Hofmann et al. propose a #ClotPro guided #algorithm for the initial haemostatic treatment of adult bleeding #trauma patients https://www.bjanaesthesia.org/article/S0007-0912(25)00708-1/fulltext

Ecarin clotting time (#ECT) was a more reliable point-of-care test for monitoring #argatroban concentration in heparin-induced thrombocytopenia (#HIT) than #aPTT https://www.bjanaesthesia.org/article/S0007-0912(25)00709-3/fulltext

Unresponsiveness under #dexmedetomidine was distinct from unresponsiveness under #propofol, and more similar to N2 sleep https://www.bjanaesthesia.org/article/S0007-0912(25)00721-4/fulltext

#Machinelearning models trained on descriptors of preceding #heartrate dynamics were able to accurate predict episodes of inadequate #anaesthesia https://www.bjanaesthesia.org/article/S0007-0912(25)00724-X/fulltext

New #BJA research - the #Bonferroniadjustment for generalised linear models in #anaesthesiaresearch was superior for controlling for #familywiseerrorrate https://www.bjanaesthesia.org/article/S0007-0912(25)00725-1/fulltext#BJA

Distinct patterns of cumulative #fluid balance trajectories emerge early in circulatory failure. Understanding these trends could reshape fluid management in #criticalcare.

#ESPEAR demonstrates that, for rib fractures, the current trial protocol for evaluating Erector Spinae Plane #ESP catheters requires modification before a definitive #RCT can proceed https://www.bjaopen.org/article/S2772-6096(25)00122-4/fulltext

#PaediatricSurgery shows very low in-hospital mortality (0.36%), representing 1 in 14 surgical cases. Across an 8-year period, paediatric surgical volumes fell post-pandemic and have not yet fully recovered https://www.bjaopen.org/article/S2772-6096(25)00129-7/fulltext

Can generative #AI reshape guideline development? This study compared #ChatGPT4 and #Gemini in generating recommendations for management of perioperative #neurocognitive disorder – watch what the authors found. Read the paper: https://www.bjanaesthesia.org/article/S0007-0912(25)00006-6/fulltext

Call for applications! Are you a UK-based non-professorial researcher in anaesthesia and/or related specialties? Submit your application to deliver the William Mapleson Lecture 2026! Deadline 27/2/26 https://www.bjanaesthesia.org/news-do/william-mapleson-lecture-applications-invited-bja-2026

#Opioid prescribing practices are a modifiable, actionable target for intervention. From national policy to perioperative prescribing decisions, this article outlines opportunities to reduce opioid-related harm https://www.bjaopen.org/article/S2772-6096(25)00133-9/fulltext

CALL FOR PAPERS! Submit your article on #perioperative #haemodynamic #management for the next BJA Special Issue! Deadline for submissions: 31st Dec 2026

Are wearables always better? In older adults, accelerometer data failed to outperform the M-DASI-4Q questionnaire for identifying reduced functional capacity and #frailty https://www.bjaopen.org/article/S2772-6096(25)00134-0/fulltext

The BJA editors depend on the expert opinion of outside reviewers in making decisions about manuscripts submitted to the British Journal of Anaesthesia and would like to thank the following reviewers for their help during 2025. Thank you! #peerreview #science

Bilateral transperineal pudendal nerve block offers effective analgesia for #haemorrhoid surgery. This trial will compare efficacy and complications of blind nerve stimulator vs ultrasound-guided techniques https://www.bjaopen.org/article/S2772-6096(25)00136-4/fulltext

Call for applications! Are you a UK-based non-professorial researcher in anaesthesia and/or related specialties? Submit your application to deliver the William Mapleson Lecture 2026! Deadline 27/2/26 https://www.bjanaesthesia.org/news-do/william-mapleson-lecture-applications-invited-bja-2026

#TAVI is often performed under local anaesthetic with conscious sedation #LA-CS. Data from #SOLVE-TAVI suggest LA-CS patients reach #BIS depths typical of general anaesthesia – raising questions about over-sedation https://www.bjaopen.org/article/S2772-6096(25)00126-1/fulltext

Ovsak & Gan look at Huang et al.’s analysis around #GLP-1RA’s and #gastricemptying and ask who qualifies as ‘high risk’ enough to require a 24h liquid diet preoperatively? https://www.bjanaesthesia.org/article/S0007-0912(25)00685-3/fulltext

Check out the January issue of the BJA #miniflipbook with articles on: #hyperfibrinolysis #paediatricfasting #climateresilience #opioiduse #mitochondrialbioenergetics and the #DAS2025 guidelines https://ow.ly/MYzM50XW0a6#miniflipbook#hyperfibrinolysis#paediatricfasting#climateresilience#opioiduse#mitochondrialbioenergetics#DAS2025#AnSky#MedSky

Is nociplastic pain, such as fibromyalgia, associated with impaired executive function? This visual abstract highlights findings from a recent prospective cohort study by Kelleher et al. exploring this relationship. Read more: https://www.bjanaesthesia.org/article/S0007-0912(25)00530-6/fulltext

Thank you to our international team of peer reviewers at #BJAOpen. We value and depend on the expert opinion of scientific reviewers to guide editorial decision making and to provide high-quality and impactful science. Thank you!

More around #GLP-1RA’s and #fasting – does an overly restrictive regime introduce unintended harm? What #factors affect #pulmonaryaspiration risk? https://www.bjanaesthesia.org/article/S0007-0912(25)00692-0/fulltext

Perioperative #dexmedetomidine did not reduce death or complications in adults undergoing #CPB assisted #cardiacsurgery https://www.bjanaesthesia.org/article/S0007-0912(25)00691-9/fulltext

New #DAS2025 guidelines for management of unanticipated difficult adult #trachealintubation with an emphasis on maximising likelihood of success at the #firstattempt https://www.bjanaesthesia.org/article/S0007-0912(25)00693-2/fulltext

α2-adrenergic receptor agonists are safe at clinical doses on healthy nerves but can increase neurotoxicity in compromised nerves – new #systematicreview from #BJA https://www.bjanaesthesia.org/article/S0007-0912(25)00700-7/fulltext

#Transcriptomic #meta-analysis of #immunecells in #chronicpain conditions identified genes and sex-specific signatures in this new study from Perez & Tawflig https://www.bjanaesthesia.org/article/S0007-0912(25)00664-6/fulltext

Would you like to become a member of the British Journal of Anaesthesia Editorial Board of BJA Education? The BJA is seeking applicants with expertise in: ➡️Intensive care medicine ➡️General anaesthesia ➡️Perioperative medicine ➡️Regional anaesthesia Learn more 👉 https://ow.ly/t4hz50Y00rG

@katy-skier.bsky.social @acumpstey.bsky.social & @tomabbott.bsky.social (social media editor for @bjajournals.bsky.social) discuss the growing importance of social media in scientific communication, alternative metrics, and platform trials in clinical research. www.topmedtalk.com/podcasts/the...

Check out the January issue of the BJA #miniflipbook with articles on: #hyperfibrinolysis #paediatricfasting #climateresilience #opioiduse #mitochondrialbioenergetics and the #DAS2025 guidelines https://ow.ly/MYzM50XW0a6#miniflipbook#hyperfibrinolysis#paediatricfasting#climateresilience#opioiduse#mitochondrialbioenergetics#DAS2025#AnSky#MedSky

Does obstructive sleep disordered breathing (#oSDB) severity predict post-adenotonsillectomy pain? Frigon et al. found three distinct pain trajectories related to oSDB severity and early pain scores https://www.bjanaesthesia.org/article/S0007-0912(25)00665-8/fulltext

Differences in the activity and #functionalconnectivity of the rodent cerebellar vermis and somatosensory-motor cortex could contribute to sex differences in #acutepainperception https://www.bjanaesthesia.org/article/S0007-0912(25)00666-X/fulltext

The Mrgprd receptor in mouse #dorsalrootganglion neurones could be providing a key role in the progression of #opioidtolerance https://www.bjanaesthesia.org/article/S0007-0912(25)00667-1/fulltext

In non-Asian patients undergoing #cardiacsurgery with #CPB, low-dose landiolol did not reduce incidence of postoperative #atrialfibrillation https://www.bjanaesthesia.org/article/S0007-0912(25)00669-5/fulltext

Can #prehab really improve #recovery after colorectal surgery? Watch this new video as Dr Chelsia Gillis explains the results of a pragmatic #RCT that explore the effect of prehab on length of stay, protein inadequacy, and functional recovery. #ERAS https://youtu.be/W1GYI4DEwNc

#Propofol exposure increased #apoptosis and #autophagy in #cerebralorganoids and correlated with #RNAdysregulation in clinical serum profiling from #paediatricanaesthesia patients https://www.bjanaesthesia.org/article/S0007-0912(25)00670-1/fulltext

This single-centre double-blind #RCT showed #argipressin infusion vs #placebo did not affect blood loss or transfusion requirements in #hepaticresection, but did lower #postoperativecomplications https://www.bjanaesthesia.org/article/S0007-0912(25)00672-5/fulltext

Check out the January issue of the BJA #miniflipbook with articles on: #hyperfibrinolysis #paediatricfasting #climateresilience #opioiduse #mitochondrialbioenergetics and the #DAS2025 guidelines https://ow.ly/MYzM50XW0a6#miniflipbook#hyperfibrinolysis#paediatricfasting#climateresilience#opioiduse#mitochondrialbioenergetics#DAS2025#AnSky#MedSky

A new #nationalsurvey of #anaesthetistsintraining with over 5 years’ experience reveals low levels of confidence with #paediatricresuscitation and #stabilisation, particularly under the age of 1 https://www.bjanaesthesia.org/article/S0007-0912(25)00640-3/fulltext

New in the #BJA – a seven-step guide to facilitate the use of entrustment-supervision scales embedded within #SLEs https://www.bjanaesthesia.org/article/S0007-0912(25)00641-5/fulltext

#Benzodiazepines do not improve #pain or quality of recovery & have an uncertain effect on #patientsatisfaction in this new #systematicreview and #meta-analysis https://www.bjanaesthesia.org/article/S0007-0912(25)00663-4/fulltext

How can one explain #brainfog in individuals experiencing nociplastic #pain symptoms? In this new video, Dr Kelleher analyses the association between executive function and nociplastic pain. Read the full paper here: https://www.bjanaesthesia.org/article/S0007-0912(25)00530-6/fulltext

The #NAP8 team discuss why they chose to focus on #regionalanaesthesia (and other) complications and the potential #challenges that lie ahead for the project https://www.bjanaesthesia.org/article/S0007-0912(25)00630-0/fulltext

Check out the January issue of the BJA #miniflipbook with articles on: #hyperfibrinolysis #paediatricfasting #climateresilience #opioiduse #mitochondrialbioenergetics and the #DAS2025 guidelines https://ow.ly/1NOn50XVY34#miniflipbook#hyperfibrinolysis#paediatricfasting#climateresilience#opioiduse#mitochondrialbioenergetics#DAS2025#AnSky#MedSky

New #BJA #editorial discussing the ASRA vs PAUSE-2 approaches to #DOACs with #neuraxialanaesthesia and deep peripheral nerve blocks (#PNBs) – can a shorter interruption period offer comparable safety? https://www.bjanaesthesia.org/article/S0007-0912(25)00631-2/fulltext

Recorded at @bjajournals.bsky.social AGM, this week’s @topmedtalk.bsky.social looks at translational research. @acumpstey.bsky.social, @katy-skier.bsky.social & Gareth Ackland discuss the autonomic nervous system and its implications for postoperative outcomes. www.topmedtalk.com/podcasts/unr...

Propofol can attenuate the #renoprotective effects of remote ischaemic preconditioning (#RIPC) compared with #sevoflurane – new from the #HypnoRenalRIP https://www.bjanaesthesia.org/article/S0007-0912(25)00632-4/fulltext

#Plasma resuscitation reduced #systemicinflammation vs #balancedsaltsolution after induced low-dose #LPS #endotoxaemia but did not affect #glycocalyx degradation https://www.bjanaesthesia.org/article/S0007-0912(25)00638-5/fulltext

A #physiology-based framework for personalised #PEEP management during #generalanaesthesia in #patientswithobesity from Boesing et al. https://www.bjanaesthesia.org/article/S0007-0912(25)00639-7/fulltext

#Anaesthetists are leading efforts to reduce #N2O usage, via mitigation of leaks and reduced clinical use, but more work is needed to further reduce its #environmentaleffects https://www.bjanaesthesia.org/article/S0007-0912(25)00613-0/fulltext

#Propofol can directly target the #locuscoeruleus #norepinephrine neurone axons to suppress presynaptic norepinephrine release as an in vivo presynaptic mechanism of its #generalanaesthesia effects https://www.bjanaesthesia.org/article/S0007-0912(25)00615-4/fulltext