@johncreedon.bsky.social Hi John, loved the Jimmy Crowley track & delighted to see the love & support for a national, regional & local treasure. Listening to his singing is an education in itself. Wishing the man himself the very best at this difficult time in his life.

Minimal life by computer Progress toward a true virtual cell will depend on uniting AI’s pattern-finding power with the causal rigor of mechanistic models go.nature.com/48muYvd

A decade of research in review For Nature Biotechnology’s 30th anniversary, our editors look back at a few of their favorite papers published in the past decade go.nature.com/4sWhZs1

“We can’t afford cancer research but $11 billion for one week of an absurd war is fine” is a hell of an argument

Very much looking forward to this public interview with the inimitable Ella McSweeney based around THE LIE OF THE LAND and hosted by UCD One Health. It’s on Weds Mar 25th from 7pm. www.eventbrite.ie/e/ella-ms-sw...

The time is ripe for transitioning the field of immunotherapy to in vivo engineering as ex vivo engineering is now mature, with extensive knowledge on the safety & lifesaving aspect of these immunotherapies especially in blood cancers, solid tumors & autoimmunity go.nature.com/4r732m4 rdcu.be/e2yJa

Getting beyond the liver has been a key goal for developers of oligonucleotide-based drugs. For many tissues - notably the CNS, muscle & heart - antibody-oligonucleotide conjugates can elicit therapeutic effects well beyond those of unmodified siRNA or antisense drugs. www.nature.com/articles/s41...

Powerful piece in STAT this morning from some NIH staff members who have resigned www.statnews.com/2026/01/10/n... 1/3

Dogmatism, not data, drives RFK Jr.'s damaging anti-vax agenda. www.science.org/content/arti...

12 former commissioners of the FDA came together to write a Perspectives piece for the New England Journal of Medicine; raising our concerns about recent changes to vaccine approval policy at the FDA and its implications for patients and public health.

One more lane, one more road won't fix this. It never have and it never will! The only solution is to fundamentally change our transport system away from private cars towards active and public transport.

Something is rotten in the state of science publishing... As if the external attacks from RFK Jr. et al weren't enough, dodgy operators are undermining it from within.

Pretty much ANY statistic you see cited to frighten you about vaccines comes from the VAERS database. (Including the recent evidence-free missive from Vinay Prasad). Here's why VAERS can NEVER be a proper source for population-level vaccine risk estimates. Thread [1/9]

#Measles deaths down 88% since 2000, says @who.int . Vaccines have saved almost 59m lives in this time - but cases are on the rise again - vigilance against the world's most contagious virus is essential. #vaccineswork www.who.int/news/item/28...

Great to hear a scientist and environmentalist - @elainemcgoff.bsky.social - and a farmer in nitrates derogation separately say the same thing here: that the government-led drive for maximum productivity was a MASSIVE mistake, with our rivers and (now, potentially) farmers paying the price.

Just out in @natbiotech.nature.com - a deep dive into what's next in idiopathic pulmonary fibrosis after the approval of @boehringerglobal.bsky.social's Jascayd (nerandomilast). There's still huge scope for innovation here - & many good ideas being pursued. www.nature.com/articles/s41...

Good piece by Eric Stokstad on an unusual and very damaging toxic algal bloom - we can expect more of these as #climatechange creates #ecosystems havoc www.science.org/content/arti...

You could equally argue that humans are the only irrational species. I have a lot of respect for the decision-making processes of other species.

‪Over the weekend our letter, in response to John FitzGerald's article earlier last week, was published in the @irishtimes.com We corrected several incorrect claims that were made in the article. with @hannahdaly.ie @colmduff.bsky.social David Styles www.irishtimes.com/opinion/lett...

"The argument that paying more for medicines leads to more innovation is unfounded." Good editorial in @thelancet.com www.thelancet.com/journals/lan...

A paper in Nature reports that mRNA vaccines targeting SARS-CoV-2, COVID-19, also sensitize tumours to immune checkpoint inhibitors. #medsky 🧪

@tcddublin.bsky.social clinical trial shows repeated infusions of #ketamine of no benefit to patients hospitalised with #depression jamanetwork.com/journals/jam...

@johncreedon.bsky.social John, it's actually a murder of crows - but if there are only two or three it can be downgraded to an attempted murder ;)

The upcoming release of the 1926 census records of Ireland will be celebrated across a major public programme of events next year

No Kings!

Most transcription factors were historically considered undruggable. But some innovative biotechs are changing all that - & big pharma is starting to pay attention (and big bucks). Out now in @natbiotech.nature.com www.nature.com/articles/s41...

MSF strongly condemns the killing of Omar Hayek by Israeli forces this morning in #Gaza. Our thoughts are with his family and colleagues. Omar is our fourteenth colleague to be killed in Gaza since the war started. We call yet again for an end to the genocide.

Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems. Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here: www.nature.com/articles/s41...

Impressive degree of mendacity to try insist on a Tylenol autism link, given its flatly contradicted by better data, like this study of >2 million Danish kids. There's a grim history of false "causes" for autism, a dogwhistle RFK Jr & Trump blowing.. jamanetwork.com/journals/jam...

@johncreedon.bsky.social Delighted to hear Gavin Friday's Angel John An old favourite & arguably the funkiest tune that ever came out of Ireland

The Gaza Famine is the world’s famine. A preventable, predictable famine. Enough. Ceasefire. Open all crossings, north and south. Let us get food in, unimpeded and at massive scale.

The main thing - is it not already clear - RFKr Jr is uniquely unqualified to lead the HHS. All main agencies under his watch - NIH, FDA, CMS - are also headed by incompetent contrarian peddlers of disinformation, conspiracy theories, and pseudoscience. This will, and already does, cost lives.

Defending US democracy: the role of scientists @science.org www.science.org/doi/10.1126/...

new out in Nature www.nature.com/articles/s41...

Ivan Sugrue @ucc.ie shares insights in new APC @nature.com - NJP Antimicrobials and Resistance paper: Trans-kingdom conservation of mechanism between bacterial actifensin and eukaryotic defensins. This is an output of the @erc.europa.eu project BACtheWINNER. #ERC #AMR #microbiome ➡️ bit.ly/3H34mox

Researchers have been sneaking secret messages into their papers in an effort to trick AI tools into giving them a positive peer-review report Read the full story: www.nature.com/articles/d41...

The #Glacier Loss Day is reached in Switzerland! From now on all melt that occurs on glaciers until October is unsustainable. This tipping point has only been reached so early in the record-shattering year 2022. Expect big ice loss due to the prolonged melt season and feedback effects

Elon Musk casually, and illegally, dismantled USAID. According to a new study in the Lancet, that action will lead to *14 million* premature deaths between 2025 and 2030. Again: Elon Musk is directly responsible for 14 million coming deaths. 4.5 million will be children.

New paper hot off the press www.nature.com/articles/s41... We analysed over 40,000 computer vision papers from CVPR (the longest standing CV conf) & associated patents tracing pathways from research to application. We found that 90% of papers & 86% of downstream patents power surveillance 1/

@johncreedon.bsky.social So lovely to hear Albatross John Was awestruck by its beauty the 1st time I heard it way back when It's a singular piece of music

🔔🧪 Super interesting… and promising! Stephen Wallace and his team at University of Edinburgh produced #paracetamol using genetically modified #E.coli bacteria from polyethylene terephthalate (PET), the main component of #plastic bottles. 🦠💊 #RecyclingPlastic 👉 www.nature.com/articles/s41...

#Argentina played the percentages so smartly. And they play with such skill, pride and passion. Sky Sports must be fuming, but triumphant neocolonial processions are always a tricky proposition. There won't be a cow milked in the Pampas tonight. Great game of #rugby. #LionsTour

Individualized #cancer #vaccines targeting #neoantigens have shown promise in small-scale studies, but the field is waiting on data from Merck's & Moderna's phase 3 trial of the #mRNA vaccine Intismeran autogene in #melanoma. Just out in @natbiotech.nature.com www.nature.com/articles/s41...

Pleased to share our latest report, coauthored with Ciara Doherty at UCC’s Energy Policy and Modelling Group. We looked at how Ireland’s national carbon budget pathways stack up against EU climate obligations (ETS, ESR, EED, and the proposed 2040 target).

In Orkney, council owned wind farms return £5.5M every year to fund public services. We have nothing like this in Ireland. The entire model is geared towards state facilitation of multinational energy companies and investors. ENGOs need to get behind public-commons partnerships.

The new Save Our Sprat campaign will be holding a public demonstration in Bantry Square at 11am on Friday (day after tomorrow), calling for a moratorium on sprat fishing in Irish waters. I'll be there, can you come along too? The more, the better!! ✊️✊️✊️ 🐟 🌊 🦭 🐋 🐳🌊

Elon Musk's Grok AI Chatbot introduces climate denialism when asked about the threat of climate change. It's the only one of the major AI chatbot companies that gives such answers. And it just started doing so a few months ago. www.eenews.net/articles/is-...