Proud to see our work featured in the broader context of the Human Cell Atlas with us focusing on chronic muscle and brain inflammation | www.swr.de/wissen/human...

🚨 New preprint: Topography Aware Optimal Transport for Alignment of Spatial Omics Data We present our new alignment framework TOAST www.biorxiv.org/content/10.1...

Deep cervical lymph nodes of patients with multiple sclerosis have an altered B cell compartment that transcriptionally resembles an EBV infection @sciimmunology.bsky.social www.science.org/doi/10.1126/...

Excellent - congrats

🚗 NEW #NatureMedicine paper reports results from a first-in-human trial of CAR-macrophages! Safe & feasible to manufacture, efficacy limited. More work needed in this space! @natureportfolio.nature.com #immunotherapy #CARTcells #macrophages www.nature.com/articles/s41...

Rare disease research relies on collecting genomic and clinical data across multiple countries. Learn more about the Solve-RD project and how it aims to collect and harmonise #raredisease data across multiple European partners. 🧬🖥️ www.ebi.ac.uk/about/news/a...

Great piece of work, congrats

Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe2+ through TRPML1 channel www.nature.com/articles/s41... @naturecomms.bsky.social

Excited to see Moscot (moscot-tools.org) published in @Nature! We scaled Optimal Transport (OT) in single-cell genomics & added multimodality together with spatiotemporal trajectory inference, finding exciting new biology in the pancreas! 🚀 Read at www.nature.com/articles/s41...

Great work, Ethan and team, congrats!

Molecular dynamics of neural stem cells (NSCs) and their surrounding niche in the #aging mouse #hippocampus using multimodal transcriptomics 🧪🧠 www.nature.com/articles/s41...

A new large language of life model (LLLM) for the transcriptome that predicts gene expression within and across human cell types www.nature.com/articles/s41... @nature.com For more on the remarkable surge of LLLMs see erictopol.substack.com/p/learning-t...

Method of moments framework for differential expression analysis of single-cell RNA sequencing data www.cell.com/cell/fullte...

How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3) doi.org/10.1038/s415...

A single-cell mass cytometry-based atlas of the developing mouse brain 🧪🧠 www.nature.com/articles/s41...

Transsynaptic labeling and transcriptional control of zebrafish neural circuits using trans-Tango 🧪🧠 www.nature.com/articles/s41...

Happy holidays with a new review about what glial cells are doing in MS patholoy featuring latest developments and tools, thanks @kooistrasm.bsky.social for teaming up and putting this together - have fun reading: onlinelibrary.wiley.com/doi/10.1002/...

Our ChromBPNet preprint out! www.biorxiv.org/content/10.1... Huge congrats to Anusri! This was quite a slog (for both of us) but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Bluetorial coming soon below 1/

Big congrats to the team - beautiful single cell atlas of MS brain pathology

Fantastic work - congrats

Happy to share our review on how different lipids shape microglial biology in #GLIA journal. 💫 onlinelibrary.wiley.com/doi/full/10.... 👉🏽with Gaurav Chopra, Caitlin Randolph, and @katherinewalker.bsky.social

@marissascavuzzo.bsky.social, @lschirmer.bsky.social, @mtvector.bsky.social, Yin Shen, @sloanlab.bsky.social, Na Sun, @tesarlab.bsky.social, @fabiantheis.bsky.social, @tollkuhn.bsky.social, Maria Antonietta Tosches, Madeleine Urbanek, Christopher Walsh, ...

In @science.org this week, Simic, Watchmaker, Zamvil, Okada, and Lim engineer #TCells specific for #CNS #ECM antigens to deliver payloads selectively to the #brain!

Wonderful to see our latest work out in Nat Neurosci side by side with the special collection articles on single-cell omics in neuroscience. Kudos again to @celialm.bsky.social and @paubadiam.bsky.social for carrying this piece over the line www.nature.com/articles/s41...

Beautiful collection - was fun contributing, thanks

Our Alliance provides seed-funds for testing innovative ideas develop high-end technologies. Call for all Alliance members to apply jointly with Core Facility / Technology Platform members. Apply by January 24, 2025. More details on our webpage: www.health-life-sciences.de/opportunitie...

Fantastic Grand Round by Francisco Quintana @harvardmed.bsky.social here at the Medical Facultx Mannheim, Heidelberg University. Great discussions, many new ideas exchanged on CNS immunity. @researchlifesci.bsky.social @neurooncologyhd.bsky.social