🥳 We are excited to share the first publication from the Bohlen Lab! "Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B but not T cell development and function" www.nature.com/articles/s41... together with the Tangye Lab and @bloodgenes.bsky.social and many more! 1/n

What protects some people from leukemia? Thrilled to share my work at @bloodgenes.bsky.social lab, now published in @science.org. We identify an inherited genetic variant that protects stem cells from blood cancers by reducing risk of CHIP. t.co/ExgWIJQe6y 🧵👇(1/n)

Already 53 phenomenal papers published in the @jhumimmunity.org ! Look it up and submit your best papers to the only journal focused on human inborn errors of immunity, their phenocopies, and related topics in human immunology: rupress.org/jhi

Human genetic influences on early B cell development. New review from Anna-Lena Neehus (@alneehus.bsky.social‬), Neil Romberg (@romberglab.bsky.social‬), and Vijay Sankaran (@bloodgenes.bsky.social‬) @bostonchildrens.bsky.social‬: rupress.org/jhi/article/...

@alneehus.bsky.social‬, @romberglab.bsky.social‬ and @bloodgenes.bsky.social‬ review how genetic variation impacts early B cell development, & discuss inherited rare variants & more common polymorphisms that predispose to B cell-related immune disorders & malignancies rupress.org/jhi/article/...

A must-read for anyone interested in human B cell physiology or pathology !

Delighted to have our work on Polygenic Modifiers of #TelomereBiologyDisorders, led by Michael Poeschla, @sashagusevposts.bsky.social, @mitchiela.bsky.social, @sharonsavage.bsky.social, @tummalalab.bsky.social, + co, published in @jclinical-invest.bsky.social today: www.jci.org/articles/vie...

📢📢Published today in @jem.org 📢📢 New human inborn error of immunity. We describe the first reported human with a monogenic disorder caused by the disruption of ZBTB7B, which encodes the transcription factor ThPOK. rupress.org/jem/article/... @ubcmedicine.bsky.social @bcchresearch.bsky.social

Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains @jem.org @casanovalab.bsky.social rupress.org/jem/article/...

Out today in @science.org! What if you could chart cells' regulatory programs at unprecedented resolution? In my work with Jorge Martin-Rufino from the @bloodgenes.bsky.social lab, we dissect the genome’s control circuits and find where key genetic variation hides bit.ly/3YhBMoO

What protects individuals from developing blood cancers? Thrilled to share my work in @bloodgenes.bsky.social lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇 (1/n) www.biorxiv.org/content/10.1...

1/ Our next stellar lab alumnus is @jonathanbohlen.bsky.social - a molecular biologist and a postdoc in our Paris lab from 2021-24 who is now a research group leader at the Gene Center at @lmumuenchen.bsky.social www.genzentrum.uni-muenchen.de/index.html

Fantastic to write this Spotlight piece for @cp-trendsmolecmed.bsky.social with @sshelton.bsky.social that covers an exciting recent @nejm.org study (www.nejm.org/doi/full/10....): authors.elsevier.com/a/1koWQ5Eb1B...

Journal of Human Immunity (JHI) @jhumimmunity.org is here! Read the inaugural editorial by @casanovalab.bsky.social outlining #JHI’s vision as the destination for groundbreaking research in human immunity and inborn errors of immunity. https://buff.ly/4hRGpOb #OpenAccess

🧬 Join Institut Imagine as a Junior Group Leader! - Junior Group Leader in Systems and Computational Biology - Junior Group Leader in RNA Biology and Epigenomics - Junior Group Leader in Artificial Intelligence for Genetics, Biology & Medicine To submit your application : lnkd.in/enm-U2tH

I am incredibly fortunate to be able to work with this amazing group @hhmi.bsky.social, @bostonchildrens.bsky.social, @danafarber.bsky.social, @harvardmed.bsky.social, @broadinstitute.org!!! 🙏🩸🧬

Excited to launch this new journal with a great team, and the support of both RUP and IAPIDS, and the entire community of human inborn errors of immunity !

The 2024 IUIS Inborn Errors of Immunity (IEI) Classification has arrived! Explore our latest insights now at www.iuis.org/committees/iei (link in bio). Find the report under “Annual 2024 Report”!

#WeekendRead! #LiveForever! Ramalingam Butler &co show @ #Science #Immunology that during #inflammaging thrombospondin-1 drives #interferon signatures & reduces detoxification pathways in hematopoietic stem cells causing loss of self-renewal, increased myeloid differentiation & systemic inflammation

Stem cell-like states confer poor outcomes in blood cancer—but what mechanisms drive this and how can they be therapeutically targeted? In our new preprint, we show how a single TF represses one enhancer to maintain a subset of high-risk leukemias: 🧵👇 www.biorxiv.org/content/10.1...

Delighted to have our work led by #RichardVoit from our group featured on the cover of #CellStemCell today. Artwork by the amazing @drawimpacts.bsky.social: www.cell.com/cell-stem-ce... Stay tuned as we work on initiating a clinical trial for this approach!

What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)? Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼