Barbara Pernaute
@bpernaute.bsky.social
📤 182
📥 183
📝 16
Developmental biologist. Group Leader
@cabd-upo-csic.bsky.social
reposted by
Barbara Pernaute
José Silva & Lab
about 2 months ago
Very happy to share the work of Huanhuan Li et al. While not a natural embryo, you might not have known that if I hadn’t told you. (1/3)
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reposted by
Barbara Pernaute
Jacob (Yaqub) Hanna - يعقوب حنا
about 2 months ago
1/n Fun journey continues: Our new
@cp-cellstemcell.bsky.social
paper out on how the Inherent & Dormant Plasticity of Mouse Naive PSCs can be "Exaggerated" to Directly form ~E8.5 Transgene-Free (TF) Mouse SEMs & WITHOUT inducing 8-16-Morula-like "Embryo Founder Cells".
www.cell.com/cell-stem-ce...
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Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and iPSCs
Hanna and colleagues show that signaling pathway modulation amplifies the inherent flexibility of genetically unmodified mouse naive PSCs to adopt extra-embryonic cell fate potential. This endows them...
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909%2825%2900262-0
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reposted by
Barbara Pernaute
Tugce Aktas
3 months ago
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
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Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology
Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...
https://www.nature.com/articles/s41580-025-00867-8
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reposted by
Barbara Pernaute
Aydan Bulut-Karslioglu
3 months ago
⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.
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reposted by
Barbara Pernaute
Esteban Hoijman
3 months ago
How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos. Check our story:
www.cell.com/cell-host-mi...
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reposted by
Barbara Pernaute
Centro Andaluz de Biología del Desarrollo
5 months ago
Los cursos de verano en
#olavidecarmona
son 🔝 Nuestras compañeras
@anafminan.bsky.social
, Sol Sotillos y
@proteolaura.bsky.social
organizan el curso ‘Modelos genéticos en investigación, de la bacteria al ratón’ dividido en dos partes! Info ⤵️
www.upo.es/formacionper...
www.upo.es/formacionper...
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🚨🚨#Hiring! 3 year
#postdoc
position open in my lab
@cabd-upo-csic.bsky.social
to study the interplay between DNA damage responses and
#preimplantation
embryo development. Fully funded by EARLYFATE
#ERCCoG
📆 Apply by 23rd May 2023 🔗Details below
@sebioldev.bsky.social
Please RT!🙏
5 months ago
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reposted by
Barbara Pernaute
Centro Andaluz de Biología del Desarrollo
5 months ago
🧐🧐🧐 Amazing course in Clinical Embryology 📍Santander 🗓️ July 28th-August 1st 💰4 scholarships available by
@sebioldev.bsky.social
Counts with great line up of speakers including
@bpernaute.bsky.social
from
#CABD
add a skeleton here at some point
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reposted by
Barbara Pernaute
Moreno-Mateos Lab
6 months ago
First seen in Biorxiv and now published and updated with more data in
@naturecomms.bsky.social
. With this work we have further enhanced CRISPR-Cas RNA targeting in vivo using transient approaches such as RNP or mRNA-gRNA in zebrafish embryos as vertebrate model.
www.nature.com/articles/s41...
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Enhanced RNA-targeting CRISPR-Cas technology in zebrafish - Nature Communications
CRISPR-Cas13 RNA-targeting systems comprise an invaluable set of tools in the fields of basic and applied sciences. Here, Moreno-Sánchez, Hernández-Huertas, and Nahón-Cano et al. enhanced the use of t...
https://www.nature.com/articles/s41467-025-57792-9?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20250316&utm_content=10.1038/s41467-025-57792-9
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reposted by
Barbara Pernaute
ME Torres-Padilla
7 months ago
Paper out !!🥳big thanks to all authors
@marliesoomen.bsky.social
@diego-rt.bsky.social
@kaessmannlab.bsky.social
@jonathangoeke.bsky.social
@lorenzamottes.bsky.social
& 'bluesky-less' Lots of interesting new TE (& genes) biology Data fully browsable💻 👉
embryo.helmholtz-munich.de/shiny_embryo/
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reposted by
Barbara Pernaute
Isabel Almudi
8 months ago
Happy to share our Slow cooked work together with
@mcgregorlab.bsky.social
,
@posnienlab.bsky.social
,
@nuneslab.bsky.social
sky.social
and Saad Arif and the collaboration of
@maikekittelmann.bsky.social
, Fernando Casares &
@laurensr.bsky.social
and many other friends
rdcu.be/d8whP
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Heterochrony in orthodenticle expression is associated with ommatidial size variation between Drosophila species
https://rdcu.be/d8whP
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reposted by
Barbara Pernaute
The OLoghlen LAB
8 months ago
Hello early researchers! Interesting in doing a PhD in senescence, ageing and cancer? We have an open position in our lab in Spain! Please retweet or reach out if interested!
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reposted by
Barbara Pernaute
Manuel Irimia
9 months ago
🚨🚨🚨 If you're a bioinformatician who loves: 🧬
#SingleCell
#LongReadSequencing
&
#AlternativeSplicing
🚀 Collaborating and travelling Apply to work with us at the spectacular BIMSB (
@mdc-berlin.bsky.social
) in Berlin +
@upf.edu
[email protected]
in Barcelona. Qs:
www.transdevolab.com
Please RT! 🙏
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reposted by
Barbara Pernaute
Srinivas Lab
10 months ago
Happy to share our latest review by
@shifaant.bsky.social
with
@cwhanna.bsky.social
. A detailed look at extraembryonic tissues – the 'other half' of the conceptus.
www.nature.com/articles/s41...
@natrevmcb.bsky.social
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Origin, fate and function of extraembryonic tissues during mammalian development - Nature Reviews Molecular Cell Biology
During mammalian embryogenesis, extraembryonic tissues are required for the patterning and morphogenesis of the embryo. This Review discusses how signalling networks and epigenetic modifications regul...
https://www.nature.com/articles/s41580-024-00809-w?utm_source=twitter&utm_medium=social&utm_campaign=nrm
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reposted by
Barbara Pernaute
Mireya Plass
10 months ago
Please RT: In my lab we are looking for computational
#postdoc
researchers to apply to a
#juandelacierva
or
#embo
postdoctoral fellowships to work on projects on post-transcriptional regulation on single-cell data (method development and/or data analysis). Contact me if you are interested!
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reposted by
Barbara Pernaute
Arnau Sebé-Pedrós
10 months ago
Honored and excited to receive an
#ERCCoG
grant. Big thanks to my colleagues, former mentors and, most importantly, my amazing lab members. Together, we will be exploring cell type evolution across timescales, from population variation (with
@xgrau.bsky.social
) to regulatory sequences across phyla.
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Really excited to share that I got an
#ERCCoG
The project EARLYFATE will explore the interplay between DNA damage responses and the very first events of mammalian embryo development. Huge thanks to all colleagues, former mentors and lab members for their help and support!
10 months ago
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reposted by
Barbara Pernaute
Isabel Almudi
10 months ago
Happy to share our latest work, together with the Casares lab, studying the outstanding regenerative capabilities of mayflies
royalsocietypublishing.org/doi/10.1098/...
@geneticsub.bsky.social
@irbio-ub.bsky.social
@cabd-upo-csic.bsky.social
@sebioldev.bsky.social
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Gill regeneration in the mayfly Cloeon uncovers new molecular pathways in insect regeneration | Open Biology
The capacity to regenerate lost organs is widespread among animals, and yet the number of species in which regeneration has been experimentally probed using molecular and functional assays is very sma...
https://royalsocietypublishing.org/doi/10.1098/rsob.240118
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reposted by
Barbara Pernaute
Teresa Rayon
10 months ago
2nd edition of the EMBO Workshop on Dev timing & evolution will take place in Paris. 6-9 May 2025. Save the date!!!
coming-soon.embo.org/w25-105
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reposted by
Barbara Pernaute
James Briscoe
10 months ago
Fascinating & unexpected from the Rodriguez lab on cell competition acting as a nutrient sensor Winner cells increase L-Proline uptake in losers, repressing their survival pathway (ISR) to kill them Explains old observations that starvation prevents competition
www.biorxiv.org/content/10.1...
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Sensing of extracellular L-Proline availability by the integrated stress response determines the outcome of cell competition.
Cell competition is a quality control acting from development to the adult that eliminates cells that are less-fit than their neighbours. How winner cells induce the elimination of losers during this ...
https://www.biorxiv.org/content/10.1101/2024.11.28.625863v1
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reposted by
Barbara Pernaute
Michelle Percharde
10 months ago
Happy to share our first
#bluetorial
& our latest
#preprint
, lead by postdoc
@paulchammas.bsky.social
. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state:
#TEsky
#MERVL
www.biorxiv.org/content/10.1...
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