Who Is Mariano Barbacid? The Scientist Behind Pancreatic Cancer's Biggest Breakthrough | #cancer #PancreaticCancer

An update to the Hallmarks of Cancer framework for understanding (and researching) what causes human cancers. spkl.io/63321Aqwbc Douglas Hanahan @cp-cell.bsky.social

This #AI has chemical expertise -- and helps synthesize 35 new compounds | #ChemSky #CompChemSky

Surprising way #cancer cells clear problematic proteins in the brain | #Alzheimers

A paper in Nature presents AlphaGenome, a deep learning model that can predict the function of long DNA sequences, up to one million base pairs. The tool can predict how DNA sequence variations affect different biological processes. go.nature.com/4t5JQa7 🧬 🧪

A few roses from the garden. #bloomscrolling

Anthropic looks to raise $20 billion at more than $300 billion valuation, according to reports.

Roses from our walk this morning. | #bloomscrolling

The AACR is pleased to announce the Fellows of the AACR Academy Class of 2026. The Academy honors distinguished scientists whose contributions have propelled significant advances in cancer research and treatment. Learn more: buff.ly/ZZ268R4 #AACRFellows

Sunset at low tide. Ocean Beach, San Diego, California #SanDiego #sunset #OceanBeach #landscapelovers

Scientists just cracked the hidden rules of #cancer #evolution

J.P. Morgan Healthcare Conference books S.F. for three more years - San Francisco Business Times www.bizjournals.com/sanfrancisco...

🚀New @IHIEurope project launched: LIGAND-AI. Led by @thesgconline & @Pfizer_UK, the project will generate open protein-ligand interaction datasets to power AI models for drug discovery. EMBL-EBI will archive data & integrate results into @ChEMBL. www.ebi.ac.uk/about/news/t... #OpenData

Why Pancreatic Cancer is So Deadly: New Study Reveals Hidden Invasion Pathway | #cancer #PancreaticCancer

Discovery reveals how acetylation controls key enzyme linked to cancer growth | #cancer

Three years after launching from the lab of University of California, San Francisco chemist Jim Wells, the start-up EpiBiologics has raised $107 million in series B funding to propel its protein-degrading drug candidates into human trials. cen.acs.org/pharmaceutic... #chemsky 🧪

A one-shot gene therapy to make a lifetime's worth of GLP-1 (like Ozempic) @FractylHealth. But it requires direct injection to the pancreas and there are lots of unknowns. A clinical trial is starting soon. Front page @washingtonpost.com today gift link www.washingtonpost.com/health/2026/...

Just re-read the wonderful "How to write consistently boring scientific literature" As important as ever with the increasing amount of homogeneous AI-generated/inspired text doi.org/10.1111/j.00...

September 3rd 2024 Geraniums

Heavy. Ocean Beach, San Diego, California #SanDiego #OceanBeach

Researchers have unveiled DrugCLIP, a new AI-driven screening program they say could speed up drug discovery. cen.acs.org/pharmaceutic... #chemsky 🧪

Corcept racks up phase 3 #cancer win to bounce back from FDA Cushing’s rejection

A beautiful white rose from our morning walk. | #bloomscrolling

The needle in the haystack problem: spotting novel drug targets among redundant evidence. Our solution? A time-series novelty metric for Open Targets Platform associations. Thanks to Coté Falaguera & @opentargets.org partners for making this happen.

Nice piece on recent work published in ACS Cent Sci 👏 axial.acs.org/medicinal-ch...

Why do so many apparently healthy people die or get severely ill from infections that would be considered low risk? For one, we don't have any way of assessing a person's immune system function in the clinic nature.com/articles/d41...

A vaccine to prevent colon cancer. Proof-of-concept for strong immune response and safety via neoantigens given to people carrying mutations for Lynch syndrome nature.com/articles/s41...

The Shingles vaccine is linked to slowing biological aging and reducing inflammation academic.oup.com/biomedgeront...

Good!

✨PUBLISHED @natgenet.nature.com 📰Tamoxifen induces PI3K activation in #uterinecancer. By Kirsten Kübler, Gad Getz, Rinath Jeselsohn and colleagues. ⬇️ www.nature.com/articles/s41...

In silico agrees on $66M deal to split rights for preclinical NLRP3 inhibitor with new Chinese biotech

Blossoms from our plum tree last spring. #bloomscrolling

A decades-long push to identify clear biomarkers for anxiety and depression is at last achieving results.

In a post to Github on Tuesday, the social media giant purported to share its secret sauce.

Isomorphic has signed its third pharma deal, this time with J&J, to further advance AI-made drugs. endpoints.news/jj-isomorphi...

Art of the Deal

I built an alternative Jupyter frontend as a native Mac app. It's also reactive (no weird state issues), supports SQL as first class, has autocomplete, is uv-native amd works with agents (like an *existing* ChatGPT subscription that you already pay for)

Simple blood test can predict which breast cancer treatment will work best, study finds | #cancer #BreastCancer

Millions of people worldwide carry genetic mutations that weaken their immune system. A feature in Nature reports on the research to find ways to treat and prevent severe infections in those people. #medsky 🧪

DNA's hidden 'traffic controller' protein may hold clues to #cancer prevention

Kids with brain #cancer were already in a life and death struggle. Then came Trump

Chemist determine the structure of fuzzy coat that surrounds tau proteins | #Alzheimers #proteomics #genesky

How’s biopharma feeling heading into 2026? We asked everyone at Endpoints at #JPM26 — and the answers land somewhere between breakthrough and cautious optimism. Follow the latest from San Francisco in our live blog: endpoints.news/jpm26-day-3-...

Not good to see the rise in p-tau181, a marker of brain inflammation tied to increased risk of Alzheimer's disease, in a prospective cohort (mean age 56 years) with #LongCovid and neurological symptoms www.thelancet.com/journals/ebi...

STAT"s @matthewherper.bsky.social gives a run down on how #JPM26 has been thus far. Check out all our coverage of the event here: www.statnews.com/topic/jpm/

I wonder how many could have predicted this finding - AI tools boost individual scientists but could limit research topics www.nature.com/articles/d41... www.nature.com/articles/s41... 🧪

Aurora Therapeutics has emerged from stealth with $16 million in funding from Menlo Ventures to expand the potential of gene editing to treat rare diseases. Its initial program focuses on phenylketonuria, a genetic metabolic disorder. cen.acs.org/business/sta... #chemsky 🧪

Scientists finally uncover why statins cause muscle pain