This one is a bit of a departure from the usual and definitely a work in progress! We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below. Read on for details... 1/x

🚨 We have an open #postdoc position to join my new group at the University of Milan🇮🇹 to pioneer innovative #antiviral strategies using novel protein degradation technologies🧬🦠 🔗 Details below 🔬 If you are a molecular biologist interested in viruses and new technologies, get in touch!! ✉️ #hiring #TPD

RFK Jr. is upset that a recent large Danish study in Annals of Internal Medicine, conducted over 20 yrs in 1 M kids, found no association between aluminum in childhood vaccines & 50 different health conditions. His request for the retraction was rejected. 🧪 www.reuters.com/business/hea...

We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).

And of course, it was fantastic as always to listen to Richard Henderson and Nigel Unwin

Awesome lineup for the “Structure of Bacteriorhodopsin: 50 Years On” symposium @mrclmb.bsky.social : Niko Grigorieff, John Rubinstein, Gebhard Schertler, Bridget Carragher, and many more.

I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs. Plant, Bacterial, Archaeal Non-model Bioeng Custom Lab Hardware Turn Key Genetic Design Please repost for reach 💚

Really cool work on diffusing structures into cryo-EM densities by Ellen Zhong et. al arxiv.org/html/2506.04... #cryoem

🚨 We're Hiring! We're looking for a passionate and skilled EM Specialist to join our team! 📅 Application Deadline: July 9th, 2025 🔗 Learn more and apply here: careers.humantechnopole.it/o/electron-m...

Hey, I’m looking for a bachelor level textbook on Synthetic Biology (ok for students with basic molecular biology knowledge): any suggestions please?? Perhaps @atinygreencell.bsky.social ?

A Florida weatherman telling his viewers he can no longer be confident in his forecasts due to cuts to atmospheric science is the kind of resistance content I’m here for. Kudos, Sir.🌦️

15+ open positions are up on our #SynBio Job Board for early, mid-career and late-career professionals! Discover the jobs here: community.igem.org/job-board

Finisce nel modo più inglorioso uno dei più grandi fallimenti politici ed economici della Repubblica. I centri per migranti in Albania, costati 933 milioni di €, a detta del Premier Rama, non possono funzionare. Ecco cosa succede quando governi a colpi di slogan e propaganda.

David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏 youtu.be/8YhJM6zxYDw?...

Molto ben scritto! Diffondete anche e soprattutto fuori di questa bolla.

Friends, if anyone is looking for an electron microscopist outside of the US, I'm listening. Open to any country, regardless of weather. Can do cryo, room temp, image anything from tissues to nanoparticles, viruses, catalysts, etc. Thanks for any lead(s).

Almost every line of this story would have been simply unbelievable a few months ago: —Pioneering cancer researcher; —*Arrested* at airport in Boston; —Now indefinite ICE detention in Louisiana; —"Crime": not declaring some frog-embryo samples for research. Read it. www.nbcnews.com/news/us-news...

I wished Columbia had done the right thing, too.

Highly recommended PhD opportunity!

'(...) German research institute BioMed X is stepping in to offer a lifeline. The institute has opened a matchmaking program to align threatened NIH grants with potential new funders from the pharmaceutical industry.' www.fiercebiotech.com/research/ger...

Noticeably silent amid the upheaval at HHS? Big pharma. Every new drug has NIH somewhere in its DNA--and NIH funding supports the training of their workforce. Now they're finding out FDA isn't safe, either. Wrote about how keeping quiet isn't working My latest @opinion.bloomberg.com (gift link):

BREAKING: We are suing the Trump admin on behalf of our members for unlawfully cutting off $400 million in federal funding for crucial public health research to force Columbia University to surrender its academic independence. Stay Tuned.

23andMe just went bankrupt — which means everyone’s whole genome is about to be sold off to the highest bidder. If you’ve ever used 23andMe, delete your data ASAP. Instructions below. #youarebeingwatched oag.ca.gov/news/press-r...

🎉 Excited to share that my independent laboratory will start in Autumn 2025 at the University of Milan🇮🇹. We will study #RSV viral replication factories for novel #TPD antiviral strategies🦠🔬 📢 We're #hiring soon! 🙌 If interested in our science 🧬 and want to know more, feel free to drop us an email! 📩

🧪what with the demolition of #NIH funded #research, where, dare I ask, are our friends from #bigpharma? y'all good? mooched enough off of public-access NIH-funded research? Stocked up with PhD level scientists who were trained on NIH training grants to tide you over until Academia comes back?

Wow… this is an instant addition to next year’s molecular biology class!

The new Call for Access to services provided by the National Facilities of Human Technopole is online! Check out our *new services*! Fully funded access to services, including consumables, as well as complete access to HT and training (for services for which it is applicable)

Some positive news: Researchers have developed a simple blood test that can detect pancreatic cancer early, and save lives. Find out how it works @nature.com 🧪https://www.nature.com/articles/d41586-025-00438-z

Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify Sign the Petition: chng.it/kK2HMP5pGk "Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."

🎉 Thrilled to announce that after 5 years in Cambridge, I’m returning to Italy to start my own lab at the University of #Milan!🇮🇹 Funded by the Italian Science Fund, we’ll study viral replication factories for new antiviral strategies🦠🧬🔬 Postdoc positions openings soon🌟 Want to join? Get in touch! 📩

“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO

Interested in membrane proteins, biophysics, structures and hormone transport in plants?☘️🔬👩‍🔬🧪 Our new Plant-PATH center is launching soon, and we are looking for 1-2 PhD students to join from day 1.⭐ - Deadline 1. Feb 2025. - Details and application link: tinyurl.com/44hf9zkd Please repost 💚

We have an opening for a 4 yr PhD interested in membrane remodelling and cryo-EM/ET of a minimal cell division machinery: edu.nl/bukan You will be part of the EVOLF consortium in which 30 leading biochemists/biophysicists work together to explore if and how we can build autonomous synthetic cells.

If you're a postdoc looking for opportunities, we are recruiting another *19* new assistant professors with outstanding startup conditions, as part of the Data-Driven Life Science initiative In Sweden! Check out the people who started a year ago, and apply here: www.scilifelab.se/news/second-...

Considering a PhD in molecular biology? There’s still time to apply to join the LMB in October 2024. Applications close on 3rd DEC. Visit our website for more info: www2.mrc-lmb.cam.ac.uk/students/int...

300,000 women die from cervical cancer every year. But this is a cancer we can effectively eliminate with the HPV vaccine. This is something very few people know about. Article from my colleague @scientificdiscovery.dev: ourworldindata.org/hpv-vaccinat...

📣We are looking for an enthusiastic postdoctoral candidate to work on an interdisciplinary project combining Biochemistry of extremophiles and Structural Biology! 🤝The position will be held in collaboration with Donato Giovannelli and Vikas Trivedi ! 📩Contact: [email protected]

😱📣 BlueSky-ers: WE NEED YOUR HELP!!! 🙏 All of you who ever liked a lecture of mine... All of you who liked one of the courses I teach in... All of you I work(ed) with in one way or another... All of you who see my desperation! 😜 PLEASE re-post! 🙏 careers.humantechnopole.it/o/postdoc-in...

Worldwide, air pollution from burning fossil fuels is responsible for about 1 in 5 deaths It really doesn't have to be this way www.hsph.harvard.edu/c-change/new...

This is such a beautiful article: I don’t work on Archea, but this made me wish that I did🙂For sure it’s gonna be in my next Molecular Biology class as it wonderfully integrates many topics: mobile elements, methylation, restriction enzymes, virus-host interactions, CRISPR-Cas…WOW

🎉 Huge congratulations to Maryam Shakarami on graduating with top marks in her Master’s in Molecular Biology and Genetics from @DBB_UniPV! 🌟 #MolecularBiology

Ho firmato l’appello "La ricerca corre, non può aspettare la burocrazia" di @ass_coscioni. Fallo anche tu a questo link https://www.associazionelucacoscioni.it/landing/la-ricerca-corre-non-puo-aspettare-la-burocrazia...

Beautiful work adding key details on the biogenesis of secretory and membrane proteins by the translocon https://elifesciences.org/articles/95814

I reviewed the AlphaFold3 paper from DeepMind for the journal Nature. I tried really hard to get the editors to demand that DeepMind release the code (even an executable) so people could do the many high-throughput studies we saw for AF2 (see image from my review). I failed. So just a server 4 now.

👉🏽A proposal to boost the European Research Area (ERA) by including in the EU single market a “fifth freedom” for free movement of research, innovation, knowledge and...

In case you missed our April webinar with Brian Trippe on De novo design of protein structure and function with RFdiffusion., it is now available on the SBGridTV YouTube channel. www.youtube.com/watch?v=828W...