How can #AI help decode our #immune systems and help for next generation #diagnostics? Here is a technical overview from the @airr-community.bsky.social diagnostics working group on where we currently are on this problem: doi.org/10.1016/j.im...

Very proud to have been a jury member at the newly revived @iscb.bsky.social RSG Belgium hackathon! Exciting to see so many people giving their best efforts tackling challenging #bioinformatics problems!

The AIRR Diagnostics WG commentary is now available, wherein our members discuss both the challenges of current #AIRR-based #diagnostics, as well as the future directions that we see the field going into! www.sciencedirect.com/science/arti...

That's it. #ATCR25 is over! Thanks again to all attendees, speakers and support staff for making this an amazing meeting!

Last #ATCR25 speaker: Paul Thomas on deciphering the T cell receptor recognition code.

Fifth speaker on #ATCR25 day 2: Michael Birnbaum on high throughput TCR analysis and generation.

Fifth speaker, #ATCR25 day 2: Encarnita Mariotti-Ferrandiz on TCR repertoire signatures in auto immune and infectious disease.

Fourth speaker, #ATCR25 day 2: Hashem Koohy on decoding antigen-specific T cell recognition.

Third speaker, #ATCR25 day 2, Soumya Raychaudhuri on how the HLA affects the TCR repertoire, and how the TCR affects cell fate.

Second speaker, #ATCR25 day 2: Antonio Lanzavecchia on CD8 T cell immunodominance

First speaker, second #ATCR25 day: Mark Davis on analyzing the T cell response.

#ATCR25 short talk 8: Nicole Mifsud on the immune signatures of alloreactive T cells during transplantation rejection.

#ATCR25 short talk 7: Vincent Van Deuren on using TRIASSIC to identify convergent TCR clusters in the synovial fluid of rheumatoid arthritis patients.

#ATCR25 short talk 6: Orian Bricard on using TWISTAR to identify cognate cancer epitopes of a TCR of interest.

#ATCR25 short talk 5: Giancarlo Croce on using phage display screening to identify cancer-specific TCRs at the epitope level.

#ATCR25 short talk 4: Mikhail Pogorelyy on TIRTLseq for a cheaper paired TCR sequencing.

#ATCR25 short talk 3: Bjorn Kwee on the possibility that TCR-epitope prediction is poor because the underlying data has more false positives than commonly believed.

#ATCR25 short talk 2: Abi Colley on building a TCR-epitope data set capturing variability on both the TCR and epitope side to build an annotation model.

#ATCR short talk 1: Sofie Gielis on the influence of data on TCR-epitope predictions.

Fifth #ATCR25 speaker: @kischober.bsky.social on how T cell receptor avidity influences clonal expansion following antigen exposure in a "natural experiment" (vaccination)

Fourth #ATCR25 speaker: Dietmar Zehn on the formation of seemingly exhausted T cells during acute infections, with the theory that this is tied to the affinity of the TCR-pMHC interaction.

Third #ATCR25 talk by Hannah Meyer on using BATMAN to model the TCR cross reactivity space.

Second #ATCR25 talk by Johanna Olweus on using therapeutic TCR T cells to target cancer antigens

First #ATCR25 talk by Dirk Busch on the diversity and cross-reactivity of epitope-specific TCRs, which might be a redundancy of our immune system to anticipate escape mutations.

Ready to start the #ATCR25 meeting celebrating 10 years of the AUDACIS consortium with this amazing line-up of speakers!

#ATCR25 acceptance notifications just went out! We had 76 abstracts of very high quality, but could only accept 8 for short talks (so 10%). Huge thanks to our review committee for making though decisions. Really excited where the #TCR field is going based on the abstracts I saw!

#Abstract submission deadline for #ATCR2025 is this Friday! We are again very grateful to have such a strong lineup of #Tcell-receptor experts joining us in Antwerp. Currently at 80% capacity so do not wait to register. www.uantwerpen.be/atcr2025

Attending the public PhD defence of Sebastiaan Valkiers on the topic of: "Decoding the TCR landscape in MS" Jury members: @enkrnita.bsky.social @yvansaeys.bsky.social Bart Goethals Promoters: @krislaukens.bsky.social @pmeysman.bsky.social

Registration and abstract submission to ATCR2025 in May are now open! We have assembled a truly inspiring keynote lineup to discuss everything #T-cell-receptor! www.uantwerpen.be/atcr2025

Yellow4FLAVI's Bluesky account is now live!! #EUproject funded by @EU_HaDEA #HorizonEurope #Health Visit our website yellow4flavi.eu #flavivirus #yellowfever #vaccine #pandemic #zika #dengue #lifesciences #EUcooperation

Very excited that today the FWO granted my two #immunology #AI research projects! * One on modelling #Tcells after #vaccination with my good friend Benson Ogunjimi * One on mapping the human #MHC presentation space with the ever talented Wout Bittremieux

The annual gathering of #Antwerp bioinformatics at the @biomina.bsky.social Research Day kicked off by @krislaukens.bsky.social ! Always amazing to see how varied #bioinformatics applications are!

Unlocking the secrets of our immune system is like discovering hidden treasures in a library, where each book holds the key to better health. @pmeysman.bsky.social @cziscience.bsky.social www.science.org/doi/10.1126/... #ImmunoSky 🧪

Happy with the first official citation of ImmuneWatch DETECT in a publication 👇 ImmuneWatch DETECT finds the specificity of T cell receptor clusters in a new Science Advances paper www.immunewatch.com/news/immunew...

Our massive effort to recontextualize #single #T-cell data is now out in Science Advances! We developed a new system, STEGO, to do a TCR-first analysis, and reanalyzed 12 studies and more than 500 000 individual T-cells. Supported by @cziscience.bsky.social ! doi.org/10.1126/scia...

Why do TCR analysis tools (tcrdist, nettcr, etc) rely on substitution matrices made for evolution, like blosum? And could we improve them with a dedicated substitution matrix? academic.oup.com/bib/article/...

Calling all T-cell aficionado's. Come and join us next year (27-28 May 2025) for the fourth Antwerp T-Cell Receptor conference organised by @pmeysman.bsky.social, @krislaukens.bsky.social and Benson Ogunjimi. I'll also be there! www.uantwerpen.be/en/conferenc... #ImmunoSky