Ahmed Hassan (@ahmedhas.bsky.social)

The HIP mouse and all of its organs are completely invisible to allogeneic immune cells Hypoimmune (HIP) allogeneic cell therapeutics hold the promise to allow off-the-shelf treatments for a broad patient population. Our HIP approach includes the depletion of MHC class I and II molecules and the overexpression of Cd47. Here, we report the engineering of HIP mice that stably exhibit the HIP phenotype in all cell types. Parabiosis experiments were designed to broadly assess immune evasiveness of all HIP blood cells in fully allogeneic BALB/c mice. HIP blood cells did not induce any immune response and achieved stable engraftment in BALB/c mice. https://www.cell.com/iscience/fulltext/S2589-0042(24)02719-6