Donnie Dania took this brilliant photo in 2025. Talk about being in the right place at the right time. Goodnight

Join us next Tuesday (May 19, 11am ET) for the Colton Consortium Virtual Seminar featuring Montserrat Anguera, PhD (Penn Vet) who will be covering "Sex Differences in Autoimmune Disease: Xist RNA-Mediated Mechanisms That Influence B Cell Function." Registration required: https://bit.ly/4wwhLdP

Protective maternal gut instincts www.nature.com/articles/d41... So thankful to @nature.com for the opportunity to highlight another exciting example of immunology learned from mothers, “protective maternal gut instincts” by @aiinglim.bsky.social @princetonmolbio.bsky.social

Such a fantastic week at #KSBeyondAntibiotics26! Amazing science, timely conversations about AMR & bacterial infections, and AWESOME people. Thanks to my co-organizers and everyone who joined us in beautiful Breckenridge! @dariavantyne.bsky.social @maribyndloss.bsky.social @kimingeneva.bsky.social

Early life γδT cell activation enforces intestinal barrier integrity during intergenerational C. difficile colonization https://www.biorxiv.org/content/10.64898/2026.04.28.721483v1

Excited to share the final part of my postdoc work, where we investigate the impact of antimicrobial treatment on susceptibility to hospital-acquired Acinetobacter baumannii pneumonia. Thanks to our amazing group of collaborators for their contributions to this study! www.pnas.org/doi/10.1073/...

Yesterday we moved into the new Morgan Center for Research and Innovation at @childrensphila.bsky.social. This new space will be home to the Moustafa Lab, the CHOP Microbiome Sequencing Core, and CMM @centermicrobialmed.bsky.social. We are already getting ready to be back at the bench next week.1/2

Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.

And don’t forget to register for #ICMI2026!!

Had a great time talking C. diff on the #MattersMicrobial podcast! Thanks so much to @markowenmartin.bsky.social for being such a fantastic host and for the great conversation!

This week, our Data Security team added 25 events to the timeline, shining a spotlight on the Trump administration’s efforts to grab yet more personal data from Americans.

Today, the 2026 Penn Colton Center for #Autoimmunity Symposium brings together the Penn #autoimmune research community—spanning diverse disease areas and the full continuum of discovery—to share new insights in diagnosing, treating, and preventing autoimmune diseases.

Tomorrow is the last day to submit an abstract for @keystonesymposia.bsky.social meeting Beyond Antibiotics: Emerging Strategies Combating Bacterial Infections. It is going to be an amazing meeting and we have a few slots left! keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26

Dysbiosis is not a change in the microbiota composition, it is a change in the host environment and compositional changes are secondary to this underlying cause

Thanks for highlighting our work with the other outstanding recent discoveries

Back story (link.growkudos.com/1pt9jbrx24g) behind our recent publication... Maternal Krüppel-like factor 2 (KLF2)+ CD4 T cells promote fertility and fetal tolerance | PNAS www.pnas.org/doi/10.1073/...

Enhancing Diabetic Wound Healing: A little help from Alcaligenes faecalis? #Microbiome #ActAgainstAmputation diabeticfootonline.c...

Another twist to why newborn babies more vulnerable to infection. Beyond immune cell immaturity, layering, active suppression... maternal pathogen-targeted antibodies still protect. Grateful @Nature sharing this hopefully uplifting glass half (99.9%)-full perspective www.nature.com/articles/s41...

Orlaith Keenan in the Zackular lab (@joeyzacks.bsky.social) defends her thesis tomorrow!

Why Do Women with IBD Face Higher Risk of Pregnancy Complications? @babiesresearch.bsky.social @cincyresearch.bsky.social www.pnas.org/doi/10.1073/... @pnas.org scienceblog.cincinnatichildrens.org/why-do-women...

A different perspective. Always helpful.

Excited to see this story published! Congrats @jeylee.bsky.social and @abaumler.bsky.social!

❤️An important message from our CSO, EVP, & team captain Dr. Sue Furth! Dr. Furth + the Research Institute team will be joining April's I ♥ CHOP Run, Walk & Virtual Challenge presented by Philadelphia Insurance Companies. Join us, support, or learn more: chop.donordrive.com/teams/CHOPRe...

Natural maternal immunity protects neonates from Escherichia coli sepsis @cincyresearch.bsky.social @babiesresearch.bsky.social @nature.com www.nature.com/articles/s41...

Felt good to Stand Up For Science today in Seattle🔬🧬🧪💪 @standupforscience.bsky.social

β-hydroxybutyrate supplementation is a promising, readily implementable strategy to improve CAR-T cell function against various cancers @cellcellpress.bsky.social www.cell.com/cell/fulltex... @marcoruella.bsky.social @penncancer.bsky.social @maayanlevy.bsky.social @stanforduniversity.bsky.social

"The challenge now is not whether brutalism should be admired, but whether its underlying values can be taken seriously again..."

#MucosalMonday means a new podcast episode with @societymucosalimm.bsky.social! Join @marionbrunck.bsky.social @ashu-mangalam.bsky.social @kknoop.bsky.social for discussions, mysteries, and the latest research at MI! www.iheart.com/podcast/269-...

Ramadan Mubarak everyone

Antibody cocktails derived from pediatricians cooperatively neutralize and protect rodents against RSV and hMPV by targeting conserved epitopes www.science.org/doi/10.1126/...

Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis @pnas.org #Mathis @harvardmed.bsky.social www.pnas.org/doi/10.1073/...

Thrilled to share this study tracking Staph aureus carriage and transmission across the NICU using genomics! Work done w @pjplanet.bsky.social & @ahmedmicrobes.bsky.social and made possible by @centermicrobialmed.bsky.social. Study co-led by the amazing @qianxuan.bsky.social & Lakshmi Srinivasan!

Over 3 years we performed WGS-based surveillance of S. aureus in the NICU at @childrensphila.bsky.social, sequencing both surveillance and bloodstream infection isolates, to understand how colonization, transmission, and persistence are associated with invasive infection in high-risk neonates.

"I fielded mail from all manner of people...what they often evinced was better than interest, better even than bibliophilia; it was the rare & precious capacity to be interested in what they didn’t already know interested them. It was a willingness to be changed." www.newyorker.com/books/page-t...

Taken together: The neonatal liver undergoes a developmentally hard-wired Treg wave facilitated by cDC1s needed to restrain activation and promote tolerance in conventional T cells that respond to both microbes and self in early life. (10/10) Link: tinyurl.com/neoliver

🚨 PhD position 🚨 My new group @HZI_de is hiring! Project: DC–T cell interactions in the neonatal gut to develop better oral vaccines. Looking for candidates w/ immunology and/or bioinformatics background. Apply 👉 www.helmholtz-hzi.de/karriere/job...

To strengthen the European research on early life immunology we have started the EFIS study ELINE Info and seminar announcement 👇🏼 #EFIS#ELINE#immunology

My sister-in-law's dad died last week, in hospice in the VA hospital in Minneapolis. I just learned Alex Pretti was part of his care team. They shot Alex less than 1/2 mile from my niece's house while doing the same observation work that my niece is doing. These are real people. Step up folks!

Congress is not powerless. Democrats must unify around an actual agenda. 1. Vote no on DHS funding bill. 2. Repeal the multi-year $75 billion funding for ICE. 3. End qualified immunity for ICE agents. 4. Investigate and prosecute every single ICE agent who broke the law.

Happy New Year, all! Reminder that the deadline for abstract selected talks is Jan 7th for @keystonesymposia.bsky.social meeting "Beyond Antibiotics: Emerging Strategies Combating Bacterial Infection." Register today and join us in Breckenridge!! It is going to be an awesome meeting!

It's not too late to get your flu shot. Flu circulates year round but more intensely during flu season. For N. hemisphere: Onset: October–November Peak: December–February (most often January) Decline: March Tail end: April–May (occasionally later) This is why we give shots until the end of February

Friday we lost a brilliant mind, colleague, and friend to her battle with pancreatic cancer. Those who knew her will remember Helene Andrews-Polymenis for her warmth, generosity and leadership. She will be missed by many. RIP

Excited to share research co-led by Gabby & Adam in @jem.org! Grateful to the NIH & @scripps.edu for support.

I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...

Feel better during the day than at night during #influenza? Find out the “Role of IL-10 signaling in the #circadian control of host response to influenza infection” www.mucosalimmunology.org/article/S193...

I'm happy to share a perspective that @soniamodilevsky.bsky.social and I wrote about a new and exciting paper in @science.org with big implications for IBD. Check it out: A bacterial toxin disarms gut defenses against inflammation | Science www.science.org/doi/10.1126/...

Another banger from the @harriswang.bsky.social Lab this month! “Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut” www.nature.com/articles/s41...

Very excited to share our latest work in Science on metagenomic editing (MetaEdit) of the gut microbiome in vivo & directly modifying unculturable immune-modulatory SFB bug in the small intestine. 🦠🧬🛠️ www.science.org/doi/10.1126/...