Shaheen Sikandar
@ssikandar.bsky.social
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Assistant Professor, UC - Santa Cruz Cancer and stem cell biologist! www.sikandarlab.com
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Shaheen Sikandar
Rob Clarke
6 days ago
Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause. Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts:
urldefense.com/v3/__https:/...
Brilliant team science
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Anti-progestin therapy targets hallmarks of breast cancer risk
Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...
https://urldefense.com/v3/__https://rdcu.be/eOqrx__;!!PDiH4ENfjr2_Jw!HpCkacdjlh1gXOv02IAWFgfMLJnnPyhaDOKmmkMoL41COINEPZh-osC4KeQIMnx_mPBkaSfNUqY_zzJH1_ki-J8-U_ZH-c66WCRxEKhZrP2B$
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Shaheen Sikandar
Aguirre-Ghiso Lab
about 1 month ago
Are 90% of cancer-related deaths due to metastasis? Apparently the overuse of this percentage in reviews has created confusion and questioning of whether this is true. The answer, which is as always cancer type dependent, may be in these references that also people claim they cannot find.
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Shaheen Sikandar
Aguirre-Ghiso Lab
about 1 month ago
Delighted to host Dr. Javier Bravo Cordero at our Cancer Dormancy Institute Seminar Series. Don't miss his exceptional work!
@cdi-einstein.bsky.social
@einsteinmededu.bsky.social
@einsteincellbio.bsky.social
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Shaheen Sikandar
Camila dos Santos
about 2 months ago
Are you looking for a reliable strategy to quantify the architecture of mammary tissue using whole mount images?? Well, maybe you should check MaGNet, our new computational based and user friendly approach (and you probably can adapt it to other organs as well).
link.springer.com/article/10.1...
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MaGNet: A Network-Based Method for Quantitative Analysis of the Mammary Ductal Tree in Developing Female Mice - Journal of Mammary Gland Biology and Neoplasia
The mammary gland is a uniquely dynamic organ with a branching architecture that develops entirely after birth in response to hormonal cues. A common approach in mammary gland biology is the evaluation of branching morphogenesis to characterize the role of developmental, physiological and molecular perturbations on branching tissue invasion, growth, and maintenance. Yet, the field still lacks a fully open-sourced, quantitative framework to analyze whole-mount mammary tissue images, as a commonly utilized methodology. Here, we present MaGNet (Mammary Gland Network analysis tool), a method that leverages network theory to characterize key features of ductal branching during mammary gland development. Applying this pipeline to mammary gland images captured at three pubertal timepoints, we achieved reproducible quantification of ductal tree expansion across development. In addition, this network analysis pipeline captures ductal expansion induced by pregnancy hormones. By providing open-source tools to the research community, this method may increase reproducibility and broad applicability across diverse organ systems, model organisms, and developmental stages.
https://link.springer.com/article/10.1007/s10911-025-09589-1
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Shaheen Sikandar
BrunetLab
about 2 months ago
Interesting in aging, immune function, and organ health? Join us for a super exciting joint Keystone Symposia in Banff, Canada in March 2026!!
@ericverdin.bsky.social
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So proud of my graduate student Andrew Olander, who received his NIH/NCI F31 fellowship to study how early pregnancy affects the aging of mammary epithelial cells! Earlier this year, it felt like the odds were against us, but it finally came in! 🍾
#BreastCancer
#aging
#stemcells
2 months ago
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www.cell.com/neuron/abstr...
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Social interaction in mice suppresses breast cancer progression via a corticoamygdala neural circuit
Wen et al. reveal that social interaction reduces breast cancer progression by activating ACCGlu→BLAGlu circuits, inhibiting intratumoral sympathetic activity. This neural mechanism enhances antitumor...
https://www.cell.com/neuron/abstract/S0896-6273(25)00509-4
3 months ago
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Shaheen Sikandar
bioRxiv Cell Biology
3 months ago
Directional cell motility facilitates side-branching in the mammary epithelium in a tension-sensitive manner
https://www.biorxiv.org/content/10.1101/2025.07.30.667704v1
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www.nature.com/articles/s41...
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Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature
Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...
https://www.nature.com/articles/s41586-025-09332-0
3 months ago
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Shaheen Sikandar
Narita Lab
4 months ago
Spread the news! We are excited to expand our research team, working on cellular senescence, at the Cancer Research UK Cambridge Institute, University of Cambridge.
jobs.cam.ac.uk/job/52026/
jobs.cam.ac.uk/job/52027/
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Shaheen Sikandar
Nature
6 months ago
Some types of cell are more likely than others to give rise to tumours. A rapid cell cycle is a newly identified predictor of cancer susceptibility.
https://go.nature.com/42WjSd1
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The cell-division cycle is faster in cell types prone to forming cancer
Some types of cell are more likely than others to give rise to tumours. A rapid cell cycle is a newly identified predictor of cancer susceptibility.
https://go.nature.com/3GAgqwZ
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reposted by
Shaheen Sikandar
Journal of Clinical Investigation
7 months ago
Mitochondrial transfer between bone marrow cells! Avital Mendelson & team show mitochondrial transfer from megakaryocytes to bone marrow mesenchymal stromal cells lowers platelet activation and the process is disrupted in sickle cell disease:
buff.ly/Q1HGsUY
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Shaheen Sikandar
bioRxiv Cell Biology
7 months ago
Progesterone Receptor Expressing Basal Cells and Progesterone Receptor-Primed Progenitors Redefine the Mammary Epithelial Hierarchy
https://www.biorxiv.org/content/10.1101/2025.04.16.648786v1
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Shaheen Sikandar
Sounak Sahu
10 months ago
Excited to share our latest study in
@nature.com
We used a humanized-mouse ES cell model to explore the functional consequences of all possible BRCA2 missense variants. We've clinically classified >6,500 variants and >1,200 reported in ClinVar!
www.nature.com/articles/s41...
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Saturation genome editing-based clinical classification of BRCA2 variants - Nature
CRISPR–Cas9-based saturation genome editing in a humanized mouse embryonic stem cell line was used for comprehensive functional characterization of single nucleotide variants in a region of BRCA2, and...
https://www.nature.com/articles/s41586-024-08349-1
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reposted by
Shaheen Sikandar
Biancastella Cereser
11 months ago
Hi! This is a brief summary of our favourite work 🧬 - we described the mutational landscape of the healthy human breast and determined differences in clone size and mutations between parous (mothers) and nulliparous women. Have a read here
@naturecomms.bsky.social
! 🔬
www.nature.com/articles/s41...
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reposted by
Shaheen Sikandar
Emilia Peuhu
8 months ago
Please repost ☺️🙏
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news.ucsc.edu/2025/03/bell...
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Student-built app slashes weeks off brain mapping to speed up neuroscience research
UC Santa Cruz neuroscientists aiming to better understand how specific brain connectivity contributes to perception, thoughts, and behavior are leveraging artificial intelligence to enhance their stud...
https://news.ucsc.edu/2025/03/bell-jar-brain-mapping.html
8 months ago
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Shaheen Sikandar
Nature Cancer
8 months ago
Betty Kim & Wen Jiang and colleagues report the design and characterization of an antibody–toxin conjugate targeting CD47, promoting anti-tumor immunity in preclinical cancer models.
@bettykimmdphd.bsky.social
@wenjiang-nano.bsky.social
@mdanderson.bsky.social
⬇️
www.nature.com/articles/s43...
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An antibody–toxin conjugate targeting CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy - Nature Cancer
Schrank et al. report the design and characterization of an antibody–toxin conjugate targeting CD47, promoting anti-tumor immunity in preclinical cancer models.
https://www.nature.com/articles/s43018-025-00919-0?utm_source=twitter&utm_medium=social&utm_campaign=natcancer
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Shaheen Sikandar
UC Santa Cruz Science
8 months ago
What would federal funding cuts do to a community's local economy, its people, & the next generation? UC Santa Cruz Science Professors Needhi Bhalla, Susan Carpenter, & Carol Greider state it plainly and painfully in yesterday's Santa Cruz Sentinel article.
www.santacruzsentinel.com/2025/03/20/g...
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Guest Commentary | Trump is turning off the lights on biomedical research: Why it matters for Santa Cruz
“These cuts aren’t just about UCSC; they’re about Santa Cruz,” writes Needhi Bhalla, Susan Carpenter and Carol Greider in a Guest Commentary. “This crucial NIH support fuels our l…
https://www.santacruzsentinel.com/2025/03/20/guest-commentary-trump-is-turning-off-the-lights-on-biomedical-research-why-it-matters-for-santa-cruz/
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