The Psychedelics & Pain Community on Circle for patients, facilitators, healthcare providers and others interested in how psychedelics can be effective tools for those living with pain conditions. •access to PPA’s research database •moderated w/ password-protection community.psychedelicsandpain.org

Excellent story from @aniloza.bsky.social and colleague at STAT on the MOSAIC program. www.statnews.com/2025/12/08/t... 1/4

Psilocybin helps the brain unlearn fear by silencing specific neural pathways

TIL about a memorial ceremony in Iceland in 2019 to mark the end of a glacier, changing the place name from Okjökull to Ok (jökull = glacier). Uncompromising wording on the bronze plaque: "This is to acknowledge that we know what is happening and what needs to be done. Only you know if we did it".

Further evidence that widespread covid vaccination is better for everybody.

For only the second time in recorded history, an Atlantic season has produced three Category 5 hurricanes... the previous year was 2005. This puts 2025 in an elite class of hurricane seasons. It also means that nearly 7% of all known Category 5 hurricanes have occurred just in this year. #Melissa

What do you think the findings of Zheng et al., published in @science.org’s #ScienceAdvances mean for the emotional experience of pain? Check out Qiufu Ma’s comment on this and his other #PapersoftheWeek picks here bit.ly/3LoHSjB #ScienceAdvances#PapersoftheWeek#PRF

Welcome to the new Dark Ages. In one self inflicted blow the US is giving up on knowledge generation, technical innovation and medical advances for a generation or more. This is Trump and Vought. This is their doing.

🧠The Amygdala in the brain makes and regulates Emotions. 👃People with post-COVID smell loss show microstructural changes in their Amygdala and have higher depression and anxiety scores. SARS-CoV-2 can affect smell & also emotions long term. buff.ly/904lVX4 #medsky 🛟😷🧪

Big week for all you second-gen psychedelics and non-hallucinatory neuroplastogens fans! New results from Zalsupindole - promotes greater neuroplasticity than ketamine, psilocybin, or DMT, without any of the pesky psychedelic side (fun?) effects. pubs.acs.org/doi/abs/10.1...

So they didn’t like the ad. Let’s just post Reagan’s 5 min speech against tariffs as it appears on YouTube. Over and over. On all platforms (some of y’all are still on X). *1981 Sherrilyn horrified by 2025 Sherrilyn saying “let’s post Reagan’s speech.” youtu.be/5t5QK03KXPc

Women are being erased at the Pentagon. Women are being erased from history. And now a woman has been erased from the desecrated White House.

Antarctica may have passed a climate tipping point of no return, scientists are warning, with mounting evidence that a sudden slump in sea ice formation since 2016 is linked to human-induced ocean warming.

“their nanoparticle-based vaccine can effectively prevent melanoma, pancreatic and triple-negative breast cancer in mice. Not only did up to 88% of the vaccinated mice remain tumor-free (depending on the cancer), but the vaccine reduced—and in some cases completely prevented—the cancer’s spread.”

Shingles vaccination is associated with a powerful reduction of the risk of dementia edzardernst.com/2025/10/shin...

Neuroscientists are starting to unravel the amygdala’s complexity, shedding new light on PTSD

New episode: Joe & Kyle on breathwork, creativity myths, DMT & stroke findings, and our next chapter in community. Tune in: bit.ly/3It5N0v

Has anyone performed a tone-pain conditioning task, specifically using a laser, in mice? If so, please answer this question on #PainResearcher bit.ly/3UKLXAl #PRF bit.ly/3VjLLZ9

In this article, Court Wing writes about the transdiagnostic potential of psychedelics, including but not limited to, MDMA, LSD, DMT, and Ibogaine. Learn more: maps.org/news/bulleti...

The only thing wrong with this editorial is that is too late. Where was this disbelief from 2020-2024? It’s been obvious for years that Makary snd Bhattacharya are bad faith actors. The evidence is abundant and public. sciencebasedmedicine.org/questions/

Called it on the couch at NYU…five years ago. www.nature.com/articles/s41...

Some interesting little details in this new study. Particularly fascinating is the suggestion some therapeutic benefits from psilocybin emerge out of the complex interplay between both 5-HT2a and 5-HT1a receptors. It's not just one or the other.

China started its own Visa to outcompete the US for talent since we recently tacked on a $100k fee. The plan they have could work but they are running into considerable domestic opposition. www.wired.com/story/china...

Your thoughts on the future of Long COVID clinics? www.medscape.com/viewarticle/...

Researchers increasingly seem to be moving data to EU platforms, primarily due to data privacy and surveillance concerns. I've also started to notice people who aren't in the tech world doing this too. Is anyone else observing this trend?

Whoa. From what I've seen it was tiny and would've burned up in our atmosphere, but I haven't seen any confirmation of that. If true we were in no danger.

#booksky for #literaryfiction 📚💙 Essay-review: Andrew Katzenstein on Thomas Pynchon’s latest novel, Shadow Ticket — brisker than his other work; it’s full of his usual vaudevillian sensibility & addresses his favorite theme: how to live freely under powerful systems of control. archive.is/DaP1B

We are thrilled to announce that our NEW Large Language Model will be released on 11.18.25.

If Homan got caught taking a bag of $50,000 in cash, who else in Trump’s administration is doing it? www.nytimes.com/2025/09/20/u...

🎯 Our signature Bullseye chart has just been refreshed, mapping the global pipeline of psychedelic drug candidates, from discovery through to (potential) approval. Explore the latest Bullseye Charts + the full live Tracker now: psychedelicalpha.com/news/q325-ps...

(1/10) We’re excited to share our new preprint (doi.org/10.1101/2025...), which uncovers the spatiomolecular landscape of the human nucleus accumbens (NAc), by integrating snRNA-seq with Visium spatial transcriptomics across 10 control donors. 🧠 #NAcLIBD #snRNAseq #10xVisium

This! NIH staff are doing heroic work to help save the scientific enterprise. If you are a PI, drop them an email and say thank you! I did last week!

Just published in World Psychiatry our study "Trauma under psychedelics: how psychoactive substances impact trauma processing" . Amazing work led by @ophirnetzer.bsky.social with the brave survivors of the Nova festival attack. Huge team effort, thx to all! 👉 doi.org/10.1002/wps....

Science is under siege from weaponised disinformation – posing a threat to human civilisation | Michael Mann and Peter Hotez

Trump & Vought are hijacking our government - stealing funds appropriated by Congress, throwing sand in the gears, ending programs Americans rely on. I see this first hand.

My Long Covid “brain fog” presents as a TBI & I agree with being…. “unprepared for the resentment toward me and the doubt in my diagnosis from my IQ measuring higher than average (although much lower than pre-injury) & for the slow devolution of respect in my knowledge and reasoning skills.”

It has often been suggested that psychotherapy works because patients expect it will work before they have even started treatment. But what if treatment expectations are an emergent phenomenon that develops in the course of psychotherapy and contributes to a successful outcome?

Just heard from someone who had a 1% grant not funded through NIMH. Why? Perhaps no payline for 2026? 2025 all full up? Unclear. But totally bonkers and indicative of the complete gutting of the NIH/NIMH senior and grants processing peeps. The ones who remain are working so hard.

I care for children in the hospital on inpatient & consult services. Most weeks there are at least a few kids admitted with vaccine preventable diseases. Often in children who can’t get vaccinated themselves. 15 years in pediatrics and I’ve never seen a single one admitted with vaccine injury.

@nature.com I love this article - but WHY are the only share options to X and Facebook when the whole point of the article is that science-based posts get more shares here? www.nature.com/articles/d41...

Good.

Was rummaging through old articles and found this one of Demetre Daskalakis. Apparently, back in 2013, he went to New York City's gay sex clubs and bathhouses and administered meningitis vaccines and helped beat an outbreak.

Can anyone recommend a real academic expert on left-wing extremism, terrorism (like eco-fascism), or left-wing authoritarian movements? Many seem to be partisans posing as researchers, rather than genuine researchers with partisan views.

BREAKING: BlueSky is blocking access to Mississippi. This is the No. 1 platform for @mississippifreepress.org. We ditched X for BlueSky early this year. And now, at 3 pm on a Friday, poof. I don't know what we'll do next. Keep up with us using our newsletter at mfp.ms/subscribe.

We still don’t know if microdosing psychedelics is effective or a placebo, but is it safe? Could microdosing activate cardiac 5HT2B receptors and cause valvulopathy? New work online at pubs.acs.org/doi/pdf/10.1... from @deffinger.bsky.social suggests that - at least in mice - the answer is no. 1/

Thomas Deininger uses plastic waste to create sculptures,or should I say,works of Genius!!!!!!

A good piece in @theatlantic.com by Rogé Karma, which offers another sharp critique of Macedo and Lee's "In Covid's Wake," which just recycles the greatest hits of COVID contrarianism. Because they're Princeton professors, it's gotten a lot of attention, but Rogé Karma takes it apart step by step.

The bidirectional interplay between central nerve system-driven symptoms and chronic primary pain provides valuable insight into potential therapeutic and prevention targets in chronic #pain management www.bjanaesthesia.org/article/S000...