New preprint alert: we use sign errors as a test of how well TWAS works. Very worryingly we find that TWAS gets the sign wrong around 1/3 of the time (compared to 50% for pure guessing). You can read more about our analysis here, and what we think is going on 👇

So, who are the the Functional Genomics Working Group? 🎯Our goal is to understand how genes🧬, cells🦠and molecules💠contribute to psychiatric disorders🧠 We work with other PGC groups and different 'omics data (methylation, cytometry, single cell etc.) to do this🧪 🧵1/3

Phenomenal talk from @hyejungwon.bsky.social who is visiting us @lieberinstitute.bsky.social for the day. Groundbreaking work w/ important implications and roadmap for using rapidly emerging information on psychiatric genetics to prioritize variants and understand their impact on 🧠 function

Our "Atlas of Variant Effects 2030 Roadmap" is live: zenodo.org/records/1542... 1/n

How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬 New paper out in @natcomms.nature.com today: www.nature.com/articles/s41... @ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social

Silencing of transgenes during iPSC differentiation is a frequent problem. 🧬🫢 Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪 Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!

Watch the video📽️attached to see what each of these awesome #FemsinSTEM are up to! 🧵3/3

Very good new preprint by @nanamatoba.bsky.social @hyejungwon.bsky.social @steinlab.bsky.social, using a Massively Parallel Reporter Assay to gain insight into regulatory elements associated with inter-individual differences in cortical structure (Wnt response sensitivity plays a prominent role)🧪🧠🧬

1/ I am beyond thrilled to share our new paper in @CellCellPress! We explored the regulatory principles underlying pleiotropy in psychiatric disorders. www.cell.com/cell/abstrac...

Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders @cellcellpress.bsky.social @hyejungwon.bsky.social cell.com/cell/fulltex...

Very elegant Massively Parallel Reporter Assay approach pursued by @hyejungwon.bsky.social & members of her group to reveal shared genetic variants of eight psychiatric disorders, out in Cell: www.cell.com/cell/abstrac...

OK, I've made a Starter Pack on Neuroepigenetics, Chromatin, and Gene Regulation! Please share and let me know who else should be added to this list. go.bsky.app/6LWE4dr