McGregor Lab
@mcgregorlab.bsky.social
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Fly and Spider Evo Devo
http://mcgregor-evo-devo-lab.net/McGregor_lab/home.html
reposted by
McGregor Lab
Ella Preger 🎗️
12 days ago
Check out our new preprint on the evolution of enhancer loss. Turns out there are 50 ways to lose a function. We found four of them.
www.biorxiv.org/content/10.1...
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Distinct mechanisms decommission redundant enhancers to facilitate phenotypic evolution
The evolutionary loss of morphological traits is often driven by changes in gene regulation. Many developmental genes are controlled by multiple, redundant enhancers, raising the question of how robus...
https://www.biorxiv.org/content/10.1101/2025.10.27.684981v1
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McGregor Lab
Lauren Sumner-Rooney
23 days ago
Exciting times ahead - I'm beyond delighted to be joining
@bristolbiosci.bsky.social
in 2026! 🎉🕷️🎉🐌🎉 I'm also looking for a PhD student to join
@multipleye-lab.bsky.social
in our new home! Come and study the effects of light pollution on the evolution and development of spider eyes with us 🌃🕷️👀 👇
add a skeleton here at some point
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McGregor Lab
the Node
about 1 month ago
Applications are open for 10 ECR funded places at The Company of Biologists Workshop on 'Novelty, Co-option and Divergence During Gene Network Evolution', organised by James Hombría and Antónia Monteiro. 📅 Deadline: Friday 5 December Further information:
www.biologists.com/workshops/ju...
add a skeleton here at some point
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McGregor Lab
Julio Rozas
5 months ago
How did evolution drive massive genome contraction during oceanic island colonization? A new paper from our lab.
www.biorxiv.org/content/10.1...
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McGregor Lab
Richard Merrill
6 months ago
Interested in a PhD connecting sensory ecology and evolutionary genetics? Applications are now open for a project on the Speciation Genomics of Eye Size Variation in Heliconius Butterflies in our lab at LMU Munich:
www.evol.bio.lmu.de/research/mer...
Please repost!
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McGregor Lab
Chema Martin
8 months ago
🚨Registration for the UK
#EvoDevo
meeting is open! Join us on July 11th in London to enjoy an exciting day of talks, posters, friends, and superb science! -Registration (only £5!):
shorturl.at/9cQGL
-More info:
londonevodevo.ac.uk
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Very happy to have been part of this fantastic collaboration!
add a skeleton here at some point
8 months ago
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McGregor Lab
Neil Shubin
9 months ago
Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.
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Congrats on the paper! Really nice work!
add a skeleton here at some point
9 months ago
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McGregor Lab
Franck Pichaud
10 months ago
3D printed fly ommatidium generated by our Wellcome Optical biology PhD student Courtney Lancaster
@courtneyl7a7.bsky.social
@lmcb-ucl.bsky.social
@ucllifesciences.bsky.social
@wellcometrust.bsky.social
Visualising 3d bioimaging data !
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McGregor Lab
Gabriele Uhl
10 months ago
Very happy to share our paper on the sense of smell in spiders.
www.pnas.org/doi/10.1073/...
#chemicalecology
,
#pheromon
,
#sensoryorgans
#spiders
,
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PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
https://www.pnas.org/doi/10.1073/pnas.2415468121
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New preprint from our lab. Great work by
@maaseremedios.bsky.social
in collaboration with Ralf Janssen looking at gene regulation and expression after whole genome duplication by comparing a spider and harvestman:
www.biorxiv.org/content/10.1...
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Assessing the impact of whole genome duplication on gene expression and regulation during arachnid development
Whole genome duplication (WGD) generates new genetic material that can contribute to the evolution of the regulation of developmental processes and phenotypic diversification. A WGD occurred in an anc...
https://www.biorxiv.org/content/10.1101/2024.12.18.628675v1
11 months ago
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McGregor Lab
Evolution Letters
11 months ago
A shared developmental genetic basis for sexually antagonistic male and female adaptations in the toothed water strider
doi.org/10.1093/evle...
Now in
@evolletters.bsky.social
by Claudia Pruvôt et al.
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A shared developmental genetic basis for sexually antagonistic male and female adaptations in the toothed water strider
Abstract. Sexual conflict can drive the divergence of male and female phenotypes and cross-species comparative analyses have documented patterns of correla
https://doi.org/10.1093/evlett/qrae056
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McGregor Lab
Hosken Lab Cornwall
11 months ago
Postdoc @ evol-lab. A Leverhulme funded 3-year postdoc studying body shape evolution (through a sexual conflict lens) on Exeter's Penryn (UK) campus. Starts April 2025. Contact David Hosken @ U of Exeter for detail.
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McGregor Lab
Maike Kittelmann
11 months ago
Great opportunity to do a
#PhD
with me! Think
#Drosophila
#eyes
are fun to work with? Love to do
#microscopy
? Want to look into organ size regulation and evolution? Maybe even in a pest species? Get in touch and check out how to apply via Oxford Brookes University:
tinyurl.com/37h7pudv
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Oxford Brookes Helps Train Future Science Leaders - Oxford Brookes University
Oxford Brookes partners with leading institutions to train the next generation of researchers addressing global challenges in life and environmental sciences.
https://tinyurl.com/37h7pudv
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McGregor Lab
Shen Tian 田申
11 months ago
Our miRNA story is now in
@science.org
! We found a microRNA, not a protein, that finally solved a long-standing evolutionary mystery of wing coloration in butterflies and moths. (1/n)
www.science.org/doi/10.1126/...
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A microRNA is the effector gene of a classic evolutionary hotspot locus
In Lepidoptera (butterflies and moths), the genomic region around the gene cortex is a “hotspot” locus, repeatedly implicated in generating intraspecific melanic wing color polymorphisms across 100 mi...
https://www.science.org/doi/10.1126/science.adp7899
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McGregor Lab
Mari Museridze
12 months ago
What better way to start on 🦋 than by sharing our new publication?
www.science.org/doi/10.1126/...
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Entangled and non-modular enhancer sequences producing independent spatial activities
Regulatory mapping at a developmental gene reveals an unexpected architecture of entangled, rather than modular, enhancers.
https://www.science.org/doi/10.1126/sciadv.adr9856
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McGregor Lab
Zoë Schultz
12 months ago
Come look at some cute spider embryos with stunning 🧬expression with me! This gene is very exciting, and will be a major part of my PhD research! Watch this space for new updates🔬
@mcgregorlab.bsky.social
#EvoDevo
#Biology
#phdlife
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McGregor Lab
Jen Perry
12 months ago
A really exciting new study: evidence that males evolve better sight in order to detect female dishonesty in dance flies. One for the textbooks! A male resistance trait! Great one from @rosalindmurray @luc_bussiere @dtgwynne & team
academic.oup.com/evolut/advan...
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Sexually antagonistic coevolution can explain female display signals and male sensory adaptations
Abstract. The prevalence and diversity of female ornaments pose a challenge to evolutionary theory because males should prefer mates that spend resources o
https://academic.oup.com/evolut/advance-article/doi/10.1093/evolut/qpae133/7777002
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New review on the evolution of insect male terminalia I wrote with Daniela Nunes:
www.cell.com/trends/genet...
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Developmental evolution in fast-forward: insect male genital diversification
Insect male genitalia are among the fastest evolving structures of animals. Studying these changes among closely related species represents a powerful approach to dissect developmental processes and g...
https://www.cell.com/trends/genetics/fulltext/S0168-9525(24)00256-7
12 months ago
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McGregor Lab
Amber Ridgway 🪰
12 months ago
@mcgregorlab.bsky.social
and I had the pleasure of writing a dispatch article discussing the latest work from
@gavinrrice.bsky.social
and
@rebeizlab.bsky.social
. You can find it over on this link:
www.sciencedirect.com/science/arti...
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reposted by
McGregor Lab
Rich Meisel
12 months ago
If you're interested in the evolution of sex determination, check out this opinion piece from Tom Kocher,
@tonygamble.bsky.social
,
@behrenskristen.bsky.social
, Will Gammerdinger, and me. We argue that genetic variation in sex determination is probably more prevalent that most people think.
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Yes, polygenic sex determination is a thing!
The process of sexual development in animals is modulated by a variety of mechanisms. Some species respond to environmental cues, while, in others, sex determination is thought to be controlled by a s...
https://www.cell.com/trends/genetics/fulltext/S0168-9525(24)00237-3
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McGregor Lab
Amber Ridgway 🪰
about 1 year ago
Drosophila and IF staining folks: any recommendations for antibody generation companies? I would also be looking to get the company (or a different company) to express and purify the target antigen too. Thanks in advance!!
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McGregor Lab
James Briscoe
about 1 year ago
Analysis of implications for science spend of UK budget Appears worst fears of folding in Horizon Europe/ERC budget are not going to happen
www.sciencecampaign.org.uk/analysis-and...
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CaSE responds to the 2024 Autumn Budget - CaSE
https://www.sciencecampaign.org.uk/analysis-and-publications/detail/case-responds-to-the-2024-autumn-budget/
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McGregor Lab
Amber Ridgway 🪰
about 1 year ago
Such a wonderful piece of research! Great work yet again by
@gavinrrice.bsky.social
and the
@rebeizlab.bsky.social
lab
add a skeleton here at some point
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McGregor Lab
Vivek Nityananda
about 1 year ago
Job Alert! New postdoc position in our lab investigating cognitive biases in wild bumblebees. Thanks to Wild Animal Initiative for the funding. Position for 31 months. Deadline: December 9th. Please apply/boost
#PostdocJob
#AcademicJobs
#Bees
jobs.ncl.ac.uk/job/Newcastl...
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McGregor Lab
Rachel C Thayer
about 1 year ago
Our paper, identifying all the cell types in the Drosophila melanogaster female reproductive tract (uterus, female-limited glands, sperm storage organs) is out today! We used single-nuclei RNA sequencing and a lot of in situ cross-validation
www.pnas.org/doi/10.1073/pnas.2409850121
🪰 🧬🧪 1/n
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McGregor Lab
bioRxivpreprint
about 1 year ago
Temperature affects conspecific and heterospecific mating rates in Drosophila https://www.biorxiv.org/content/10.1101/2024.10.28.620639v1
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Temperature affects conspecific and heterospecific mating rates in Drosophila https://www.biorxiv.org/content/10.1101/2024.10.28.620639v1
Behavioral mating choices and mating success are important factors in the development of reproductiv
https://www.biorxiv.org/content/10.1101/2024.10.28.620639v1
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McGregor Lab
Mark Rebeiz
about 1 year ago
Our new @CurrentBiology paper provides a rare glimpse into a morphological novelty in Drosophila eugracilis In it, @gavinrrice and colleagues, infer and reproduce the likely initial steps of a novelty's formation
www.sciencedirect.com/science/arti...
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McGregor Lab
Todd Oakley
about 1 year ago
I am thrilled to announce publication of a new paper led by Seth Frazer, showing we can accurately predict opsin phenotypes from their gene sequences
academic.oup.com/gigascience/...
🧪
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https://academic.oup.com/gigascience/article/doi/10.1093/gigascience/giae073/7845193
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McGregor Lab
bioRxiv Genetics
about 1 year ago
Contextualising transcription factor binding during embryogenesis using natural sequence variation https://www.biorxiv.org/content/10.1101/2024.10.24.619975v1
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Contextualising transcription factor binding during embryogenesis using natural sequence variation https://www.biorxiv.org/content/10.1101/2024.10.24.619975v1
Understanding how genetic variation impacts transcription factor (TF) binding remains a major challe
https://www.biorxiv.org/content/10.1101/2024.10.24.619975v1
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McGregor Lab
Amber Ridgway 🪰
about 1 year ago
If that wasn’t exciting enough, feast your eyes on the C15 stain in the developing female terminal - very fitting for the Halloween season. Have fun reading! Thank you
@mcgregorlab.bsky.social
for the support and guidance during this project. It was a blast!
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Our new pre-print exploring the role and interactions of leg patterning genes in developing Drosophila terminalia - great work by
@amberridgway.bsky.social
add a skeleton here at some point
about 1 year ago
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McGregor Lab
Robert Reed
about 1 year ago
Check out this new perspective article on cis-regulatory evolution by Reed Lab grad student Jeanne McDonald!
www.sciencedirect.com/science/arti...
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Beyond modular enhancers: new questions in cis-regulatory evolution
Our understanding of how cis-regulatory elements work has advanced rapidly, outpacing our evolutionary models. In this review, we consider the implica…
https://www.sciencedirect.com/science/article/abs/pii/S0169534724001708
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McGregor Lab
Luisa F. Pallares
over 1 year ago
Couple of days left to apply for our postdoc position! If you want to chat in person, I will be at
#TAGC24
#PEQG24
next week
add a skeleton here at some point
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McGregor Lab
James Briscoe
over 1 year ago
Commentary summarising current state of the
#DevBio
field with concrete proposals & a call to action - Increase organismal diversity - Improve funding (& support reviewing) - Encourage new entrants to the field - Support data sharing & public outreach
journals.biologists.com/dev/article/...
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Daniela Nunes is looking for a Postdoc/Postgrad Research Associate to work on our BBSRC funded Project to understand organ size specification and evolution. To join our team submit your application here by March 3rd:
www.jobs.ac.uk/job/DFR180/p...
Please re-post.
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Postdoctoral/Postgraduate Research Associate at Oxford Brookes University
Looking for a new job opportunity in academia? Check out this job opening for a Postdoctoral/Postgraduate Research Associate on jobs.ac.uk!
https://www.jobs.ac.uk/job/DFR180/postdoctoral-postgraduate-research-associate
over 1 year ago
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McGregor Lab
Patrícia Beldade
over 1 year ago
Fresh out of the academic oven, new paper with Elvira Lafuente & David Duneau. Developmental plasticity, body pigmentation, temperature effects, Drosophila melanogaster, and lots of genes. What is there not to like?
onlinelibrary.wiley.com/doi/10.1111/...
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Looking forward to discussing this really excellent paper in our lab JournalPub today at the Victoria:
elifesciences.org/articles/90846
over 1 year ago
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McGregor Lab
Vivek Nityananda
almost 2 years ago
🧪New paper with Théo Robert and Karolina Tarapata finally out! 🎉🎉 Learning modifies attention during bumblebee visual search Read more here:
link.springer.com/article/10.1...
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Learning modifies attention during bumblebee visual search - Behavioral Ecology and Sociobiology
Abstract The role of visual search during bee foraging is relatively understudied compared to the choices made by bees. As bees learn about rewards, we predicted that visual search would be modified t...
https://link.springer.com/article/10.1007/s00265-024-03432-z
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McGregor Lab
Amber Ridgway 🪰
almost 2 years ago
What a week!! Defended my thesis and I am now Dr Ridgway (don’t think it’s settled in just yet) and our paper has been published today in Current Biology! Thank you
@mcgregorlab.bsky.social
for an incredible PhD experience and all authors who helped shape this paper into a great story 🪰🪰
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Sox21b underlies the rapid diversification of a novel male genital structure between Drosophila spec...
Ridgway et al. show that the transcription factor Sox21b represses the size of the posterior lobes of male Drosophila genitalia. Sox21b expression differs during posterior lobe development between D....
https://www.cell.com/current-biology/fulltext/S0960-9822(24)00022-8
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Congratulations to
@amberridgway.bsky.social
on successful defence of her great PhD thesis yesterday and publication of her cool new paper today in Current Biology on the role of Sox21b in the rapid diversification of a novel male genital structure:
www.cell.com/current-biol...
almost 2 years ago
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McGregor Lab
Maike Kittelmann
almost 2 years ago
I am looking for a PhD student to work on Drosophila eye development and genetic regulation. We have funded Nigel Groome studentships here at Oxford Brookes University and a great collaborative fly community. Deadline is 26th January. More info here:
tinyurl.com/2m4v546v
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Congratulations Nico! That is really great news!
add a skeleton here at some point
almost 2 years ago
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reposted by
McGregor Lab
Lauren Sumner-Rooney
almost 2 years ago
This work was led by Luis Baudouin Gonzalez, myself, and
@mcgregorlab.bsky.social
, with help from Anna Schoenauer, Amber Harper, Daniel Leite, @POMSteinhoff, @Pechmann_M, @saadarif81, Valeriia Telizhenko, Atal Pande @multipleye_lab & Carolin Kosiol, funded by @LeverhulmeTrust at @morethanadodo
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Very happy to have been part of this cool work comparing eye development across spiders. Beautiful in situs by Luis Baudouin Gonzalez in a range of spiders and well done to all other authors. Many thanks to
@laurensr.bsky.social
for all her amazing work leading the study and the paper.
add a skeleton here at some point
almost 2 years ago
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McGregor Lab
Sebastian Kittelmann
almost 2 years ago
Want to understand how Hox proteins interact with each other and their co-factors to specify cell fate? Interested in nuclear receptors and how they control transcription? Want to do your PhD in a supportive and collaborative environment? Check
tinyurl.com/3udpv43x
or
tinyurl.com/588rh7ws
and DM me.
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PhD in The Oxford Interdisciplinary Bioscience Doctoral Training Partnership at Oxford Brookes Unive...
We offer 2 places on the BBSRC funded DTP in the areas of plant cell biology, mammalian cell biology, molecular biology, parasitology and bioimaging.
http://tinyurl.com/588rh7ws
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McGregor Lab
Sebastian Kittelmann
almost 2 years ago
Several positions opening in my lab and the Centre for Functional Genomics at Oxford Brookes: - 2 PhD positions via the Oxford Bioscience DTP - a fully funded PhD in my lab, co-supervised by Darren Williams, KCL - a research tech position (0.5 FTE) to help tagging Drosophila transcription factors
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McGregor Lab
Sebastian Kittelmann
almost 2 years ago
Interested in how hormone binding changes the interactions of hormonal receptors and influences target gene expression? Co-supervised by Darren Williams (KCL), this PhD project will look particularly into how hormones influence neurodevelopment. More details at
tinyurl.com/ykumzvzh
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Unravelling Context-Specific Hormonal Control of Gene Expression in Drosophila at Oxford Brookes Uni...
PhD Project - Unravelling Context-Specific Hormonal Control of Gene Expression in Drosophila at Oxford Brookes University, listed on FindAPhD.com
http://tinyurl.com/ykumzvzh
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