Dual-Antigen Membranous Nephropathy doi.org/10.1016/j.kint.2025.10.006 #NephSky #MedSky #membranousnephropathy @mayoclinicpath.bsky.social @arkanalabs.bsky.social @lynncornell.bsky.social @aaronstorey.bsky.social

Research suggests Clonal hematopoiesis of indeterminate potential (CHIP) may contribute to CKD and its comorbidities, necessitating additional research. https://bit.ly/JASN0739 @drflashheart.bsky.social @pnatarajanmd.bsky.social @zhiyu.bsky.social #ASNJASN

Interesting case of AL-amyloidosis, kappa type. IF showed clear kappa restriction(pictured); amyloid A IHC was very strong but mass spec confirmed AL-k amyloid (patient has a k-plasma cell dyscrasia). Never seen so much non-specific AA staining before. Mass spec FTW. #renalpath #pathsky #nephsky

A polyoma virus 'crescents' in a case of BK nephropathy in a kidney transplant patient. SV40 demonstrates parietal epithelial cell positivity on deeper levels. BK viremia >3 million recently. #renalpath #pathsky #nephsky

Intra-capillary occlusive basophilic polymer "emboli" caught incidentally in the allograft biopsy of a patient with longstanding peripheral vascular disease (PVD) who purportedly had a recent procedure for PVD treatment while on a visit to another country.

The IKMG 7th International meeting will be held September 26-27th, 2025 in Lisbon, Portugal. To see the preliminary program & register for the meeting by September 19, 2025, please visit: ikmg2025.com Early bird pricing ends June 1, 2025 #pathsky #nephsky #medsky

Save the Date for the 6th International Renal Pathology Conference in Antigua, Guatemala, February 11-14, 2026! Chair:Carmen Avila @asnkidney.bsky.social @theisn.org @kidney.org @csnscn.bsky.social @ukkidney.org @senefrologia.bsky.social @sfndt.bsky.social @oegn.bsky.social #pathsky #nephsky #medsky

Hematuria is an undisputable biomarker of IgAN, although with "insufficient specificity" #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/28739649/

Pt with CMML & subnephrotic proteinuria & renal dysfunction Extramedullary hematopoiesis •Hematopoietic tissue outside BM •Due to hematologic malignancy/lack BM hematopoiesis (HP) •Histology: TIN + trilineage HP #renalpath #pathsky #nephsky #hemepath

Are you a patient with Alport syndrome? The 2025 In-Person Alport Connect meeting will be in Chicago on July 19-20th. Child and teen programming available. See you there! alportsyndrome.org/for-patients...

Happy to share our publication on a case of Minimal Change Podocytopathy with coexisting Thin Basement Membrane following exposure to Semaglutide @juancarlosqvelez.bsky.social karger.com/gdz/article/...

The autoimmune architecture of childhood idiopathic #nephroticsyndrome doi.org/10.1016/j.kint.2024.10.027 #KIMiniReview #OpenAccess #NephSky #SkyNeph #MedSky

Interested in learning about the CRLF2 assay by flow cytometry, and perhaps performing it in your lab? Check out this module from the International Clinical Cytometry Society for tips! #HemePath #FlowCytometry #FlowEdu

1st case on BlueSky - Acute cryoglobulinemic GN in an adult patient with elevated HCV viral load and positive HCV RNA; Immunofluorescence shows positive cryo staining for IgG, IgM (IgM>IgG), C3, kappa and lambda; EM image shows fragmented cryo within capillary loop with swollen endothelial cell.

Nice review on the cross talk between glomeruli and tubules and the complex interplay between them that underlies progressive kidney injury. From two of my fantastic colleagues Dr. Harris and Dr. Fogo! @vumc-insights.bsky.social www.nature.com/articles/s41...

New (FREE) on the #AJKDBlog: Timothy Yau interviews Dr. Anuja Java about Clinical Genetic Testing in Nephrology: Core Curriculum 2024 https://bit.ly/3VtjcZp

Interested in onconephrology? Here is an interesting study reporting renal biopsies with anticancer drug use: registry data from 🇯🇵: interstitial nephritis and TMA most common with cancer chemotherapy, GN often in association with immune checkpoint inhibitors academic.oup.com/ckj/article/...

Absence of proteinuria may not be trustworthy evidence that IgAN treatment is working. #iganephropathy #igan #kidneywk #kidneydisease #nephsky

The photomicrograph shows glomerular tuft retraction with markedly corrugated glomerular basement membranes and periglomerular fibrosis. (1/2)

Diagnosis, management and treatment of the #Alport syndrome – 2024 #guideline on behalf of ERKNet, ERA and ESPN #nephsky academic.oup.com/ndt/advance-...

Another relatively common finding in lupus nephritis EM evaluation. Cytoplasmic myelin bodies most likely related to hydroxychloroquine effect. In this case present in rare endothelial cell. Some vague laminated structures in tubular lysosomes as well. #renalpath #nephrology #pathsky #nephsky

"Obesity defined by high BMI is highly prevalent in people with CKD, and patients have health, health care, and social disparity" "...G3-4 with a BMI ≥30 appeared to have a higher risk of CKD progression and ... CKD G5D with BMI ≥30 kg/m2 were less likely to receive transplant" shorturl.at/hoWXj

The final version of our paper www.nejm.org/doi/10.1056/... One APOL1 risk variant is associated with CKD & FSGS. We have a solid basis for new mechanistic studies in our journey to find durable cure for APOL1 KD @opeyemiolabisi.bsky.social @kidneyomicsamps.bsky.social @genetickidneydoc.bsky.social

CKD, proteinuria, Crohn's disease. KBx w/focally granulomatous tubulointerstitial nephritis and IgAN. Common findings in IBD patients (pubmed.ncbi.nlm.nih.gov/38344742/). Pt on TNFa inhibitor (pubmed.ncbi.nlm.nih.gov/36706240/) also reported IgAN/TIN associations. #renalpath #pathsky #nephrology.

Explore our response to “Predictors of Kidney Recovery in Acute Interstitial Nephritis.”The findings emphasize the critical role of a pre biopsy diagnosis by maintaining a high index of suspicion for AIN @wisit661.bsky.social www.kireports.org/article/S246...

www.hematology.org/education/tr... Constantine Kanakis, MD and I attempt to give #pathsky and #hemesky a primary for the bone marrow biopsy!

Was great fun to talk to @nephrosparks.bsky.social about digenic Alport syndrome. Give it a listen!

Is it a faux pas to recycle a Tweet/X post here..? Somethings are worth say twice! Delighted to be involved in CAR-T trial in lupus. Better treatment v much needed in our patients with kidney disease. CAR-T and autoimmunity- watch this space! #NephSky #HaemSky www.uclh.nhs.uk/news/uclh-an...

Reminder that EM is still useful even when no gloms available. Example case of light chain deposition disease. IF highly suspicious with kappa restriction along tubular basement membranes; EM was helpful to confirm the diagnosis: powdery deposits on TBMs. #renalpath #nephrology #pathsky

Interesting case of ANCA GN apparently triggered by COVID infection. Also showed concurrent membranous features with MPO+(IHC below) IgG (IF below) deposits as has been described: www.sciencedirect.com/science/arti.... #renalpath #nephrology #pathsky

🫘🧬Complement testing in patients with C3 Glomerulopathy doi.org/10.1093/ndt/... @ndt journal

Classic case of kidney biopsy in a patient with Fabry disease. Foamy podocyte and tubular cytoplasm. Myelin inclusions in lysosomes by EM (no gloms for EM; but tubules still useful). #renalpath #nephrology #pathsky

An algorithmic approach to genetic 🧬 testing in patients with FSGS 🔬 and implications in adult patients ca. 2024 #Nephpearls 👉 pubmed.ncbi.nlm.nih.gov/38765809/

If you are wondering where the latest kidney.wiki feature drop is I have spent a solid 60 minutes over the past two days pretending to be a bison chasing and headbutting my 2 year old (per his incessant demands - "mo' bis'!), so, I'm working on it?

Study screening urine samples from patients with lupus nephritis revealed that urinary calgranulin B, MCP-1, and IGFBP-5 levels could specifically predict the severity of active glomerular lesions, interstitial inflammation, and interstitial fibrosis, respectively In A&R acr.tw/4egRPcI 🩺