There is still time to register for the QBI Multiplex Image Analysis and Computational Pathology workshop! Details below.

I will arrive at your therapeutic area with a molecule so chiral, so offensive to your multi-parameter optimization algorithm, that your model will flag it as “not drug-like.” It will then proceed to work, in vivo. inpreparation.substack.com/p/go-ahead-a...

From Segmentation to Pipelines: AI-Assisted Bioimage Analysis with Python 21-24 September 2026, Erasmus MC Rotterdam (The Netherlands) Application deadline: 25 July 2026 More information & signing up: courses.microscopie.nl?event_id=527

Announcing a Multiplex Image Analysis and Computational Pathology workshop through the Quantitative BioImaging Society Talks on cell segmentation and phenotyping, data normalization, spatial analysis, and more! Hosted by @lji.org in San Diego, CA, Sept. 15-16 quantitativebioimaging.com/miacp2026/

25 minutes of Photuris tremulans fireflies in Tennessee's smoky mountains.

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

The world’s largest sand battery got through Finland’s harshest winter in years. 2,000 tonnes of sand, heated to 500-600°C by cheap power, feeding district heating in Pornainen. And it worked. Result from one install: oil down 100%, emissions down 70%. Industrial process heat is the real prize.

More about the Cowlitz Tribe's beaver relocation program, which is among the largest in the West. "Beavers are amazing ecosystem engineers and create high-quality, complex wetland habitats that support biodiversity and ecosystem properties that can help buffer projected impacts of climate change.”

Birdsky! I need advice. This little bird has been sitting unnaturally still near my back door, and didn't even move when my kid excitedly banged on the glass. It's def alive, but I think not healthy? Is there anything I can do to help it?

I just called my reps with @5calls.org, you should too: 5calls.org

Absolutely incredible Nutella ad.

Last week I shared results showing large variability between Imaris/Arivis/Aivia vs Python/ImageJ/CellProfiler. Much was due to small code issues (x/y swaps, microns vs pixels). After fixing, results are much closer—no big log-scale gaps. Some variability remains, but large errors weren’t real.

Well this is maddening

Love is in the air at Edinburgh zoo. Pebbling marks the start of the breeding season for Gentoo penguins. Kids at Edinburgh Children's Hospital Charity painted pebbles for the penguins to choose from and present to their mates.

Cool, useful, project. www.sciencedetective.org/scientific-d...

Good morning from the harbor seal factory! We got several working harbor seal families ready to challenge the establishment! Here you can see a mother teaching their baby about the union. Get em started young! #UnionsForAll #SealSky 🦭 🦑

Videos are now available from the 2025 QuPath Training Course, from @iamichaelnelson.bsky.social, @zmikulski.bsky.social, and myself. Watch for multiplex tutorials! For image analysis inspiration! Or just watch to hear me speak like an overcaffeinated squirrel! www.youtube.com/playlist?lis...

🔬 🖥️ Applications are open for the CSHL course Quantitative Imaging: From Acquisition to Analysis (April 6–21, 2026)! An intensive, hands-on course covering advanced fluorescence microscopy and quantitative image analysis using open-source tools. 🗓️ Apply online by Jan 30, 2026

Quantitative Fluorescence Microscopy 2026: Registration Open! An international course in #fluorescence #microscopy and imaging for advanced grad students, postdoc trainees, imaging core managers and researchers who are incorporating the technology into their laboratories. 🧪 🐟🎸 🍎 👩‍🔬 🌎 🖥️ 🧬

Holy CRAP. Retired engineer takes random pics of *kids*, without consent or attribution, bins them into “autistic” or “not autistic”, and uploads that “data” for free on Kaggle. Well over a HUNDRED papers are published, 38 in Springer Nature, 25 in IEEE, using it. And no reviewers objected? WTF.🧪

XXL NEWS! Greg and Alex are coming to America in January 2026 to spread the word of the Taskmaster. Shows in Chicago, Boston, Philadelphia, Washington D.C. and New York! Sign up to the mailing list for pre-sale access. taskmaster.tv/taskmaster-l...

Science works

"Runctitiononal features"? "Medical fymblal"? "1 Tol Line storee"? This gets worse the longer you look at it. But it's got to be good, because it was published in Nature Scientific Reports last week: www.nature.com/articles/s41... h/t @asa.tsbalans.se

Fifteen Years xkcd.com/3172/

Python notebook from a two year old paper: Oh, no, I cannot run, there is a slight mismatch of a logging library. ImageJ plugin from 2001 running on Quantum Java 51 in 2078: Your 100 petabyte temporal hologram was successfully thresholded.

Just 4 days until the start of I2K and its 33 totally free image analysis tutorials and events! Please share with your "home networks", especially early career researchers - the videos will be amazing and high-impact no matter how many people attend live, BUT (1/x)

California – this Election Day, vote yes on Prop 50. California’s Prop 50 says that if Republicans are going to abuse the system to try and hang onto power, we’re going to counteract that abuse and create a level playing field in the midterm elections. Make a plan to vote yes on Prop 50.

Took my daughter to one of the San Diego No Kings rallies, because even she knows that you have to stand up and say No to bullies.

Wouldn’t it be cool if this photo of Obama receiving his Noble Peace Prize went viral today? 🔄

I'm thrilled to share that our work studying microglia morphological changes in early Alzheimer's in mice is up! www.biorxiv.org/content/10.1...

We are thrilled to announce that our NEW Large Language Model will be released on 11.18.25.

While I’m at it: You guys know what to do!! youtu.be/jPCJIB1f7jk?...

Happy Fluorescence Friday! Rainbow Z projection of lymph node follicular dendritic cells.

Who say what now?!! BLUEY THE MOVIE?!! #bluey #myChildWillBeTooOldButIllStillGo www.bluey.tv/blog/date-an...

I got this in my head and I couldn't focus on work until it existed. Microscopy image file alignment chart, based on how I feel if you give me an image to analyze:

Ready to automate your #microscopy #imageanalysis tasks? Applications are now open for our next "Introduction to Image Analysis" training course, in London at the @crick.ac.uk on October 27th-28th, 2025! 🔬💻 More info ⬇️ www.crick.ac.uk/whats-on/int...

It's not just #NIH. It's not just #NSF. It's not just #NASA. The whole scientific community has to make clear that all science across fed agencies is being destroyed in the US. We can't just ask for our particular piece of the pie. The whole pie is being thrown out - saving your bit won't work.

Every flashbang could instead be a meal for a poor kid. Every hotel room for a National Guardsman deployed to fire at our neighbors could house a homeless vet. Every "less-than-lethal" bullet pulled from a journalist's eye could be already needed healthcare for anyone else. All of this is a choice.

It's not that we might lose our jobs. It's that all of it will disappear or mutate beyond recognition. I worry we're not talking or thinking enough about this deeper sadness hiding behind our immediate anxieties and it's this heaviness that has us all at a breaking point.

Cleansing the timeline with video from the Cincinnati Zoo & Botanical Garden.

🚀 Tired of manual image analysis or scared of scripting? Our self-paced “ImageJ Macro Scripting for Automatic Image Analysis” course makes automation easy—no coding experience needed! Start from scratch & build pro-level macros. www.biovoxxel.de/individual-w... #ImageJ #MacroScripting

Bioimaging and bioimage analysis friends, some help if you have 2-3 mins; for a paper, we're trying to estimate the number of biologists trained in open source software or tools in the last ~5 years. (1/2) #bioimaging #microscopy #bioimageanalysis

WATCH: Elephants at the San Diego Zoo Safari Park react to Monday's 5.2 magnitude earthquake that shook San Diego County. The elephants formed an "alert circle" meant to protect the young and the entire herd from any threats, according to the San Diego Zoo Wildlife Alliance.

Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.

If you train people in ImageJ, Fiji, whatever, even if it isn't your day job, please let us know, and please share this post! Thanks a ton, we really appreciate it. (2/2) forms.gle/C8dUpg8qZkbD... #bioimaging #microscopy #bioimageanalysis

This is high art

We can upload 3 minute videos now. YOU KNOW THE RULE

Everyone knows about the time Sen Cory Booker literally rescued a woman from a burning building, right? And helped a freezing dog and shoveled snow for disabled constituents? There's a reason we called him Super Mayor!

In 25 years of covering national security, I’ve never seen a story like this: Senior Trump officials discussed planning for the U.S. attack on Yemen in a Signal group--and inadvertently added the editor-in-chief of The Atlantic. www.theatlantic.com/politics/arc...

The actions by Columbia University- first asking police to come violently end student protest, and now allowing students to be illegally arrested and threatened with deportation for exercising their first amendment rights- make me embarrassed to be an alum.