New preprint from our lab, led by our postdocs Dara Annett and Kate Morling in collaboration with Selwood Lab! We developed a modified cyclosporine, BG147, which enhances lentivector gene therapy transduction, ex vivo in HSPC and in vivo in mouse photoreceptors, by degrading IFITM3. Check it out!

Very excited to see our work appear alongside findings from @aaronwhiteley.bsky.social & @benmorehouse.bsky.social ! www.nature.com/articles/s41...

Are viruses capable of regulating protein synthesis in the nuanced way of cellular organisms? Kinda! I’m excited to share some of my postdoc work that leveraged giant DNA viruses to address this question.

Now online at @nature.com we show how the Panoptes defense system protects against viruses that attempt immune evasion - and expands our understanding of the role of oligonucleotides in immunity. Check out this work co-led with @benadler.bsky.social here: www.nature.com/articles/s41...

Jane Goodall, primatologist and ambassador for #wildlife, dies at 91. Her research transformed our understanding of wild #chimpanzees and their behavior. She inspired many young scientists. A life in pictures: www.nytimes.com/2025/10/01/s... #rip #janegoodall @nytimes.com

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

🚀We’re hiring! Join our international team at @ciid-heidelberg.bsky.social and @uniheidelberg.bsky.social as a PhD Student or Postdoctoral Researcher to lead cutting edge research projects at the virus-host interface Postdoc: tinyurl.com/d5sdhbnp PhD: tinyurl.com/bdz5e5u6

"If we lose hope, we're doomed." We must continue Dr. Jane Goodall's mission and all fight for the future of the planet.

Jane Goodall, the trailblazing naturalist whose intimate observations of chimpanzees in the African wild produced powerful insights that transformed basic conceptions of humankind, has died. She was 91. Read more about her legacy www.latimes.com/obituaries/s...

Jane Goodall, world-renowned primatologist, dies aged 91

Beginner's charm 😊 Want to do disruptive #science? Papers from #research teams with a substantial number of beginners are highly disruptive and innovative, a new study shows. www.nature.com/articles/d41... @nature.com #ScienceCareer

🚨 New paper in Eurosurveillance - @karatasmustafa.bsky.social We used shotgun metagenomics on indoor air in a Belgian daycare to track respiratory, enteric & skin viruses. 👉 40/42 samples contained human viruses—even when kids seemed healthy! 📄 Read here: pubmed.ncbi.nlm.nih.gov/41000028/

Super interesting virus: #hepatitas 😅 E virus #HEV! @daothilab.bsky.social looked into its ORF2 protein and how it counteracts cell-intrinsic immune responses. Congrats Ann-Kathrin, Loan and team, and thanks for having us on board! dx.plos.org/10.1371/jour... (Hepatitas® by the Orange Superbrain)

Size distribution and viral RNA load of influenza virus-laden airborne particles emitted from pigs over the course of an H1N1 infection www.nature.com/articles/s41...

Viro3D paper is out! We predicted 85,000 protein structures from human & animal viruses. 1/5 🧵 📑 Paper doi.org/10.1038/s443... 🔭 Explore virosphere viro3d.cvr.gla.ac.uk

🚨 New Web Resource Alert! 🚨 We're delighted to share Viro3D a database of >85000 viral protein structure predictions from >4400 human & animal viruses. 🔗 viro3d.cvr.gla.ac.uk 📄 www.embopress.org/doi/full/10.... @molsystbiol.org @cvrinfo.bsky.social @uofgmvls.bsky.social #Virology #AlphaFold 🧪 🦠

Cryo-EM structure of influenza polymerase bound to the cRNA promoter provides insights into the mechanism of virus replication https://www.biorxiv.org/content/10.1101/2025.09.23.677976v1

www.nature.com/articles/s41... Stunning work from the Chandran lab!

Finding the tick-borne encephalitis cellular gateway could transform prevention and treatment go.nature.com/3Kqp5E9

A one-time gene therapy can markedly slow the progression of Huntington’s disease, potentially paving the way for the first ever treatment to alter the course of this rare, inherited brain disorder. go.nature.com/4nu6YMs

🚨 Latest publication from our group and our exceptional collaborators. Led by postdoctoral fellows Drs. Chiok and Jenik. We attempted to test the permissivity of diverse patient origin airway organoid-derived cultures to MERS-CoV and SARS-CoV-2. #LZCI #LoveVirology journals.asm.org/doi/10.1128/...

I am delighted to share this preprint describing the structure and transcriptomics analysis of adenovirus D10 - a fantastic collaboration - and a lot of hard work by Kasim and Rosie.

And the sister paper from collaborator and good friend Katie Doores ... A deeper dive into how some of these broadly neutralising #sarbecovirus #coronavirus #sars2 #covid antibodies actually work www.biorxiv.org/content/10.1...

Our first post on here and it's a doozy 😍🤩. Our epic piece on #sarbecovirus host range. #virology #sars2 #covid #vaccines. Enjoy and please repost. www.biorxiv.org/content/10.1...

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

www.biorxiv.org/content/10.1... #microsky but feels more like Horrible Histories!

We helped identifying the kinase JNK as a host factor for successfull coronavirus infection. JNK regulates phosporylation of the the common cold human coronavirus 229E nuleocapsid protein. You can read about it in npj Viruses: www.nature.com/articles/s44... #TRACiR #corona #science #virus #rub

🚨📝 New work via @thepandemicinst.bsky.social now preprinted! We took ~19000 sequences of avian influenza virus and trained machine learning models on >40000 genomic/proteomic features - the resulting ensemble can predict zoonotic potential with AUC=0.95. More below! www.biorxiv.org/content/10.1...

Our latest preprint evaluates sampling strategies for the detection of avian influenza virus from the environment @profgemmell.bsky.social @dwinter.bsky.social www.biorxiv.org/content/10.1...

I am very excited to share our preprint: ‘Divergent antibody-mediated population immunity to H5, H7 and H9 subtype potential pandemic influenza viruses’. The first authors are Lucas Benjamin Stolle, Jai Bolton, Rebecca Steventon & Reanna Gregory. lnkd.in/eeYmfvdE

Excited to announce our latest preprint, exploring the stereochemistry & antiviral properties of natural product MM46115 (pellemicin) against influenza. 🦠 💊 Big thanks to all co authors, including @afifahtasnim.bsky.social @craigpthomp.bsky.social and others. www.biorxiv.org/content/10.1...

🧪🍎📃 Important new study: Animal products, especially beef, pose much higher extinction risks for wildlife than grains, legumes, or vegetables. This means shifting land use toward more plant-based diets can give greater opportunities to restore biodiversity and help save species from extinction.

Beer drinkers were 44% more attractive to mosquitoes than people who had abstained for at least 12 hours, cannabis users were 35% more attractive, and those who had slept with someone else the night before were 46% more attractive, new research finds. https://scim.ag/3Vk5rMw

Highly pathogenic avian influenza H5N1 reaches Gough Island, where it is associated with mortality in three Tristan skuas. This is worrying because Gough Island is an important breeding site for seabirds, including several species of global conservation concern. www.biorxiv.org/content/10.1...

In new study led by Xiaohui Ju, we define how mutations to Chikungunya virus envelope proteins affect entry in human vs mosquito cells. Sheds light on functional constraints & enables us to make loss-of-tropism mutants, which could be of use for vaccines. www.biorxiv.org/content/10.1...

In new study led by @ckikawa.bsky.social, we provide near real-time data on human neutralizing antibody landscape to influenza by measuring ~26,000 titers to >100 recent viral strains Data can inform vaccine selection & evolutionary/epidemiological modeling www.biorxiv.org/content/10.1...

Understanding the future risk of bat coronavirus spillover into humans: correlating sarbecovirus receptor usage, host range, and antigenicity. https://www.biorxiv.org/content/10.1101/2025.09.03.673949v1

'TRIM28 is a target for paramyxovirus V proteins'. Work led by Gauthier Lieber seeks to address whether host activation of endogenous retroelements contributes to antiviral defences. In support of this idea, he describes a viral mechanism that might limit this host response. doi.org/10.1371/jour...

I am excited to share my graduate work in the Sabatini and @bartellab.bsky.social labs. Since their discovery, we have known lysosomes possess RNase activity; however, their substrates were not known. Surprisingly we find specific RNAs are targeted for degradation! www.biorxiv.org/content/10.1...

New preprint! 🥳🎉 We looked at viral coinfection patterns at the largest scale ever in wildlife. We found a strong association among CoVs, PMVs, and influenza A, and higher coinfection rates in wildlife trade; plus, evidence that bats accumulate persistent infections. www.biorxiv.org/content/10.1...

Cow B3.13 vs EA-2020-C: 🔺 replication in cow mammary gland cells, 🔺 viral polymerase activity + 🔺 interferon antagonism in cow cells. Many IAVs able to replicated in bovine cells, particularly mammary gland. 👉 www.biorxiv.org/content/10.1...

New paper alert! We suggest caution in the analyses of viral auxiliary metabolic genes and propose a new overarching term - 'auxiliary viral genes' (AVGs) to describe different types of such genes. @simrouxvirus.bsky.social #phagesky #Microsky www.nature.com/articles/s41...

#Perspective A discussion on virus-encoded auxiliary metabolic genes and a framework for the biological interpretation of these genes. #MicroSky 🦠 www.nature.com/articles/s41...

Influenza A virus circumvents the innate immune response through the sequestration of double-stranded RNA journals.asm.org/doi/10.1128/...

Effect of increased CpG and UpA dinucleotides in the West Nile virus genome on virus transmission by Culex mosquitoes and pathogenesis in a vertebrate host journals.asm.org/doi/10.1128/...

Pre-print: our description of RZ affiliate ZNFX1 is now online. On binding viral RNA, ZNFX1 generates parallel Ub currents, coordinating Ub-dependent RNA silencing and aggregate resolution. Huge effort from first authors Dan Squair and @eilidhrivers.bsky.social www.biorxiv.org/content/10.1...

Coronavirus NSP14 Drives Internal m7G Modification to Rewire Host Splicing and Promote Viral Replication https://www.biorxiv.org/content/10.1101/2025.09.03.673802v1

📖Publication Alert🚨 Our PhD student @sjanshoff.bsky.social published a paper on the prevalence of the emerging Alongshanvirus (ALSV) in horses across the Americas, Europe and Oceania 🐎🌍 www.sciencedirect.com/science/arti... #TRACiR #virology #scicomm #teamscience

The cow udder may be a mixing vessel where different strains of influenza can recombine--"underscoring its potential role in generating novel influenza viruses with pandemic risk." [Preprint] www.biorxiv.org/content/10.1...

The cow udder is a potential mixing vessel for influenza A viruses https://www.biorxiv.org/content/10.1101/2025.08.29.673079v1