Cormac Sheridan
@cormacsheridan.bsky.social
📤 1117
📥 785
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Freelance science journalist - I write about what works in biotech - and what doesn't.
pinned post!
Getting beyond the liver has been a key goal for developers of oligonucleotide-based drugs. For many tissues - notably the CNS, muscle & heart - antibody-oligonucleotide conjugates can elicit therapeutic effects well beyond those of unmodified siRNA or antisense drugs.
www.nature.com/articles/s41...
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Now with oligos: antibody–oligonucleotide conjugates are the new drug modality to watch - Nature Biotechnology
Developers have married gene-modulating oligonucleotides with the targeted precision of antibodies, and the first filings using such conjugates in Duchenne muscular dystrophy are imminent.
https://www.nature.com/articles/s41587-025-02987-0
4 days ago
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Getting beyond the liver has been a key goal for developers of oligonucleotide-based drugs. For many tissues - notably the CNS, muscle & heart - antibody-oligonucleotide conjugates can elicit therapeutic effects well beyond those of unmodified siRNA or antisense drugs.
www.nature.com/articles/s41...
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Now with oligos: antibody–oligonucleotide conjugates are the new drug modality to watch - Nature Biotechnology
Developers have married gene-modulating oligonucleotides with the targeted precision of antibodies, and the first filings using such conjugates in Duchenne muscular dystrophy are imminent.
https://www.nature.com/articles/s41587-025-02987-0
4 days ago
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Jeremy Berg
16 days ago
Powerful piece in STAT this morning from some NIH staff members who have resigned
www.statnews.com/2026/01/10/n...
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The NIH has lost its scientific integrity. So we left
“We can no longer lend our credibility to an organization that has lost its integrity,” write four scientists and administrators who recently resigned from the NIH.
https://www.statnews.com/2026/01/10/nih-resign-protest-four-leaders-cite-interference-censorship/
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Dogmatism, not data, drives RFK Jr.'s damaging anti-vax agenda.
www.science.org/content/arti...
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What’s the fuss about aluminum in vaccines?
Despite extensive safety record, U.S. health advisers are set to discuss claimed link to asthma
https://www.science.org/content/article/what-s-fuss-about-aluminum-vaccines
about 2 months ago
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Scott Gottlieb, MD
about 2 months ago
12 former commissioners of the FDA came together to write a Perspectives piece for the New England Journal of Medicine; raising our concerns about recent changes to vaccine approval policy at the FDA and its implications for patients and public health.
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Ola Løkken Nordrum
about 2 months ago
One more lane, one more road won't fix this. It never have and it never will! The only solution is to fundamentally change our transport system away from private cars towards active and public transport.
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'We've done all we can do to fix M50,' warns TII
Transport Infrastructure Ireland says there is almost nothing it can do to address traffic gridlock on the M50, while accepting that the road has reached capacity
https://www.rte.ie/news/primetime/2025/1202/1546829-m50-commuting/
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Something is rotten in the state of science publishing... As if the external attacks from RFK Jr. et al weren't enough, dodgy operators are undermining it from within.
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about 2 months ago
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Raywat Deonandan 🍁🇨🇦
about 2 months ago
Pretty much ANY statistic you see cited to frighten you about vaccines comes from the VAERS database. (Including the recent evidence-free missive from Vinay Prasad). Here's why VAERS can NEVER be a proper source for population-level vaccine risk estimates. Thread [1/9]
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#Measles
deaths down 88% since 2000, says
@who.int
. Vaccines have saved almost 59m lives in this time - but cases are on the rise again - vigilance against the world's most contagious virus is essential.
#vaccineswork
www.who.int/news/item/28...
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Measles deaths down 88% since 2000, but cases surge
Global immunization efforts have led to an 88% drop in measles deaths between 2000 and 2024, according to a new report from the World Health Organization (WHO). Nearly 59 million lives have been saved...
https://www.who.int/news/item/28-11-2025-measles-deaths-down-88--since-2000--but-cases-surge
about 2 months ago
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Eoghan Daltun 🌍
2 months ago
Great to hear a scientist and environmentalist -
@elainemcgoff.bsky.social
- and a farmer in nitrates derogation separately say the same thing here: that the government-led drive for maximum productivity was a MASSIVE mistake, with our rivers and (now, potentially) farmers paying the price.
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Just out in
@natbiotech.nature.com
- a deep dive into what's next in idiopathic pulmonary fibrosis after the approval of
@boehringerglobal.bsky.social
's Jascayd (nerandomilast). There's still huge scope for innovation here - & many good ideas being pursued.
www.nature.com/articles/s41...
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FDA approves new mechanism to treat idiopathic pulmonary fibrosis, expanding limited arsenal - Nature Biotechnology
The first-in-class small molecule Jascayd targets a fibrotic signaling cascade, offering new hope in a stagnant therapeutic field, as several other programs near maturity.
https://www.nature.com/articles/s41587-025-02908-1
2 months ago
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Good piece by Eric Stokstad on an unusual and very damaging toxic algal bloom - we can expect more of these as
#climatechange
creates
#ecosystems
havoc
www.science.org/content/arti...
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Australia’s unprecedented toxic algal bloom has a surprise culprit
A relatively unknown species is producing a notorious neurotoxin, devastating sea life
https://www.science.org/content/article/australia-s-unprecedented-toxic-algal-bloom-has-surprise-culprit?et_rid=60656375&et_cid=5788567
3 months ago
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You could equally argue that humans are the only irrational species. I have a lot of respect for the decision-making processes of other species.
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3 months ago
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Róisín Moriarty
3 months ago
Over the weekend our letter, in response to John FitzGerald's article earlier last week, was published in the
@irishtimes.com
We corrected several incorrect claims that were made in the article. with
@hannahdaly.ie
@colmduff.bsky.social
David Styles
www.irishtimes.com/opinion/lett..
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Philip Ball
3 months ago
"The argument that paying more for medicines leads to more innovation is unfounded." Good editorial in
@thelancet.com
www.thelancet.com/journals/lan...
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Drug pricing and pharmaceutical innovation: a false promise
The UK is facing a pharma exodus. Major pharmaceutical companies have withdrawn about £2 billion in proposed investment from the country, blaming insufficient government investment. Central to the dis...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02160-9/fulltext
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Nature Portfolio
3 months ago
A paper in Nature reports that mRNA vaccines targeting SARS-CoV-2, COVID-19, also sensitize tumours to immune checkpoint inhibitors.
#medsky
🧪
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SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
https://go.nature.com/48K7wJp
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@tcddublin.bsky.social
clinical trial shows repeated infusions of
#ketamine
of no benefit to patients hospitalised with
#depression
jamanetwork.com/journals/jam...
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Serial Ketamine Infusions for Depression
This randomized clinical trial evaluates outcomes following adjunctive ketamine infusions vs midazolam for depression.
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2840552
3 months ago
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@johncreedon.bsky.social
John, it's actually a murder of crows - but if there are only two or three it can be downgraded to an attempted murder ;)
3 months ago
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RTÉ News
3 months ago
The upcoming release of the 1926 census records of Ireland will be celebrated across a major public programme of events next year
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Centenary celebrations for release of 1926 census
The upcoming release of the 1926 census records of Ireland will be celebrated across a major public programme of events next year.
https://www.rte.ie/news/2025/1022/1540065-1926-census/
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Pam Ronald
3 months ago
No Kings!
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Most transcription factors were historically considered undruggable. But some innovative biotechs are changing all that - & big pharma is starting to pay attention (and big bucks). Out now in
@natbiotech.nature.com
www.nature.com/articles/s41...
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Big pharma seduced by transcription factors again. What has changed? - Nature Biotechnology
Long considered undruggable, transcription factors have finally become fair game for a clutch of innovative biotechs who are combining biological insights with innovative chemistry to bring into play ...
https://www.nature.com/articles/s41587-025-02862-y
3 months ago
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Cormac Sheridan
Doctors Without Borders / Médecins Sans Frontières (MSF)
4 months ago
MSF strongly condemns the killing of Omar Hayek by Israeli forces this morning in
#Gaza
. Our thoughts are with his family and colleagues. Omar is our fourteenth colleague to be killed in Gaza since the war started. We call yet again for an end to the genocide.
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Ben Adler
4 months ago
Today in
@nature.com
, we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems. Check out
@erinedoherty.bsky.social
and my work from
@doudna-lab.bsky.social
lab here:
www.nature.com/articles/s41...
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A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature
Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.
https://www.nature.com/articles/s41586-025-09569-9
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Cormac Sheridan
Dr David Robert Grimes
4 months ago
Impressive degree of mendacity to try insist on a Tylenol autism link, given its flatly contradicted by better data, like this study of >2 million Danish kids. There's a grim history of false "causes" for autism, a dogwhistle RFK Jr & Trump blowing..
jamanetwork.com/journals/jam...
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Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability
This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.
https://jamanetwork.com/journals/jama/fullarticle/2817406
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@johncreedon.bsky.social
Delighted to hear Gavin Friday's Angel John An old favourite & arguably the funkiest tune that ever came out of Ireland
4 months ago
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Cormac Sheridan
Tom Fletcher
5 months ago
The Gaza Famine is the world’s famine. A preventable, predictable famine. Enough. Ceasefire. Open all crossings, north and south. Let us get food in, unimpeded and at massive scale.
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Kristian G. Andersen
5 months ago
The main thing - is it not already clear - RFKr Jr is uniquely unqualified to lead the HHS. All main agencies under his watch - NIH, FDA, CMS - are also headed by incompetent contrarian peddlers of disinformation, conspiracy theories, and pseudoscience. This will, and already does, cost lives.
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Eric Topol
6 months ago
Defending US democracy: the role of scientists
@science.org
www.science.org/doi/10.1126/...
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Cormac Sheridan
Vjosa Musliu
about 2 years ago
Grant our little ones a death as beautiful as they are. “I Grant You Refuge” - Hiba Abu Nada
proteanmag.com/2023/11/03/i...
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Cormac Sheridan
Barbara Marte
6 months ago
new out in Nature
www.nature.com/articles/s41...
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NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity - Nature
An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated recruitment ...
https://www.nature.com/articles/s41586-025-09303-5
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Cormac Sheridan
APC Microbiome Ireland
6 months ago
Ivan Sugrue
@ucc.ie
shares insights in new APC
@nature.com
- NJP Antimicrobials and Resistance paper: Trans-kingdom conservation of mechanism between bacterial actifensin and eukaryotic defensins. This is an output of the
@erc.europa.eu
project BACtheWINNER.
#ERC
#AMR
#microbiome
➡️
bit.ly/3H34mox
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Cormac Sheridan
Nature
7 months ago
Researchers have been sneaking secret messages into their papers in an effort to trick AI tools into giving them a positive peer-review report Read the full story:
www.nature.com/articles/d41...
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Matthias Huss
7 months ago
The
#Glacier
Loss Day is reached in Switzerland! From now on all melt that occurs on glaciers until October is unsustainable. This tipping point has only been reached so early in the record-shattering year 2022. Expect big ice loss due to the prolonged melt season and feedback effects
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David Roberts
7 months ago
Elon Musk casually, and illegally, dismantled USAID. According to a new study in the Lancet, that action will lead to *14 million* premature deaths between 2025 and 2030. Again: Elon Musk is directly responsible for 14 million coming deaths. 4.5 million will be children.
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Evaluating the impact of two decades of USAID interventions and projecting the effects of defunding on mortality up to 2030: a retrospective impact evaluation and forecasting analysis
USAID funding has significantly contributed to the reduction in adult and child mortality across low-income and middle-income countries over the past two decades. Our estimates show that, unless the a...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01186-9/fulltext
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Dr Abeba Birhane
7 months ago
New paper hot off the press
www.nature.com/articles/s41...
We analysed over 40,000 computer vision papers from CVPR (the longest standing CV conf) & associated patents tracing pathways from research to application. We found that 90% of papers & 86% of downstream patents power surveillance 1/
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Computer-vision research powers surveillance technology - Nature
An analysis of research papers and citing patents indicates the extensive ties between computer-vision research and surveillance.
https://www.nature.com/articles/s41586-025-08972-6#MOESM1
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@johncreedon.bsky.social
So lovely to hear Albatross John Was awestruck by its beauty the 1st time I heard it way back when It's a singular piece of music
7 months ago
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Cormac Sheridan
🦋 Gourdon Lab 🦠🔬
7 months ago
🔔🧪 Super interesting… and promising! Stephen Wallace and his team at University of Edinburgh produced
#paracetamol
using genetically modified
#E.coli
bacteria from polyethylene terephthalate (PET), the main component of
#plastic
bottles. 🦠💊
#RecyclingPlastic
👉
www.nature.com/articles/s41...
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A biocompatible Lossen rearrangement in Escherichia coli - Nature Chemistry
Biocompatible chemistry merges chemo-catalytic reactions with cellular metabolism for sustainable small-molecule synthesis. Now a biocompatible Lossen rearrangement has been demonstrated to control ba...
https://www.nature.com/articles/s41557-025-01845-5
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#Argentina
played the percentages so smartly. And they play with such skill, pride and passion. Sky Sports must be fuming, but triumphant neocolonial processions are always a tricky proposition. There won't be a cow milked in the Pampas tonight. Great game of
#rugby
.
#LionsTour
7 months ago
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Individualized
#cancer
#vaccines
targeting
#neoantigens
have shown promise in small-scale studies, but the field is waiting on data from Merck's & Moderna's phase 3 trial of the
#mRNA
vaccine Intismeran autogene in
#melanoma
. Just out in
@natbiotech.nature.com
www.nature.com/articles/s41...
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Individualized mRNA cancer vaccines make strides - Nature Biotechnology
The first cancer vaccines matched to a person’s unique tumor neoantigens are forging ahead, with expectations running high as the field awaits results from the first pivotal trial.
https://www.nature.com/articles/s41587-025-02708-7
7 months ago
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Cormac Sheridan
Hannah Daly
8 months ago
Pleased to share our latest report, coauthored with Ciara Doherty at UCC’s Energy Policy and Modelling Group. We looked at how Ireland’s national carbon budget pathways stack up against EU climate obligations (ETS, ESR, EED, and the proposed 2040 target).
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Cormac Sheridan
Patrick Bresnihan
8 months ago
In Orkney, council owned wind farms return £5.5M every year to fund public services. We have nothing like this in Ireland. The entire model is geared towards state facilitation of multinational energy companies and investors. ENGOs need to get behind public-commons partnerships.
add a skeleton here at some point
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Eoghan Daltun 🌍
8 months ago
The new Save Our Sprat campaign will be holding a public demonstration in Bantry Square at 11am on Friday (day after tomorrow), calling for a moratorium on sprat fishing in Irish waters. I'll be there, can you come along too? The more, the better!! ✊️✊️✊️ 🐟 🌊 🦭 🐋 🐳🌊
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Scott Waldman
8 months ago
Elon Musk's Grok AI Chatbot introduces climate denialism when asked about the threat of climate change. It's the only one of the major AI chatbot companies that gives such answers. And it just started doing so a few months ago.
www.eenews.net/articles/is-...
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Is climate change a threat? It depends, says Elon Musk’s AI chatbot.
The latest version of Grok is promoting fringe climate viewpoints in a way it hasn’t done before, observers say.
https://www.eenews.net/articles/is-climate-change-a-threat-it-depends-says-elon-musks-ai-chatbot/
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Cormac Sheridan
Middle East Eye (Unofficial)
8 months ago
Ireland moves to ban trade with Israeli-occupied territories -
https://www.middleeasteye.net/live-blog/live-blog-update/ireland-moves-ban-trade-israeli-occupied-territories
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Ireland moves to ban trade with Israeli-occupied territories
<article data-history-node-id="423122" about="https://www.middleeasteye.net/live-blog/live-blog-update/ireland-moves-ban-trade-israeli-occupied-territories" class="live-blog-update default clearfix"> <h2> <a href="https://www.middleeasteye.net/live-blog/live-blog-update/ireland-moves-ban-trade-israeli-occupied-territories" rel="bookmark"> <span class="field field-title">Ireland moves to ban trade with Israeli-occupied territories</span> </a> </h2> <div class="content"> <div class="field field-field-text"> <p><meta charset="UTF-8"></p> <p>The Irish government approved on Tuesday the drafting of a bill to ban the import of goods from Israeli settlements considered illegal under international law, an unprecedented move for a European Union member.</p> <p>The move comes after the International Court of Justice last year said Israeli occupation of the West Bank, East Jerusalem and Gaza Strip was illegal under international law, in an advisory opinion the Irish government said guided its decision.</p> <p>"The government has agreed to advance legislation prohibiting trade in goods with illegal settlements in the occupied Palestinian territory," a foreign ministry spokesperson told AFP.</p> <p>"It is the government’s view that this is an obligation under international law," they added. </p> <p><meta charset="UTF-8"></p> <p>Before the cabinet decision, Foreign Minister Simon Harris told reporters he hoped other EU countries would follow Ireland's lead.</p> <p>"What I hope today is when this small country in Europe makes the decision and becomes one of the first countries, and probably the first country, in the Western world to consider legislation in this space, I do hope it inspires other European countries to join us," said Harris, who is also Irish deputy prime minister.</p> </div> </div> </article>
https://www.middleeasteye.net/live-blog/live-blog-update/ireland-moves-ban-trade-israeli-occupied-territories
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Kevin Mitchell
8 months ago
Happy to claim my place on the top of the hill in this diagram! Clearly I have the objectively most right opinion on "What is Life?" I don't make the rules - the data have spoken! 😊 cc
@drmichaellevin.bsky.social
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Without the Normans we'd still be drinking Lyons Tea :))
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8 months ago
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The Ontario of his soul has left the Dublin of his body. Paul Durcan was special, and we loved him. Rest easy, gentle poet.
8 months ago
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time.com/7285045/resi...
Alondra Nelson's powerful rejection of "creeping normalization of authoritarian approaches to knowledge management and academic freedom". Essential reading.
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Why I’m Resigning from the NSF and Library of Congress
I cannot participate in systems that require dishonesty as the price of belonging.
https://time.com/7285045/resigning-national-science-foundation-library-congress/
9 months ago
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Will the 'skinny jabs' become known as the 'buzz killers'? GLP-1 receptor agonists have curbed some people's
#addictions
to
#alcohol
,
#smoking
,
#cocaine
, or
#opioids
. Research is gaining real momentum. Just out in Nature Biotechnology
@natbiotech.nature.com
www.nature.com/articles/s41...
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Not just obesity: GLP-1 receptor agonists advance on addiction - Nature Biotechnology
GLP-1 agonists may lessen alcohol, smoking and possibly drug addictions. Evidence from clinical trials remains sparse, but that is about to change.
https://www.nature.com/articles/s41587-025-02644-6
9 months ago
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