com/news/2025/7/...

1/10 Last #NephJC we discussed the combination therapy of empagliflozin and finerenone 💊 #TenPostNephJC 🌵From a therapeutic dessert to a flood of options in diabetic kidney disease (DKD) - what is the best timing to keep the kidneys afloat

📢 In BMJo: That’s why I wanted him to go on dialysis-a qualitative analysis of older patients’ & family members’ perspectives on kidney failure treatment rdcu.be/ewi4l @lucyselman.bsky.social @leilarooshenas.bsky.social @peolcsw.bsky.social @wolfsonpallcare.bsky.social @flissmurtagh.bsky.social

🎨 Beautiful visual abstract by @shelliefravel.bsky.social #NephJC www.nephjc.com/news/...#NephJC

T0b: #NephJC In DKD, the residual risk with flozins added to RASi, still remains high. We need every option in the arsenal, if we hope for better outcomes. So, here are the 4 pillars of modern cardio-renal therapy: medicinetoday.com.au...#NephJC

🖊️ Do you feel #KidneyDisease is overlooked? It’s time to act. Sign our open letter to the Prime Minister calling for a national #CKDstrategy & a better future for kidney patients 👉 www.ukkidney.org/prime-minist... @Kidney_Research @kidneycareuk @NKF_UK @PKDCharity @UKKidney

www.kireports.org/article/S246... If all roads to lead to dialysis, the kidney failure population will experience unmet needs unseen for decades. @lucyselman.bsky.social @flissmurtagh.bsky.social @kidneycoalition.bsky.social @rcpdmeetings.bsky.social @kidneyint.bsky.social

🧠 New publication latent TB screening in CKD 📈 TB incidence in UK dialysis patients > some high-burden countries, yet national screening guidance unclear. We call for equitable access 👉 : doi.org/10.1093/ckj/... #Nephrology #TB #CKD #LTBI #PublicHealth #Dialysis #HealthEquity #MigrationHealth

Huge Danish trial of nudges Patient level (N 22,000) + practice level (1500 practice cluster with N 28,000 pts) To increase RASination & Flozination www.ahajournals.org/doi/abs/10.1... in @ahajournals.bsky.social at #ERA25 Absolutely null effect - is the baseline too high to improve upon?

Core Curriculum by @nephcrit.bsky.social , @hswapnil.medsky.social , Abdulghani Omar Kabli, Oleksa G. Rewa, and Edward G. Clark: Continuous Kidney Replacement Therapies: Core Curriculum 2025 bit.ly/TeixeiraCC25 (FREE)

Foundational therapies in ESRD for heart failure Dr Matt Graham-Brown from Leicester presents at #NephGR www.youtube.com/watch?v=Ar11... (Rounds from Feb, late share!)

There you have it: BEDMED published in @jama.com jamanetwork.com/journals/jam... h/t @drjmluther.bsky.social No difference in bedtime versus morning BP meds - as expected #NephSky #Hypertension 1/

@kidneyresearchuk.org are enabling pharmacist-led research. I applied last year www.kidneyresearchuk.org/2025/04/22/p... Supported by @kindaibrahim @rosalynnaustin @jigneshpatel @davidwheeler @ukkidney.org @arcwessex.bsky.social

Genetic mutations in the terminal complement system may lead to increased susceptibility to preeclampsia. Targeting the terminal complement pathway could be a potential therapeutic strategy. bit.ly/KN1705-19 @silvishah.bsky.social #ASNKidneyNews

📢 New @RenalRadar paper! The study explores how nephrotic syndrome progresses & the link between proteinuria & kidney failure risk. 🔍 Insights will help clinicians identify higher risk patients earlier & improve clinical trial design. Read more 👉 ow.ly/xVyz50VTPQP

Promising! flozination in ADPKD (mostly older adults with DM or CVD) - presumably those with another valid indication - associated with slower GFR slope journals.lww.com/cjasn/pages/... in @asnpublications.bsky.social #CJASN With no obvious harm signal

The ADPKD @kdigo.org guideline episode of @freelyfiltered.bsky.social www.nephjc.com/freelyfilter... Joel, Nayan, AC, with Sophia Ambruso coining a new word for posting here (bleat!) And Charles Edelstein dropping lot of wisdom + @rheaultm.bsky.social with a cameo #NephSky

💡New SPOTLIGHT ✨ As part of our 75th celebrations, we're featuring the AKI SIG — a powerhouse of collaboration. From mapping UK AKI services to developing the world’s first AKI Master Patient Index, the group is transforming #AKICare👏 Explore more about the SIG's work: www.ukkidney.org/75-...#AKICare👏

📣 New paper now online @ckj-era.bsky.social: How do patient information documents present dialysis and conservative kidney management? A document analysis. academic.oup.com/ckj/advance-... @flissmurtagh.bsky.social @peolcsw.bsky.social @wolfsonpallcare.bsky.social @danafarber.bsky.social

Great to hear some further detail from @rpharms.com professional liability insurance. Currently 3-yr cover retrospective cover, AON challenged by audience member, consideration for a possible change. Nice one Ishaq! 😉 Run off built in!!! Indefinitely!!!! No additional charge. #CPCongess #PharmSky

Dapagliflozin in non-diabetic CKD with low/high ACR - OPTIMISE CKD observational design Pretty flat GFR slopes? academic.oup.com/ckj/article/... on @ckj-era.bsky.social #NephSky #OpenAccess

Fabulous couple of days @cpcongress.bsky.social presenting my present bpspubs.onlinelibrary.wiley.com/doi/10.1111/... and future research plans www.kidneyresearchuk.org/2025/04/22/p... & with UK Renal Pharmacy preventing progression to end stage kidney disease @kidneyresearchuk.org @ukkidney.org

Excess dosing of #carboplatin may occur when the Cockcroft-Gault equation is used for dosing, causing adverse events. #cockcroftgault #nephrology #oncology www.docwirenews.com/post/effect-...

It doesn’t take long, only takes 10-15 min

When to use spironolactone, eplerenone or finerenone in the spectrum of cardiorenal diseases doi.org/10.1093/ndt/...

The illegal kidney transplant trade continues Now centered in Kenya, with donors from Africa, Azerbaijan and elsewhere Recipients from Western Europe, Russia, and other places www.spiegel.de/internationa... With an Indian in the center #NephSky #PublicHealth h/t @jbrianbyrd.bsky.social

💉Immune checkpoint inhibitors: 🦸‍♂️heroes in cancer🦀, 🦹‍♂️villains for kidneys 🫘? #ICI-AKI can hit both Glomeruli (C3GN, MCD, vasculitis) & Tubulointerstitium (ATIN, ATN, tubulitis) 📖 doi.org/10.34067/KID... 🆕 @asnpublications.bsky.social K360 #Onconephrology #Nephrology #AKI #NephSky #NephPearls

The ASIs have arrived www.nejm.org/doi/full/10.... Aldosterone synthase inhibitors - first one to finish the phase 3 line #Lorundrostat #Hypertension

Look after patients with neonatal sepsis in sub-Saharan Africa? 🫵We want to hear from YOU! ❓Why❓ Exploring clinicians experiences of diagnostics, antibiotics + guidelines 📢 English, French or Portuguese 🔗 redcap.sun.ac.za/surveys/?s=N9A…

In 2009 as a nephrology trainee I asked a wise old nephrologist what his practice was regarding CKD-MBD as I was confused. His reply “well Chris I mostly ignore it unless the values are awful because there isn’t a shred of evidence for any of it…” Turns out he’s still right!

Couple of mock examples for illustration from two extremes #NephSky #PharmSky #EMIMCC

just learned this & mind blown 🤯 CKD-EPI, MDRD etc give us GFR corrected for body surface area (ml/min/1.73m2) BUT we're supposed to use the *absolute* GFR (ml/min) for drug dosing (eg KDIGO 2024 guidelines below; FDA agrees) in obesity, the computer's ml/min/1.73m2 can be way too low #EMIMCC

T0b: During the last decades, metformin keeps proving it's more than just a glucose fixer—it's weight-neutral, heart-friendly, and quietly doing the most behind the scenes #NephJC Adapted from link.springer.com/ar...#NephJC

Stopping vs. Continuing Metformin in Patients With Advanced CKD: A Nationwide Scottish Target Trial Emulation Study ca. 2025 from @ajkd.bsky.social #Nephpearls #NephJC #NephSky #VisualAbstract by @nephroseeker.medsky.social 👉 pubmed.ncbi.nlm.nih.gov/39521399/

Paxlovid in advanced CKD, matched study with VA data in @ajkd.bsky.social www.ajkd.org/article/S027... cc @christosargyrop.bsky.social - validates our approach 😎 #COVID #NephSky

We had excellent rounds on the topic from Dr Carla Nester a few weeks ago youtu.be/Fo6J__RgWA0?... #NephSky #NephGR

What's C3G It is not a new disease But the term C3 glomerulopathy was accepted in 2013 #NKFClinicals

Ultra rapid prednisone taper (median 14 days!) in ANCA vasculitis from the Imperial group www.kireports.org/article/S246... in @kireports.bsky.social #NephSky

Interesting paper @asnpublications.bsky.social ​SGLT2 inhibitors prevent kidney magnesium loss caused by cisplatin #flozins improve Mg reabsorption in the thick ascending limb and distal convoluted tubule VA by @corinateodosiu.bsky.social #nephsky #medsky journals.lww.com/jasn/abstrac...